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Clifford J. Garratt – One of the best experts on this subject based on the ideXlab platform.

  • Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels.
    Heart rhythm, 2017
    Co-Authors: Yawer Saeed, Ian P. Temple, Zoltan Borbas, Andrew Atkinson, Joseph Yanni, Michal Maczewski, Urszula Mackiewicz, Mariam Aly, Sunil Jit R. J. Logantha, Clifford J. Garratt
    Abstract:

    Background Aging is associated with an increased incidence of atrioventricular nodal (AVN) dysfunction. Objective The aim of this study was to investigate the structural and functional remodeling in the atrioventricular junction (AVJ) with aging. Methods Electrophysiology, histology, and immunohistochemistry experiments on male Wistar Hannover rats aged 3 months (n = 24) and 2 years (n = 15) were performed. Atrio-His (AH) Interval, Wenkebach cycle length (WBCL), and AVN effective refractory period (AVNERP) were measured. Cesium (2 mM) was used to block hyperpolarization-activated cyclic nuclnucleotide–gated (HCN) channels, while ryanodine (2 μM) was used to block ryanodine 2 (RyR2) channels. Protein expression from different regions of the AVJ was studied using immunofluorescence. The expression of connexins (connexin 43 and connexin 40), ion channels (Hyperpolarization-activated cyclic nuclnucleotide-gated channel 4 (HCN4), voltage sensitive sodium channel (Na v 1.5), and L-Type calcium channel (Ca v 1.3)), and calcium handling proteins (RyR2 and sarco/endoplasmic retireticulum calcium ATPaset type 2a (SERCA2a)) were measured. Morphological characteristics were studied with histology. Results Without drugs to block HCN and RyR2 channels, there was prolongation of the AH Interval, WBCL, and AVNERP ( P P P v 1.5, and RyR2 downregulate in the regions of the AVJ and connexin 40, SERCA2a, and Ca v 1.3 upregulate ( P Conclusion Heterogeneous ion channel expression changes were observed in the AVJ with aging. For the first time, we have shown that HCN and RyR2 play an important role in AVN dysfunction with aging.

  • Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels.
    Heart rhythm, 2017
    Co-Authors: Yawer Saeed, Ian P. Temple, Zoltan Borbas, Andrew Atkinson, Joseph Yanni, Michal Maczewski, Urszula Mackiewicz, Mariam Aly, Sunil Jit R. J. Logantha, Clifford J. Garratt
    Abstract:

    Background Aging is associated with an increased incidence of atrioventricular nodal (AVN) dysfunction. Objective The aim of this study was to investigate the structural and functional remodeling in the atrioventricular junction (AVJ) with aging. Methods Electrophysiology, histology, and immunohistochemistry experiments on male Wistar Hannover rats aged 3 months (n = 24) and 2 years (n = 15) were performed. Atrio-His (AH) Interval, Wenkebach cycle length (WBCL), and AVN effective refractory period (AVNERP) were measured. Cesium (2 mM) was used to block hyperpolarization-activated cyclic nuclnucleotide–gated (HCN) channels, while ryanodine (2 μM) was used to block ryanodine 2 (RyR2) channels. Protein expression from different regions of the AVJ was studied using immunofluorescence. The expression of connexins (connexin 43 and connexin 40), ion channels (Hyperpolarization-activated cyclic nuclnucleotide-gated channel 4 (HCN4), voltage sensitive sodium channel (Nav1.5), and L-Type calcium channel (Cav1.3)), and calcium handling proteins (RyR2 and sarco/endoplasmic retireticulum calcium ATPaset type 2a (SERCA2a)) were measured. Morphological characteristics were studied with histology. Results Without drugs to block HCN and RyR2 channels, there was prolongation of the AH Interval, WBCL, and AVNERP (P Conclusion Heterogeneous ion channel expression changes were observed in the AVJ with aging. For the first time, we have shown that HCN and RyR2 play an important role in AVN dysfunction with aging.

Yoshio Hatano – One of the best experts on this subject based on the ideXlab platform.

Yawer Saeed – One of the best experts on this subject based on the ideXlab platform.

  • Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels.
    Heart rhythm, 2017
    Co-Authors: Yawer Saeed, Ian P. Temple, Zoltan Borbas, Andrew Atkinson, Joseph Yanni, Michal Maczewski, Urszula Mackiewicz, Mariam Aly, Sunil Jit R. J. Logantha, Clifford J. Garratt
    Abstract:

    Background Aging is associated with an increased incidence of atrioventricular nodal (AVN) dysfunction. Objective The aim of this study was to investigate the structural and functional remodeling in the atrioventricular junction (AVJ) with aging. Methods Electrophysiology, histology, and immunohistochemistry experiments on male Wistar Hannover rats aged 3 months (n = 24) and 2 years (n = 15) were performed. Atrio-His (AH) Interval, Wenkebach cycle length (WBCL), and AVN effective refractory period (AVNERP) were measured. Cesium (2 mM) was used to block hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, while ryanodine (2 μM) was used to block ryanodine 2 (RyR2) channels. Protein expression from different regions of the AVJ was studied using immunofluorescence. The expression of connexins (connexin 43 and connexin 40), ion channels (Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4), voltage sensitive sodium channel (Na v 1.5), and L-Type calcium channel (Ca v 1.3)), and calcium handling proteins (RyR2 and sarco/endoplasmic reticulum calcium ATPaset type 2a (SERCA2a)) were measured. Morphological characteristics were studied with histology. Results Without drugs to block HCN and RyR2 channels, there was prolongation of the AH Interval, WBCL, and AVNERP ( P P P v 1.5, and RyR2 downregulate in the regions of the AVJ and connexin 40, SERCA2a, and Ca v 1.3 upregulate ( P Conclusion Heterogeneous ion channel expression changes were observed in the AVJ with aging. For the first time, we have shown that HCN and RyR2 play an important role in AVN dysfunction with aging.

  • Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels.
    Heart rhythm, 2017
    Co-Authors: Yawer Saeed, Ian P. Temple, Zoltan Borbas, Andrew Atkinson, Joseph Yanni, Michal Maczewski, Urszula Mackiewicz, Mariam Aly, Sunil Jit R. J. Logantha, Clifford J. Garratt
    Abstract:

    Background Aging is associated with an increased incidence of atrioventricular nodal (AVN) dysfunction. Objective The aim of this study was to investigate the structural and functional remodeling in the atrioventricular junction (AVJ) with aging. Methods Electrophysiology, histology, and immunohistochemistry experiments on male Wistar Hannover rats aged 3 months (n = 24) and 2 years (n = 15) were performed. Atrio-His (AH) Interval, Wenkebach cycle length (WBCL), and AVN effective refractory period (AVNERP) were measured. Cesium (2 mM) was used to block hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, while ryanodine (2 μM) was used to block ryanodine 2 (RyR2) channels. Protein expression from different regions of the AVJ was studied using immunofluorescence. The expression of connexins (connexin 43 and connexin 40), ion channels (Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4), voltage sensitive sodium channel (Nav1.5), and L-Type calcium channel (Cav1.3)), and calcium handling proteins (RyR2 and sarco/endoplasmic reticulum calcium ATPaset type 2a (SERCA2a)) were measured. Morphological characteristics were studied with histology. Results Without drugs to block HCN and RyR2 channels, there was prolongation of the AH Interval, WBCL, and AVNERP (P Conclusion Heterogeneous ion channel expression changes were observed in the AVJ with aging. For the first time, we have shown that HCN and RyR2 play an important role in AVN dysfunction with aging.

Jin Long Huang – One of the best experts on this subject based on the ideXlab platform.

Keisuke Fujii – One of the best experts on this subject based on the ideXlab platform.