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Alanine Aminotransferase

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Steven E Kahn – 1st expert on this subject based on the ideXlab platform

  • contribution of metabolic factors to Alanine Aminotransferase activity in persons with other causes of liver disease
    Gastroenterology, 2005
    Co-Authors: George N Ioannou, Noel S Weiss, Edward J Boyko, Steven E Kahn


    Background & Aims: Nonalcoholic fatty liver disease has been defined by the presence of hepatic steatosis in the absence of other chronic liver diseases. We sought to determine whether obesity, insulin resistance, and the metabolic syndrome, which are the main risk factors for nonalcoholic fatty liver disease, are associated with similar elevations in serum Alanine Aminotransferase activity in persons with and those without other causes of chronic liver disease. Methods: Adult participants of the third National Health and Nutrition Examination Survey were divided into those with causes of chronic liver disease (n = 1037), defined as viral hepatitis, excessive alcohol consumption, or increased transferrin-iron saturation, and those without (n = 8004). Results: Among persons with other causes of chronic liver disease, obesity (adjusted odds ratio, 4.9; 95% confidence interval, 2.5–9.4), insulin resistance (adjusted odds ratio, 6.8; 95% confidence interval, 3.0–15.5, comparing the highest and the lowest quartile), and the metabolic syndrome (adjusted odds ratio, 3.3; 95% confidence interval, 1.4–8.0) were all strongly associated with increased Alanine Aminotransferase activity (>43 IU/L). Among persons without other causes of chronic liver disease, statistically similar associations were identified. Conclusions: Obesity, insulin resistance, and the metabolic syndrome are strong predictors of increased Alanine Aminotransferase activity in the US population, both in persons with and in persons without other causes of chronic liver disease. We hypothesize that metabolic fatty liver disease related to these conditions is the cause of the increased Alanine Aminotransferase activity and may be underrecognized in persons with other causes of chronic liver disease.

Robert J Heine – 2nd expert on this subject based on the ideXlab platform

  • liver Alanine Aminotransferase insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus
    European Journal of Clinical Investigation, 2005
    Co-Authors: Roger K Schindhelm, Michaela Diamant, Stephan J L Bakker, R A J M Van Dijk, Peter G Scheffer, Tom Teerlink, P J Kostense, Robert J Heine


    Background Plasma levels of liver transaminases, including Alanine Aminotransferase (ALT), are elevated in most cases of nonalcoholic fatty liver disease (NAFLD). Elevated ALT levels are associated with insulin resistance, and subjects with NAFLD have features of the metabolic syndrome that confer high-risk cardiovascular disease. Alanine Aminotransferase predicts the development of type 2 diabetes (DM2) in subjects with the metabolic syndrome. However, the role of elevated ALT levels in subjects with overt DM2 has yet not been explored. Materials and methods In a cross-sectional study, 64 normotriglyceridaemic subjects with DM2 were studied with regard to the relation between liver transaminases with whole-body insulin sensitivity, measured with the euglycaemic hyperinsulinaemic clamp and with brachial artery flow-mediated dilation (FMD) as a marker of endothelial dysfunction. Results On average, patients were normotriglyceridaemic (plasma triglycerides 1.3 +/- 0.4 mmol L-1) and had good glycaemic control (HbA1c 6.2 +/- 0.8%). The mean ALT level was 15.0 +/- 7.5 U L-1, and the mean aspartate Aminotransferase concentration equalled 10.6 +/- 2.6 U L-1. Alanine Aminotransferase levels were negatively associated with whole-body insulin sensitivity as well as with FMD (both P = 0.03, in multivariate analyses; regression coefficients beta [95%CI]: -0.76 [-1.4 to -0.08] and -0.31 [-0.58 to -0.03] respectively). Conclusions In metabolically well-controlled patients with DM2, ALT levels are related to decreased insulin-sensitivity and an impaired conduit vessel vascular function.

Mindie H Nguyen – 3rd expert on this subject based on the ideXlab platform

  • serum Alanine Aminotransferase and hepatitis b dna flares in pregnant and postpartum women with chronic hepatitis b
    The American Journal of Gastroenterology, 2016
    Co-Authors: Christine Y Chang, Natali Aziz, Mugilan Poongkunran, Asad Javaid, Huy N Trinh, Mindie H Nguyen


    Serum Alanine Aminotransferase and Hepatitis B DNA Flares in Pregnant and Postpartum Women with Chronic Hepatitis B

  • histological disease in asian americans with chronic hepatitis b high hepatitis b virus dna and normal Alanine Aminotransferase levels
    The American Journal of Gastroenterology, 2009
    Co-Authors: Mindie H Nguyen, Huy N Trinh, Ruel T Garcia, Gerald Weiss, Huy A Nguyen, Khanh K Nguyen, Emmet B Keeffe


    Histological Disease in Asian-Americans With Chronic Hepatitis B, High Hepatitis B Virus DNA, and Normal Alanine Aminotransferase Levels