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Zhongliang Chen – One of the best experts on this subject based on the ideXlab platform.

  • New steroid saponins from the seeds of Allium tuberosum L.
    Food Chemistry, 2003
    Co-Authors: Shengmin Sang, Aina Lao, Shi-long Mao, Zhongliang Chen
    Abstract:

    Abstract Eight new steroidal saponins, including four spirostanol, three furostanol and one cholesterol saponin, have been isolated from the seeds of Allium tuberosum . On the basis of acid hydrolysis and comprehensive spectroscopic analyses, their structures were established as tuberoside N , (25 S )-5β-spirostan-2β, 3β-diol 3- O -β- d -glucopyranosyl-(1→2)-[α- l -rhamnopyranosyl (1→4)]-β- d -glucopyranoside; tuberoside O , (25 S )-5β-spirostan-2β, 3β, 5-triol 3- O -β- d -glucopyranoside; tuberoside P , (25 S )-5β-spirostan-2β, 3β, 5-triol 3- O -α- l -rhamnopyranosyl (1→4)-β- d -glucopyranoside; tuberoside Q , (24 S , 25 S )-5β-spirostan-2β, 3β, 5, 24-tetraol 3- O -α- l -rhamnopyranosyl (1→4)-β- d -glucopyranoside; tuberoside R , 26- O -β- d -glucopyranosyl-(25 S )-5β-furost-20(22)-ene-2β, 3β, 5, 26-tetraol 3- O -β- d -glucopyranoside; tuberoside S , 26- O -β- d -glucopyranosyl-(25 S )-5β-furost-20(22)-ene-3β, 26-diol 3- O -β- d -glucopyranosyl-(1→2)-[α- l -rhamnopyranosyl (1→4)]-β- d -glucopyranoside; tuberoside T , 26- O -β- d -glucopyranosyl-(25 S )-5α-furost-20(22)-ene-3β, 26-diol 3- O -α- l -rhamnopyranosyl (1→2)-[α- l -rhamnopyranosyl (1→4)]-β- d -glucopyranoside and tuberoside U , 16- O -β- d -glucopyranosyl-(22 S , 25 S )-cholest-5-ene-3β, 16β, 22, 26-tetraol 3- O -α- l -rhamnopyranosyl (1→2)-[α- l -rhamnopyranosyl (1→4)]-β- d -glucopyranoside, respectively.

  • Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum.
    Journal of Asian natural products research, 2002
    Co-Authors: Shengmin Sang, Aina Lao, Min-liang Zou, Xiong-wen Zhang, Zhongliang Chen
    Abstract:

    Tuberoside M ( 1 ), isolated from the seeds of Allium tuberosum , shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC 50 value of 6.8 u w g/ml. On the basis of spectral data and chemical reaction, its structure was established as (25 S )-5 g; -spirostane-1 g; ,3 g; -diol 3- O – f; – l -rhamnopyranosyl-(1 M 4)- g; – d -glucopyranoside.

  • new spirostanol saponins from chinese chives Allium tuberosum
    Journal of Agricultural and Food Chemistry, 2001
    Co-Authors: Shengmin Sang, Zhongliang Chen, Chitang Ho
    Abstract:

    Three new spirostanol saponins have been isolated from the seeds of Allium tuberosum. On the basis of acid hydrolysis and comprehensive spectroscopic analysis, their structures were established as tuberoside J, (25R)-5α-spirostan-2α,3β,27-triol 3-O-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside; tuberoside K, (25R)-5α-spirostan-2α,3β,27-triol 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranoside; and tuberoside L, 27-O-β-d-glucopyranosyl-(25R)-5α-spirostan-2α,3β,27-triol 3-O-α-d-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranoside. Keywords: Allium tuberosum; Liliaceae; spirostanol saponins, tuberosides J, K, and L

Shengmin Sang – One of the best experts on this subject based on the ideXlab platform.

  • New steroid saponins from the seeds of Allium tuberosum L.
    Food Chemistry, 2003
    Co-Authors: Shengmin Sang, Aina Lao, Shi-long Mao, Zhongliang Chen
    Abstract:

    Abstract Eight new steroidal saponins, including four spirostanol, three furostanol and one cholesterol saponin, have been isolated from the seeds of Allium tuberosum . On the basis of acid hydrolysis and comprehensive spectroscopic analyses, their structures were established as tuberoside N , (25 S )-5β-spirostan-2β, 3β-diol 3- O -β- d -glucopyranosyl-(1→2)-[α- l -rhamnopyranosyl (1→4)]-β- d -glucopyranoside; tuberoside O , (25 S )-5β-spirostan-2β, 3β, 5-triol 3- O -β- d -glucopyranoside; tuberoside P , (25 S )-5β-spirostan-2β, 3β, 5-triol 3- O -α- l -rhamnopyranosyl (1→4)-β- d -glucopyranoside; tuberoside Q , (24 S , 25 S )-5β-spirostan-2β, 3β, 5, 24-tetraol 3- O -α- l -rhamnopyranosyl (1→4)-β- d -glucopyranoside; tuberoside R , 26- O -β- d -glucopyranosyl-(25 S )-5β-furost-20(22)-ene-2β, 3β, 5, 26-tetraol 3- O -β- d -glucopyranoside; tuberoside S , 26- O -β- d -glucopyranosyl-(25 S )-5β-furost-20(22)-ene-3β, 26-diol 3- O -β- d -glucopyranosyl-(1→2)-[α- l -rhamnopyranosyl (1→4)]-β- d -glucopyranoside; tuberoside T , 26- O -β- d -glucopyranosyl-(25 S )-5α-furost-20(22)-ene-3β, 26-diol 3- O -α- l -rhamnopyranosyl (1→2)-[α- l -rhamnopyranosyl (1→4)]-β- d -glucopyranoside and tuberoside U , 16- O -β- d -glucopyranosyl-(22 S , 25 S )-cholest-5-ene-3β, 16β, 22, 26-tetraol 3- O -α- l -rhamnopyranosyl (1→2)-[α- l -rhamnopyranosyl (1→4)]-β- d -glucopyranoside, respectively.

  • Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum.
    Journal of Asian natural products research, 2002
    Co-Authors: Shengmin Sang, Aina Lao, Min-liang Zou, Xiong-wen Zhang, Zhongliang Chen
    Abstract:

    Tuberoside M ( 1 ), isolated from the seeds of Allium tuberosum , shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC 50 value of 6.8 u w g/ml. On the basis of spectral data and chemical reaction, its structure was established as (25 S )-5 g; -spirostane-1 g; ,3 g; -diol 3- O – f; – l -rhamnopyranosyl-(1 M 4)- g; – d -glucopyranoside.

  • new spirostanol saponins from chinese chives Allium tuberosum
    Journal of Agricultural and Food Chemistry, 2001
    Co-Authors: Shengmin Sang, Zhongliang Chen, Chitang Ho
    Abstract:

    Three new spirostanol saponins have been isolated from the seeds of Allium tuberosum. On the basis of acid hydrolysis and comprehensive spectroscopic analysis, their structures were established as tuberoside J, (25R)-5α-spirostan-2α,3β,27-triol 3-O-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside; tuberoside K, (25R)-5α-spirostan-2α,3β,27-triol 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranoside; and tuberoside L, 27-O-β-d-glucopyranosyl-(25R)-5α-spirostan-2α,3β,27-triol 3-O-α-d-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranoside. Keywords: Allium tuberosum; Liliaceae; spirostanol saponins, tuberosides J, K, and L

Min Yin – One of the best experts on this subject based on the ideXlab platform.

Opeyemi Joshua Olatunji – One of the best experts on this subject based on the ideXlab platform.

  • Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia induced oxidative stress and inflammation in high fat diet streptozotocin treated rats
    Biomedicine & Pharmacotherapy, 2019
    Co-Authors: Lihua Guo, Opeyemi Joshua Olatunji, Feng Liu, Min Yin
    Abstract:

    Abstract The objective of this study was to evaluate the effect of the butanol fraction from Allium tuberosum (BFAT) in high fat diet/streptozotocin (HFD/STZ) induced diabetic nephropathy. Wistar rats were fed with HFD for 4 weeks and thereafter administered with 35 mg/kg STZ intraperitoneally. Diabetic rats were treated with BFAT (100 or 400 mg/kg) and metformin (150 mg/kg) for 40 days. After treatment, the blood, urine and kidney tissues were obtained for biochemical and histological analysis. BFAT markedly decreased blood glucose, serum creatinine, blood urea nitrogen and urinary albumin levels in diabetic rats. Furthermore, BFAT upregulated renal antioxidant enzymes status (glutathione, superoxide dismutase and catalase) and decreased lipid peroxidation product in diabetic rats as well as reduced the levels of renal pro-inflammatory cytokines in diabetic rats. In addition, BFAT significantly decreased serum and renal levels of triglyceride and cholesterol in the treated diabetic rats. These results revealed that A. tuberosum possesses attenuative effects against diabetic nephropathy.

  • Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and inflammation in high fat diet/streptozotocin treated rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019
    Co-Authors: Lihua Guo, Opeyemi Joshua Olatunji, Feng Liu, Min Yin
    Abstract:

    Abstract The objective of this study was to evaluate the effect of the butanol fraction from Allium tuberosum (BFAT) in high fat diet/streptozotocin (HFD/STZ) induced diabetic nephropathy. Wistar rats were fed with HFD for 4 weeks and thereafter administered with 35 mg/kg STZ intraperitoneally. Diabetic rats were treated with BFAT (100 or 400 mg/kg) and metformin (150 mg/kg) for 40 days. After treatment, the blood, urine and kidney tissues were obtained for biochemical and histological analysis. BFAT markedly decreased blood glucose, serum creatinine, blood urea nitrogen and urinary albumin levels in diabetic rats. Furthermore, BFAT upregulated renal antioxidant enzymes status (glutathione, superoxide dismutase and catalase) and decreased lipid peroxidation product in diabetic rats as well as reduced the levels of renal pro-inflammatory cytokines in diabetic rats. In addition, BFAT significantly decreased serum and renal levels of triglyceride and cholesterol in the treated diabetic rats. These results revealed that A. tuberosum possesses attenuative effects against diabetic nephropathy.

  • Allium tuberosum: Antidiabetic and hepatoprotective activities
    Food research international (Ottawa Ont.), 2017
    Co-Authors: Xingli Tang, Opeyemi Joshua Olatunji, Yifeng Zhou, Xilin Hou
    Abstract:

    Allium tuberosum (AT) is traditionally used for treating nocturnal emissions, abdominal pain, diarrhea, sexual dysfunction and asthma. This study aimed at investigating the antidiabetic and hepatoprotective activities of the butyl alcohol fraction from the methanolic extract of A. tuberosum. For the antidiabetic activity, rats were induced with diabetes by intraperitoneal injection of 150mg/kg alloxan and treated for 30days with AT extract (100, 200 and 400mg/kg). Animals were sacrificed after the study and the fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), HDL, malondialdehyde (MDA) catalase, superoxide dismutase and glutathione levels were determined. The hepatoprotective assay, mice were pretreated for seven days with AT (100, 200 and 400mg/kg) and silymarin (100mg/kg or). Thereafter 10ml/kg of 2% v/v CCl4 was administered intraperitoneally on the 7th day to induce acute liver injury. Blood and liver samples were obtained and serum enzymes ALT, AST, ALP, SOD, GSH, CAT, MDA and pro-inflammatory mediators were assessed. AT significantly decrease FBG, serum TG, TC, MDA levels and significant increased HDL, SOD, GSH and CAT activities in the diabetic rats. In addition, AT significantly inhibited MDA, IL-1b, IL-6 and TNF-α levels and prevented the depletion of the antioxidant enzymes GSH, SOD and CAT activities in CCl4 induced liver damage. Furthermore, AT markedly reduced AST, ALT and ALP levels in the CCl4 treated mice groups. In conclusion, the antidiabetic and hepatoprotective effect of AT may be associated with its antioxidant and its ability to inhibit the pro-inflammatory mediators.

Kwon-il Seo – One of the best experts on this subject based on the ideXlab platform.

  • effects of thiosulfinates isolated from Allium tuberosum l on the growth of human cancer cells
    Journal of The Korean Society of Food Science and Nutrition, 2009
    Co-Authors: Sunyoung Park, Ki-hun Park, Jae-yong Kim, Kyungwuk Park, Kapsuk Kang, Kwon-il Seo
    Abstract:

    To develop Allium tuberosum L. as a cancer preventive food material, thiosulfinates and biological active components were isolated from Allium tuberosum L. and the apoptotic effects of thiosulfinates in human cancer cells were examined. Thiosulfinates decreased viable cell numbers in dose- and time-dependent manners. Thiosulfinates at the 20 /mL concentration inhibited more than 60% cell proliferation in HepG2 and A549 human cancer cells, respectively. Also the morphology of cells treated with thiosulfinates of 30 /mL concentration was distorted with shrunken cell mass while the cell number was lower than that of control cells. The values in the HepG2 cells were higher than those of the A549 cells. Thiosulfinates at the 30 /mL concentration showed the formation of apoptotic bodies and a nuclear condensation, and an increase in the cell populations of the sub-G1 phase in the HepG2 cells. These results indicate that thiosulfinates from Allium tuberosum L. inhibited cell proliferation in HepG2 via apoptosis.

  • Mechanisms of thiosulfinates from Allium tuberosum L. – induced apoptosis in HT-29 human colon cancer cells.
    Toxicology letters, 2009
    Co-Authors: Ju-hye Lee, Kyoung-wuk Park, Il-yun Jeong, Koji Yamada, Hee-sun Yang, Jae-yong Kim, Mi-kyung Lee, Ki-hwan Shim, Young-sook Kim, Kwon-il Seo
    Abstract:

    This study was performed to elucidate the apoptotic pathways by thiosulfinates, major biologically active components of Allium tuberosum L., in HT-29 human colon cancer cells. Thiosulfinates significantly induced cell death in dose- and time-dependent manners in HT-29 cells, which is associated with apoptosis. Thiosulfinates activated the initiator caspcaspase-8, and -9, and the effector caspcaspase-3. In the present study, thiosulfinates were found to stimulate Bid cleavage, indicating that the apoptotic action of caspase-8-mediated Bid cleavage leads to the activation of caspase-9. Thiosulfinates down-regulated the expression of the anti-apoptotic protein Bcl-2, and up-regulated the expression of the pro-apoptotic protein Bax. We also found that thiosulfinates increased the expression of AIF, a caspase-independent mitochondrial apoptosis factor, and induced DNA fragmentation and chromatin condcondensation in HT-29 cells. These results indicate that thiosulfinates from A. tuberosum L. inhibited cell proliferation and activated both the caspase-dependent and caspase-independent apoptotic pathways in HT-29 cells.

  • Cytotoxic and Antitumor Activities of Thiosulfinates from Allium tuberosum L.
    Journal of agricultural and food chemistry, 2007
    Co-Authors: Kyoung-wuk Park, So-yeon Kim, Il-yun Jeong, Myung-woo Byun, Ki-hun Park, Koji Yamada, Kwon-il Seo
    Abstract:

    In this study we isolated crude thiosulfinates from Allium tuberosum L. using CH2Cl2 and then with silica gel column chrochromatography purified S-methyl methanthiosulfinate and S-methyl 2-propene-1-thiosulfinate from the crude thiosulfinates. Subsequently, in vitro cytotoxicities against human cancer cells and in vivo antitumor activities of the thiosulfinates were investigated. Their cytotoxicities were strong in human cancer cells, in the order of S-methyl 2-propene-1-thiosulfinate, crude thiosulfinates, and S-methyl methanthiosulfinate. When thiosulfinates were administered consecutively for 7 days at 10, 30, and 50 mg/kg ip, in mice, we found significant increases in the life spans of mice that had been inoculated with Sacorma-180 tumor cells. The crude thiosulfinates also induced apoptosis in MCF-7 cancer cells. These results suggest that thiosulfinates from Allium tuberosum L. inhibit the proliferation of cancer cells via apoptosis and have antitumor activities.