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Ozan Akkus - One of the best experts on this subject based on the ideXlab platform.

  • gamma radiation sterilization reduces the high cycle fatigue life of Allograft Bone
    Clinical Orthopaedics and Related Research, 2016
    Co-Authors: Anowarul Islam, Katherine Chapin, Emily R Moore, Joel Ford, Clare M Rimnac, Ozan Akkus
    Abstract:

    Sterilization by gamma radiation impairs the mechanical properties of Bone Allografts. Previous work related to radiation-induced embrittlement of Bone tissue has been limited mostly to monotonic testing which does not necessarily predict the high-cycle fatigue life of Allografts in vivo. We designed a custom rotating-bending fatigue device to answer the following questions: (1) Does gamma radiation sterilization affect the high-cycle fatigue behavior of cortical Bone; and (2) how does the fatigue life change with cyclic stress level? The high-cycle fatigue behavior of human cortical Bone specimens was examined at stress levels related to physiologic levels using a custom-designed rotating-bending fatigue device. Test specimens were distributed among two treatment groups (n = 6/group); control and irradiated. Samples were tested until failure at stress levels of 25, 35, and 45 MPa. At 25 MPa, 83% of control samples survived 30 million cycles (run-out) whereas 83% of irradiated samples survived only 0.5 million cycles. At 35 MPa, irradiated samples showed an approximately 19-fold reduction in fatigue life compared with control samples (12.2 × 106 ± 12.3 × 106 versus 6.38 × 105 ± 6.81 × 105; p = 0.046), and in the case of 45 MPa, this reduction was approximately 17.5-fold (7.31 × 105 ± 6.39 × 105 versus 4.17 × 104 ± 1.91 × 104; p = 0.025). Equations to estimate high-cycle fatigue life of irradiated and control cortical Bone Allograft at a certain stress level were derived. Gamma radiation sterilization severely impairs the high cycle fatigue life of structural Allograft Bone tissues, more so than the decline that has been reported for monotonic mechanical properties. Therefore, clinicians need to be conservative in the expectation of the fatigue life of structural Allograft Bone tissues. Methods to preserve the fatigue strength of nonirradiated Allograft Bone tissue are needed. As opposed to what monotonic tests might suggest, the cyclic fatigue life of radiation-sterilized structural Allografts is likely severely compromised relative to the nonirradiated condition and therefore should be taken into consideration. Methods to reduce the effect of irradiation or to recover structural Allograft Bone tissue fatigue strength are important to pursue.

  • gamma radiation sterilization reduces the high cycle fatigue life of Allograft Bone
    Clinical Orthopaedics and Related Research, 2016
    Co-Authors: Anowarul Islam, Katherine Chapin, Emily R Moore, Joel Ford, Clare M Rimnac, Ozan Akkus
    Abstract:

    Background Sterilization by gamma radiation impairs the mechanical properties of Bone Allografts. Previous work related to radiation-induced embrittlement of Bone tissue has been limited mostly to monotonic testing which does not necessarily predict the high-cycle fatigue life of Allografts in vivo.

Emily R Moore - One of the best experts on this subject based on the ideXlab platform.

  • gamma radiation sterilization reduces the high cycle fatigue life of Allograft Bone
    Clinical Orthopaedics and Related Research, 2016
    Co-Authors: Anowarul Islam, Katherine Chapin, Emily R Moore, Joel Ford, Clare M Rimnac, Ozan Akkus
    Abstract:

    Sterilization by gamma radiation impairs the mechanical properties of Bone Allografts. Previous work related to radiation-induced embrittlement of Bone tissue has been limited mostly to monotonic testing which does not necessarily predict the high-cycle fatigue life of Allografts in vivo. We designed a custom rotating-bending fatigue device to answer the following questions: (1) Does gamma radiation sterilization affect the high-cycle fatigue behavior of cortical Bone; and (2) how does the fatigue life change with cyclic stress level? The high-cycle fatigue behavior of human cortical Bone specimens was examined at stress levels related to physiologic levels using a custom-designed rotating-bending fatigue device. Test specimens were distributed among two treatment groups (n = 6/group); control and irradiated. Samples were tested until failure at stress levels of 25, 35, and 45 MPa. At 25 MPa, 83% of control samples survived 30 million cycles (run-out) whereas 83% of irradiated samples survived only 0.5 million cycles. At 35 MPa, irradiated samples showed an approximately 19-fold reduction in fatigue life compared with control samples (12.2 × 106 ± 12.3 × 106 versus 6.38 × 105 ± 6.81 × 105; p = 0.046), and in the case of 45 MPa, this reduction was approximately 17.5-fold (7.31 × 105 ± 6.39 × 105 versus 4.17 × 104 ± 1.91 × 104; p = 0.025). Equations to estimate high-cycle fatigue life of irradiated and control cortical Bone Allograft at a certain stress level were derived. Gamma radiation sterilization severely impairs the high cycle fatigue life of structural Allograft Bone tissues, more so than the decline that has been reported for monotonic mechanical properties. Therefore, clinicians need to be conservative in the expectation of the fatigue life of structural Allograft Bone tissues. Methods to preserve the fatigue strength of nonirradiated Allograft Bone tissue are needed. As opposed to what monotonic tests might suggest, the cyclic fatigue life of radiation-sterilized structural Allografts is likely severely compromised relative to the nonirradiated condition and therefore should be taken into consideration. Methods to reduce the effect of irradiation or to recover structural Allograft Bone tissue fatigue strength are important to pursue.

  • gamma radiation sterilization reduces the high cycle fatigue life of Allograft Bone
    Clinical Orthopaedics and Related Research, 2016
    Co-Authors: Anowarul Islam, Katherine Chapin, Emily R Moore, Joel Ford, Clare M Rimnac, Ozan Akkus
    Abstract:

    Background Sterilization by gamma radiation impairs the mechanical properties of Bone Allografts. Previous work related to radiation-induced embrittlement of Bone tissue has been limited mostly to monotonic testing which does not necessarily predict the high-cycle fatigue life of Allografts in vivo.

Anowarul Islam - One of the best experts on this subject based on the ideXlab platform.

  • gamma radiation sterilization reduces the high cycle fatigue life of Allograft Bone
    Clinical Orthopaedics and Related Research, 2016
    Co-Authors: Anowarul Islam, Katherine Chapin, Emily R Moore, Joel Ford, Clare M Rimnac, Ozan Akkus
    Abstract:

    Sterilization by gamma radiation impairs the mechanical properties of Bone Allografts. Previous work related to radiation-induced embrittlement of Bone tissue has been limited mostly to monotonic testing which does not necessarily predict the high-cycle fatigue life of Allografts in vivo. We designed a custom rotating-bending fatigue device to answer the following questions: (1) Does gamma radiation sterilization affect the high-cycle fatigue behavior of cortical Bone; and (2) how does the fatigue life change with cyclic stress level? The high-cycle fatigue behavior of human cortical Bone specimens was examined at stress levels related to physiologic levels using a custom-designed rotating-bending fatigue device. Test specimens were distributed among two treatment groups (n = 6/group); control and irradiated. Samples were tested until failure at stress levels of 25, 35, and 45 MPa. At 25 MPa, 83% of control samples survived 30 million cycles (run-out) whereas 83% of irradiated samples survived only 0.5 million cycles. At 35 MPa, irradiated samples showed an approximately 19-fold reduction in fatigue life compared with control samples (12.2 × 106 ± 12.3 × 106 versus 6.38 × 105 ± 6.81 × 105; p = 0.046), and in the case of 45 MPa, this reduction was approximately 17.5-fold (7.31 × 105 ± 6.39 × 105 versus 4.17 × 104 ± 1.91 × 104; p = 0.025). Equations to estimate high-cycle fatigue life of irradiated and control cortical Bone Allograft at a certain stress level were derived. Gamma radiation sterilization severely impairs the high cycle fatigue life of structural Allograft Bone tissues, more so than the decline that has been reported for monotonic mechanical properties. Therefore, clinicians need to be conservative in the expectation of the fatigue life of structural Allograft Bone tissues. Methods to preserve the fatigue strength of nonirradiated Allograft Bone tissue are needed. As opposed to what monotonic tests might suggest, the cyclic fatigue life of radiation-sterilized structural Allografts is likely severely compromised relative to the nonirradiated condition and therefore should be taken into consideration. Methods to reduce the effect of irradiation or to recover structural Allograft Bone tissue fatigue strength are important to pursue.

  • gamma radiation sterilization reduces the high cycle fatigue life of Allograft Bone
    Clinical Orthopaedics and Related Research, 2016
    Co-Authors: Anowarul Islam, Katherine Chapin, Emily R Moore, Joel Ford, Clare M Rimnac, Ozan Akkus
    Abstract:

    Background Sterilization by gamma radiation impairs the mechanical properties of Bone Allografts. Previous work related to radiation-induced embrittlement of Bone tissue has been limited mostly to monotonic testing which does not necessarily predict the high-cycle fatigue life of Allografts in vivo.

Mark D Miller - One of the best experts on this subject based on the ideXlab platform.

  • two stage revision anterior cruciate ligament reconstruction using Allograft Bone dowels
    Arthroscopy techniques, 2017
    Co-Authors: Kadir Buyukdogan, Michael S Laidlaw, Mark D Miller
    Abstract:

    Revision anterior cruciate ligament (ACL) reconstruction is substantially more challenging than primary reconstruction. Management of previously malpositioned or widened tunnels often requires innovative approaches for managing bony defects. Massive osteolysis with poor Bone stock and convergence or overlapping of revision tunnels into the previously placed tunnels may necessitate a staged revision procedure. In this surgical technique description, we describe a method for the management of bony deficiencies using Allograft Bone dowels in staged revision ACL reconstruction.

  • management of bony deficiency in revision anterior cruciate ligament reconstruction using Allograft Bone dowels surgical technique
    Arthroscopy, 2005
    Co-Authors: Todd C Battaglia, Mark D Miller
    Abstract:

    Revision anterior cruciate ligament (ACL) reconstruction surgery has become increasingly common over the past decade and its popularity is likely to rise further as the number of primary ACL reconstructions increases each year. More than 75% of all cases of failed ACL reconstruction are the result of technical error and, of these, more than 70% are attributed specifically to malpositioned tunnels. Management of tunnel malposition in revision surgery often requires innovative approaches for dealing with the resultant bony defects. In addition, tunnel osteolysis may create Bone loss that interferes with desired tunnel placement. A number of options have been described for handling these bony deficiencies, many of which are technically difficult and time consuming. We describe a novel technique to address bony defects during revision ACL reconstruction using freeze-dried Allograft Bone dowels. These Allografts are readily available and can be used easily to fill deficiencies resulting from previous tunnels or osteolysis. The grafts provide sufficient structural support for redrilling of new tunnels through or next to the bony plug, allowing uncompromised tunnel placement.

Matthieu Ollivier - One of the best experts on this subject based on the ideXlab platform.

  • Posteromedial Opening-Wedge Tibial Osteotomy for Metaphyseal Varus and Abnormal Posterior Slope Correction in Failed Anterior Cruciate Ligament Reconstructions Using a Custom Cutting Guide
    Arthroscopy Techniques, 2020
    Co-Authors: Boris Corin, Adrian Wilson, Raghbir Khakha, Kristian Kley, Sebastien Parratte, Matthieu Ollivier
    Abstract:

    Anterior cruciate ligament reconstruction after graft failure may need associated Bone correction to ensure stability of the knee. This article presents a technique of posteromedial opening-wedge osteotomy using a custom cutting guide to correct increased tibial slope and metaphyseal varus deformity after recurrent graft failure. An autograft quadriceps tendon graft was selected for the revision anterior cruciate ligament graft. After exposure with an anteromedial incision a patient specific cutting guide was used to make the high tibial osteotomy. The final fixation of the posteromedial opening was achieved using a low-profile locking plate and a femoral head Allograft Bone wedge. The tibial tunnel was planned and included in the patient-specific cutting guide. The femoral tunnel was placed using an outside to in manner. Bioabsorbable screws were used as fixation devices.