The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform

Annika Lindqvist - One of the best experts on this subject based on the ideXlab platform.

  • Alpha 1 microglobulin a yellow brown lipocalin
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo.

  • Alpha(1)-Microglobulin: a yellow-brown lipocalin.
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo. (Less)

  • Bovine Alpha 1-microglobulin/bikunin. Isolation and characterization of liver cDNA and urinary Alpha 1-microglobulin.
    Biochimica et biophysica acta, 1996
    Co-Authors: Annika Lindqvist, Bo Åkerström
    Abstract:

    cDNA coding for Alpha 1-microglobulin, an immunoregulatory plasmaprotein, was isolated from bovine liver. The sequence of a total of 1258 nucleotides revealed an open reading frame of 352 amino acids. This included Alpha 1-microglobulin, 182 amino acids, and bikunin, the light chain of the plasmaprotein inter-Alpha-inhibitor, 147 amino acids. The two proteins were connected by a basic tetrapeptide, R-A-R-R, which conforms to the consensus sequence recognized by endoproteolytic cleavage enzymes. The deduced amino acid sequence showed a high degree of identity with Alpha 1-microglobulin and bikunin sequences from other species, and the Alpha 1-microglobulin part displayed sequence motifs typical for members of the lipocalin protein superfamily. A single Alpha 1-microglobulin/bikunin mRNA with a size of around 1300 nt was found in bovine liver. The mature Alpha 1-microglobulin protein was isolated from bovine urine, and partly characterized. It was found to be a globular molecule with an apparent molecular weight of 23,300, containing one N-linked and at least on O-linked oligosaccharide, one intra-chain disulfide bridge and an electrophoretic heterogeniety with a pI-value of 4.1-5.2.

Bo Åkerström - One of the best experts on this subject based on the ideXlab platform.

  • Alpha(1)-Microglobulin: a yellow-brown lipocalin.
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo. (Less)

  • Alpha 1 microglobulin a yellow brown lipocalin
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo.

  • Bovine Alpha 1-microglobulin/bikunin. Isolation and characterization of liver cDNA and urinary Alpha 1-microglobulin.
    Biochimica et biophysica acta, 1996
    Co-Authors: Annika Lindqvist, Bo Åkerström
    Abstract:

    cDNA coding for Alpha 1-microglobulin, an immunoregulatory plasmaprotein, was isolated from bovine liver. The sequence of a total of 1258 nucleotides revealed an open reading frame of 352 amino acids. This included Alpha 1-microglobulin, 182 amino acids, and bikunin, the light chain of the plasmaprotein inter-Alpha-inhibitor, 147 amino acids. The two proteins were connected by a basic tetrapeptide, R-A-R-R, which conforms to the consensus sequence recognized by endoproteolytic cleavage enzymes. The deduced amino acid sequence showed a high degree of identity with Alpha 1-microglobulin and bikunin sequences from other species, and the Alpha 1-microglobulin part displayed sequence motifs typical for members of the lipocalin protein superfamily. A single Alpha 1-microglobulin/bikunin mRNA with a size of around 1300 nt was found in bovine liver. The mature Alpha 1-microglobulin protein was isolated from bovine urine, and partly characterized. It was found to be a globular molecule with an apparent molecular weight of 23,300, containing one N-linked and at least on O-linked oligosaccharide, one intra-chain disulfide bridge and an electrophoretic heterogeniety with a pI-value of 4.1-5.2.

  • Alpha 1-Microglobulin destroys the proteinase inhibitory activity of Alpha 1-inhibitor-3 by complex formation.
    The Journal of biological chemistry, 1995
    Co-Authors: Cecilia Falkenberg, Bo Åkerström, Maria Allhorn, Ida B. Thøgersen, Zuzana Valnickova, Salvatore V. Pizzo, Guy S. Salvesen, Jan J. Enghild
    Abstract:

    The immunoregulatory plasma protein Alpha 1-microglobulin (Alpha 1-m) and the proteinase inhibitor Alpha 1-inhibitor-3 (Alpha 1I3) form a complex in rat plasma. In the present work, it was demonstrated that the Alpha 1I3.Alpha 1-m complex has no inhibitory activity, the bait region was not cleaved by low amounts of proteinases, and it was unable to covalently incorporate proteinases. The results also indicated that the thiolester bond of the Alpha 1I3.Alpha 1-m complex was broken. The Alpha 1I3.Alpha 1-m complex was cleared from the circulation much faster than native Alpha 1I3, with a half-life of approximately 7 min. Structurally, however, the Alpha 1I3.Alpha 1-m complex was similar to native Alpha 1I3 rather than Alpha 1I3 cleaved by proteinases. It is speculated that the role of Alpha 1-m is to destroy the function of Alpha 1I3 by blocking the bait region and breaking the thiolester and causing its physical elimination by rapid clearing from the blood circulation. It is also possible that the formation of complexes between Alpha 1-m and Alpha 1I3 may serve as a mean to regulate the function of Alpha 1-m since its complex with Alpha 1I3 is taken up rapidly by cellular receptors for Alpha-macroglobulins.

Tord Berggård - One of the best experts on this subject based on the ideXlab platform.

  • Alpha(1)-Microglobulin: a yellow-brown lipocalin.
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo. (Less)

  • Alpha 1 microglobulin a yellow brown lipocalin
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo.

Peter Osmark - One of the best experts on this subject based on the ideXlab platform.

  • Alpha(1)-Microglobulin: a yellow-brown lipocalin.
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo. (Less)

  • Alpha 1 microglobulin a yellow brown lipocalin
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo.

Lennart Lögdberg - One of the best experts on this subject based on the ideXlab platform.

  • Alpha(1)-Microglobulin: a yellow-brown lipocalin.
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo. (Less)

  • Alpha 1 microglobulin a yellow brown lipocalin
    Biochimica et Biophysica Acta, 2000
    Co-Authors: Bo Åkerström, Lennart Lögdberg, Tord Berggård, Peter Osmark, Annika Lindqvist
    Abstract:

    Alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes Alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the Alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo.