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Alpha-Aminobutyric Acid

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Igor P. Udovichenko – 1st expert on this subject based on the ideXlab platform

  • Immunosuppressant Peptide Abu-TGIRIS-Abu-NH2 and its Application for Treatment of Multiple Sclerosis.
    Journal of Bionanoscience, 2018
    Co-Authors: Valery I. Turobov, Viatcheslav N. Azev, Alexei B. Shevelev, Natalia V. Pozdniakova, Yulia K. Biryukova, Arkady N. Murashev, Valery M. Lipkin, Igor P. Udovichenko

    Abstract:

    : Immunosuppressant peptide immunocortin for the first time was described in 1993. It corresponds to residues 11-20 of human Ig heavy chain (conserved motif of VH domain). There are no data about production of immunocortin by proteolysis of Ig in vivo. Synthetic immunocortin in concentration ~ 10-9 M suppresses phagocytosis in peritoneal macrophages, ConA-dependent blast transformation of rat lymphocytes, exhibits ACTH-like neurotropic activity and was suggested as a potential drug for treatment of a multiple sclerosis (MS). Here, we report a sequence and method of synthesis of Abu-TGIRIS-Abu-NH2 (Abu, Alpha-Aminobutyric Acid), an artificial analogue of immunocortin. Biological trials of peritoneally injected Abu-TGIRIS-Abu-NH2 gave an evidence of its better efficacy versus immunocortin in a test for suppression of the experimental autoimmune encephalomyelitis (EAE) in Dark Agouti (DA) rats.

  • Immunosuppressant Peptide Abu-TGIRIS-Abu-NH_2 and its Application for Treatment of Multiple Sclerosis
    BioNanoScience, 2018
    Co-Authors: Valery I. Turobov, Viatcheslav N. Azev, Alexei B. Shevelev, Natalia V. Pozdniakova, Yulia K. Biryukova, Arkady N. Murashev, Valery M. Lipkin, Igor P. Udovichenko

    Abstract:

    Immunosuppressant peptide immunocortin for the first time was described in 1993. It corresponds to residues 11–20 of human Ig heavy chain (conserved motif of V_H domain). There are no data about production of immunocortin by proteolysis of Ig in vivo. Synthetic immunocortin in concentration ~ 10^−9 M suppresses phagocytosis in peritoneal macrophages, ConA-dependent blast transformation of rat lymphocytes, exhibits ACTH-like neurotropic activity and was suggested as a potential drug for treatment of a multiple sclerosis (MS). Here, we report a sequence and method of synthesis of Abu-TGIRIS-Abu-NH_2 (Abu, Alpha-Aminobutyric Acid), an artificial analogue of immunocortin. Biological trials of peritoneally injected Abu-TGIRIS-Abu-NH_2 gave an evidence of its better efficacy versus immunocortin in a test for suppression of the experimental autoimmune encephalomyelitis (EAE) in Dark Agouti (DA) rats.

Trond Riise – 2nd expert on this subject based on the ideXlab platform

  • Cerebrospinal fluid proteins andfree aminoAcids in *patients withsolvent induced chronic toxic encephalopathy andhealthy controls
    , 1990
    Co-Authors: Benteelisabeth Moen, Kyvik Kr, B A Engelsen, Trond Riise

    Abstract:

    Theconcentrations ofprotein, albumin,IgG, andfreeaminoAcids inthecerebrospinal fluid of16patients withchronictoxicencephalopathyduetoorganic solvents weremeasured. Thepatient groupconsisted ofallpatients with thisdiagnosis inaneurological department in 1985. Thediagnosis wasbasedonneuraesthenic symptoms,pathological psychometric performance,andverified exposuretoneurotoxic organic solvents. A control groupof16patients withmyalgias orbackache, orboth,andno signs ofdisease wasusedforcomparison. The purposewastostudypossible changesinthe cerebrospinal fluidthatmightcontribute to understanding theaetiology ofsolvent induced chronictoxicencephalopathy. A risein protein, albumin,andIgGwasfoundinthe patient groupcomparedwiththecontrol group,aswellasreducedconcentrations of phosphoethanolamine, taurine, homocarnosine, ethanolamine, Alpha-Aminobutyric Acid, andleucine. Usingastepwise multiple regressionanalysis, taurinewas negatively correlated toexposure tosolvents. Thesefindings may indicate membranealterations inthe central nervoussystemrelated toexposure to organic solvents.

  • Cerebrospinal fluid proteins and free amino Acids in patients with solvent induced chronic toxic encephalopathy and healthy controls.
    Occupational and Environmental Medicine, 1990
    Co-Authors: Bente E. Moen, B A Engelsen, Kyvik Kr, Trond Riise

    Abstract:

    The concentrations of protein, albumin, IgG, and free amino Acids in the cerebrospinal fluid of 16 patients with chronic toxic encephalopathy due to organic solvents were measured. The patient group consisted of all patients with this diagnosis in a neurological department in 1985. The diagnosis was based on neuraesthenic symptoms, pathological psychometric performance, and verified exposure to neurotoxic organic solvents. A control group of 16 patients with myalgias or backache, or both, and no signs of disease was used for comparison. The purpose was to study possible changes in the cerebrospinal fluid that might contribute to understanding the aetiology of solvent induced chronic toxic encephalopathy. A rise in protein, albumin, and IgG was found in the patient group compared with the control group, as well as reduced concentrations of phosphoethanolamine, taurine, homocarnosine, ethanolamine, Alpha-Aminobutyric Acid, and leucine. Using a stepwise multiple regression analysis, taurine was negatively correlated to exposure to solvents. These findings may indicate membrane alterations in the central nervous system related to exposure to organic solvents.

Valery I. Turobov – 3rd expert on this subject based on the ideXlab platform

  • Immunosuppressant Peptide Abu-TGIRIS-Abu-NH2 and its Application for Treatment of Multiple Sclerosis.
    Journal of Bionanoscience, 2018
    Co-Authors: Valery I. Turobov, Viatcheslav N. Azev, Alexei B. Shevelev, Natalia V. Pozdniakova, Yulia K. Biryukova, Arkady N. Murashev, Valery M. Lipkin, Igor P. Udovichenko

    Abstract:

    : Immunosuppressant peptide immunocortin for the first time was described in 1993. It corresponds to residues 11-20 of human Ig heavy chain (conserved motif of VH domain). There are no data about production of immunocortin by proteolysis of Ig in vivo. Synthetic immunocortin in concentration ~ 10-9 M suppresses phagocytosis in peritoneal macrophages, ConA-dependent blast transformation of rat lymphocytes, exhibits ACTH-like neurotropic activity and was suggested as a potential drug for treatment of a multiple sclerosis (MS). Here, we report a sequence and method of synthesis of Abu-TGIRIS-Abu-NH2 (Abu, Alpha-Aminobutyric Acid), an artificial analogue of immunocortin. Biological trials of peritoneally injected Abu-TGIRIS-Abu-NH2 gave an evidence of its better efficacy versus immunocortin in a test for suppression of the experimental autoimmune encephalomyelitis (EAE) in Dark Agouti (DA) rats.

  • Immunosuppressant Peptide Abu-TGIRIS-Abu-NH_2 and its Application for Treatment of Multiple Sclerosis
    BioNanoScience, 2018
    Co-Authors: Valery I. Turobov, Viatcheslav N. Azev, Alexei B. Shevelev, Natalia V. Pozdniakova, Yulia K. Biryukova, Arkady N. Murashev, Valery M. Lipkin, Igor P. Udovichenko

    Abstract:

    Immunosuppressant peptide immunocortin for the first time was described in 1993. It corresponds to residues 11–20 of human Ig heavy chain (conserved motif of V_H domain). There are no data about production of immunocortin by proteolysis of Ig in vivo. Synthetic immunocortin in concentration ~ 10^−9 M suppresses phagocytosis in peritoneal macrophages, ConA-dependent blast transformation of rat lymphocytes, exhibits ACTH-like neurotropic activity and was suggested as a potential drug for treatment of a multiple sclerosis (MS). Here, we report a sequence and method of synthesis of Abu-TGIRIS-Abu-NH_2 (Abu, Alpha-Aminobutyric Acid), an artificial analogue of immunocortin. Biological trials of peritoneally injected Abu-TGIRIS-Abu-NH_2 gave an evidence of its better efficacy versus immunocortin in a test for suppression of the experimental autoimmune encephalomyelitis (EAE) in Dark Agouti (DA) rats.