The Experts below are selected from a list of 105 Experts worldwide ranked by ideXlab platform
Thavendran Govender - One of the best experts on this subject based on the ideXlab platform.
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catalytic asymmetric carbon carbon bond forming reactions catalyzed by tetrahydroisoquinoline tiq n n dioxide ligands
Tetrahedron-asymmetry, 2013Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran GovenderAbstract:The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.
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Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands
Tetrahedron: Asymmetry, 2013Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran GovenderAbstract:The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.
Pher G Andersson - One of the best experts on this subject based on the ideXlab platform.
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catalytic asymmetric carbon carbon bond forming reactions catalyzed by tetrahydroisoquinoline tiq n n dioxide ligands
Tetrahedron-asymmetry, 2013Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran GovenderAbstract:The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.
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Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands
Tetrahedron: Asymmetry, 2013Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran GovenderAbstract:The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.
Zamani E D Cele - One of the best experts on this subject based on the ideXlab platform.
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catalytic asymmetric carbon carbon bond forming reactions catalyzed by tetrahydroisoquinoline tiq n n dioxide ligands
Tetrahedron-asymmetry, 2013Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran GovenderAbstract:The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.
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Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands
Tetrahedron: Asymmetry, 2013Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran GovenderAbstract:The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.
Ji-chen Zhang - One of the best experts on this subject based on the ideXlab platform.
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Highly Efficient Synthesis of Polysubstituted 1,2-Dihydroquinolines via Tandem Reaction of α-Ketoesters and Arylamines Catalyzed by Indium Triflate
ACS Catalysis, 2011Co-Authors: Ji-chen ZhangAbstract:A simple and efficient method for the synthesis of polysubstituted 1,2-dihydroquinolines has been developed via an indium(III) catalyzed tandem reaction of Alpha-Ketoesters with primary or secondary aromatic amines. With respect to the reactions of pyruvates with amines indium triflate (1 mol %) demonstrated superior catalytic activity and efficiency compared with previously AuCl(3)/AgSbF(6) (5 mol %/15 mol %) cocatalyst. The reactions of alpha-alkyl substituted ketoesters and arylamines, which could not be effectively accomplished by the previous AuCl(3)/AgSbF(6) and HNO(3) catalytic systems smoothly in the presence of 10 mol % In(OTf)(3) to afford the desired products in moderate to good yields (43%-91%).
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Brønsted acid (HNO3)-catalyzed tandem reaction of α-ketoesters and arylamines: efficient synthesis of 1,2-dihydroquinoline derivatives
Tetrahedron Letters, 2011Co-Authors: Ji-chen Zhang, Wei WeiAbstract:A simple and convenient Bronsted acid (HNO3)-catalyzed tandem reaction of Alpha-Ketoesters with primary or secondary aromatic amines for the synthesis of polysubstituted 1,2-dihydroquinolines has been developed via a tandem process, which has the advantages of ready availability of catalyst, operation simplicity, atom efficiency as well as low toxicity. In particular, tricyclic dihydroquinolines, generally prepared with multi-processes, could also be constructed in this one-pot procedure. (C) 2011 Elsevier Ltd. All rights reserved.
Hendrik G Kruger - One of the best experts on this subject based on the ideXlab platform.
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catalytic asymmetric carbon carbon bond forming reactions catalyzed by tetrahydroisoquinoline tiq n n dioxide ligands
Tetrahedron-asymmetry, 2013Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran GovenderAbstract:The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.
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Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands
Tetrahedron: Asymmetry, 2013Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran GovenderAbstract:The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.
