Alpha-Ketoester - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Alpha-Ketoester

The Experts below are selected from a list of 105 Experts worldwide ranked by ideXlab platform

Alpha-Ketoester – Free Register to Access Experts & Abstracts

Thavendran Govender – One of the best experts on this subject based on the ideXlab platform.

  • catalytic asymmetric carbon carbon bond forming reactions catalyzed by tetrahydroisoquinoline tiq n n dioxide ligands
    Tetrahedron-asymmetry, 2013
    Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender
    Abstract:

    The use of TIQ-N,N’-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.

  • Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands
    Tetrahedron: Asymmetry, 2013
    Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender
    Abstract:

    The use of TIQ-N,N’-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.

Pher G Andersson – One of the best experts on this subject based on the ideXlab platform.

  • catalytic asymmetric carbon carbon bond forming reactions catalyzed by tetrahydroisoquinoline tiq n n dioxide ligands
    Tetrahedron-asymmetry, 2013
    Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender
    Abstract:

    The use of TIQ-N,N’-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.

  • Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands
    Tetrahedron: Asymmetry, 2013
    Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender
    Abstract:

    The use of TIQ-N,N’-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.

Zamani E D Cele – One of the best experts on this subject based on the ideXlab platform.

  • catalytic asymmetric carbon carbon bond forming reactions catalyzed by tetrahydroisoquinoline tiq n n dioxide ligands
    Tetrahedron-asymmetry, 2013
    Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender
    Abstract:

    The use of TIQ-N,N’-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.

  • Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands
    Tetrahedron: Asymmetry, 2013
    Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender
    Abstract:

    The use of TIQ-N,N’-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.

Ji-chen Zhang – One of the best experts on this subject based on the ideXlab platform.

  • Highly Efficient Synthesis of Polysubstituted 1,2-Dihydroquinolines via Tandem Reaction of α-Ketoesters and Arylamines Catalyzed by Indium Triflate
    ACS Catalysis, 2011
    Co-Authors: Ji-chen Zhang
    Abstract:

    A simple and efficient method for the synthesis of polysubstituted 1,2-dihydroquinolines has been developed via an indium(III) catalyzed tandem reaction of Alpha-Ketoesters with primary or secondary aromatic amines. With respect to the reactions of pyruvates with amines indium triflate (1 mol %) demonstrated superior catalytic activity and efficiency compared with previously AuCl(3)/AgSbF(6) (5 mol %/15 mol %) cocatalyst. The reactions of alpha-alkyl substituted ketoesters and arylamines, which could not be effectively accomplished by the previous AuCl(3)/AgSbF(6) and HNO(3) catalytic systems smoothly in the presence of 10 mol % In(OTf)(3) to afford the desired products in moderate to good yields (43%-91%).

  • Brønsted acid (HNO3)-catalyzed tandem reaction of α-ketoesters and arylamines: efficient synthesis of 1,2-dihydroquinoline derivatives
    Tetrahedron Letters, 2011
    Co-Authors: Ji-chen Zhang, Wei Wei
    Abstract:

    A simple and convenient Bronsted acid (HNO3)-catalyzed tandem reaction of Alpha-Ketoesters with primary or secondary aromatic amines for the synthesis of polysubstituted 1,2-dihydroquinolines has been developed via a tandem process, which has the advantages of ready availability of catalyst, operation simplicity, atom efficiency as well as low toxicity. In particular, tricyclic dihydroquinolines, generally prepared with multi-processes, could also be constructed in this one-pot procedure. (C) 2011 Elsevier Ltd. All rights reserved.

Hendrik G Kruger – One of the best experts on this subject based on the ideXlab platform.

  • catalytic asymmetric carbon carbon bond forming reactions catalyzed by tetrahydroisoquinoline tiq n n dioxide ligands
    Tetrahedron-asymmetry, 2013
    Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender
    Abstract:

    The use of TIQ-N,N’-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.

  • Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands
    Tetrahedron: Asymmetry, 2013
    Co-Authors: Zamani E D Cele, Sphelele C Sosibo, Pher G Andersson, Hendrik G Kruger, Glenn E M Maguire, Thavendran Govender
    Abstract:

    The use of TIQ-N,N’-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated Alpha-Ketoesters, excellent yields (up to 93%) and moderate to good enantioselectivities (70-89% ee) were obtained. The catalytic hetero-ene reaction of 2-methoxypropene with phenylglyoxal gave the ene product in excellent yield (95%) with moderate enantioselectivity (77% ee). The catalyst system performed well at temperatures ranging from 0 to 30 degrees C and relatively low catalyst loading (0.2-5 mol %) with dichloromethane being the preferred solvent for all reactions.