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Parvin Yarmohamadi - One of the best experts on this subject based on the ideXlab platform.
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the effect of Althaea officinalis l root alcoholic extract on blood sugar level and lipid profiles of streptozotocin induced diabetic rats
iranian endodontic journal, 2015Co-Authors: Saeed Changizi Ashtiyani, Parvin YarmohamadiAbstract:The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats Changizi Ashtiyani S1, Yarmohammadi P1, Hosseini N2, Salehi I3, Ramezani M4 Abstract Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight). Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P<0.05). in diabetic rats treated, at all doses (200, 400, 800 mg/kg). Significant improvement was also observed in dyslipidemia (p<0.05). caused by diabetes mellitus, as confirmed by reduced levels of total cholesterol, triglycerides, LDL and significantly elevated levels of HDL. Fasting blood glucose levels of glibenclamide treated rats 200 mg/kg doses of the extract were significantly lower than those in the diabetic control group (P<0.05). However levels of fasting blood glucose in the group treated with 400, 800 mg/kg doses of the extract had no significant difference, as compared to the group treated with glibenclamide (P<0.05). Conclusion: Results of this study discovered significant hypolipidemic and hypoglycemic effects for the extract of Althaea officinalis in Wistar rats. Keywords: Althea officinalis, Diabetes, Dyslipidemia, Streptozotocin
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The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats
iranian endodontic journal, 2015Co-Authors: Saeed Changizi Ashtiyani, Parvin YarmohamadiAbstract:The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats Changizi Ashtiyani S1, Yarmohammadi P1, Hosseini N2, Salehi I3, Ramezani M4 Abstract Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight). Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P
Ralf Kinscherf - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory and anti oxidative effects of phytohustil and root extract of Althaea officinalis l on macrophages in vitro
Frontiers in Pharmacology, 2020Co-Authors: Gabriel A Bonaterra, Kevin Bronischewski, Pascal Hunold, Hans Schwarzbach, Enniou Heinrich, Careen Fink, Heba Azizkalbhenn, J Muller, Ralf KinscherfAbstract:Introduction: The medicinal plant marshmallow (Althaea officinalis L.), that has been known for many centuries, is used for the treatment of cough. Application of medicinal extracts of marshmallow roots shows immediate effects like a protective film on the inflamed mucosa. Because the soothing layer of marshmallow reduces irritation of the mucous system, a faster regeneration is supported by defense mechanisms required to protect the respiratory tract from environmental injury. Macrophages (MΦ), which belong to a group of multipurpose defensive cells, provide the first line of defense against mucosal invasive pathogens. The present study was performed to investigate, whether the herbal medicinal product have anti-inflammatory or anti-oxidative effects on pro-inflammatorily activated MΦ or after oxidative stress induction, with special attention to elucidate their effects on the mechanism of intracellular defense as well as on their migratory capacity. Results: Treatment of PMA-differentiated human THP-1 MΦ with Phytohustil® increased their viability without affecting the cell number. Phytohustil® or root extracts of Althaea officinalis (L) – an active component of Phytohustil® - were able to protect human THP-1 MΦ against H2O2-induced cytotoxicity and H2O2-induced ROS production. Moreover, Phytohustil®, root extracts of Althaea officinalis (L) or diclofenac used as anti-inflammatory reference substance, inhibited the LPS-induced release of tumor necrosis factor (TNF) as well as of IL6 in human THP-1 MΦ. Treatment of human THP-1 MΦ with Phytohustil®, its excipients or root extracts of Althaea officinalis (L) didn´t impair the mitochondrial membrane potential (MMP). Finally, Phytohustil®, and root extract of Althaea officinalis (L.) activated the migratory capacity of human THP-1 MΦ. Conclusions: The present in vitro investigations indicate protective, i.e. anti-oxidative and anti-inflammatory effects of root extracts of Althaea officinalis (L.) and Phytohustil®, additionally improving the migratory capacity of MΦ. These anti-inflammatory effect were similar or even better than effects of diclofenac. Thus, our data support and may explain the positive effect of Phytohustil® observed in patients during the therapy of inflamed buccal mucosal membranes and against the adverse effects of cough.
Saeed Changizi Ashtiyani - One of the best experts on this subject based on the ideXlab platform.
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the effect of Althaea officinalis l root alcoholic extract on blood sugar level and lipid profiles of streptozotocin induced diabetic rats
iranian endodontic journal, 2015Co-Authors: Saeed Changizi Ashtiyani, Parvin YarmohamadiAbstract:The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats Changizi Ashtiyani S1, Yarmohammadi P1, Hosseini N2, Salehi I3, Ramezani M4 Abstract Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight). Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P<0.05). in diabetic rats treated, at all doses (200, 400, 800 mg/kg). Significant improvement was also observed in dyslipidemia (p<0.05). caused by diabetes mellitus, as confirmed by reduced levels of total cholesterol, triglycerides, LDL and significantly elevated levels of HDL. Fasting blood glucose levels of glibenclamide treated rats 200 mg/kg doses of the extract were significantly lower than those in the diabetic control group (P<0.05). However levels of fasting blood glucose in the group treated with 400, 800 mg/kg doses of the extract had no significant difference, as compared to the group treated with glibenclamide (P<0.05). Conclusion: Results of this study discovered significant hypolipidemic and hypoglycemic effects for the extract of Althaea officinalis in Wistar rats. Keywords: Althea officinalis, Diabetes, Dyslipidemia, Streptozotocin
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The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats
iranian endodontic journal, 2015Co-Authors: Saeed Changizi Ashtiyani, Parvin YarmohamadiAbstract:The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats Changizi Ashtiyani S1, Yarmohammadi P1, Hosseini N2, Salehi I3, Ramezani M4 Abstract Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight). Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P
Maryam Rezaei - One of the best experts on this subject based on the ideXlab platform.
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evaluation of the antibacterial activity of the Althaea officinalis l leaf extract and its wound healing potency in the rat model of excision wound creation
avicenna journal of phytomedicine, 2015Co-Authors: Maryam Rezaei, Zeynab Dadgar, Ali Noorizadeh, Seyed Alireza Mesbahnamin, Iraj Pakzad, Elham DavodianAbstract:Objectives: Wound is defined simply as the disruption of the biochemical, cellular, and anatomic continuity of a tissue. Plants and their extracts known as phytomedicine have immense potential for the management and treatment of wounds. Materials and Methods: Due to the undesirable side effects, in the control and treatment of the wound infections, it is recommended to use natural materials such as phytochemicals instead of chemically synthesized drugs. Thus, the aim of this research was to study the anti-microbial and wound healing potential of Althaea officinalis L. hydroalchoholic extract in comparison with ciprofloxacin, gentamicin, and penicillin antibiotics on clinical strains as well as pathogenic bacteria such as Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Listeria monocytogenes under in vitro conditions using micro broth dilution and disc diffusion methods. Moreover, MIC and MBC of its hydroalchoholic extract was also evaluated. Results: The results showed that although Althaea officinalis L. extract was not effective on gram-negative bacteria but it was efficacious on gram-positive bacteria. The extract was also tested in the form of topical administration on excision wound model in rats. In the extract-treated wounds, the wound healing percent was significantly increased in comparison with controls. Conclusions: Based on this research, herbal extract of officinalis L. can be a great candidate for the treatment of gram-positive infections and merits further studies.
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Evaluation of the antibacterial activity of the Althaea officinalis L. leaf extract and its wound healing potency in the rat model of excision wound creation.
avicenna journal of phytomedicine, 2015Co-Authors: Maryam Rezaei, Zeynab Dadgar, Iraj Pakzad, Ali Noori-zadeh, Seyed Alireza Mesbah-namin, Elham DavodianAbstract:Wound is defined simply as the disruption of the biochemical, cellular, and anatomic continuity of a tissue. Plants and their extracts known as phytomedicine have immense potential for the management and treatment of wounds. Materials and Methods: Due to the undesirable side effects, in the control and treatment of the wound infections, it is recommended to use natural materials such as phytochemicals instead of chemically synthesized drugs. Thus, the aim of this research was to study the anti-microbial and wound healing potential of Althaea officinalis L. hydroalchoholic extract in comparison with ciprofloxacin, gentamicin, and penicillin antibiotics on clinical strains as well as pathogenic bacteria such as Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Listeria monocytogenes under in vitro conditions using micro broth dilution and disc diffusion methods. Moreover, MIC and MBC of its hydroalchoholic extract was also evaluated. Results: The results showed that although Althaea officinalis L. extract was not effective on gram-negative bacteria but it was efficacious on gram-positive bacteria. The extract was also tested in the form of topical administration on excision wound model in rats. In the extract-treated wounds, the wound healing percent was significantly increased in comparison with controls. Conclusions: Based on this research, herbal extract of officinalis L. can be a great candidate for the treatment of gram-positive infections and merits further studies.
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Protective effects of Althaea officinalis L. extract in 6-hydroxydopamine-induced hemi-Parkinsonism model: behavioral, biochemical and histochemical evidence
The Journal of Physiological Sciences, 2014Co-Authors: Maryam Rezaei, Masoud AlirezaeiAbstract:It is well known that Parkinson’s disease (PD) is the second most common neurodegenerative disorder in humans. In this regard, the neuroprotective effect of Althaea officinalis (AO) has already been reported. Therefore, this study examined whether administration of AO extract would improve behavioral, biochemical and structural abnormalities in an experimental animal model of PD in rats. For this purpose, we induced hemi-Parkinsonism by unilateral intranigral injection of 6-hydroxydopamine (6-OHDA, 8 μg/5 μl saline-ascorbate). The rats were pretreated i.p. with AO extract (10 mg/kg) started 6 days before surgery and continued until the 3rd day post-surgery. Regarding oxidative stress, brain MDA concentration (as a lipid peroxidation marker) increased significantly in the 6-OHDA-administered group in comparison with rats pretreated with AO extract. It was found that AO treatment attenuated rotational behavior in the 6-OHDA-administered group and protected the neurons of substantia nigra pars compacta against 6-OHDA toxicity. Overall, AO extract administration indicated neuroprotective effects against 6-OHDA-induced hemi-Parkinsonism in rats.
Careen Fink - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory and anti oxidative effects of phytohustil and root extract of Althaea officinalis l on macrophages in vitro
Frontiers in Pharmacology, 2020Co-Authors: Gabriel A Bonaterra, Kevin Bronischewski, Pascal Hunold, Hans Schwarzbach, Enniou Heinrich, Careen Fink, Heba Azizkalbhenn, J Muller, Ralf KinscherfAbstract:Introduction: The medicinal plant marshmallow (Althaea officinalis L.), that has been known for many centuries, is used for the treatment of cough. Application of medicinal extracts of marshmallow roots shows immediate effects like a protective film on the inflamed mucosa. Because the soothing layer of marshmallow reduces irritation of the mucous system, a faster regeneration is supported by defense mechanisms required to protect the respiratory tract from environmental injury. Macrophages (MΦ), which belong to a group of multipurpose defensive cells, provide the first line of defense against mucosal invasive pathogens. The present study was performed to investigate, whether the herbal medicinal product have anti-inflammatory or anti-oxidative effects on pro-inflammatorily activated MΦ or after oxidative stress induction, with special attention to elucidate their effects on the mechanism of intracellular defense as well as on their migratory capacity. Results: Treatment of PMA-differentiated human THP-1 MΦ with Phytohustil® increased their viability without affecting the cell number. Phytohustil® or root extracts of Althaea officinalis (L) – an active component of Phytohustil® - were able to protect human THP-1 MΦ against H2O2-induced cytotoxicity and H2O2-induced ROS production. Moreover, Phytohustil®, root extracts of Althaea officinalis (L) or diclofenac used as anti-inflammatory reference substance, inhibited the LPS-induced release of tumor necrosis factor (TNF) as well as of IL6 in human THP-1 MΦ. Treatment of human THP-1 MΦ with Phytohustil®, its excipients or root extracts of Althaea officinalis (L) didn´t impair the mitochondrial membrane potential (MMP). Finally, Phytohustil®, and root extract of Althaea officinalis (L.) activated the migratory capacity of human THP-1 MΦ. Conclusions: The present in vitro investigations indicate protective, i.e. anti-oxidative and anti-inflammatory effects of root extracts of Althaea officinalis (L.) and Phytohustil®, additionally improving the migratory capacity of MΦ. These anti-inflammatory effect were similar or even better than effects of diclofenac. Thus, our data support and may explain the positive effect of Phytohustil® observed in patients during the therapy of inflamed buccal mucosal membranes and against the adverse effects of cough.
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phytochemical characterization of low molecular weight constituents from marshmallow roots Althaea officinalis and inhibiting effects of the aqueous extract on human hyaluronidase 1
Journal of Natural Products, 2017Co-Authors: Jandirk Sendker, Careen Fink, Ines Boker, Isabelle Lengers, S Brandt, Joachim Jose, Timo D Stark, Thomas Hofmann, Heba Abdelaziz, A HenselAbstract:Extract RE was obtained from the roots of Althaea officinalis in a yield of 8.1%, related to the dried plant material, by extraction with MeOH–H2O (1:1), followed by precipitation with EtOH to remove high molecular weight constituents. Phytochemical investigation of RE revealed the presence of N-phenylpropenoyl-l-amino acid amides 1–5, 8% glycine betaine 6, about 9% total amino acids with proline as the main compound, and about 61% mono- and oligomeric carbohydrates with sucrose as the main compound. Further fractionation revealed the presence of a hypolaetin diglycoside (12) and four hypolaetin glycosides (7–9 and 11) with O-sulfocarbohydrate moieties; additionally, 4′-O-methylisoscutellarein-8-O-β-d-(3″-O-sulfo)glucuronopyranoside (10) and the diglycosylated coumarin haploperoside D (13) were identified. The hypolaetin-O-sulfoglycosides 7–10 are new natural products. RE inhibited the enzymatic activity of surface-displayed human hyaluronidase-1 on Escherichia coli F470 cells with an IC50 of 7.7 mg/mL. R...
