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Althaea

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Parvin Yarmohamadi – 1st expert on this subject based on the ideXlab platform

  • the effect of Althaea officinalis l root alcoholic extract on blood sugar level and lipid profiles of streptozotocin induced diabetic rats
    iranian endodontic journal, 2015
    Co-Authors: Saeed Changizi Ashtiyani, Parvin Yarmohamadi

    Abstract:

    The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats

    Changizi Ashtiyani S1, Yarmohammadi P1, Hosseini N2, Salehi I3, Ramezani M4

    Abstract
    Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight).
    Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P<0.05). in diabetic rats treated, at all doses (200, 400, 800 mg/kg). Significant improvement was also observed in dyslipidemia (p<0.05). caused by diabetes mellitus, as confirmed by reduced levels of total cholesterol, triglycerides, LDL and significantly elevated levels of HDL. Fasting blood glucose levels of glibenclamide treated rats 200 mg/kg doses of the extract were significantly lower than those in the diabetic control group (P<0.05). However levels of fasting blood glucose in the group treated with 400, 800 mg/kg doses of the extract had no significant difference, as compared to the group treated with glibenclamide (P<0.05). Conclusion: Results of this study discovered significant hypolipidemic and hypoglycemic effects for the extract of Althaea officinalis in Wistar rats.
    Keywords: Althea officinalis, Diabetes, Dyslipidemia, Streptozotocin

  • The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats
    iranian endodontic journal, 2015
    Co-Authors: Saeed Changizi Ashtiyani, Parvin Yarmohamadi

    Abstract:

    The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats

    Changizi Ashtiyani S1, Yarmohammadi P1, Hosseini N2, Salehi I3, Ramezani M4

    Abstract
    Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight).
    Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P

Ralf Kinscherf – 2nd expert on this subject based on the ideXlab platform

  • anti inflammatory and anti oxidative effects of phytohustil and root extract of Althaea officinalis l on macrophages in vitro
    Frontiers in Pharmacology, 2020
    Co-Authors: Gabriel A Bonaterra, Kevin Bronischewski, Pascal Hunold, Hans Schwarzbach, Enniou Heinrich, Careen Fink, Heba Azizkalbhenn, J Muller, Ralf Kinscherf

    Abstract:

    Introduction: The medicinal plant marshmallow (Althaea officinalis L.), that has been known for many centuries, is used for the treatment of cough. Application of medicinal extracts of marshmallow roots shows immediate effects like a protective film on the inflamed mucosa. Because the soothing layer of marshmallow reduces irritation of the mucous system, a faster regeneration is supported by defense mechanisms required to protect the respiratory tract from environmental injury. Macrophages (MΦ), which belong to a group of multipurpose defensive cells, provide the first line of defense against mucosal invasive pathogens. The present study was performed to investigate, whether the herbal medicinal product have anti-inflammatory or anti-oxidative effects on pro-inflammatorily activated MΦ or after oxidative stress induction, with special attention to elucidate their effects on the mechanism of intracellular defense as well as on their migratory capacity. Results: Treatment of PMA-differentiated human THP-1 MΦ with Phytohustil® increased their viability without affecting the cell number. Phytohustil® or root extracts of Althaea officinalis (L) – an active component of Phytohustil® – were able to protect human THP-1 MΦ against H2O2-induced cytotoxicity and H2O2-induced ROS production. Moreover, Phytohustil®, root extracts of Althaea officinalis (L) or diclofenac used as anti-inflammatory reference substance, inhibited the LPS-induced release of tumor necrosis factor (TNF) as well as of IL6 in human THP-1 MΦ. Treatment of human THP-1 MΦ with Phytohustil®, its excipients or root extracts of Althaea officinalis (L) didn´t impair the mitochondrial membrane potential (MMP). Finally, Phytohustil®, and root extract of Althaea officinalis (L.) activated the migratory capacity of human THP-1 MΦ. Conclusions: The present in vitro investigations indicate protective, i.e. anti-oxidative and anti-inflammatory effects of root extracts of Althaea officinalis (L.) and Phytohustil®, additionally improving the migratory capacity of MΦ. These anti-inflammatory effect were similar or even better than effects of diclofenac. Thus, our data support and may explain the positive effect of Phytohustil® observed in patients during the therapy of inflamed buccal mucosal membranes and against the adverse effects of cough.

Saeed Changizi Ashtiyani – 3rd expert on this subject based on the ideXlab platform

  • the effect of Althaea officinalis l root alcoholic extract on blood sugar level and lipid profiles of streptozotocin induced diabetic rats
    iranian endodontic journal, 2015
    Co-Authors: Saeed Changizi Ashtiyani, Parvin Yarmohamadi

    Abstract:

    The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats

    Changizi Ashtiyani S1, Yarmohammadi P1, Hosseini N2, Salehi I3, Ramezani M4

    Abstract
    Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight).
    Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P<0.05). in diabetic rats treated, at all doses (200, 400, 800 mg/kg). Significant improvement was also observed in dyslipidemia (p<0.05). caused by diabetes mellitus, as confirmed by reduced levels of total cholesterol, triglycerides, LDL and significantly elevated levels of HDL. Fasting blood glucose levels of glibenclamide treated rats 200 mg/kg doses of the extract were significantly lower than those in the diabetic control group (P<0.05). However levels of fasting blood glucose in the group treated with 400, 800 mg/kg doses of the extract had no significant difference, as compared to the group treated with glibenclamide (P<0.05). Conclusion: Results of this study discovered significant hypolipidemic and hypoglycemic effects for the extract of Althaea officinalis in Wistar rats.
    Keywords: Althea officinalis, Diabetes, Dyslipidemia, Streptozotocin

  • The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats
    iranian endodontic journal, 2015
    Co-Authors: Saeed Changizi Ashtiyani, Parvin Yarmohamadi

    Abstract:

    The Effect of Althaea officinalis.L Root Alcoholic Extract on Blood Sugar Level and Lipid Profiles of Streptozotocin Induced-Diabetic Rats

    Changizi Ashtiyani S1, Yarmohammadi P1, Hosseini N2, Salehi I3, Ramezani M4

    Abstract
    Introduction: Althaea officinalis is listed among potential anti-diabetic herbal medicines. This study aimed to investigate the effect of the alcoholic extract of Althaea officinalis root on lowering blood sugar and lipid profiles in the treatment of type I diabetes. Materials and Methods: Seventy male Wistar rats were divided into 7 groups (n=10 each) as follows: Non-diabetic control, sham receiving normal saline (NS), and the diabetic control groups, which received extract of Althaea officinalis at doses of 200, 400, 800 mg/kg body weight respectively through gastric gavage and glibenclamide 5 mg/kg, for a period of 4 weeks. Diabetes was induced by streptozotocin (STZ) (60 mg/kg body weight).
    Results: The hydroalcoholic extract of Althaea officinalis significantly decreased blood glucose levels (P