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Cassiano Kuchenbecker Rosing – One of the best experts on this subject based on the ideXlab platform.

  • Effects of Chronic Ethanol Consumption and Ovariectomy on the Spontaneous Alveolar Bone Loss in Rats.
    International journal of dentistry, 2020
    Co-Authors: Priscila Cunha Nascimento, Cassiano Kuchenbecker Rosing, Leonardo Oliveira Bittencourt, Soraya O Pinto, Luana N. S. Santana, Renata Duarte De Souza-rodrigues, Armando L Pereira-neto, Cristiane Socorro Ferraz Maia, Rafael Rodrigues Lima
    Abstract:

    Postmenopausal estrogen deficiency and ethanol (EtOH) abuse are known risk factors for different diseases including Bone tissues. However, little is known about the synergic effects of EtOH abuse and estrogen deficiency on Alveolar Bone Loss in women. The present study evaluated the effects of EtOH chronic exposure and ovariectomy on the Alveolar Bone Loss in female rats. For this, 40 female Wistar rats were randomly divided into 4 groups: control, EtOH exposure, ovariectomy (OVX), and OVX plus EtOH exposure. Initially, half of the animals were ovariectomized at 75 days of age. After that, the groups received distilled water or EtOH 6.5 g/kg/day (20% w/v) for 55 days via gavage. Thereafter, animals were sacrificed and the mandibles were collected, dissected, and separated into hemimandibles. Alveolar Bone Loss was evaluated by measuring the distance between the cementoenamel junction and the Alveolar Bone crest through a stereomicroscope in 3 different anatomical regions of the tissue. One-way ANOVA and post hoc Tukey were used to compare groups ( ). The results showed that the ovariectomy and EtOH exposure per se were able to induce Alveolar Bone Loss, and their association did intensify significantly the effect. Therefore, OVX associated with heavy EtOH exposure increase the spontaneous Alveolar Bone Loss in rats.

  • Effect of obesity on Alveolar Bone Loss in experimental periodontitis in Wistar rats.
    Journal of applied oral science : revista FOB, 2012
    Co-Authors: Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Daniele Sigal Linhares, Cassiano Kuchenbecker Rosing
    Abstract:

    Obesity has been linked to higher inflammatory status and periodontal breakdown. OBJECTIVE: The purpose of this study was to investigate the effect of obesity on Alveolar Bone Loss in experimental periodontitis in rats. MATERIAL AND METHODS: Twenty-four female Wistar rats were randomly divided into two groups: obese (n=13), which were fed with “cafeteria diet” (CAF diet – high amounts of sucrose and fat) for 90 days in order to gain weight, and non-obese (n=11) regularly fed rats. Ligature-induced experimental periodontitis was created in all animals. Body weight differed statistically between obese and non-obese groups (277.59 and 223.35 g, respectively) at the moment of the ligature placement. Morphometric registration of Alveolar Bone Loss was carried out after 30 days of ligature placement to determine the effect of obesity on the progression of experimental periodontitis. RESULTS: Intra-group comparisons showed significantly higher Alveolar Bone Loss mean values in maxillary teeth with ligature (P

  • Correlation analysis of Alveolar Bone Loss in buccal/palatal and proximal surfaces in rats
    Brazilian oral research, 2012
    Co-Authors: Carolina Barrera De Azambuja, Eduardo Jose Gaio, Juliano Cavagni, Marcius Comparsi Wagner, Cassiano Kuchenbecker Rosing
    Abstract:

    The aim was to correlate Alveolar Bone Loss in the buccal/pala- tal and the mesial/distal surfaces of upper molars in rats. Thirty-three, 60-day-old, male Wistar rats were divided in two groups, one treated with alcohol and the other not treated with alcohol. All rats received silk ligatures on the right upper second molars for 4 weeks. The rats were then euthanized and their maxillae were split and defleshed with sodium hypochlorite (9%). The cemento-enamel junction (CEJ) was stained with 1% methylene blue and the Alveolar Bone Loss in the buccal/palatal sur- faces was measured linearly in 5 points on standardized digital photo- graphs. Measurement of the proximal sites was performed by sectioning the hemimaxillae, restaining the CEJ and measuring the Alveolar Bone Loss linearly in 3 points. A calibrated and blinded examiner performed all the measurements. Intraclass Correlation Coefficient revealed values of 0.96 and 0.89 for buccal/lingual and proximal surfaces, respectively. The Pearson Correlation Coefficient (r) between measurements in buccal/ palatal and proximal surfaces was 0.35 and 0.05 for the group treated with alcohol, with and without ligatures, respectively. The best corre- lations between buccal/palatal and proximal surfaces were observed in animals not treated with alcohol, in sites both with and without liga- tures (r = 0.59 and 0.65, respectively). A positive correlation was found between Alveolar Bone Loss in buccal/palatal and proximal surfaces. The correlation is stronger in animals that were not treated with alcohol, in sites without ligatures. Areas with and without ligature-induced peri- odontal destruction allow detection of Alveolar Bone Loss in buccal/pala- tal and proximal surfaces.

Young Joon Lee – One of the best experts on this subject based on the ideXlab platform.

  • Inhibitory effects of Persicariae Rhizoma aqueous extracts on experimental periodontitis and Alveolar Bone Loss in Sprague-Dawley rats
    Experimental and therapeutic medicine, 2016
    Co-Authors: Su Jin Kang, C. H. Han, Eun Kyung Lee, Bong Hyo Lee, Young Joon Lee
    Abstract:

    Persicariae Rhizoma (PR) is the dried stem parts of Persicaria tinctoria H. Gross (Polygonaceae), and has been traditionally used as anti-inflammatory and detoxifying agent. In the present study, the effects of PR aqueous extracts on ligation-induced experimental periodontitis (EPD) and associated Alveolar Bone Loss in rats were examined. Following the induction of EPD in rats, PR extracts were orally administered once a day for 10 days, and the changes and gains in body weight, Alveolar Bone Loss and total aerobic bacterial counts of buccal gingiva were observed with histopathological analysis. In addition, anti-inflammatory effects were evaluated by monitoring myeloperoxidase (MPO) activities, and interleukin (IL)-1β and tumor necrosis factor (TNF)-α contents, and anti-oxidant effects were investigated by measuring inducible nitric oxide synthase (iNOS) activities and malondialdehyde (MDA) levels. Bacterial proliferation, periodontitis and associated Alveolar Bone Loss induced by ligature placement were significantly and dose-dependently inhibited by the treatment with PR extracts. The inhibitory effects of 200 mg/kg PR were similar to those of 5 mg/kg indomethacin on ligation-induced periodontitis and associated Alveolar Bone Losses in this study. The results suggest that PR effectively inhibits ligature placement-induced periodontitis and Alveolar Bone Loss in rats via antibacterial, antioxidative and anti-inflammatory activities.

  • Effects of Polycan, a β-glucan, on experimental periodontitis and Alveolar Bone Loss in Sprague-Dawley rats.
    Journal of periodontal research, 2012
    Co-Authors: Y. S. Kim, Su Jin Kang, J. W. Kim, H. R. Cho, S. B. Moon, K. Y. Kim, Hyeung-sik Lee, C. H. Han, Young Joon Lee
    Abstract:

    Kim YS, Kang SJ, Kim JW, Cho HR, Moon SB, Kim KY, Lee HS, Han CH, Ku SK, Lee YJ. Effects of Polycan, a β-glucan, on experimental periodontitis and Alveolar Bone Loss in Sprague-Dawley rats. J Periodont Res 2012; 47: 800–810. © 2012 John Wiley & Sons A/S Background and Objective:  Polycan is a promising candidate for the treatment of periodontal disease. This study was undertaken to examine whether Polycan, a type of β-glucan, has a protective effect on ligature-induced experimental periodontitis and related Alveolar Bone Loss in Sprague-Dawley rats. Material and Methods:  Polycan was orally administered, daily, for 10 d, at 21.25, 42.5 or 85 mg/kg, beginning 1 d after ligation. Changes in body weight and Alveolar Bone Loss were monitored, and the anti-inflammatory effects of Polycan were determined by measuring the levels of myeloperoxidase (MPO), interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) in gingival tissue. We also evaluated inducible nitric oxide synthase (iNOS) activity and malondialdehyde (MDA) concentrations as a measure of the antioxidant effect. Results:  Ligature placement led to a marked decrease in body weight, increased Alveolar Bone Loss and increased concentrations of MPO, IL-1β, TNF-α and MDA, as well as increased iNOS activity and inflammatory cell infiltration and decreased collagen-fiber content. Histological examination revealed increases in the number and activity of osteoclast cells, decreases in Alveolar Bone volume and elevated percentages of osteclasts on the Alveolar Bone surface. Daily oral treatment with 42.5 or 85 mg/kg of Polycan for 10 d led to significant, dose-dependent inhibition of the effect of ligature placement. Conclusion:  Taken together, these results suggest that 10 d of oral treatment with Polycan effectively inhibits ligature placement-induced periodontitis and related Alveolar Bone Loss via an antioxidant effect.

Su Jin Kang – One of the best experts on this subject based on the ideXlab platform.

  • Inhibitory effects of Persicariae Rhizoma aqueous extracts on experimental periodontitis and Alveolar Bone Loss in Sprague-Dawley rats
    Experimental and therapeutic medicine, 2016
    Co-Authors: Su Jin Kang, C. H. Han, Eun Kyung Lee, Bong Hyo Lee, Young Joon Lee
    Abstract:

    Persicariae Rhizoma (PR) is the dried stem parts of Persicaria tinctoria H. Gross (Polygonaceae), and has been traditionally used as anti-inflammatory and detoxifying agent. In the present study, the effects of PR aqueous extracts on ligation-induced experimental periodontitis (EPD) and associated Alveolar Bone Loss in rats were examined. Following the induction of EPD in rats, PR extracts were orally administered once a day for 10 days, and the changes and gains in body weight, Alveolar Bone Loss and total aerobic bacterial counts of buccal gingiva were observed with histopathological analysis. In addition, anti-inflammatory effects were evaluated by monitoring myeloperoxidase (MPO) activities, and interleukin (IL)-1β and tumor necrosis factor (TNF)-α contents, and anti-oxidant effects were investigated by measuring inducible nitric oxide synthase (iNOS) activities and malondialdehyde (MDA) levels. Bacterial proliferation, periodontitis and associated Alveolar Bone Loss induced by ligature placement were significantly and dose-dependently inhibited by the treatment with PR extracts. The inhibitory effects of 200 mg/kg PR were similar to those of 5 mg/kg indomethacin on ligation-induced periodontitis and associated Alveolar Bone Losses in this study. The results suggest that PR effectively inhibits ligature placement-induced periodontitis and Alveolar Bone Loss in rats via antibacterial, antioxidative and anti-inflammatory activities.

  • Effects of Polycan, a β-glucan, on experimental periodontitis and Alveolar Bone Loss in Sprague-Dawley rats.
    Journal of periodontal research, 2012
    Co-Authors: Y. S. Kim, Su Jin Kang, J. W. Kim, H. R. Cho, S. B. Moon, K. Y. Kim, Hyeung-sik Lee, C. H. Han, Young Joon Lee
    Abstract:

    Kim YS, Kang SJ, Kim JW, Cho HR, Moon SB, Kim KY, Lee HS, Han CH, Ku SK, Lee YJ. Effects of Polycan, a β-glucan, on experimental periodontitis and Alveolar Bone Loss in Sprague-Dawley rats. J Periodont Res 2012; 47: 800–810. © 2012 John Wiley & Sons A/S Background and Objective:  Polycan is a promising candidate for the treatment of periodontal disease. This study was undertaken to examine whether Polycan, a type of β-glucan, has a protective effect on ligature-induced experimental periodontitis and related Alveolar Bone Loss in Sprague-Dawley rats. Material and Methods:  Polycan was orally administered, daily, for 10 d, at 21.25, 42.5 or 85 mg/kg, beginning 1 d after ligation. Changes in body weight and Alveolar Bone Loss were monitored, and the anti-inflammatory effects of Polycan were determined by measuring the levels of myeloperoxidase (MPO), interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) in gingival tissue. We also evaluated inducible nitric oxide synthase (iNOS) activity and malondialdehyde (MDA) concentrations as a measure of the antioxidant effect. Results:  Ligature placement led to a marked decrease in body weight, increased Alveolar Bone Loss and increased concentrations of MPO, IL-1β, TNF-α and MDA, as well as increased iNOS activity and inflammatory cell infiltration and decreased collagen-fiber content. Histological examination revealed increases in the number and activity of osteoclast cells, decreases in Alveolar Bone volume and elevated percentages of osteclasts on the Alveolar Bone surface. Daily oral treatment with 42.5 or 85 mg/kg of Polycan for 10 d led to significant, dose-dependent inhibition of the effect of ligature placement. Conclusion:  Taken together, these results suggest that 10 d of oral treatment with Polycan effectively inhibits ligature placement-induced periodontitis and related Alveolar Bone Loss via an antioxidant effect.

  • effects of calcium gluconate on experimental periodontitis and Alveolar Bone Loss in rats
    Basic & Clinical Pharmacology & Toxicology, 2011
    Co-Authors: Saekwang Ku, Yun Sub Sung, Su Jin Kang
    Abstract:

    We examined the effects of calcium gluconate, an anti-inflammatory calcium salt, on ligature-induced experimental periodontitis and related Alveolar Bone Loss. Calcium gluconate was orally administered daily for 10 days at 250, 125 or 62.5 mg/kg, beginning 1 day after ligation. We recorded changes in body-weight and Alveolar Bone Loss and quantified the anti-inflammatory effects of calcium gluconate by measuring levels of myeloperoxidase (MPO), IL-1β and TNF-α. We also evaluated inducible nitric oxide synthase (iNOS) activity and malondialdehyde (MDA) concentration as a measure of antioxidant effects. Ligature placement produced a marked decrease in body-weight, increased Alveolar Bone Loss, and led to increased MPO, IL-1β, TNF-α and MDA concentrations, as well as elevated iNOS activity, increased inflammatory cell infiltration and decreased collagen fibre content in gingival tissue. Histopathology revealed decreased Alveolar Bone volume, increased osteoclast cell numbers and activity, and an elevated percentage of osteclasts on the Alveolar Bone surface. The effects of ligature placement were significantly and dose-dependently inhibited by 10 days of daily oral treatment with 250 and 125 mg/kg of calcium gluconate. The results suggest that 10 days daily oral treatment with calcium gluconate effectively inhibits ligature placement-induced periodontitis and related Alveolar Bone Loss via antioxidant effects.