The Experts below are selected from a list of 48 Experts worldwide ranked by ideXlab platform
Janet E Foley - One of the best experts on this subject based on the ideXlab platform.
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endemic skunk Amdoparvovirus in free ranging striped skunks mephitis mephitis in california
Transboundary and Emerging Diseases, 2019Co-Authors: Elle Glueckert, Deana L Clifford, Maris Brennwhite, Jennine Ochoa, Mourad W Gabriel, Greta M Wengert, Janet E FoleyAbstract:The genus Amdoparvovirus includes the newly discovered skunk Amdoparvovirus and the well-characterized Aleutian disease virus which causes significant health impacts in farmed mink worldwide. In 2010-2013, an outbreak of fatal Amdoparvovirus-associated disease was documented in free-ranging striped skunks (Mephitis mephitis) from the San Francisco Bay Area of California. To characterize the geographic distribution, earliest occurrence and abundance of this virus, as well as possible impacts on sympatric mustelids of conservation concern, we tested blood samples from skunks throughout California and fishers (Pekania pennanti) from northern California for Amdoparvovirus DNA. Amdoparvovirus DNA was detected in 64.8% of sampled skunks (140/216), and test-positive skunks were distributed widely throughout the state, from as far north as Humboldt County and south to San Diego County. The first test-positive skunks were detected from 2004, prior to the 2010-2013 outbreak. No significant spatial or temporal clustering of infection was detected. Although healthy and clinically ill animals tested positive for Amdoparvovirus DNA, histopathologic evaluation of a subset from clinically ill skunks indicated that positive PCR results were associated with pneumonia as well as there being more than one inflammatory type lesion. None of 38 fishers were PCR-positive. Given the widespread geographic distribution and lack of a clear epizootic centre, our results suggest the presence of an endemic skunk-associated Amdoparvovirus strain or species. However, if the virus is not host-specific, skunks' ubiquitous presence across rural and urban habitats may pose a risk to susceptible domestic and wild species including mustelids of conservation concern such as fishers and Pacific martens (Martes caurina).
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ALEUTIAN DISEASE VIRUS-LIKE VIRUS ( Amdoparvovirus SP.) INFECTING FREE-RANGING STRIPED SKUNKS ( MEPHITIS MEPHITIS) IN THE MIDWESTERN USA.
Journal of wildlife diseases, 2017Co-Authors: Federico Giannitti, Mohammadreza Sadeghi, Marc Schwabenlander, Janet E FoleyAbstract:ABSTRACT: Aleutian disease virus (ADV) and closely related (ADV-like) viruses are Parvoviridae members (genus Amdoparvovirus) that primarily infect farmed mustelids and have been detected in humans and free-ranging Carnivora from North America. We describe ADV-like/Amdoparvovirus sp. infection in four free-ranging striped skunks (Mephitis mephitis) from the Midwestern US.
Andrew S Lang - One of the best experts on this subject based on the ideXlab platform.
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full genetic characterization and epidemiology of a novel Amdoparvovirus in striped skunk mephitis mephitis
Emerging microbes & infections, 2017Co-Authors: Marta Canuti, Hillary E Doyle, Ann P Britton, Andrew S LangAbstract:Amdoparvovirus is a newly defined parvoviral genus that contains four species (Carnivore Amdoparvovirus 1-4), including the well-known Aleutian mink disease virus (AMDV). Amdoparvoviruses cause an immune-associated and often lethal wasting syndrome in Mustelidae and Caninae hosts. In this study, we molecularly investigated Amdoparvoviruses detected in 44 striped skunks (Mephitis mephitis) found dead in and around Vancouver, British Columbia, Canada. Some of the animals exhibited pathological changes compatible with Amdoparvovirus-associated disease. The nearly complete genomic sequence was obtained for seven different strains and our analyses show how this virus, which we named skunk Amdoparvovirus (SKAV), should be classified as a separate species within the genus (proposed Carnivore Amdoparvovirus 5). We detected co-infections, recombinant genomes, at least three separate viral lineages, and preliminary evidence for geographic segregation of lineages. Furthermore, we proved that similar viruses, only partially characterized in previous studies and labeled as AMDV, circulate in skunks from other distant areas of North America (Ontario and California) and found evidence for spillover events in mink (Neovison vison). Although SKAVs are capable of causing disease in infected animals, a high proportion of sub-clinical infections has been observed, suggesting these animals might act as asymptomatic carriers and pose a threat to wild and captive carnivores. Finally, we highlight the need for more specific diagnostic tests and further molecular investigations to clarify the epidemiology and host- and geographical distributions of Amdoparvoviruses in terrestrial carnivores, especially because the whole spectrum of viral diversity in this group is likely still unknown.
Deana L Clifford - One of the best experts on this subject based on the ideXlab platform.
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endemic skunk Amdoparvovirus in free ranging striped skunks mephitis mephitis in california
Transboundary and Emerging Diseases, 2019Co-Authors: Elle Glueckert, Deana L Clifford, Maris Brennwhite, Jennine Ochoa, Mourad W Gabriel, Greta M Wengert, Janet E FoleyAbstract:The genus Amdoparvovirus includes the newly discovered skunk Amdoparvovirus and the well-characterized Aleutian disease virus which causes significant health impacts in farmed mink worldwide. In 2010-2013, an outbreak of fatal Amdoparvovirus-associated disease was documented in free-ranging striped skunks (Mephitis mephitis) from the San Francisco Bay Area of California. To characterize the geographic distribution, earliest occurrence and abundance of this virus, as well as possible impacts on sympatric mustelids of conservation concern, we tested blood samples from skunks throughout California and fishers (Pekania pennanti) from northern California for Amdoparvovirus DNA. Amdoparvovirus DNA was detected in 64.8% of sampled skunks (140/216), and test-positive skunks were distributed widely throughout the state, from as far north as Humboldt County and south to San Diego County. The first test-positive skunks were detected from 2004, prior to the 2010-2013 outbreak. No significant spatial or temporal clustering of infection was detected. Although healthy and clinically ill animals tested positive for Amdoparvovirus DNA, histopathologic evaluation of a subset from clinically ill skunks indicated that positive PCR results were associated with pneumonia as well as there being more than one inflammatory type lesion. None of 38 fishers were PCR-positive. Given the widespread geographic distribution and lack of a clear epizootic centre, our results suggest the presence of an endemic skunk-associated Amdoparvovirus strain or species. However, if the virus is not host-specific, skunks' ubiquitous presence across rural and urban habitats may pose a risk to susceptible domestic and wild species including mustelids of conservation concern such as fishers and Pacific martens (Martes caurina).
Elle Glueckert - One of the best experts on this subject based on the ideXlab platform.
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endemic skunk Amdoparvovirus in free ranging striped skunks mephitis mephitis in california
Transboundary and Emerging Diseases, 2019Co-Authors: Elle Glueckert, Deana L Clifford, Maris Brennwhite, Jennine Ochoa, Mourad W Gabriel, Greta M Wengert, Janet E FoleyAbstract:The genus Amdoparvovirus includes the newly discovered skunk Amdoparvovirus and the well-characterized Aleutian disease virus which causes significant health impacts in farmed mink worldwide. In 2010-2013, an outbreak of fatal Amdoparvovirus-associated disease was documented in free-ranging striped skunks (Mephitis mephitis) from the San Francisco Bay Area of California. To characterize the geographic distribution, earliest occurrence and abundance of this virus, as well as possible impacts on sympatric mustelids of conservation concern, we tested blood samples from skunks throughout California and fishers (Pekania pennanti) from northern California for Amdoparvovirus DNA. Amdoparvovirus DNA was detected in 64.8% of sampled skunks (140/216), and test-positive skunks were distributed widely throughout the state, from as far north as Humboldt County and south to San Diego County. The first test-positive skunks were detected from 2004, prior to the 2010-2013 outbreak. No significant spatial or temporal clustering of infection was detected. Although healthy and clinically ill animals tested positive for Amdoparvovirus DNA, histopathologic evaluation of a subset from clinically ill skunks indicated that positive PCR results were associated with pneumonia as well as there being more than one inflammatory type lesion. None of 38 fishers were PCR-positive. Given the widespread geographic distribution and lack of a clear epizootic centre, our results suggest the presence of an endemic skunk-associated Amdoparvovirus strain or species. However, if the virus is not host-specific, skunks' ubiquitous presence across rural and urban habitats may pose a risk to susceptible domestic and wild species including mustelids of conservation concern such as fishers and Pacific martens (Martes caurina).
Marta Canuti - One of the best experts on this subject based on the ideXlab platform.
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full genetic characterization and epidemiology of a novel Amdoparvovirus in striped skunk mephitis mephitis
Emerging microbes & infections, 2017Co-Authors: Marta Canuti, Hillary E Doyle, Ann P Britton, Andrew S LangAbstract:Amdoparvovirus is a newly defined parvoviral genus that contains four species (Carnivore Amdoparvovirus 1-4), including the well-known Aleutian mink disease virus (AMDV). Amdoparvoviruses cause an immune-associated and often lethal wasting syndrome in Mustelidae and Caninae hosts. In this study, we molecularly investigated Amdoparvoviruses detected in 44 striped skunks (Mephitis mephitis) found dead in and around Vancouver, British Columbia, Canada. Some of the animals exhibited pathological changes compatible with Amdoparvovirus-associated disease. The nearly complete genomic sequence was obtained for seven different strains and our analyses show how this virus, which we named skunk Amdoparvovirus (SKAV), should be classified as a separate species within the genus (proposed Carnivore Amdoparvovirus 5). We detected co-infections, recombinant genomes, at least three separate viral lineages, and preliminary evidence for geographic segregation of lineages. Furthermore, we proved that similar viruses, only partially characterized in previous studies and labeled as AMDV, circulate in skunks from other distant areas of North America (Ontario and California) and found evidence for spillover events in mink (Neovison vison). Although SKAVs are capable of causing disease in infected animals, a high proportion of sub-clinical infections has been observed, suggesting these animals might act as asymptomatic carriers and pose a threat to wild and captive carnivores. Finally, we highlight the need for more specific diagnostic tests and further molecular investigations to clarify the epidemiology and host- and geographical distributions of Amdoparvoviruses in terrestrial carnivores, especially because the whole spectrum of viral diversity in this group is likely still unknown.