The Experts below are selected from a list of 1305 Experts worldwide ranked by ideXlab platform
Xiaofeng Wu - One of the best experts on this subject based on the ideXlab platform.
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Palladium-Catalyzed Amide Synthesis via Aminocarbonylation of Arylboronic Acids with Nitroarenes
Organic Letters, 2019Co-Authors: Jin-bao Peng, Da Li, Hui-qing Geng, Xiaofeng WuAbstract:A palladium-catalyzed Aminocarbonylation of aryl boronic acids with nitroarenes for the synthesis of amides has been developed. A wide range of substrates were well-tolerated and gave the corresponding amides in moderate to good yields. No external oxidant or reductant was needed in this procedure. This procedure provides a redox-economical process for the synthesis of amides.
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a highly efficient palladium catalyzed Aminocarbonylation snar approach to dibenzoxazepinones
ChemInform, 2015Co-Authors: Chaoren Shen, Helfried Neumann, Xiaofeng WuAbstract:Various 2-aminophenols and 2-bromofluorobenzenes are used as substrates for the convenient one-pot synthesis of a wide range of dibenzoxazepinones by a palladium-catalyzed Aminocarbonylation/aromatic nucleophilic substitution sequence.
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A Highly-Efficient Palladium-Catalyzed Aminocarbonylation/SNAr Approach to Dibenzoxazepinones.
ChemInform, 2015Co-Authors: Chaoren Shen, Helfried Neumann, Xiaofeng WuAbstract:Various 2-aminophenols and 2-bromofluorobenzenes are used as substrates for the convenient one-pot synthesis of a wide range of dibenzoxazepinones by a palladium-catalyzed Aminocarbonylation/aromatic nucleophilic substitution sequence.
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a highly efficient palladium catalyzed Aminocarbonylation snar approach to dibenzoxazepinones
Green Chemistry, 2015Co-Authors: Chaoren Shen, Helfried Neumann, Xiaofeng WuAbstract:A convenient procedure for the synthesis of dibenzoxazepinones has been developed. Utilizing the protocol of one-pot palladium-catalyzed Aminocarbonylation/aromatic nucleophilic substitution (SNAr) sequence, with 2-aminophenols and 2-bromofluorobenzenes as the substrates, the desired dibenzo[b,e][1,4]oxazepin-11(5H)-ones were prepared in moderate to excellent yields. The broad substrate scope and functional group tolerance of the reaction makes this approach a practical method for the synthesis of valuable dibenzoxazepinone and its derivatives. Mechanistic studies suggest that Aminocarbonylation proceeds prior to SNAr.
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A highly-efficient palladium-catalyzed Aminocarbonylation/SNAr approach to dibenzoxazepinones
Green Chemistry, 2015Co-Authors: Chaoren Shen, Helfried Neumann, Xiaofeng WuAbstract:A convenient procedure for the synthesis of dibenzoxazepinones has been developed. Utilizing the protocol of one-pot palladium-catalyzed Aminocarbonylation/aromatic nucleophilic substitution (SNAr) sequence, with 2-aminophenols and 2-bromofluorobenzenes as the substrates, the desired dibenzo[b,e][1,4]oxazepin-11(5H)-ones were prepared in moderate to excellent yields. The broad substrate scope and functional group tolerance of the reaction makes this approach a practical method for the synthesis of valuable dibenzoxazepinone and its derivatives. Mechanistic studies suggest that Aminocarbonylation proceeds prior to SNAr.
Giancarlo Cravotto - One of the best experts on this subject based on the ideXlab platform.
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highly efficient microwave assisted co Aminocarbonylation with a recyclable pd ii tpp β cyclodextrin cross linked catalyst
ChemInform, 2015Co-Authors: Emanuela Calcio Gaudino, Diego Carnaroglio, Katia Martina, Giovanni Palmisano, Andrea Penoni, Giancarlo CravottoAbstract:A new recyclable catalytic system based on Pd(II) embedded in cross-linked cyclodextrin is found to be very efficient in Aminocarbonylation reactions of aryl iodides (I).
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highly efficient microwave assisted co Aminocarbonylation with a recyclable pd ii tpp β cyclodextrin cross linked catalyst
Organic Process Research & Development, 2015Co-Authors: Emanuela Calcio Gaudino, Diego Carnaroglio, Katia Martina, Giovanni Palmisano, Andrea Penoni, Giancarlo CravottoAbstract:The incorporation of the carbonyl moiety into organic molecules using a three-component matrix, including carbon monoxide, an organic halide, and a nucleophilic component, offers a simple and versatile approach to the formation of carboxylic acids, anhydrides, esters, amides, and ketones. The design of a sustainable synthetic protocol for Aminocarbonylation can be efficiently accomplished using a multifaceted strategy that combines solid green catalysts and suitable enabling techniques. The safe and synergistic use of carbon monoxide in a microwave reactor under pressure may be able to create a technological breakthrough in Aminocarbonylation reactions. Moreover, a new recyclable catalytic system “CβCAT” based on Pd(II)-triphenylphosphine embedded in cross-linked β-cyclodextrin (hexamethylene diisocyanate) has been found to be very efficient in aryl iodide Aminocarbonylation reactions.
László Kollár - One of the best experts on this subject based on the ideXlab platform.
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High-yielding synthesis of N-triazolyl carboxamides via palladium-catalysed Aminocarbonylation
Tetrahedron, 2017Co-Authors: Máté Gergely, Borbála Boros, László KollárAbstract:Abstract Aminocarbonylation of alkenyl and aryl iodides in the presence of 4-amino-4H-1,2,4-triazole as N-nucleophile was carried out in the presence of palladium catalysts. Both types of substrates have shown high chemoselectivity toward carboxamides, i.e. practically no double carbon monoxide insertion resulting in 2-ketocarboxamides took place. The results have been rationalised on the basis of mechanistic aspects of Aminocarbonylation.
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Palladium-catalysed Aminocarbonylation of diiodopyridines
Tetrahedron, 2017Co-Authors: Attila Takács, Georgina Márta Varga, Johanna Kardos, László KollárAbstract:Abstract The Aminocarbonylation of 2,5- and 2,3-diiodopyridine, as well as 2-chloro-3,4-diiodopyridine with carbon monoxide and various primary and secondary amines was carried out using palladium-catalysed Aminocarbonylation. The formation of the products containing carboxamide and ketocarboxamide functionalities was accompanied by the formation of imides when ortho-diiodo compounds were used as substrates. In spite of several possible reaction pathways, most of the products were synthesised as major product in yields of synthetic interest by the appropriate modification of the reaction conditions.
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Synthesis of bornene-2,2′-diamino-1,1′-binaphthalene conjugates in palladium-catalysed Aminocarbonylations
Tetrahedron-asymmetry, 2016Co-Authors: Gábor Mikle, Borbála Boros, László KollárAbstract:Abstract Palladium-catalysed Aminocarbonylation of a terpenoic iodoalkene (2-iodo-bornene) model compound with both enantiomerically pure and racemic 2,2′-diamino-1,1′-binaphthalene (BINAM) as the N -nucleophile was carried out. All of the diastereoisomers of the monocarboxamide ( N -bornenyl carboxamide) and dicarboxamide ( N , N ′-dinorbornenylcarboxamide) derivatives were synthesised. The diastereoselectivities of the Aminocarbonylation were investigated in both cases: either racemic BINAM was used as the N -nucleophile in the Aminocarbonylation of enantiomerically pure 2-iodobornene or racemic iodobornene was aminocarbonylated with enantiomerically pure BINAM with moderate diastereoselectivities. In this way, all possible diastereoisomers of binaphthalene–bornene conjugates were synthesised in moderate to high yields by asymmetric (diastereoselective) Aminocarbonylation.
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Synthesis of amino-substituted pyridylglyoxylamides via palladium-catalysed Aminocarbonylation
Tetrahedron, 2016Co-Authors: Gyöngyi Szőke, Andrea Petz, Attila Takács, Zoltán Berente, László KollárAbstract:Abstract Palladium-catalysed Aminocarbonylation of iodopyridine model compounds (4-amino-3-iodopyridine and 3-amino-4-iodopyridine) with various primary and secondary amines including amino acid methyl esters was carried out. The two substrates behave in a completely different manner under Aminocarbonylation conditions: 4-amino-3-iodopyridine gave the corresponding 2-ketocarboxamides (nicotinamide analogues) due to double carbon monoxide insertion, while 3-amino-4-iodopyridine reacted as a bifunctional substrate resulting in a dicarboxamide containing two pyridyl moieties.
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4‐Amino‐TEMPO as N‐Nucleophile in Palladium‐Catalyzed Aminocarbonylation
Journal of Heterocyclic Chemistry, 2016Co-Authors: Máté Gergely, Attila Takács, László KollárAbstract:Palladium-catalyzed Aminocarbonylation of iodobenzene and iodoalkenes (1-iodocyclohexene, 4-tert-butyl-1- iodocyclohexene, α-iodostyrene, 17-iodoandrost-16-ene) was carried out using a free radical (4-amino-TEMPO) for the first time. Its reduced form (4-amino-2,2,6,6-tetramethylpiperidine) was also used as N-nucleophile. The free radical was partially reduced under Aminocarbonylation conditions; however, the isolation of carbonylated products bearing a stable radical moiety was successfully accomplished. It was proved that the reduction of the 1-oxyl functionality took place to higher extent when more severe conditions (40 bar CO pressure) were used. The mixture of carboxamide and 2-ketocarboxamide products was obtained using iodobenzene because of single and double carbon monoxide insertion, respectively. In turn, carboxamide derivatives were formed exclusively when iodoalkenes were used as substrates.
Emanuela Calcio Gaudino - One of the best experts on this subject based on the ideXlab platform.
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highly efficient microwave assisted co Aminocarbonylation with a recyclable pd ii tpp β cyclodextrin cross linked catalyst
ChemInform, 2015Co-Authors: Emanuela Calcio Gaudino, Diego Carnaroglio, Katia Martina, Giovanni Palmisano, Andrea Penoni, Giancarlo CravottoAbstract:A new recyclable catalytic system based on Pd(II) embedded in cross-linked cyclodextrin is found to be very efficient in Aminocarbonylation reactions of aryl iodides (I).
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highly efficient microwave assisted co Aminocarbonylation with a recyclable pd ii tpp β cyclodextrin cross linked catalyst
Organic Process Research & Development, 2015Co-Authors: Emanuela Calcio Gaudino, Diego Carnaroglio, Katia Martina, Giovanni Palmisano, Andrea Penoni, Giancarlo CravottoAbstract:The incorporation of the carbonyl moiety into organic molecules using a three-component matrix, including carbon monoxide, an organic halide, and a nucleophilic component, offers a simple and versatile approach to the formation of carboxylic acids, anhydrides, esters, amides, and ketones. The design of a sustainable synthetic protocol for Aminocarbonylation can be efficiently accomplished using a multifaceted strategy that combines solid green catalysts and suitable enabling techniques. The safe and synergistic use of carbon monoxide in a microwave reactor under pressure may be able to create a technological breakthrough in Aminocarbonylation reactions. Moreover, a new recyclable catalytic system “CβCAT” based on Pd(II)-triphenylphosphine embedded in cross-linked β-cyclodextrin (hexamethylene diisocyanate) has been found to be very efficient in aryl iodide Aminocarbonylation reactions.
Jinheng Li - One of the best experts on this subject based on the ideXlab platform.
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room temperature palladium catalyzed intramolecular oxidative Aminocarbonylation of vinylic c sp2 h bonds with amines and co
European Journal of Organic Chemistry, 2014Co-Authors: Xuheng Yang, Kai Li, Renjie Song, Jinheng LiAbstract:A new, mild route to access 3-methyleneindolin-2-ones is presented that proceeds through a room-temperature, palladium-catalyzed intramolecular oxidative Aminocarbonylation of alkenes with amines and CO. This method represents a new Aminocarbonylation strategy by employing an oxidative functionalization of a vinyl C(sp2)–H bond.
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Room‐Temperature Palladium‐Catalyzed Intramolecular Oxidative Aminocarbonylation of Vinylic C(sp2)–H Bonds with Amines and CO
European Journal of Organic Chemistry, 2013Co-Authors: Xu‐heng Yang, Kai Li, Ren‐jie Song, Jinheng LiAbstract:A new, mild route to access 3-methyleneindolin-2-ones is presented that proceeds through a room-temperature, palladium-catalyzed intramolecular oxidative Aminocarbonylation of alkenes with amines and CO. This method represents a new Aminocarbonylation strategy by employing an oxidative functionalization of a vinyl C(sp2)–H bond.
