Carbon Monoxide

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And Xiaogang Zhang - One of the best experts on this subject based on the ideXlab platform.

Brian L. Goodall - One of the best experts on this subject based on the ideXlab platform.

Stefan W. Ryter - One of the best experts on this subject based on the ideXlab platform.

  • Carbon Monoxide in sepsis.
    Antioxidants & redox signaling, 2007
    Co-Authors: Alexander Hoetzel, Tamas Dolinay, Rene Schmidt, Augustine M K Choi, Stefan W. Ryter
    Abstract:

    Despite modern practices in critical care medicine, sepsis or systemic inflammatory response syndrome remains a leading cause of morbidity and mortality in the intensive care unit. Thus, the need to identify new therapeutic tools for the treatment of sepsis is urgent. In this context, Carbon Monoxide has become a promising therapeutic molecule that can potentially prevent uncontrolled inflammation in sepsis. In humans, Carbon Monoxide arises endogenously from the degradation of heme by heme oxygenase enzymes. Both endogenously synthesized and exogenously applied Carbon Monoxide can exert antiinflammatory and antiapoptotic effects in cells and tissues. Based on these properties, Carbon Monoxide, when applied at low concentration, conferred protection in a variety of cellular and rodent models of sepsis, and furthermore reduced morbidity and mortality in vivo. Therefore, application of Carbon Monoxide may have a major impact on the future of sepsis treatment. This review summarizes evidence for salutary effects of Carbon Monoxide in sepsis of various organs, including lung, heart, kidney, liver, and intestine, and discusses the potential translation of the data into human clinical trials.

Haifei Zhang - One of the best experts on this subject based on the ideXlab platform.

Stefanos N. Kales - One of the best experts on this subject based on the ideXlab platform.

  • Carbon Monoxide intoxication.
    American family physician, 1993
    Co-Authors: Stefanos N. Kales
    Abstract:

    Carbon Monoxide poisoning usually results from inhalation of exhaust fumes from motor vehicles, smoke from fires or fumes from faulty heating systems. Carbon Monoxide has a high affinity for hemoglobin, with which it forms carboxyhemoglobin. The resulting decrease in both oxygen-carrying capacity and oxygen release can lead to end-organ hypoxia. The clinical presentation is nonspecific. Headache, dizziness, fatigue and nausea are common in mild to moderate Carbon Monoxide poisoning. In more severe cases, tachycardia, tachypnea and central nervous system depression occur. When Carbon Monoxide intoxication is suspected, empiric treatment with 100 percent oxygen should be initiated immediately. The diagnosis is confirmed by documenting an elevated carboxyhemoglobin level. Hyperbaric oxygen therapy is recommended in patients with neurologic dysfunction, cardiac dysfunction or a history of unconsciousness.