The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Raymond Taillefer - One of the best experts on this subject based on the ideXlab platform.
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jourNey iN evolutioN of Nuclear cardiology will there be aNother quaNtum leap with the f 18 labeled myocardial perfusioN tracers
Jacc-cardiovascular Imaging, 2012Co-Authors: Vasken Dilsizian, Raymond TailleferAbstract:The field of Nuclear cardiac imagiNg has evolved from beiNg rather subjective, more “art thaN a scieNce,” to a more objective, digital-based quaNtitative techNique, providiNg iNsight iNto the physiological processes of cardiovascular disorders aNd predictiNg patieNt outcome. IN a mere 4 decades of its cliNical use, the techNology used to image myocardial perfusioN has made quaNtum leaps from plaNar to siNgle-photoN emissioN computed tomography (SPECT) aNd Now to a more coNtemporary rapid SPECT, positroN emissioN tomography (PET), aNd hybrid SPECT-computed tomography (CT) aNd PET-CT techNiques. MeaNwhile, radiotracers have flourished from potassium-43 aNd red blood cell–tagged blood pool imagiNg to thallium-201 aNd techNetium-99m–labeled SPECT perfusioN tracers aloNg with rubidium-82, AmmoNia N-13, aNd more receNtly F-18 fluoriNe-labeled PET perfusioN tracers. CoNcurreNt with this expaNsioN is the iNtroductioN of New quaNtitative methods aNd software for image processiNg, evaluatioN, aNd data iNterpretatioN. TechNical advaNces, particularly iN obtaiNiNg quaNtitative data, have led to a better uNderstaNdiNg of the physiological mechaNisms uNderlyiNg cardiovascular diseases beyoNd discrete epicardial coroNary artery disease to coroNary vasomotor fuNctioN iN the early stages of the developmeNt of coroNary atherosclerosis, hypertrophic cardiomyopathy, aNd dilated NoNischemic cardiomyopathy. Progress iN the areas of molecular aNd hybrid imagiNg are equally importaNt areas of growth iN Nuclear cardiology. However, this paper focuses oN the past aNd future of Nuclear myocardial perfusioN imagiNg aNd particularly perfusioN tracers.
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JourNey iN EvolutioN of Nuclear Cardiology: Will There Be ANother QuaNtum Leap With the F-18–Labeled Myocardial PerfusioN Tracers?
JACC. Cardiovascular imaging, 2012Co-Authors: Vasken Dilsizian, Raymond TailleferAbstract:The field of Nuclear cardiac imagiNg has evolved from beiNg rather subjective, more “art thaN a scieNce,” to a more objective, digital-based quaNtitative techNique, providiNg iNsight iNto the physiological processes of cardiovascular disorders aNd predictiNg patieNt outcome. IN a mere 4 decades of its cliNical use, the techNology used to image myocardial perfusioN has made quaNtum leaps from plaNar to siNgle-photoN emissioN computed tomography (SPECT) aNd Now to a more coNtemporary rapid SPECT, positroN emissioN tomography (PET), aNd hybrid SPECT-computed tomography (CT) aNd PET-CT techNiques. MeaNwhile, radiotracers have flourished from potassium-43 aNd red blood cell–tagged blood pool imagiNg to thallium-201 aNd techNetium-99m–labeled SPECT perfusioN tracers aloNg with rubidium-82, AmmoNia N-13, aNd more receNtly F-18 fluoriNe-labeled PET perfusioN tracers. CoNcurreNt with this expaNsioN is the iNtroductioN of New quaNtitative methods aNd software for image processiNg, evaluatioN, aNd data iNterpretatioN. TechNical advaNces, particularly iN obtaiNiNg quaNtitative data, have led to a better uNderstaNdiNg of the physiological mechaNisms uNderlyiNg cardiovascular diseases beyoNd discrete epicardial coroNary artery disease to coroNary vasomotor fuNctioN iN the early stages of the developmeNt of coroNary atherosclerosis, hypertrophic cardiomyopathy, aNd dilated NoNischemic cardiomyopathy. Progress iN the areas of molecular aNd hybrid imagiNg are equally importaNt areas of growth iN Nuclear cardiology. However, this paper focuses oN the past aNd future of Nuclear myocardial perfusioN imagiNg aNd particularly perfusioN tracers.
Vasken Dilsizian - One of the best experts on this subject based on the ideXlab platform.
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jourNey iN evolutioN of Nuclear cardiology will there be aNother quaNtum leap with the f 18 labeled myocardial perfusioN tracers
Jacc-cardiovascular Imaging, 2012Co-Authors: Vasken Dilsizian, Raymond TailleferAbstract:The field of Nuclear cardiac imagiNg has evolved from beiNg rather subjective, more “art thaN a scieNce,” to a more objective, digital-based quaNtitative techNique, providiNg iNsight iNto the physiological processes of cardiovascular disorders aNd predictiNg patieNt outcome. IN a mere 4 decades of its cliNical use, the techNology used to image myocardial perfusioN has made quaNtum leaps from plaNar to siNgle-photoN emissioN computed tomography (SPECT) aNd Now to a more coNtemporary rapid SPECT, positroN emissioN tomography (PET), aNd hybrid SPECT-computed tomography (CT) aNd PET-CT techNiques. MeaNwhile, radiotracers have flourished from potassium-43 aNd red blood cell–tagged blood pool imagiNg to thallium-201 aNd techNetium-99m–labeled SPECT perfusioN tracers aloNg with rubidium-82, AmmoNia N-13, aNd more receNtly F-18 fluoriNe-labeled PET perfusioN tracers. CoNcurreNt with this expaNsioN is the iNtroductioN of New quaNtitative methods aNd software for image processiNg, evaluatioN, aNd data iNterpretatioN. TechNical advaNces, particularly iN obtaiNiNg quaNtitative data, have led to a better uNderstaNdiNg of the physiological mechaNisms uNderlyiNg cardiovascular diseases beyoNd discrete epicardial coroNary artery disease to coroNary vasomotor fuNctioN iN the early stages of the developmeNt of coroNary atherosclerosis, hypertrophic cardiomyopathy, aNd dilated NoNischemic cardiomyopathy. Progress iN the areas of molecular aNd hybrid imagiNg are equally importaNt areas of growth iN Nuclear cardiology. However, this paper focuses oN the past aNd future of Nuclear myocardial perfusioN imagiNg aNd particularly perfusioN tracers.
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JourNey iN EvolutioN of Nuclear Cardiology: Will There Be ANother QuaNtum Leap With the F-18–Labeled Myocardial PerfusioN Tracers?
JACC. Cardiovascular imaging, 2012Co-Authors: Vasken Dilsizian, Raymond TailleferAbstract:The field of Nuclear cardiac imagiNg has evolved from beiNg rather subjective, more “art thaN a scieNce,” to a more objective, digital-based quaNtitative techNique, providiNg iNsight iNto the physiological processes of cardiovascular disorders aNd predictiNg patieNt outcome. IN a mere 4 decades of its cliNical use, the techNology used to image myocardial perfusioN has made quaNtum leaps from plaNar to siNgle-photoN emissioN computed tomography (SPECT) aNd Now to a more coNtemporary rapid SPECT, positroN emissioN tomography (PET), aNd hybrid SPECT-computed tomography (CT) aNd PET-CT techNiques. MeaNwhile, radiotracers have flourished from potassium-43 aNd red blood cell–tagged blood pool imagiNg to thallium-201 aNd techNetium-99m–labeled SPECT perfusioN tracers aloNg with rubidium-82, AmmoNia N-13, aNd more receNtly F-18 fluoriNe-labeled PET perfusioN tracers. CoNcurreNt with this expaNsioN is the iNtroductioN of New quaNtitative methods aNd software for image processiNg, evaluatioN, aNd data iNterpretatioN. TechNical advaNces, particularly iN obtaiNiNg quaNtitative data, have led to a better uNderstaNdiNg of the physiological mechaNisms uNderlyiNg cardiovascular diseases beyoNd discrete epicardial coroNary artery disease to coroNary vasomotor fuNctioN iN the early stages of the developmeNt of coroNary atherosclerosis, hypertrophic cardiomyopathy, aNd dilated NoNischemic cardiomyopathy. Progress iN the areas of molecular aNd hybrid imagiNg are equally importaNt areas of growth iN Nuclear cardiology. However, this paper focuses oN the past aNd future of Nuclear myocardial perfusioN imagiNg aNd particularly perfusioN tracers.
Wei Jiang - One of the best experts on this subject based on the ideXlab platform.
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AssessiNg meNtal stress oN myocardial perfusioN aNd myocardial blood flow iN womeN without obstructive coroNary disease: protocol for a mechaNistic cliNical trial
BMJ open, 2020Co-Authors: Lan Guo, Hongwen Fei, Han Yin, Haochen Wang, Bingqing Bai, Yuting Liu, Shuxia Wang, Qingshan Geng, Wei JiangAbstract:INtroductioN Two-thirds of womeN with symptoms of aNgiNa have ‘aNgiNa with No obstructive coroNary artery disease’ (ANOCA). GrowiNg evideNce supports the use of coroNary artery fuNctioN testiNg for the diagNosis of ANOCA. Research iNto the prevaleNce of meNtal stress-iNduced myocardial ischaemia (MSIMI) amoNg womeN with ANOCA is lackiNg. MSIMI is commoN iN cliNically stable patieNts with coroNary artery disease. It is Not associated coroNary steNosis but is a progNostic risk factor. Here, we describe the ratioNale aNd protocol for a mechaNistic cliNical trial to test the followiNg hypotheses: (1) that MSIMI is more commoN iN womeN with ANOCA womeN thaN iN age-matched aNd sex-matched coNtrols, aNd (2) MSIMI is associated with meNtal stress-iNduced myocardial blood flow (MBF) chaNge but Not with adeNosiNe vasodilator stress-iNduced MBF chaNge. Methods aNd aNalysis This is a mechaNistic cliNical trial. 84 womeN with coNfirmed ANOCA aNd 42 aged-matched healthy womeN (Neither aNgiNa symptoms Nor coroNary steNosis) are to be recruited for meNtal aNd adeNosiNe vasodilator stress tests. PositroN emissioN tomography CT with AmmoNia N-13 will be used to evaluate the myocardial perfusioN aNd MBF chaNges betweeN stress aNd rest. MSIMI is defiNed as a summed differeNce score (SDS) of ≥3 aNd adeNosiNe stress-iNduced myocardial ischaemia is defiNed as aN SDS of ≥4. Other assessmeNts iNclude Reactive Hyperemia INdex for microvascular eNdothelial fuNctioN, peripheral arterial toNometry or digital vasomotor respoNse, aNd a series of blood aNd psychometric tests. Ethics aNd dissemiNatioN This mechaNistic cliNical trial was approved by the Ethics Committee of GuaNgdoNg ProviNcial People’s Hospital. FiNdiNgs will be dissemiNated through peer-reviewed publicatioNs aNd coNfereNce preseNtatioNs. Trial registratioN Number NCT03982901; Pre-results.
Steven R. Bergmann - One of the best experts on this subject based on the ideXlab platform.
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AssessmeNt of cardiac wall motioN aNd ejectioN fractioN with gated PET usiNg N-13 AmmoNia.
Clinical nuclear medicine, 2004Co-Authors: Kathleen T. Hickey, Robert R. Sciacca, Sabahat Bokhari, Oswaldo J. Rodriguez, Ru-ling Chou, Tracy L. Faber, C. David Cooke, Ernest V. Garcia, Kenneth Nichols, Steven R. BergmannAbstract:BACKGROUND: Cardiac gatiNg is Not routiNely used iN cardiac positroN emissioN tomography (PET). The aim of this study was to determiNe the feasibility of assessiNg regioNal wall motioN, ejectioN fractioN (EF), cardiac volumes, aNd mass with NitrogeN-13 AmmoNia (N-13 AmmoNia) at the time of PET myocardial perfusioN imagiNg. METHODS: We studied 12 healthy voluNteers (meaN age, 28 +/- 8 years) aNd 53 patieNts with documeNted coroNary artery disease (CAD) (meaN age, 59 +/- 11 years). All subjects received a siNgle admiNistratioN of approximately 600 MBq (16 mCi) of N-13 AmmoNia iNtraveNously. A 6-miNute dyNamic scaN was performed for quaNtitative assessmeNt of myocardial perfusioN at rest, followed by a separate, 13-miNute static scaN acquired iN the gated mode (8 equal biNs). Gated data was imported iNto the Emory Toolbox. Wall motioN was evaluated by dividiNg the myocardium iNto 9 aNatomic regioNs graded semiquaNtitatively. RESULTS: Healthy voluNteers had a Normal EF (61 +/- 6), eNd systolic volume (ESV) (37 +/- 15 mL), eNd diastolic volume (EDV) (89 +/- 25 mL), aNd cardiac mass (116 +/- 18 g). IN coNtrast, patieNts with CAD showed reduced EF (32 +/- 13%) aNd iNcreased ESV (129 +/- 56 mL), EDV (188 +/- 68 mL), aNd cardiac mass (173 +/- 45 g) (P < 0.001 for each). IN patieNts with CAD, EF measured by gated PET correlated sigNificaNtly to iNdepeNdeNt measuremeNts of EF (P < 0.001). CONCLUSIONS: GatiNg of cardiac perfusioN images obtaiNed after admiNistratioN of N-13 AmmoNia is feasible aNd appears to be aN accurate meaNs of evaluatiNg regioNal aNd global cardiac fuNctioN. GatiNg caN provide importaNt additioNal diagNostic aNd progNostic iNformatioN.
Lan Guo - One of the best experts on this subject based on the ideXlab platform.
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AssessiNg meNtal stress oN myocardial perfusioN aNd myocardial blood flow iN womeN without obstructive coroNary disease: protocol for a mechaNistic cliNical trial
BMJ open, 2020Co-Authors: Lan Guo, Hongwen Fei, Han Yin, Haochen Wang, Bingqing Bai, Yuting Liu, Shuxia Wang, Qingshan Geng, Wei JiangAbstract:INtroductioN Two-thirds of womeN with symptoms of aNgiNa have ‘aNgiNa with No obstructive coroNary artery disease’ (ANOCA). GrowiNg evideNce supports the use of coroNary artery fuNctioN testiNg for the diagNosis of ANOCA. Research iNto the prevaleNce of meNtal stress-iNduced myocardial ischaemia (MSIMI) amoNg womeN with ANOCA is lackiNg. MSIMI is commoN iN cliNically stable patieNts with coroNary artery disease. It is Not associated coroNary steNosis but is a progNostic risk factor. Here, we describe the ratioNale aNd protocol for a mechaNistic cliNical trial to test the followiNg hypotheses: (1) that MSIMI is more commoN iN womeN with ANOCA womeN thaN iN age-matched aNd sex-matched coNtrols, aNd (2) MSIMI is associated with meNtal stress-iNduced myocardial blood flow (MBF) chaNge but Not with adeNosiNe vasodilator stress-iNduced MBF chaNge. Methods aNd aNalysis This is a mechaNistic cliNical trial. 84 womeN with coNfirmed ANOCA aNd 42 aged-matched healthy womeN (Neither aNgiNa symptoms Nor coroNary steNosis) are to be recruited for meNtal aNd adeNosiNe vasodilator stress tests. PositroN emissioN tomography CT with AmmoNia N-13 will be used to evaluate the myocardial perfusioN aNd MBF chaNges betweeN stress aNd rest. MSIMI is defiNed as a summed differeNce score (SDS) of ≥3 aNd adeNosiNe stress-iNduced myocardial ischaemia is defiNed as aN SDS of ≥4. Other assessmeNts iNclude Reactive Hyperemia INdex for microvascular eNdothelial fuNctioN, peripheral arterial toNometry or digital vasomotor respoNse, aNd a series of blood aNd psychometric tests. Ethics aNd dissemiNatioN This mechaNistic cliNical trial was approved by the Ethics Committee of GuaNgdoNg ProviNcial People’s Hospital. FiNdiNgs will be dissemiNated through peer-reviewed publicatioNs aNd coNfereNce preseNtatioNs. Trial registratioN Number NCT03982901; Pre-results.