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W Gottschling - One of the best experts on this subject based on the ideXlab platform.
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vaginal ureaplasma urealyticum colonization influence on pregnancy outcome and neonatal morbidity
Infection, 1997Co-Authors: Marianne Abelehorn, Jochen Peters, Orsolya Genzelboroviczeny, C Wolff, Andrea Zimmermann, W GottschlingAbstract:The effects ofUreaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized withU. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls,U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p<0.001), chorioAmnionitis (0% vs 10%; p<0.05), premature rupture of membranes (12% vs 35%; p<0.001) and preterm delivery (10% vs 41%; p<0.001). The rate of vertical transmission ranged from 38% in term infants to 95% in very low birth weight infants.U. urealyticum colonization at birth was associated with an increased risk for the development of respiratory distress syndrome (9% vs 51%), intraventricular hemorrhage (1% vs 7%) and bronchopulmonary dysplasia (4% vs 17%) in very low birth weight infants (<1500 g). It is concluded that maternalU. urealyticum colonization is associated with Amnionitis, chorioAmnionitis and preterm delivery, and that tracheal colonization withU. urealyticum increases the risk for respiratory and neurological complications in very low birth weight infants.
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VaginalUreaplasma urealyticum colonization: Influence on pregnancy outcome and neonatal morbidity
Infection, 1997Co-Authors: M. Abele-horn, Jochen Peters, C Wolff, Andrea Zimmermann, O. Genzel-boroviczény, W GottschlingAbstract:The effects of Ureaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized with U. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls, U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p
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Vaginal Ureaplasma urealyticum Colonization: Influence on Pregnancy Outcome and Neonatal Morbidity
Infection, 1997Co-Authors: M. Abele-horn, Jochen Peters, C Wolff, Andrea Zimmermann, O. Genzel-boroviczény, W GottschlingAbstract:The effects ofUreaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized withU. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls,U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p
Bo Hyun Yoon - One of the best experts on this subject based on the ideXlab platform.
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timing of histologic progression from chorio deciduitis to chorio deciduo Amnionitis in the setting of preterm labor and preterm premature rupture of membranes with sterile amniotic fluid
PLOS ONE, 2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:BACKGROUND Histologic chorio-deciduitis and chorio-deciduo-Amnionitis (Amnionitis) in extra-placental membranes are known to represent the early and advanced stages of ascending intra-uterine infection. However, there are no data in humans about the time required for chorio-deciduitis to develop and for chorio-deciduitis without Amnionitis to progress to chorio-deciduitis with Amnionitis, and the effect of prolongation of pregnancy on the development of chorio-deciduitis and Amnionitis in patients with preterm labor and intact membranes (PTL) and preterm premature rupture of membranes (preterm-PROM). We examined these issues in this study. METHODS The study population consisted of 289 women who delivered preterm (133 cases with PTL, and 156 cases with preterm-PROM) and who had sterile amniotic fluid (AF) defined as a negative AF culture and the absence of inflammation as evidenced by a matrix metalloproteinase-8 (MMP-8) level <23 ng/ml. We examined the association between amniocentesis-to-delivery interval and inflammatory status in the extra-placental membranes (i.e., inflammation-free extra-placental membranes, choroi-deciduitis only, and chorio-deciduitis with Amnionitis) in patients with PTL and preterm-PROM. RESULTS Amniocentesis-to-delivery interval was longer in cases of chorio-deciduitis with Amnionitis than in cases of chorio-deciduitis only in both PTL (median [interquartile-range (IQR)]; 645.4 [319.5] vs. 113.9 [526.9] hours; P = 0.005) and preterm-PROM (131.3 [135.4] vs. 95.2 [140.5] hours; P<0.05). Amniocentesis-to-delivery interval was an independent predictor of the development of both chorio-deciduitis and Amnionitis after correction for confounding variables such as gestational age at delivery in the setting of PTL, but not preterm-PROM. CONCLUSIONS These data confirm for the first time that, in cases of both PTL and preterm-PROM with sterile AF, more time is required to develop chorio-deciduitis with Amnionitis than chorio-deciduitis alone in extra-placental membranes. Moreover, prolongation of pregnancy is an independent predictor of the development of both chorio-deciduitis and Amnionitis in cases of PTL with sterile AF.
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Timing of Histologic Progression from Chorio-Deciduitis to Chorio-Deciduo-Amnionitis in the Setting of Preterm Labor and Preterm Premature Rupture of Membranes with Sterile Amniotic Fluid
PloS one, 2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:BACKGROUND Histologic chorio-deciduitis and chorio-deciduo-Amnionitis (Amnionitis) in extra-placental membranes are known to represent the early and advanced stages of ascending intra-uterine infection. However, there are no data in humans about the time required for chorio-deciduitis to develop and for chorio-deciduitis without Amnionitis to progress to chorio-deciduitis with Amnionitis, and the effect of prolongation of pregnancy on the development of chorio-deciduitis and Amnionitis in patients with preterm labor and intact membranes (PTL) and preterm premature rupture of membranes (preterm-PROM). We examined these issues in this study. METHODS The study population consisted of 289 women who delivered preterm (133 cases with PTL, and 156 cases with preterm-PROM) and who had sterile amniotic fluid (AF) defined as a negative AF culture and the absence of inflammation as evidenced by a matrix metalloproteinase-8 (MMP-8) level
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Relationship of various independent variables with the development of chorio-deciduitis and Amnionitis analyzed by overall logistic regression analysis in PTL with sterile amniotic fluid.
2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:PTL, preterm labor and intact membranes; CI, confidence interval.Relationship of various independent variables with the development of chorio-deciduitis and Amnionitis analyzed by overall logistic regression analysis in PTL with sterile amniotic fluid.
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Relationship of various independent variables with the development of chorio-deciduitis and Amnionitis analyzed by overall logistic regression analysis in preterm-PROM with sterile amniotic fluid.
2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:preterm-PROM, preterm premature rupture of membranes; CI, confidence interval.Relationship of various independent variables with the development of chorio-deciduitis and Amnionitis analyzed by overall logistic regression analysis in preterm-PROM with sterile amniotic fluid.
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Frequency of inflammation in placental compartments according to amniocentesis-to-delivery interval.
2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:The frequency of chorio-deciduitis (A), Amnionitis (B), funisitis (C), and chorionic plate inflammation (D) according to amniocentesis-to-delivery interval (i.e., ≤2 days, 2–7 days, and >7 days) is shown in patients with PTL and preterm-PROM. Frequency and P-values are shown.
Chanwook Park - One of the best experts on this subject based on the ideXlab platform.
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timing of histologic progression from chorio deciduitis to chorio deciduo Amnionitis in the setting of preterm labor and preterm premature rupture of membranes with sterile amniotic fluid
PLOS ONE, 2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:BACKGROUND Histologic chorio-deciduitis and chorio-deciduo-Amnionitis (Amnionitis) in extra-placental membranes are known to represent the early and advanced stages of ascending intra-uterine infection. However, there are no data in humans about the time required for chorio-deciduitis to develop and for chorio-deciduitis without Amnionitis to progress to chorio-deciduitis with Amnionitis, and the effect of prolongation of pregnancy on the development of chorio-deciduitis and Amnionitis in patients with preterm labor and intact membranes (PTL) and preterm premature rupture of membranes (preterm-PROM). We examined these issues in this study. METHODS The study population consisted of 289 women who delivered preterm (133 cases with PTL, and 156 cases with preterm-PROM) and who had sterile amniotic fluid (AF) defined as a negative AF culture and the absence of inflammation as evidenced by a matrix metalloproteinase-8 (MMP-8) level <23 ng/ml. We examined the association between amniocentesis-to-delivery interval and inflammatory status in the extra-placental membranes (i.e., inflammation-free extra-placental membranes, choroi-deciduitis only, and chorio-deciduitis with Amnionitis) in patients with PTL and preterm-PROM. RESULTS Amniocentesis-to-delivery interval was longer in cases of chorio-deciduitis with Amnionitis than in cases of chorio-deciduitis only in both PTL (median [interquartile-range (IQR)]; 645.4 [319.5] vs. 113.9 [526.9] hours; P = 0.005) and preterm-PROM (131.3 [135.4] vs. 95.2 [140.5] hours; P<0.05). Amniocentesis-to-delivery interval was an independent predictor of the development of both chorio-deciduitis and Amnionitis after correction for confounding variables such as gestational age at delivery in the setting of PTL, but not preterm-PROM. CONCLUSIONS These data confirm for the first time that, in cases of both PTL and preterm-PROM with sterile AF, more time is required to develop chorio-deciduitis with Amnionitis than chorio-deciduitis alone in extra-placental membranes. Moreover, prolongation of pregnancy is an independent predictor of the development of both chorio-deciduitis and Amnionitis in cases of PTL with sterile AF.
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Timing of Histologic Progression from Chorio-Deciduitis to Chorio-Deciduo-Amnionitis in the Setting of Preterm Labor and Preterm Premature Rupture of Membranes with Sterile Amniotic Fluid
PloS one, 2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:BACKGROUND Histologic chorio-deciduitis and chorio-deciduo-Amnionitis (Amnionitis) in extra-placental membranes are known to represent the early and advanced stages of ascending intra-uterine infection. However, there are no data in humans about the time required for chorio-deciduitis to develop and for chorio-deciduitis without Amnionitis to progress to chorio-deciduitis with Amnionitis, and the effect of prolongation of pregnancy on the development of chorio-deciduitis and Amnionitis in patients with preterm labor and intact membranes (PTL) and preterm premature rupture of membranes (preterm-PROM). We examined these issues in this study. METHODS The study population consisted of 289 women who delivered preterm (133 cases with PTL, and 156 cases with preterm-PROM) and who had sterile amniotic fluid (AF) defined as a negative AF culture and the absence of inflammation as evidenced by a matrix metalloproteinase-8 (MMP-8) level
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Relationship of various independent variables with the development of chorio-deciduitis and Amnionitis analyzed by overall logistic regression analysis in PTL with sterile amniotic fluid.
2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:PTL, preterm labor and intact membranes; CI, confidence interval.Relationship of various independent variables with the development of chorio-deciduitis and Amnionitis analyzed by overall logistic regression analysis in PTL with sterile amniotic fluid.
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Relationship of various independent variables with the development of chorio-deciduitis and Amnionitis analyzed by overall logistic regression analysis in preterm-PROM with sterile amniotic fluid.
2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:preterm-PROM, preterm premature rupture of membranes; CI, confidence interval.Relationship of various independent variables with the development of chorio-deciduitis and Amnionitis analyzed by overall logistic regression analysis in preterm-PROM with sterile amniotic fluid.
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Frequency of inflammation in placental compartments according to amniocentesis-to-delivery interval.
2015Co-Authors: Chanwook Park, Joong Shin Park, Errol R Norwitz, Kyung Chul Moon, Jong Kwan Jun, Bo Hyun YoonAbstract:The frequency of chorio-deciduitis (A), Amnionitis (B), funisitis (C), and chorionic plate inflammation (D) according to amniocentesis-to-delivery interval (i.e., ≤2 days, 2–7 days, and >7 days) is shown in patients with PTL and preterm-PROM. Frequency and P-values are shown.
Jochen Peters - One of the best experts on this subject based on the ideXlab platform.
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vaginal ureaplasma urealyticum colonization influence on pregnancy outcome and neonatal morbidity
Infection, 1997Co-Authors: Marianne Abelehorn, Jochen Peters, Orsolya Genzelboroviczeny, C Wolff, Andrea Zimmermann, W GottschlingAbstract:The effects ofUreaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized withU. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls,U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p<0.001), chorioAmnionitis (0% vs 10%; p<0.05), premature rupture of membranes (12% vs 35%; p<0.001) and preterm delivery (10% vs 41%; p<0.001). The rate of vertical transmission ranged from 38% in term infants to 95% in very low birth weight infants.U. urealyticum colonization at birth was associated with an increased risk for the development of respiratory distress syndrome (9% vs 51%), intraventricular hemorrhage (1% vs 7%) and bronchopulmonary dysplasia (4% vs 17%) in very low birth weight infants (<1500 g). It is concluded that maternalU. urealyticum colonization is associated with Amnionitis, chorioAmnionitis and preterm delivery, and that tracheal colonization withU. urealyticum increases the risk for respiratory and neurological complications in very low birth weight infants.
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VaginalUreaplasma urealyticum colonization: Influence on pregnancy outcome and neonatal morbidity
Infection, 1997Co-Authors: M. Abele-horn, Jochen Peters, C Wolff, Andrea Zimmermann, O. Genzel-boroviczény, W GottschlingAbstract:The effects of Ureaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized with U. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls, U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p
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Vaginal Ureaplasma urealyticum Colonization: Influence on Pregnancy Outcome and Neonatal Morbidity
Infection, 1997Co-Authors: M. Abele-horn, Jochen Peters, C Wolff, Andrea Zimmermann, O. Genzel-boroviczény, W GottschlingAbstract:The effects ofUreaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized withU. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls,U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p
Andrea Zimmermann - One of the best experts on this subject based on the ideXlab platform.
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vaginal ureaplasma urealyticum colonization influence on pregnancy outcome and neonatal morbidity
Infection, 1997Co-Authors: Marianne Abelehorn, Jochen Peters, Orsolya Genzelboroviczeny, C Wolff, Andrea Zimmermann, W GottschlingAbstract:The effects ofUreaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized withU. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls,U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p<0.001), chorioAmnionitis (0% vs 10%; p<0.05), premature rupture of membranes (12% vs 35%; p<0.001) and preterm delivery (10% vs 41%; p<0.001). The rate of vertical transmission ranged from 38% in term infants to 95% in very low birth weight infants.U. urealyticum colonization at birth was associated with an increased risk for the development of respiratory distress syndrome (9% vs 51%), intraventricular hemorrhage (1% vs 7%) and bronchopulmonary dysplasia (4% vs 17%) in very low birth weight infants (<1500 g). It is concluded that maternalU. urealyticum colonization is associated with Amnionitis, chorioAmnionitis and preterm delivery, and that tracheal colonization withU. urealyticum increases the risk for respiratory and neurological complications in very low birth weight infants.
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VaginalUreaplasma urealyticum colonization: Influence on pregnancy outcome and neonatal morbidity
Infection, 1997Co-Authors: M. Abele-horn, Jochen Peters, C Wolff, Andrea Zimmermann, O. Genzel-boroviczény, W GottschlingAbstract:The effects of Ureaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized with U. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls, U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p
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Vaginal Ureaplasma urealyticum Colonization: Influence on Pregnancy Outcome and Neonatal Morbidity
Infection, 1997Co-Authors: M. Abele-horn, Jochen Peters, C Wolff, Andrea Zimmermann, O. Genzel-boroviczény, W GottschlingAbstract:The effects ofUreaplasma urealyticum colonization on pregnancy and neonatal outcome was prospectively studied in women with impending term or preterm delivery. One hundred and seventy women colonized withU. urealyticum as the only pathogenic microorganism and 83 women with negative cultures were enrolled for study. Compared to the controls,U. urealyticum colonization was associated with a significantly increased rate of Amnionitis (2% vs 35%; p