The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Wanchun Tang - One of the best experts on this subject based on the ideXlab platform.
-
Abstract 81: Amplitude Spectrum Area Predicts the Success of Defibrillation on Rats During Cardiopulmonary Resuscitation
Circulation, 2010Co-Authors: Yinlun Weng, Max Harry Weil, Shijie Sun, Wanchun TangAbstract:Amplitude Spectrum area (AMSA) has been used for predicting the success of defibrillation during CPR. However, the efficacy of AMSA on predicting the success of defibrillation on small animals rema...
-
The Amplitude Spectrum area correctly predicts improved resuscitation and facilitated defibrillation with head cooling.
Critical Care Medicine, 2008Co-Authors: Min-shan Tsai, Denise Barbut, Jun Guan, Joe Bisera, Becky Inderbitzen, Max Harry Weil, Wanchun TangAbstract:Objectives: When systemic hypothermia was maintained before inducing cardiac arrest, the likelihood of successful defibrillation and meaningful survival was increased. When hypothermia is induced during cardiopulmonary resuscitation, mortality is also improved. With the introduction of the Amplitude Spectrum area as a predictor of the success of electrical defibrillation, we investigated the effect of preferential head cooling initiated coincident with cardiopulmonary resuscitation on Amplitude Spectrum area as a predictor. We hypothesized that rapid head cooling initiated coincident with cardiopulmonary resuscitation improves Amplitude Spectrum area, and therefore is predictive of successful defibrillation. Design: Prospective randomized controlled study. Setting: University-affiliated research institute. Subjects: Domestic pigs. Interventions: Sixteen pigs, weighing 40.6 1.4 kg, were randomized to the hypothermia (n 8), or control (n 8) group. Ventricular fibrillation was induced and untreated for 10 mins. Cardiopulmonary resuscitation was then initiated for 5 mins followed by attempted defibrillation with a biphasic 150-J electric shock. Coincident with starting cardiopulmonary resuscitation, hypothermia was induced with evaporative intranasal cooling using a perfluorochemical. If spontaneous circulation was not restored after defibrillation, cardiopulmonary resuscitation was resumed for 1 min before the next defibrillation attempt until the animal was either successfully resuscitated or for a total of 15 mins. The target core temperature was 34°C. Control animals
-
The Amplitude Spectrum area correctly predicts improved resuscitation and facilitated defibrillation with head cooling.
Critical care medicine, 2008Co-Authors: Min-shan Tsai, Denise Barbut, Jun Guan, Joe Bisera, Becky Inderbitzen, Max Harry Weil, Wanchun TangAbstract:When systemic hypothermia was maintained before inducing cardiac arrest, the likelihood of successful defibrillation and meaningful survival was increased. When hypothermia is induced during cardiopulmonary resuscitation, mortality is also improved. With the introduction of the Amplitude Spectrum area as a predictor of the success of electrical defibrillation, we investigated the effect of preferential head cooling initiated coincident with cardiopulmonary resuscitation on Amplitude Spectrum area as a predictor. We hypothesized that rapid head cooling initiated coincident with cardiopulmonary resuscitation improves Amplitude Spectrum area, and therefore is predictive of successful defibrillation. Prospective randomized controlled study. University-affiliated research institute. Domestic pigs. Sixteen pigs, weighing 40.6 +/- 1.4 kg, were randomized to the hypothermia (n = 8), or control (n = 8) group. Ventricular fibrillation was induced and untreated for 10 mins. Cardiopulmonary resuscitation was then initiated for 5 mins followed by attempted defibrillation with a biphasic 150-J electric shock. Coincident with starting cardiopulmonary resuscitation, hypothermia was induced with evaporative intranasal cooling using a perfluorochemical. If spontaneous circulation was not restored after defibrillation, cardiopulmonary resuscitation was resumed for 1 min before the next defibrillation attempt until the animal was either successfully resuscitated or for a total of 15 mins. The target core temperature was 34 degrees C. Control animals were identically treated except for hypothermia. Five seconds of ventricular fibrillation waveform were recorded immediately preceding delivery of a shock. The ventricular fibrillation waveforms were analyzed using the Amplitude Spectrum area algorithm. A smaller epinephrine dose (60 +/- 32.1 vs. 30 +/- 0 mg/mL, p = .01) and shorter cardiopulmonary resuscitation duration (365 +/- 42 sec vs. 600 +/- 243 sec, p = .01) were required to achieve return of spontaneous circulation in the hypothermia group, compared with control. Five minutes after starting cardiopulmonary resuscitation, head temperature was reduced from 38 degrees C to 34 degrees C in the hypothermia group (p = .028). Hypothermia improved the success of electrical shocks before return of spontaneous circulation (88 +/- 18% vs. 66 +/- 19%, p = .034). Both the Amplitude Spectrum area values of initial shock (26.1 +/- 5.3 vs. 21.4 +/- 2.16 mV-Hz, p = .049) and total shocks (26.1 +/- 5.3 vs. 21.4 +/- 2.16 mV-Hz, p = .006) were significantly higher in the hypothermia group than control. Amplitude Spectrum area served as a useful predictor for improved resuscitation and facilitated defibrillation in the setting of rapid head cooling initiated coincident with cardiopulmonary resuscitation.
Roberto Latini - One of the best experts on this subject based on the ideXlab platform.
-
Amplitude Spectrum area to guide defibrillation a validation on 1617 patients with ventricular fibrillation
Circulation, 2015Co-Authors: Giuseppe Ristagno, Tommaso Mauri, Giancarlo Cesana, Andrea Finzi, Francesca Fumagalli, G P Rossi, Niccolo Grieco, Maurizio Migliori, Aida Andreassi, Roberto LatiniAbstract:Background—This study sought to validate the ability of Amplitude Spectrum area (AMSA) to predict defibrillation success and long-term survival in a large population of out-of-hospital cardiac arrests. Methods and Results—ECGs recorded by automated external defibrillators from different manufacturers were obtained from patients with cardiac arrests occurring in 8 city areas. A database, including 2447 defibrillations from 1050 patients, was used as the derivation group, and an additional database, including 1381 defibrillations from 567 patients, served as validation. A 2-second ECG window before defibrillation was analyzed, and AMSA was calculated. Univariable and multivariable regression analyses and area under the receiver operating characteristic curve were used for associations between AMSA and study end points: defibrillation success, sustained return of spontaneous circulation, and long-term survival. Among the 2447 defibrillations of the derivation database, 26.2% were successful. AMSA was signifi...
-
Abstract 137: Ranolazine Increases Amplitude Spectrum Area During Untreated Ventricular Fibrillation and Cardiopulmonary Resuscitation
Circulation, 2013Co-Authors: Francesca Fumagalli, Giuseppe Ristagno, Ilaria Russo, Lidia Staszewsky, Roberto LatiniAbstract:Background: Amplitude Spectrum area (AMSA) has been demonstrated to be related to myocardial vitality during ventricular fibrillation (VF). Deregulation of intracellular Ca2+ homeostasis plays a cr...
Francesca Fumagalli - One of the best experts on this subject based on the ideXlab platform.
-
Amplitude Spectrum area to guide defibrillation a validation on 1617 patients with ventricular fibrillation
Circulation, 2015Co-Authors: Giuseppe Ristagno, Tommaso Mauri, Giancarlo Cesana, Andrea Finzi, Francesca Fumagalli, G P Rossi, Niccolo Grieco, Maurizio Migliori, Aida Andreassi, Roberto LatiniAbstract:Background—This study sought to validate the ability of Amplitude Spectrum area (AMSA) to predict defibrillation success and long-term survival in a large population of out-of-hospital cardiac arrests. Methods and Results—ECGs recorded by automated external defibrillators from different manufacturers were obtained from patients with cardiac arrests occurring in 8 city areas. A database, including 2447 defibrillations from 1050 patients, was used as the derivation group, and an additional database, including 1381 defibrillations from 567 patients, served as validation. A 2-second ECG window before defibrillation was analyzed, and AMSA was calculated. Univariable and multivariable regression analyses and area under the receiver operating characteristic curve were used for associations between AMSA and study end points: defibrillation success, sustained return of spontaneous circulation, and long-term survival. Among the 2447 defibrillations of the derivation database, 26.2% were successful. AMSA was signifi...
-
Abstract 137: Ranolazine Increases Amplitude Spectrum Area During Untreated Ventricular Fibrillation and Cardiopulmonary Resuscitation
Circulation, 2013Co-Authors: Francesca Fumagalli, Giuseppe Ristagno, Ilaria Russo, Lidia Staszewsky, Roberto LatiniAbstract:Background: Amplitude Spectrum area (AMSA) has been demonstrated to be related to myocardial vitality during ventricular fibrillation (VF). Deregulation of intracellular Ca2+ homeostasis plays a cr...
Giuseppe Ristagno - One of the best experts on this subject based on the ideXlab platform.
-
Amplitude Spectrum area to guide defibrillation a validation on 1617 patients with ventricular fibrillation
Circulation, 2015Co-Authors: Giuseppe Ristagno, Tommaso Mauri, Giancarlo Cesana, Andrea Finzi, Francesca Fumagalli, G P Rossi, Niccolo Grieco, Maurizio Migliori, Aida Andreassi, Roberto LatiniAbstract:Background—This study sought to validate the ability of Amplitude Spectrum area (AMSA) to predict defibrillation success and long-term survival in a large population of out-of-hospital cardiac arrests. Methods and Results—ECGs recorded by automated external defibrillators from different manufacturers were obtained from patients with cardiac arrests occurring in 8 city areas. A database, including 2447 defibrillations from 1050 patients, was used as the derivation group, and an additional database, including 1381 defibrillations from 567 patients, served as validation. A 2-second ECG window before defibrillation was analyzed, and AMSA was calculated. Univariable and multivariable regression analyses and area under the receiver operating characteristic curve were used for associations between AMSA and study end points: defibrillation success, sustained return of spontaneous circulation, and long-term survival. Among the 2447 defibrillations of the derivation database, 26.2% were successful. AMSA was signifi...
-
Abstract 137: Ranolazine Increases Amplitude Spectrum Area During Untreated Ventricular Fibrillation and Cardiopulmonary Resuscitation
Circulation, 2013Co-Authors: Francesca Fumagalli, Giuseppe Ristagno, Ilaria Russo, Lidia Staszewsky, Roberto LatiniAbstract:Background: Amplitude Spectrum area (AMSA) has been demonstrated to be related to myocardial vitality during ventricular fibrillation (VF). Deregulation of intracellular Ca2+ homeostasis plays a cr...
Max Harry Weil - One of the best experts on this subject based on the ideXlab platform.
-
Abstract 81: Amplitude Spectrum Area Predicts the Success of Defibrillation on Rats During Cardiopulmonary Resuscitation
Circulation, 2010Co-Authors: Yinlun Weng, Max Harry Weil, Shijie Sun, Wanchun TangAbstract:Amplitude Spectrum area (AMSA) has been used for predicting the success of defibrillation during CPR. However, the efficacy of AMSA on predicting the success of defibrillation on small animals rema...
-
The Amplitude Spectrum area correctly predicts improved resuscitation and facilitated defibrillation with head cooling.
Critical Care Medicine, 2008Co-Authors: Min-shan Tsai, Denise Barbut, Jun Guan, Joe Bisera, Becky Inderbitzen, Max Harry Weil, Wanchun TangAbstract:Objectives: When systemic hypothermia was maintained before inducing cardiac arrest, the likelihood of successful defibrillation and meaningful survival was increased. When hypothermia is induced during cardiopulmonary resuscitation, mortality is also improved. With the introduction of the Amplitude Spectrum area as a predictor of the success of electrical defibrillation, we investigated the effect of preferential head cooling initiated coincident with cardiopulmonary resuscitation on Amplitude Spectrum area as a predictor. We hypothesized that rapid head cooling initiated coincident with cardiopulmonary resuscitation improves Amplitude Spectrum area, and therefore is predictive of successful defibrillation. Design: Prospective randomized controlled study. Setting: University-affiliated research institute. Subjects: Domestic pigs. Interventions: Sixteen pigs, weighing 40.6 1.4 kg, were randomized to the hypothermia (n 8), or control (n 8) group. Ventricular fibrillation was induced and untreated for 10 mins. Cardiopulmonary resuscitation was then initiated for 5 mins followed by attempted defibrillation with a biphasic 150-J electric shock. Coincident with starting cardiopulmonary resuscitation, hypothermia was induced with evaporative intranasal cooling using a perfluorochemical. If spontaneous circulation was not restored after defibrillation, cardiopulmonary resuscitation was resumed for 1 min before the next defibrillation attempt until the animal was either successfully resuscitated or for a total of 15 mins. The target core temperature was 34°C. Control animals
-
The Amplitude Spectrum area correctly predicts improved resuscitation and facilitated defibrillation with head cooling.
Critical care medicine, 2008Co-Authors: Min-shan Tsai, Denise Barbut, Jun Guan, Joe Bisera, Becky Inderbitzen, Max Harry Weil, Wanchun TangAbstract:When systemic hypothermia was maintained before inducing cardiac arrest, the likelihood of successful defibrillation and meaningful survival was increased. When hypothermia is induced during cardiopulmonary resuscitation, mortality is also improved. With the introduction of the Amplitude Spectrum area as a predictor of the success of electrical defibrillation, we investigated the effect of preferential head cooling initiated coincident with cardiopulmonary resuscitation on Amplitude Spectrum area as a predictor. We hypothesized that rapid head cooling initiated coincident with cardiopulmonary resuscitation improves Amplitude Spectrum area, and therefore is predictive of successful defibrillation. Prospective randomized controlled study. University-affiliated research institute. Domestic pigs. Sixteen pigs, weighing 40.6 +/- 1.4 kg, were randomized to the hypothermia (n = 8), or control (n = 8) group. Ventricular fibrillation was induced and untreated for 10 mins. Cardiopulmonary resuscitation was then initiated for 5 mins followed by attempted defibrillation with a biphasic 150-J electric shock. Coincident with starting cardiopulmonary resuscitation, hypothermia was induced with evaporative intranasal cooling using a perfluorochemical. If spontaneous circulation was not restored after defibrillation, cardiopulmonary resuscitation was resumed for 1 min before the next defibrillation attempt until the animal was either successfully resuscitated or for a total of 15 mins. The target core temperature was 34 degrees C. Control animals were identically treated except for hypothermia. Five seconds of ventricular fibrillation waveform were recorded immediately preceding delivery of a shock. The ventricular fibrillation waveforms were analyzed using the Amplitude Spectrum area algorithm. A smaller epinephrine dose (60 +/- 32.1 vs. 30 +/- 0 mg/mL, p = .01) and shorter cardiopulmonary resuscitation duration (365 +/- 42 sec vs. 600 +/- 243 sec, p = .01) were required to achieve return of spontaneous circulation in the hypothermia group, compared with control. Five minutes after starting cardiopulmonary resuscitation, head temperature was reduced from 38 degrees C to 34 degrees C in the hypothermia group (p = .028). Hypothermia improved the success of electrical shocks before return of spontaneous circulation (88 +/- 18% vs. 66 +/- 19%, p = .034). Both the Amplitude Spectrum area values of initial shock (26.1 +/- 5.3 vs. 21.4 +/- 2.16 mV-Hz, p = .049) and total shocks (26.1 +/- 5.3 vs. 21.4 +/- 2.16 mV-Hz, p = .006) were significantly higher in the hypothermia group than control. Amplitude Spectrum area served as a useful predictor for improved resuscitation and facilitated defibrillation in the setting of rapid head cooling initiated coincident with cardiopulmonary resuscitation.