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D Lontsi - One of the best experts on this subject based on the ideXlab platform.
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hypoglycemic effect of Anacardium occidentale l methanol extract and fractions on streptozotocin induced diabetic rats
2007Co-Authors: D Lontsi, Pierre Watcho, Pierre KamtchouingAbstract:4 Abstract: The effect of the methanol leaf extract, dichloromethane, ethyl acetate and n-hexane fractions from Anacardium occidentale Linn was investigated in streptozotocin-induced diabetic rats. Oral administration of methanol extract at doses of 35, 175 and 250 mg kg significantly reduced blood glucose levels in diabetic rats 1
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protective role of Anacardium occidentale extract against streptozotocin induced diabetes in rats
Journal of Ethnopharmacology, 1998Co-Authors: Pierre Kamtchouing, Selestin Dongmo Sokeng, Paul F Moundipa, Pierre Watcho, Hermine Boukeng Jatsa, D LontsiAbstract:The protective effect of Anacardium occidentale aqueous extract against streptozotocin-induced diabetes was evaluated in rats. The rats were treated with 175 mg/kg of the extract per os, twice daily; beginning 2 days before streptozotocin (STZ) injection. A total of 3 days after STZ administration, there was a 48% increase in blood glucose level in pretreated rats, compared with a 208% increase in diabetic control rats treated with STZ alone. Furthermore, these pretreated animals presented no glycosuria, a normal weight gain and a non significant increase in food and fluid intake at the end of the treatment compared with the normal control. Diabetic control animals showed a positive glycosuria, body weight loss, a real polyphagia and polydypsia. These results indicate the protective role of Anacardium occidentale extract against the diabetogenic action of STZ.
Panchanatham Sachdanandam - One of the best experts on this subject based on the ideXlab platform.
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Hypolipidemic activity of Semecarpus Anacardium in Streptozotocin induced diabetic rats
Endocrine, 2010Co-Authors: Aseervatham Jaya, Palanivelu Shanthi, Panchanatham SachdanandamAbstract:Alterations in lipid metabolism and lipoprotein disturbances have played an important role in increasing the risk of cardiovascular mortality and morbidity in diabetes. A drug that has hypoglycemic activity can be used for the treatment of hyperlipidemia also. The present study was carried out to evaluate the hypolipidemic activity of Semecarpus Anacardium . Male Wister rats weighing 250–270 g were injected with Streptozotocin at a dose of 50 mg/kg body weight and administered with S. Anacardium (300 mg/kg body weight) and Metformin (500 mg/kg body weight) for 21 days. Control and drug control groups were also included in the study. After the experimental duration, serum was collected, liver and kidney were excised and used for the analysis of lipid and lipid metabolizing enzymes. The results of the study revealed that S. Anacardium administration was able to decrease the levels of LDL, cholesterol, VLDL, TG, phospholipid and free fatty acid and increase the HDL levels and favorably modulate the lipid metabolizing enzymes in the liver and kidney. These results show that S. Anacardium exerts hypolipidemic activity in diabetic rats.
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Effect of Semecarpus Anacardium nut extract on ECM and proteases in mammary carcinoma rats.
Vascular Pharmacology, 2007Co-Authors: P. Mathivadhani, Palanivel Shanthi, Panchanatham SachdanandamAbstract:Abstract The early stages of invasion are characterized by the extracellular proteolysis and the accumulation of specialized extracellular matrix (ECM) scaffold, that are responsible for the development of vascular bed, endothelial cell proliferation and invasion of tumour cells. The ground substance of provisional matrix consists of collagen, elastin, glycoaminoglycans and proteoglycans that facilitate the interaction of tumour cells with the host environment. In the present work, we have studied the influence of Semecarpus Anacardium nut milk extract on localized differentials of ECM component and proteases involved in matrix metabolism of tumour tissue. Mammary carcinoma was induced in Sprague Dawley rats with 7,12, dimethyl benz(a)anthracene and treated with S. Anacardium nut milk extract administered orally for 14 days. The altered amount of ECM components in tumour tissues was almost reverted back to normal level in the drug treated animals. The activities of reported proteases and glycohydrolases were also decreased on treatment with S. Anacardium nut milk extract indicating decreased turnover of the matrix. Also, the factors associated with the matrix turnover and expression of MMP-1, MMP-2, MMP-3, TIMP-1 and TIMP-2 were restored back to near normal values. The stabilization of the ECM with the decreased activity of proteases might inhibit the epithelial–endothelial interaction and tumour cell migration thus, preventing the adjacent invasion and tumour growth and might be regarded as antineoplastic agent which demands further studies.
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anti inflammatory effect of semecarpus Anacardium l inn nut extract in acute and chronic inflammatory conditions
Biological & Pharmaceutical Bulletin, 2004Co-Authors: Vanu Ramkumar Ramprasath, Palanivelu Shanthi, Panchanatham SachdanandamAbstract:The article relates to investigation of the anti-inflammatory effects of Semecarpus Anacardium LINN. nut extract (SA), and also an anti-inflammatory drug, indomethacin, on carrageenan-induced paw edema and cotton pellet granuloma tests for their effects on acute and chronic phases of inflammation, respectively. The effect of SA on developing and developed adjuvant arthritis was also evaluated. SA significantly decreased the carrageenan-induced paw edema and cotton pellet granuloma. Indomethacin also decreased the acute and chronic phases of inflammation. SA decreased the adjuvant induced (arthritis) paw edema after the treatment, in both developing and developed adjuvant arthritis. These results indicate that the potent anti-inflammatory effect and therapeutic efficacy of Semecarpus Anacardium LINN. nut extract against all phases of inflammation, is comparable to that of indomethacin.
Pierre Kamtchouing - One of the best experts on this subject based on the ideXlab platform.
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hypoglycemic effect of Anacardium occidentale l methanol extract and fractions on streptozotocin induced diabetic rats
2007Co-Authors: D Lontsi, Pierre Watcho, Pierre KamtchouingAbstract:4 Abstract: The effect of the methanol leaf extract, dichloromethane, ethyl acetate and n-hexane fractions from Anacardium occidentale Linn was investigated in streptozotocin-induced diabetic rats. Oral administration of methanol extract at doses of 35, 175 and 250 mg kg significantly reduced blood glucose levels in diabetic rats 1
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antihyperglycemic and renal protective activities of Anacardium occidentale anacardiaceae leaves in streptozotocin induced diabetic rats
African Journal of Traditional Complementary and Alternative Medicines, 2005Co-Authors: Leonard Tedong, Tha Ophile Dimo, Paul Desire Djomeni Dzeufiet, Acha Emmanuel Asongalem, Dongmo Selestin Sokeng, Patrice Callard, Jean Frana Ois Flejou, Pierre KamtchouingAbstract:Earlier studies from our laboratory have indicated hypoglycaemic action of Anacardium occidentale (AO) leaves in experimental type 1 diabetes. Streptozotocin-induced diabetes in rats had been shown to be associated with functional and/or morphological changes in the kidney. Therefore, in the present investigation, we carried out studies on streptozotocin (STZ)-induced type 1 diabetes in rats chronically treated with Anacardium occidentale on the functional and histological alterations of kidneys. Albino rats were divided into 7 groups (n = 5) receiving graded doses of hexane extract of Anacardium occidentale leaf by gavage, (150 and 300 mg/kg/day) and insulin (5 IU/kg). Renal ultrastructure was studied by measuring: diameter of Bowman’s capsule, distribution and total area occupied by glomerular capillaries, PAS positive structures. AO at the dose of 300 mg/kg/day, showed significant reduction (P < 0.05) of blood glucose level, total protein excreted, glycosuria and urea in diabetic rats. Anacardium treatment, initiated 3 days after diabetes induction, reduced destruction of renal structure and other metabolic disturbances more than when treatment was initiated two weeks after. Histopathological study showed that A. occidentale significantly reduced accumulation of mucopolysaccharides in the kidneys of diabetic animals. The extract of AO at the dose of 300 mg/kg had no nephrotoxic potential in normal rats. The present study demonstrates the efficacy of Anacardium occidentale (hexane extract) in reducing diabetes-induced functional and histological alterations in the kidneys.
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protective role of Anacardium occidentale extract against streptozotocin induced diabetes in rats
Journal of Ethnopharmacology, 1998Co-Authors: Pierre Kamtchouing, Selestin Dongmo Sokeng, Paul F Moundipa, Pierre Watcho, Hermine Boukeng Jatsa, D LontsiAbstract:The protective effect of Anacardium occidentale aqueous extract against streptozotocin-induced diabetes was evaluated in rats. The rats were treated with 175 mg/kg of the extract per os, twice daily; beginning 2 days before streptozotocin (STZ) injection. A total of 3 days after STZ administration, there was a 48% increase in blood glucose level in pretreated rats, compared with a 208% increase in diabetic control rats treated with STZ alone. Furthermore, these pretreated animals presented no glycosuria, a normal weight gain and a non significant increase in food and fluid intake at the end of the treatment compared with the normal control. Diabetic control animals showed a positive glycosuria, body weight loss, a real polyphagia and polydypsia. These results indicate the protective role of Anacardium occidentale extract against the diabetogenic action of STZ.
P J Vithayathil - One of the best experts on this subject based on the ideXlab platform.
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process for isolation of cardanol from technical cashew Anacardium occidentale l nut shell liquid
Journal of Agricultural and Food Chemistry, 2002Co-Authors: Pradeep Kumar, R Paramashivappa, P J VithayathilAbstract:Commercially available technical cashew (Anacardium occidentale L.) nut shell liquid (CNSL) contains mainly cardanol (decarboxylated anacardic acid) and cardol. Cardanol, the monophenolic component of technical CNSL, is widely used as a synthon for the preparation of a number of polymers and agricultural products. This paper describes the separation of cardanol from toxic cardol. Technical CNSL was dissolved in a mixture of methanol and ammonium hydroxide (8:5) and extracted with hexane to obtain cardanol. The resultant methanolic ammonia layer was extracted with a mixture of ethyl acetate and hexane to yield cardol. This is the first industrially feasible process based on solvent extractions for the isolation of cardanol from technical CNSL. Keywords: Anacardic acid; cardol; cardanol; cashew nut shell liquid; Anacardium occidentale L.
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novel method for isolation of major phenolic constituents from cashew Anacardium occidentale l nut shell liquid
Journal of Agricultural and Food Chemistry, 2001Co-Authors: R Paramashivappa, Pradeep Kumar, P J VithayathilAbstract:Commercially available cashew (Anacardium occidentale L.) nut shell liquid (CNSL) mainly contains the phenolic constituents anacardic acid, cardol, and cardanol. These phenolic constituents are themselves heterogeneous, and each of them contains saturated, monoene, diene, and trienes in the fifteen-carbon side chain. This communication describes the separation of anacardic acid, cardol, and cardanol for industrial application. Anacardic acid was selectively isolated as calcium anacardate. The acid-free CNSL was treated with liquor ammonia and extracted with hexane/ethyl acetate (98:2) to separate the mono phenolic component, cardanol. Subsequently, ammonia solution was extracted with ethyl acetate/hexane (80:20) to obtain cardol. Keywords: Anacardic acid; cardol; cardanol; calcium salt; cashew nut shell liquid; Anacardium occidentale L.
J M Makinde - One of the best experts on this subject based on the ideXlab platform.
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effects of Anacardium occidentale stem bark extract on in vivo inflammatory models
Journal of Ethnopharmacology, 2004Co-Authors: Olumayokun A Olajide, Mutallib A Aderogba, Aduragbenro Deborah Adedapo, J M MakindeAbstract:The methanol extract of Anacardium occidentale stem bark was evaluated for activities against the lipopolysaccharide (LPS)-induced septic shock, as well as LPS-induced microvascular permeability in mice. Pre-treatment with Anacardium occidentale extract (25-200 mg/kg) caused a dose-dependent and significant (p < 0.05) reduction in the elevated levels of alanine and aspartate aminotransferases in the sera of D-galactosamine-primed mice injected with LPS. The highest dose of the extract studied (200 mg/kg) produced a 100% protection against death from sepsis. Pentoxifylline (100 mg/kg) and L-NAME (5 mg/kg) offered 100% protection against LPS-induced septic shock, and produced marked reduction in elevated levels of transferases. A dose-related inhibition of LPS-induced microvascular permability in mice was also produced by pentoxifylline, L-NAME and the extract.
