The Experts below are selected from a list of 153525 Experts worldwide ranked by ideXlab platform
Changhong Wang - One of the best experts on this subject based on the ideXlab platform.
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comparative pharmacokinetic study of paeoniflorin after Oral Administration of decoction of radix paeoniae rubra and radix paeoniae alba in rats
Journal of Ethnopharmacology, 2008Co-Authors: Changhong Wang, Yuqi He, Zhengtao Wang, Xuemei Cheng, Rui Wang, Cheng WuAbstract:Abstract An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after Oral Administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After Oral Administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69 ± 1.46 and 1.46 ± 0.29 (p 0.05) and a larger AUC (24.89 ± 7.41 μg h/ml) of paeoniflorin after Oral Administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the tmax, Cmax, AUC, t1/2, CL, and Vd among the animals Orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of tmax, Cmax, and AUC of paeoniflorin were remarkably increased (P
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comparative pharmacokinetic study of paeoniflorin after Oral Administration of decoction of radix paeoniae rubra and radix paeoniae alba in rats
Journal of Ethnopharmacology, 2008Co-Authors: Changhong Wang, Zhengtao Wang, Xuemei Cheng, Rui Wang, Jing CaoAbstract:An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after Oral Administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After Oral Administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69+/-1.46 and 1.46+/-0.29 (p<0.05)microg/ml at 1.67+/-0.43 and 0.80+/-0.35 h (p<0.05), respectively. Compared to the AUC (18.85+/-7.54 microg h/ml) after Oral Administration of the paeoniflorin solution, a smaller AUC (10.61+/-1.51 microg h/ml, p<0.05) and a larger AUC (24.89+/-7.41 microg h/ml) of paeoniflorin after Oral Administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the t(max), C(max), AUC, t(1/2), CL, and V(d) among the animals Orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of t(max), C(max), and AUC of paeoniflorin were remarkably increased (P<0.05, P<0.001) when Oral administering paeoniflorin in the decoctions of Radix Paeoniae Rubra, but t(1/2), V(d), and CL were decreased (P<0.05 or P<0.01), in comparison of the decoction of Radix Paeoniae Alba.
Cheng Wu - One of the best experts on this subject based on the ideXlab platform.
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comparative pharmacokinetic study of paeoniflorin after Oral Administration of decoction of radix paeoniae rubra and radix paeoniae alba in rats
Journal of Ethnopharmacology, 2008Co-Authors: Changhong Wang, Yuqi He, Zhengtao Wang, Xuemei Cheng, Rui Wang, Cheng WuAbstract:Abstract An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after Oral Administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After Oral Administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69 ± 1.46 and 1.46 ± 0.29 (p 0.05) and a larger AUC (24.89 ± 7.41 μg h/ml) of paeoniflorin after Oral Administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the tmax, Cmax, AUC, t1/2, CL, and Vd among the animals Orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of tmax, Cmax, and AUC of paeoniflorin were remarkably increased (P
Jing Cao - One of the best experts on this subject based on the ideXlab platform.
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comparative pharmacokinetic study of paeoniflorin after Oral Administration of decoction of radix paeoniae rubra and radix paeoniae alba in rats
Journal of Ethnopharmacology, 2008Co-Authors: Changhong Wang, Zhengtao Wang, Xuemei Cheng, Rui Wang, Jing CaoAbstract:An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after Oral Administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After Oral Administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69+/-1.46 and 1.46+/-0.29 (p<0.05)microg/ml at 1.67+/-0.43 and 0.80+/-0.35 h (p<0.05), respectively. Compared to the AUC (18.85+/-7.54 microg h/ml) after Oral Administration of the paeoniflorin solution, a smaller AUC (10.61+/-1.51 microg h/ml, p<0.05) and a larger AUC (24.89+/-7.41 microg h/ml) of paeoniflorin after Oral Administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the t(max), C(max), AUC, t(1/2), CL, and V(d) among the animals Orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of t(max), C(max), and AUC of paeoniflorin were remarkably increased (P<0.05, P<0.001) when Oral administering paeoniflorin in the decoctions of Radix Paeoniae Rubra, but t(1/2), V(d), and CL were decreased (P<0.05 or P<0.01), in comparison of the decoction of Radix Paeoniae Alba.
Rui Wang - One of the best experts on this subject based on the ideXlab platform.
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comparative pharmacokinetic study of paeoniflorin after Oral Administration of decoction of radix paeoniae rubra and radix paeoniae alba in rats
Journal of Ethnopharmacology, 2008Co-Authors: Changhong Wang, Yuqi He, Zhengtao Wang, Xuemei Cheng, Rui Wang, Cheng WuAbstract:Abstract An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after Oral Administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After Oral Administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69 ± 1.46 and 1.46 ± 0.29 (p 0.05) and a larger AUC (24.89 ± 7.41 μg h/ml) of paeoniflorin after Oral Administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the tmax, Cmax, AUC, t1/2, CL, and Vd among the animals Orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of tmax, Cmax, and AUC of paeoniflorin were remarkably increased (P
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comparative pharmacokinetic study of paeoniflorin after Oral Administration of decoction of radix paeoniae rubra and radix paeoniae alba in rats
Journal of Ethnopharmacology, 2008Co-Authors: Changhong Wang, Zhengtao Wang, Xuemei Cheng, Rui Wang, Jing CaoAbstract:An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after Oral Administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After Oral Administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69+/-1.46 and 1.46+/-0.29 (p<0.05)microg/ml at 1.67+/-0.43 and 0.80+/-0.35 h (p<0.05), respectively. Compared to the AUC (18.85+/-7.54 microg h/ml) after Oral Administration of the paeoniflorin solution, a smaller AUC (10.61+/-1.51 microg h/ml, p<0.05) and a larger AUC (24.89+/-7.41 microg h/ml) of paeoniflorin after Oral Administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the t(max), C(max), AUC, t(1/2), CL, and V(d) among the animals Orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of t(max), C(max), and AUC of paeoniflorin were remarkably increased (P<0.05, P<0.001) when Oral administering paeoniflorin in the decoctions of Radix Paeoniae Rubra, but t(1/2), V(d), and CL were decreased (P<0.05 or P<0.01), in comparison of the decoction of Radix Paeoniae Alba.
Xuemei Cheng - One of the best experts on this subject based on the ideXlab platform.
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comparative pharmacokinetic study of paeoniflorin after Oral Administration of decoction of radix paeoniae rubra and radix paeoniae alba in rats
Journal of Ethnopharmacology, 2008Co-Authors: Changhong Wang, Yuqi He, Zhengtao Wang, Xuemei Cheng, Rui Wang, Cheng WuAbstract:Abstract An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after Oral Administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After Oral Administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69 ± 1.46 and 1.46 ± 0.29 (p 0.05) and a larger AUC (24.89 ± 7.41 μg h/ml) of paeoniflorin after Oral Administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the tmax, Cmax, AUC, t1/2, CL, and Vd among the animals Orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of tmax, Cmax, and AUC of paeoniflorin were remarkably increased (P
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comparative pharmacokinetic study of paeoniflorin after Oral Administration of decoction of radix paeoniae rubra and radix paeoniae alba in rats
Journal of Ethnopharmacology, 2008Co-Authors: Changhong Wang, Zhengtao Wang, Xuemei Cheng, Rui Wang, Jing CaoAbstract:An investigation was designed and conducted to compare the pharmacokinetics difference of paeoniflorin after Oral Administration of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba to rats on separate occasions. Quantification of paeoniflorin in rat plasma was achieved using a simple and rapid HPLC method for pharmacokinetic study. After Oral Administration of decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba, paeoniflorin was absorbed and reached a maximum concentration of 3.69+/-1.46 and 1.46+/-0.29 (p<0.05)microg/ml at 1.67+/-0.43 and 0.80+/-0.35 h (p<0.05), respectively. Compared to the AUC (18.85+/-7.54 microg h/ml) after Oral Administration of the paeoniflorin solution, a smaller AUC (10.61+/-1.51 microg h/ml, p<0.05) and a larger AUC (24.89+/-7.41 microg h/ml) of paeoniflorin after Oral Administration of the decoctions of Radix Paeoniae Alba and Radix Paeoniae Rubra were obtained, respectively. There were statistically significant differences in pharmacokinetic parameters of paeoniflorin including the t(max), C(max), AUC, t(1/2), CL, and V(d) among the animals Orally administered the decoctions of Radix Paeoniae Rubra and Radix Paeoniae Alba. In particular, the parameters of t(max), C(max), and AUC of paeoniflorin were remarkably increased (P<0.05, P<0.001) when Oral administering paeoniflorin in the decoctions of Radix Paeoniae Rubra, but t(1/2), V(d), and CL were decreased (P<0.05 or P<0.01), in comparison of the decoction of Radix Paeoniae Alba.
