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Mynol Islam Vhuiyan - One of the best experts on this subject based on the ideXlab platform.
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central nervous system depressant and Analgesic Activity of aphanamixis polystachya wall parker leaf extract in mice
African Journal of Pharmacy and Pharmacology, 2009Co-Authors: Mokarram Hossain, Israt Jahan Biva, Rumana Jahangir, Mynol Islam VhuiyanAbstract:In the present study, we have investigated the possible CNS (Central Nervous System) depressant and Analgesic action of the methanol extract of Aphanamixis polystachya leaf. Its CNS depressant Activity was evaluated by using thiopental sodium-induced sleeping time, hole cross and open field tests. The Analgesic Activity was also investigated for its central and peripheral pharmacological actions using hot plate and tail immersion test and acetic acid-induced writhing test in mice respectively. The extract decreased the motor Activity and exploratory behavior of mice in hole cross and open field test (p < 0.001). Moreover, the extract significantly maximized the duration of sleeping time when administered with thiopental sodium (p < 0.001). The extract, at the dose of 250 and 500 mg/kg, produced a significant (p < 0.05, p < 0.001) increase in pain threshold both in hotplate and tail immersion methods in a dose dependent manner. The results were comparable to the reference standard Nalbuphine. In acetic acidinduced writhing test, the extract (500 mg/kg) produced a maximum of 75.9% inhibition (p < 0.001) of writhing reaction compared to the reference drug Diclofenac-Na (10 mg/kg) (78.1%). These results suggest that the extract possesses strong CNS depressant and Analgesic Activity in mice.
Dawei Qian - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory and Analgesic Activity of different extracts of commiphora myrrha
Journal of Ethnopharmacology, 2011Co-Authors: Shulan Su, Tuanjie Wang, Jinao Duan, Wei Zhou, Yuping Tang, Li Yu, Dawei QianAbstract:AIM OF THE STUDY: This present study was carried out to evaluate the anti-inflammatory and Analgesic effects of 85% ethanol extract (EE) of Commiphora myrrha and its different fractions partitioned with petroleum ether extract (EPE), ethyl acetate extract (EEA), n-butanol extract (EBu), and the water extract (ECY). Moreover, the chemical constituents in EPE were analyzed and identified by UPLC-QTOF/MS/MS. MATERIALS AND METHODS: The anti-inflammatory activities were investigated by utilizing the paw edema mice induced by formalin. In addition, we determined the levels of PGE(2) in the edema paw. While the Analgesic Activity was examined against thermally and chemically induced nociceptive pain in mice, using the acetic acid and hot-plate test methods. The effects of the administration of dolantin or indomethacin were also studied for references. The components in EPE were analyzed by the ultra-performance liquid chromatography coupled with mass spectrum. RESULTS: In the anti-inflammatory test, EE inhibited the development of paw swelling induced by formalin significantly. The pharmacological activities of the petroleum ether fraction (EPE) were stronger than the EE extract and other fractions at the dose of 100mg/kg, and furthermore significantly decreased the levels of inflammatory factor PGE(2) in the edema paw tissue at the fourth hour after formalin injection. It has been also shown that the ethanol extract (EE) significantly reduced acetic acid-induced writhing response in mice at the dose of 200mg/kg, and 100mg/kg. The petroleum ether fraction (EPE) showed significant Analgesic Activity in the model at the dose of 100mg/kg (p<0.01), and the ethyl acetate fraction (EEA) exhibited less Analgesic Activity (p<0.05). All test samples showed no significant Analgesic Activity on the hot plate pain threshold in mice. The UPLC-MS/MS chromatogram analysis of EPE stated that EPE contains the ingredients of sesquiterpenes, diterpenes, and diterpenic acids. Moreover, seven main compounds were identified. CONCLUSION: These data demonstrated that the EE and EPE posses Analgesic and anti-inflammatory activities and may support the fact the traditional application of this herb in treating various diseases associated with inflammatory pain.
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anti inflammatory and Analgesic Activity of different extracts of commiphora myrrha
Journal of Ethnopharmacology, 2011Co-Authors: Tuanjie Wang, Jinao Duan, Wei Zhou, Yuping Tang, Yongqing Hua, Dawei QianAbstract:Abstract Aim of the study This present study was carried out to evaluate the anti-inflammatory and Analgesic effects of 85% ethanol extract (EE) of Commiphora myrrha and its different fractions partitioned with petroleum ether extract (EPE), ethyl acetate extract (EEA), n -butanol extract (EBu), and the water extract (ECY). Moreover, the chemical constituents in EPE were analyzed and identified by UPLC–QTOF/MS/MS. Materials and methods The anti-inflammatory activities were investigated by utilizing the paw edema mice induced by formalin. In addition, we determined the levels of PGE 2 in the edema paw. While the Analgesic Activity was examined against thermally and chemically induced nociceptive pain in mice, using the acetic acid and hot-plate test methods. The effects of the administration of dolantin or indomethacin were also studied for references. The components in EPE were analyzed by the ultra-performance liquid chromatography coupled with mass spectrum. Results In the anti-inflammatory test, EE inhibited the development of paw swelling induced by formalin significantly. The pharmacological activities of the petroleum ether fraction (EPE) were stronger than the EE extract and other fractions at the dose of 100 mg/kg, and furthermore significantly decreased the levels of inflammatory factor PGE 2 in the edema paw tissue at the fourth hour after formalin injection. It has been also shown that the ethanol extract (EE) significantly reduced acetic acid-induced writhing response in mice at the dose of 200 mg/kg, and 100 mg/kg. The petroleum ether fraction (EPE) showed significant Analgesic Activity in the model at the dose of 100 mg/kg ( p p Conclusion These data demonstrated that the EE and EPE posses Analgesic and anti-inflammatory activities and may support the fact the traditional application of this herb in treating various diseases associated with inflammatory pain.
Y N Reddy - One of the best experts on this subject based on the ideXlab platform.
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a facile synthesis anti inflammatory and Analgesic Activity of isoxazolyl 2 3 dihydrospiro benzo f isoindole 1 3 indoline 2 4 9 triones
Bioorganic & Medicinal Chemistry Letters, 2013Co-Authors: E Rajanarendar, S Ramakrishna, Govardhan K Reddy, D Nagaraju, Y N ReddyAbstract:Abstract A new series of isoxazolyl-2,3-dihydrospiro[benzo[ f ]isoindole-1,3′-indoline]-2′,4,9-triones ( 14 ) were synthesized by reaction of 4-amino-3-methyl-5-styrylisoxazole 10 with chloroacetic acid followed by a three component reaction with substituted isatins 12 and 1,4-naphthoquinone 13 using Ceric ammonium nitrate (CAN) catalyst under aerial oxidation condition. Structures of these compounds were established on the basis of IR, 1 H NMR, 13 C NMR and mass spectral data. The title compounds 14a – j were evaluated for their anti-inflammatory and Analgesic Activity. Compounds 14d , 14e and 14f exhibited potent anti-inflammatory and Analgesic Activity as that of standard drugs.
Nariman Salakhutdinov - One of the best experts on this subject based on the ideXlab platform.
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Discovery of highly potent Analgesic Activity of isopulegol-derived (2R,4aR,7R,8aR)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2H-chromen-4-ol
Medicinal Chemistry Research, 2016Co-Authors: Ekaterina Nazimova, Irina Il’ina, Alla Pavlova, Dina Korchagina, Tat’yana Tolstikova, Konstantin Volcho, Oksana Mikhalchenko, Nariman SalakhutdinovAbstract:A large set of chiral heterocyclic compounds with the octahydro-2 H -chromene scaffold was first obtained by a reaction of (−)-isopulegol and (+)-neoisopulegol with furan-2-carbaldehyde, thiophene-2-carbaldehyde and their derivatives and isomers in the presence of montmorillonite K10 clay. Most of the (−)-isopulegol-derived compounds exhibited a significant Analgesic Activity in the acetic acid-induced writhing test. Compound 3b obtained by a reaction of (−)-isopulegol with thiophene-2-carbaldehyde demonstrated a significant Analgesic effect in this test within 15 min after oral administration at the dose of 1 mg/kg and retains the effect for at least 24 h. Compound 3b exhibited Analgesic Activity in the hot plate test also. A change in the sulfur atom position in the aromatic ring was found to lead to the effect reversal in the hot plate test.
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Highly potent Analgesic Activity of monoterpene-derived (2S,4aR,8R,8aR)-2-aryl-4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diols
Medicinal Chemistry Research, 2014Co-Authors: Irina Il’ina, Alla Pavlova, Dina Korchagina, Tat’yana Tolstikova, Konstantin Volcho, Nariman Salakhutdinov, Oksana Mikhalchenko, Evgeny PokushalovAbstract:New chiral heterocyclic compounds with a hexahydro-2 H -chromene framework were synthesized by reactions of (1 R ,2 R ,6 S )-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol with aromatic aldehydes in the presence of montmorillonite clay. The Analgesic Activity of the compounds was studied in vivo. The majority of these compounds showed significant Analgesic Activity in the acetic acid-induced writhing test; the compounds containing one hydroxy and one methoxy substituents also showed Analgesic Activity in the hot-plate test. (2 S ,4a R ,8 R ,8a R )-2-(3-Hydroxy-4-methoxyphenyl)-4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2 H -chromene-4,8-diol was as effective as the diclofenac sodium reference taken in the same dose in both tests. It has low acute toxicity and is very promising for further development.
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Synthesis and Analgesic Activity of new heterocyclic compounds derived from monoterpenoids
Medicinal Chemistry Research, 2013Co-Authors: Oksana Mikhalchenko, Alla Pavlova, Dina Korchagina, Tat’yana Tolstikova, Konstantin Volcho, Irina Il’ina, Ekaterina Morozova, Evgeny Pokushalov, Nariman SalakhutdinovAbstract:A set of new heterocyclic compounds with different types of framework, including a new type of framework, were synthesized by reactions of verbenol epoxide and (1 R ,2 R ,6 S )-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol with aromatic aldehydes containing three methoxy groups. The Analgesic Activity of these substances was studied. Three compounds possessed considerable Activity in vivo in the acetic acid-induced writhing test. (2 S ,4 R ,4a R ,8 S ,8a R )-4,7-Dimethyl-2-(2,4,5-trimethoxyphenyl)-3,4,4a,5,8,8a-hexahydro-2 H -4,8-epoxychromene exhibited high Analgesic Activity in both acetic acid-induced writhing and hot plate tests; its selectivity index IS_50 exceeded 60.
Suleyman Aydin - One of the best experts on this subject based on the ideXlab platform.
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Analgesic Activity of nepeta italica l
Phytotherapy Research, 1999Co-Authors: Suleyman Aydin, Tuba Herekman Demir, Yusuf Ozturk, Husnu Can K BaserAbstract:A screening study was performed on/by essential oils of Nepeta viscida Boiss and Nepeta italica L. using tail-flick and tail immersion (52.5°C) methods. N. italica samples were collected from three differentlocalities of Turkey. Surprisingly, only one of the essential oils showed significant Activity, which was blocked by naloxone, indicating the involvement of opioid receptors. This was seen only with the mechanical but not the thermal algesic stimulus, suggesting a specific Activity on opioid receptors, excluding mu receptors. The same, active essential oil also exhibited a non-competitive inhibition of acetylcholine contractions of isolated rat ileum but it was inactive on the isolated rat aorta. Furthermore, a correlation between the Analgesic Activity and the amount of 1,8-cineole was noticed. Copyright © 1999 John Wiley & Sons, Ltd.
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Investigation of Origanum onites, Sideritis congesta and Satureja cuneifolia Essential Oils for Analgesic Activity
Phytotherapy Research, 1996Co-Authors: Suleyman Aydin, Yusuf Ozturk, Rana Beis, K. Hüsnü Can BaşerAbstract:Essential oils, obtained by Clevenger distillation, of Sideritis congesta P. H. Davis et Hub.Mor., Satureja cuneifolia Ten. and Origanum onites L. collected from two different localities were investigated for their Analgesic Activity by using the tail-flick method in mice and by comparing with standard Analgesic drugs, morphine and fenoprofen. Among the essential oils tested, marked Analgesic Activity was found to be specific only for Origanum onites.. Surprisingly, the Analgesic Activity of Origanum oils seems to be dependent on the locality. Findings obtained in the present study strongly suggested that the Analgesic Activity is related to the carvacrol content of essential oils.