The Experts below are selected from a list of 23847 Experts worldwide ranked by ideXlab platform

William J. Meyers - One of the best experts on this subject based on the ideXlab platform.

  • an evaluation of 4 prilocaine and 3 mepivacaine compared with 2 lidocaine 1 100 000 epinephrine for inferior alveolar nerve block
    Journal of Endodontics, 1993
    Co-Authors: Celia Mclean, Mike Beck, William J. Meyers
    Abstract:

    The purpose of this study was to measure the degree of anesthesia obtained with 4% prilocaine and 3% mepivacaine compared with 2% lidocaine (1:100,000 epinephrine) for inferior alveolar nerve block. Using a repeated measures design, 30 subjects randomly received an inferior alveolar injection using masked cartridges of each solution at three successive appointments. The first molar, first premolar, lateral incisor, and contralateral canine (control) were blindly tested with an Analytic Technology pulp tester at 3-min cycles for 50 min. Anesthetic success was defined as no subject response to the maximum output of the pulp tester (80 reading) within 16 min and maintenance of this reading for 50 min. Although subjects felt numb subjectively, anesthetic success as defined here occurred in 43 to 63% of the molars, in 53 to 67% of the premolars, and in 30 to 37% of the lateral incisors. No statistically significant differences in onset, success, or failure were found among the solutions. We conclude that the three preparations are equivalent for an inferior alveolar nerve block of 50-min duration.

  • an evaluation of 4 prilocaine with 1 200 000 epinephrine and 2 mepivacaine with 1 20 000 levonordefrin compared with 2 lidocaine with 100 000 epinephrine for inferior alveolar nerve block
    Anesthesia Progress, 1991
    Co-Authors: S A Hinkley, Michael W Beck, William J. Meyers
    Abstract:

    : The purpose of this study was to measure the degree of anesthesia obtained with 4% prilocaine with 1:200,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin compared with 2% lidocaine with 1:100,000 epinephrine for inferior alveolar nerve block. Using a repeated measures design, 30 subjects randomly received an inferior alveolar injection using masked cartridges of each solution at three successive appointments. The first molar, first premolar, lateral incisor, and contralateral canine (control) were blindly tested with an Analytic Technology pulp tester at 3-min cycles for 50 min. Anesthetic success was defined as no subject response to the maximum output of the pulp tester (80 reading) within 16 min and maintenance of this reading for the remainder of the testing period.Although subjects felt numb subjectively, anesthetic success as defined here occurred in 46% to 57% of the molars, in 50% to 57% of the premolars, and in 21% to 36% of the lateral incisors. No statistically significant differences in onset, success, failure, or incidence were found among the solutions. We conclude that the three preparations are equivalent for inferior alveolar nerve block of 50-min duration.

Celia Mclean - One of the best experts on this subject based on the ideXlab platform.

  • an evaluation of 4 prilocaine and 3 mepivacaine compared with 2 lidocaine 1 100 000 epinephrine for inferior alveolar nerve block
    Journal of Endodontics, 1993
    Co-Authors: Celia Mclean, Mike Beck, William J. Meyers
    Abstract:

    The purpose of this study was to measure the degree of anesthesia obtained with 4% prilocaine and 3% mepivacaine compared with 2% lidocaine (1:100,000 epinephrine) for inferior alveolar nerve block. Using a repeated measures design, 30 subjects randomly received an inferior alveolar injection using masked cartridges of each solution at three successive appointments. The first molar, first premolar, lateral incisor, and contralateral canine (control) were blindly tested with an Analytic Technology pulp tester at 3-min cycles for 50 min. Anesthetic success was defined as no subject response to the maximum output of the pulp tester (80 reading) within 16 min and maintenance of this reading for 50 min. Although subjects felt numb subjectively, anesthetic success as defined here occurred in 43 to 63% of the molars, in 53 to 67% of the premolars, and in 30 to 37% of the lateral incisors. No statistically significant differences in onset, success, or failure were found among the solutions. We conclude that the three preparations are equivalent for an inferior alveolar nerve block of 50-min duration.

Mike Beck - One of the best experts on this subject based on the ideXlab platform.

  • an evaluation of 4 prilocaine and 3 mepivacaine compared with 2 lidocaine 1 100 000 epinephrine for inferior alveolar nerve block
    Journal of Endodontics, 1993
    Co-Authors: Celia Mclean, Mike Beck, William J. Meyers
    Abstract:

    The purpose of this study was to measure the degree of anesthesia obtained with 4% prilocaine and 3% mepivacaine compared with 2% lidocaine (1:100,000 epinephrine) for inferior alveolar nerve block. Using a repeated measures design, 30 subjects randomly received an inferior alveolar injection using masked cartridges of each solution at three successive appointments. The first molar, first premolar, lateral incisor, and contralateral canine (control) were blindly tested with an Analytic Technology pulp tester at 3-min cycles for 50 min. Anesthetic success was defined as no subject response to the maximum output of the pulp tester (80 reading) within 16 min and maintenance of this reading for 50 min. Although subjects felt numb subjectively, anesthetic success as defined here occurred in 43 to 63% of the molars, in 53 to 67% of the premolars, and in 30 to 37% of the lateral incisors. No statistically significant differences in onset, success, or failure were found among the solutions. We conclude that the three preparations are equivalent for an inferior alveolar nerve block of 50-min duration.

Johannes Khinast - One of the best experts on this subject based on the ideXlab platform.

  • control of three different continuous pharmaceutical manufacturing processes use of soft sensors
    International Journal of Pharmaceutics, 2018
    Co-Authors: Jakob Rehrl, Anssi-pekka Karttunen, Niels Nicolai, Theresa Hormann, Ossi Korhonen, Thomas Beer, Ingmar Nopens, Martin Horn, Johannes Khinast
    Abstract:

    One major advantage of continuous pharmaceutical manufacturing over traditional batch manufacturing is the possibility of enhanced in-process control, reducing out-of-specification and waste material by appropriate discharge strategies. The decision on material discharge can be based on the measurement of active pharmaceutical ingredient (API) concentration at specific locations in the production line via process Analytic Technology (PAT), e.g. near-infrared (NIR) spectrometers. The implementation of the PAT instruments is associated with monetary investment and the long term operation requires techniques avoiding sensor drifts. Therefore, our paper proposes a soft sensor approach for predicting the API concentration from the feeder data. In addition, this information can be used to detect sensor drift, or serve as a replacement/supplement of specific PAT equipment. The paper presents the experimental determination of the residence time distribution of selected unit operations in three different continuous processing lines (hot melt extrusion, direct compaction, wet granulation). The mathematical models describing the soft sensor are developed and parameterized. Finally, the suggested soft sensor approach is validated on the three mentioned, different continuous processing lines, demonstrating its versatility.

Jakob Rehrl - One of the best experts on this subject based on the ideXlab platform.

  • control of three different continuous pharmaceutical manufacturing processes use of soft sensors
    International Journal of Pharmaceutics, 2018
    Co-Authors: Jakob Rehrl, Anssi-pekka Karttunen, Niels Nicolai, Theresa Hormann, Ossi Korhonen, Thomas Beer, Ingmar Nopens, Martin Horn, Johannes Khinast
    Abstract:

    One major advantage of continuous pharmaceutical manufacturing over traditional batch manufacturing is the possibility of enhanced in-process control, reducing out-of-specification and waste material by appropriate discharge strategies. The decision on material discharge can be based on the measurement of active pharmaceutical ingredient (API) concentration at specific locations in the production line via process Analytic Technology (PAT), e.g. near-infrared (NIR) spectrometers. The implementation of the PAT instruments is associated with monetary investment and the long term operation requires techniques avoiding sensor drifts. Therefore, our paper proposes a soft sensor approach for predicting the API concentration from the feeder data. In addition, this information can be used to detect sensor drift, or serve as a replacement/supplement of specific PAT equipment. The paper presents the experimental determination of the residence time distribution of selected unit operations in three different continuous processing lines (hot melt extrusion, direct compaction, wet granulation). The mathematical models describing the soft sensor are developed and parameterized. Finally, the suggested soft sensor approach is validated on the three mentioned, different continuous processing lines, demonstrating its versatility.