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Geun Hee Seol – One of the best experts on this subject based on the ideXlab platform.

  • Trans-Anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats.
    Biomedicine & Pharmacotherapy, 2018
    Co-Authors: Eunhye Seo, Purum Kang, Geun Hee Seol

    Abstract:

    Abstract Chronic stress and smoking are major risk factors for hypertension, with stress also being a factor predisposing to smoking. Methods are needed to prevent and/or reduce hypertension induced by chronic exposure to both stress and nicotine. This study investigated whether trans-Anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-Anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-Anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-Anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to that of aerobic exercise and nifedipine. Furthermore, nifedipine combined with aerobic exercise and trans-Anethole reduced both blood pressure and vascular tone. These findings are the first to show that trans-Anethole can prevent hypertension, suggesting that trans-Anethole may be useful as a prophylactic antihypertensive agent.

  • Anti-inflammatory effects of trans-Anethole in a mouse model of chronic obstructive pulmonary disease
    Biomedicine & Pharmacotherapy, 2017
    Co-Authors: Ka Young Kim, Hui Su Lee, Geun Hee Seol

    Abstract:

    Abstract Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that is generally characterized by progressive and irreversible airflow obstruction and alveolar destruction. Long-term treatment with current medications has been associated with various adverse effects, indicating a need for alternative approaches for the prevention and treatment of COPD. This study investigated the mechanism underlying the effects of trans –Anethole in a mouse model of COPD induced by porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS). BALB/c mice were orally administered trans- Anethole (62.5, 125, 250, or 500 mg/kg) 2 h before intranasal challenge with 1.2 units of PPE and 7 μg of LPS. Lactate dehydrogenase (LDH) activity, cell counts, lung histology, cytokine production, and blood pressure were analyzed. Trans –Anethole reduced LDH activity and inflammatory cell counts, including macrophage, neutrophil, and lymphocyte counts. trans –Anethole 125 mg/kg restored the histopathological changes induced in mouse lungs by PPE and LPS. trans –Anethole reduced the serum concentrations of pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), as well as significantly reducing blood pressure during chronic inflammation. Trans –Anethole ameliorated chronic lung inflammation in a mouse model of COPD by reducing the serum concentrations of pro-inflammatory cytokines such as TNF-α and IL-6, and by reducing blood pressure. The present results indicate that trans- Anethole may be a potential therapeutic agent for prophylaxis and treatment in patients with chronic lung inflammation.

  • Foeniculum vulgare Mill. increases cytosolic Ca2+ concentration and inhibits store-operated Ca2+ entry in vascular endothelial cells.
    Biomedicine & Pharmacotherapy, 2016
    Co-Authors: A. Young Han, Hui Su Lee, Geun Hee Seol

    Abstract:

    This study assessed the effects of essential oil of Foeniculum vulgare Mill. (fennel oil) and of trans-Anethole, the main component of fennel oil, on extracellular Ca2+-induced store-operated Ca2+ entry (SOCE) into vascular endothelial (EA) cells and their mechanisms of action. Components of fennel oil were analyzed by gas chromatography-mass spectrometry. Cytosolic Ca2+ concentration ([Ca2+]c) in EA cells was determined using Fura-2 fluorescence. In the presence of extracellular Ca2+, fennel oil significantly increased [Ca2+]c in EA cells; this increase was significantly inhibited by the Ca2+ channel blockers La3+ and nifedipine. In contrast, fennel oil induced [Ca2+]c was significantly lower in Ca2+-free solution, suggesting that fennel oil increases [Ca2+]c mainly by enhancing Ca2+ influx into EA cells. [Ca2+]c mobilization by trans-Anethole was similar to that of fennel oil. Moreover, SOCE was suppressed by fennel oil and trans-Anethole. SOCE was also attenuated by lanthanum (La3+), a non-selective cation channel (NSC) blocker; 2-aminoethoxydiphenyl borane (2-APB), an inositol 1,4,5-triphosphate (IP3) receptor inhibitor and SOCE blocker; and U73122, an inhibitor of phospholipase C (PLC). Further, SOCE was more strongly inhibited by La3+ plus fennel oil or trans-Anethole than by La3+ alone. These findings suggest that fennel oil and trans-Anethole significantly inhibit SOCE-induced [Ca2+]c increase in vascular endothelial cells and that these reactions may be mediated by NSC, IP3-dependent Ca2+ mobilization, and PLC activation.

Ken-ichi Fujita – One of the best experts on this subject based on the ideXlab platform.

  • Anethole potentiates dodecanol s fungicidal activity by reducing pdr5 expression in budding yeast
    Biochimica et Biophysica Acta, 2017
    Co-Authors: Ken-ichi Fujita, Takayuki Ishikura, Yui Jono, Yoshihiro Yamaguchi, Akira Ogita, Isao Kubo, Toshio Tanaka

    Abstract:

    Abstract Background trans-Anethole (Anethole), a major component of anise oil, has a broad antimicrobial spectrum and a weaker antimicrobial potency than other available antibiotics. When combined with polygodial, nagilactone E, and n-dodecanol, Anethole has been shown to exhibit synergistic antifungal activity against a budding yeast, Saccharomyces cerevisiae, and a human opportunistic pathogenic yeast, Candida albicans. However, the mechanism underlying this synergistic effect of Anethole has not been characterized. Methods We studied this mechanism using dodecanol-treated S. cerevisiae cells and focusing on genes related to multidrug efflux. Results Although dodecanol transiently reduced the number of colony forming units, this recovered to levels similar to those of untreated cells with continued incubation beyond 24 h. Reverse transcription polymerase chain reaction analysis revealed overexpression of an ATP-binding cassette (ABC) transporter gene, PDR5, in addition to a slight increase in PDR11, PDR12, and PDR15 transcriptions in dodecanol-treated cells. In the presence of Anethole, these effects were attenuated and the fungicidal activity of dodecanol was extended. Dodecanol showed longer lasting fungicidal activity against a Δpdr5. In addition, Δpdr3 and Δlge1, lack transcription factors of PDR5 and PDR3, were partly and completely susceptible to dodecanol, respectively. Furthermore, combination of Anethole with fluconazole was also found to exhibit synergy on C. albicans. Conclusions These results indicated that although Anethole reduced the transcription of several transporters, PDR5 expression was particularly relevant to dodecanol efflux. General significance Anethole is expected to be a promising candidate drug for the inhibition of efflux by reducing the transcription of several ABC transporters.

  • Anethole potentiates dodecanol’s fungicidal activity by reducing PDR5 expression in budding yeast General subjects
    Biochimica et Biophysica Acta, 2017
    Co-Authors: Ken-ichi Fujita, Takayuki Ishikura, Yui Jono, Yoshihiro Yamaguchi, Akira Ogita, Isao Kubo, Toshio Tanaka

    Abstract:

    trans-Anethole (Anethole), a major component of anise oil, has a broad antimicrobial spectrum and a weaker antimicrobial potency than other available antibiotics. When combined with polygodial, nagilactone E, and n-dodecanol, Anethole has been shown to exhibit synergistic antifungal activity against a budding yeast, Saccharomyces cerevisiae, and a human opportunistic pathogenic yeast, Candida albicans. However, the mechanism underlying this synergistic effect of Anethole has not been characterized.We studied this mechanism using dodecanol-treated S. cerevisiae cells and focusing on genes related to multidrug efflux.Although dodecanol transiently reduced the number of colony forming units, this recovered to levels similar to those of untreated cells with continued incubation beyond 24h. Reverse transcription polymerase chain reaction analysis revealed overexpression of an ATP-binding cassette (ABC) transporter gene, PDR5, in addition to a slight increase in PDR11, PDR12, and PDR15 transcriptions in dodecanol-treated cells. In the presence of Anethole, these effects were attenuated and the fungicidal activity of dodecanol was extended. Dodecanol showed longer lasting fungicidal activity against a Δpdr5. In addition, Δpdr3 and Δlge1, lack transcription factors of PDR5 and PDR3, were partly and completely susceptible to dodecanol, respectively. Furthermore, combination of Anethole with fluconazole was also found to exhibit synergy on C. albicans.These results indicated that although Anethole reduced the transcription of several transporters, PDR5 expression was particularly relevant to dodecanol efflux.Anethole is expected to be a promising candidate drug for the inhibition of efflux by reducing the transcription of several ABC transporters.

  • Anethole induces apoptotic cell death accompanied by reactive oxygen species production and dna fragmentation in aspergillus fumigatus and saccharomyces cerevisiae
    FEBS Journal, 2014
    Co-Authors: Ken-ichi Fujita, Akira Ogita, Isao Kubo, Miki Tatsumi, Toshio Tanaka

    Abstract:

    trans-Anethole (Anethole), a major component of anise oil, has a broad antimicrobial spectrum, and antimicrobial activity that is weaker than that of other antibiotics on the market. When combined with polygodial, nagilactone E, and n-dodecanol, Anethole has been shown to possess significant synergistic antifungal activity against a budding yeast, Saccharomyces cerevisiae, and a human opportunistic pathogenic yeast, Candida albicans. However, the antifungal mechanism of Anethole has not been completely determined. We found that Anethole stimulated cell death of a human opportunistic pathogenic fungus, Aspergillus fumigatus, in addition to S. cerevisiae. The Anethole-induced cell death was accompanied by reactive oxygen species production, metacaspase activation, and DNA fragmentation. Several mutants of S. cerevisiae, in which genes related to the apoptosis-initiating execution signals from mitochondria were deleted, were resistant to Anethole. These results suggest that Anethole-induced cell death could be explained by oxidative stress-dependent apoptosis via typical mitochondrial death cascades in fungi, including A. fumigatus and S. cerevisiae.

Isao Kubo – One of the best experts on this subject based on the ideXlab platform.

  • Anethole potentiates dodecanol s fungicidal activity by reducing pdr5 expression in budding yeast
    Biochimica et Biophysica Acta, 2017
    Co-Authors: Ken-ichi Fujita, Takayuki Ishikura, Yui Jono, Yoshihiro Yamaguchi, Akira Ogita, Isao Kubo, Toshio Tanaka

    Abstract:

    Abstract Background trans-Anethole (Anethole), a major component of anise oil, has a broad antimicrobial spectrum and a weaker antimicrobial potency than other available antibiotics. When combined with polygodial, nagilactone E, and n-dodecanol, Anethole has been shown to exhibit synergistic antifungal activity against a budding yeast, Saccharomyces cerevisiae, and a human opportunistic pathogenic yeast, Candida albicans. However, the mechanism underlying this synergistic effect of Anethole has not been characterized. Methods We studied this mechanism using dodecanol-treated S. cerevisiae cells and focusing on genes related to multidrug efflux. Results Although dodecanol transiently reduced the number of colony forming units, this recovered to levels similar to those of untreated cells with continued incubation beyond 24 h. Reverse transcription polymerase chain reaction analysis revealed overexpression of an ATP-binding cassette (ABC) transporter gene, PDR5, in addition to a slight increase in PDR11, PDR12, and PDR15 transcriptions in dodecanol-treated cells. In the presence of Anethole, these effects were attenuated and the fungicidal activity of dodecanol was extended. Dodecanol showed longer lasting fungicidal activity against a Δpdr5. In addition, Δpdr3 and Δlge1, lack transcription factors of PDR5 and PDR3, were partly and completely susceptible to dodecanol, respectively. Furthermore, combination of Anethole with fluconazole was also found to exhibit synergy on C. albicans. Conclusions These results indicated that although Anethole reduced the transcription of several transporters, PDR5 expression was particularly relevant to dodecanol efflux. General significance Anethole is expected to be a promising candidate drug for the inhibition of efflux by reducing the transcription of several ABC transporters.

  • Anethole potentiates dodecanol’s fungicidal activity by reducing PDR5 expression in budding yeast General subjects
    Biochimica et Biophysica Acta, 2017
    Co-Authors: Ken-ichi Fujita, Takayuki Ishikura, Yui Jono, Yoshihiro Yamaguchi, Akira Ogita, Isao Kubo, Toshio Tanaka

    Abstract:

    trans-Anethole (Anethole), a major component of anise oil, has a broad antimicrobial spectrum and a weaker antimicrobial potency than other available antibiotics. When combined with polygodial, nagilactone E, and n-dodecanol, Anethole has been shown to exhibit synergistic antifungal activity against a budding yeast, Saccharomyces cerevisiae, and a human opportunistic pathogenic yeast, Candida albicans. However, the mechanism underlying this synergistic effect of Anethole has not been characterized.We studied this mechanism using dodecanol-treated S. cerevisiae cells and focusing on genes related to multidrug efflux.Although dodecanol transiently reduced the number of colony forming units, this recovered to levels similar to those of untreated cells with continued incubation beyond 24h. Reverse transcription polymerase chain reaction analysis revealed overexpression of an ATP-binding cassette (ABC) transporter gene, PDR5, in addition to a slight increase in PDR11, PDR12, and PDR15 transcriptions in dodecanol-treated cells. In the presence of Anethole, these effects were attenuated and the fungicidal activity of dodecanol was extended. Dodecanol showed longer lasting fungicidal activity against a Δpdr5. In addition, Δpdr3 and Δlge1, lack transcription factors of PDR5 and PDR3, were partly and completely susceptible to dodecanol, respectively. Furthermore, combination of Anethole with fluconazole was also found to exhibit synergy on C. albicans.These results indicated that although Anethole reduced the transcription of several transporters, PDR5 expression was particularly relevant to dodecanol efflux.Anethole is expected to be a promising candidate drug for the inhibition of efflux by reducing the transcription of several ABC transporters.

  • Anethole induces apoptotic cell death accompanied by reactive oxygen species production and dna fragmentation in aspergillus fumigatus and saccharomyces cerevisiae
    FEBS Journal, 2014
    Co-Authors: Ken-ichi Fujita, Akira Ogita, Isao Kubo, Miki Tatsumi, Toshio Tanaka

    Abstract:

    trans-Anethole (Anethole), a major component of anise oil, has a broad antimicrobial spectrum, and antimicrobial activity that is weaker than that of other antibiotics on the market. When combined with polygodial, nagilactone E, and n-dodecanol, Anethole has been shown to possess significant synergistic antifungal activity against a budding yeast, Saccharomyces cerevisiae, and a human opportunistic pathogenic yeast, Candida albicans. However, the antifungal mechanism of Anethole has not been completely determined. We found that Anethole stimulated cell death of a human opportunistic pathogenic fungus, Aspergillus fumigatus, in addition to S. cerevisiae. The Anethole-induced cell death was accompanied by reactive oxygen species production, metacaspase activation, and DNA fragmentation. Several mutants of S. cerevisiae, in which genes related to the apoptosis-initiating execution signals from mitochondria were deleted, were resistant to Anethole. These results suggest that Anethole-induced cell death could be explained by oxidative stress-dependent apoptosis via typical mitochondrial death cascades in fungi, including A. fumigatus and S. cerevisiae.