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Andrew E. Rosenberg - One of the best experts on this subject based on the ideXlab platform.

  • Aneurysmal Bone Cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes
    Oncogene, 2005
    Co-Authors: Andre M. Oliveira, Antonio R. Perez-atayde, Mark C. Gebhardt, Andrew E. Rosenberg, Paola Dal Cin, Chang-jie Chen, James R Neff, George D Demetri, Julia A Bridge, Jonathan A. Fletcher
    Abstract:

    Aneurysmal Bone Cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9 , COL1A1 , TRAP150 , and OMD genes

  • soft tissue Aneurysmal Bone Cyst a clinicopathologic study of five cases
    The American Journal of Surgical Pathology, 2002
    Co-Authors: Gunnlaugur P Nielsen, Christopher D M Fletcher, Michael D Smith, Leon Rybak, Andrew E. Rosenberg
    Abstract:

    We describe five primary soft tissue tumors that had histologic features identical to intraosseous Aneurysmal Bone Cyst. The tumors occurred in three females and two males, who ranged in age from 8 to 37 years (median 28 years). They arose in the deep soft tissue of the upper extremities, thigh, and groin region and typically presented as a rapidly growing mass; no involvement of the adjacent Bones was identified. The tumors ranged in size from 2.5 to 9 cm (median 4 cm). Grossly, they were surrounded by a thin rim of Bone and on sectioning had hemorrhagic Cystic spaces delineated by fibrous septa. Histologically, the Cystic spaces were filled with blood and the fibrous septa were composed of fibroblasts, osteoclast-type giant cells, and woven Bone. Cytogenetic analysis of one tumor showed 46,XY,t(17;17)(p13;q12), a result similar to that which has been reported for intraosseous Aneurysmal Bone Cyst. The differential diagnosis includes a variety of Bone-forming and giant cell-containing tumors, the most important being extraskeletal osteosarcoma. Follow-up showed that four patients are free of disease 16 months to 10 years after surgery; one tumor regrew after incomplete initial excision, but the patient has been free of disease 16 months after a second operation. Soft tissue Aneurysmal Bone Cyst is an uncommon benign tumor that can be treated by simple excision, and it should be distinguished from a variety of other reactive and neoplastic processes.

Zhenhua Zhou - One of the best experts on this subject based on the ideXlab platform.

  • Aneurysmal Bone Cyst secondary to giant cell tumor of the mobile spine a report of 11 cases
    Spine, 2011
    Co-Authors: Xinghai Yang, Jianru Xiao, Dapeng Feng, Quan Huang, Wei Zheng, Wending Huang, Zhenhua Zhou
    Abstract:

    STUDY DESIGN A retrospective analysis was performed. OBJECTIVE To analyze the characteristics of Aneurysmal Bone Cyst arising from giant cell tumor of the mobile spine and to discuss the outcome of corresponding surgical and nonsurgical treatment. SUMMARY OF BACKGROUND DATA Giant cell tumors are generally benign neoplasms that exhibit aggressive behavior with a tendency to recur locally. Aneurysmal Bone Cysts are benign, highly vascular osseous lesions. Although both of them have been described separately in previous literatures, few reports have described Aneurysmal Bone Cyst secondary to giant cell tumor of the mobile spine. METHODS Between January 2004 and December 2009, 11 patients were identified with an Aneurysmal Bone Cyst arising from giant cell tumor of the mobile spine. Four patients underwent subtotal tumor resection followed by radiotherapy, and the other 7 patients underwent total tumor resection. Patients with lesions located below T6 were treated with selective arterial embolization before surgery. Clinical data and the efficacy of surgery were analyzed via chart review RESULTS Of the eleven patients identified for inclusion in this study, the average age was 33 months (range ∇ 14-65 months). The mean length of follow-up was 31 months. Seven patients kept disease-free during the follow-ups. The remaining four patients recurred and one died of local re-recurrence and lung metastasis. CONCLUSION Unlike primary Aneurysmal Bone Cyst, secondary Aneurysmal Bone Cyst arising from giant cell tumor of the mobile spine has a more aggressive tendency to recurrence locally. Complete resection with systematic radiotherapy should be undertaken for the treatment of Aneurysmal Bone Cyst secondary to giant cell tumor of the mobile spine, which is associated with a good prognosis for local tumor control. As complete or as radical an operation as possible should be performed at first presentation. The best chance for the patient is the first chance. Selective preoperative embolization is advised to minimize intraoperative blood loss.

P Picci - One of the best experts on this subject based on the ideXlab platform.

  • Aneurysmal Bone Cyst of the mobile spine report on 41 cases
    Spine, 2001
    Co-Authors: S Boriani, Franco Bertoni, R Biagini, S Bandiera, De Iure F, Laura Campanacci, Alessandro Gasbarrini, P Picci
    Abstract:

    Study design Forty-one cases of Aneurysmal Bone Cyst of the mobile spine were retrospectively reviewed. Objectives To evaluate the role of surgical and nonsurgical treatment of Aneurysmal Bone Cyst of the spine. Summary of background data Ten to 30% of Aneurysmal Bone Cysts arise from the mobile spine, frequently occurring in pediatric patients. The course of the disease depends on the aggressiveness of the tumor, as well as the treatment. Intralesional surgery seems to be an effective treatment, as well as radiotherapy and embolization. Methods All charts, radiographs, and images were reviewed. The composite information provided by this review allowed for oncologic and surgical staging of these cases. Thirty-two patients underwent curettage (14 of them followed by radiotherapy), four were submitted to selective arterial embolization, three received radiotherapy alone, and two underwent en bloc-excision. Results All patients were found alive and disease free at final follow-up evaluation. Two recurrences followed one incomplete curettage and one embolization. The combination of curettage and radiotherapy, although effective, showed the greatest incidence of late axial deformity. Selective arterial embolization was curative in three of four cases and did not affect the possibility of surgery in case of local recurrence. Conclusions If confirmed on larger series, selective arterial embolization seems to be the first treatment option for spine Aneurysmal Bone Cyst, because of the low cost-to-benefit ratio. Diagnosis must be certain, based on pathognomonic radiographic pattern or on histologic study.- In case of neurologic involvement, pathologic fracture, technical impossibility of performing embolization, or local recurrence after at least two embolization procedures, complete intralesional excision would be the therapy of choice.

  • solid variant of Aneurysmal Bone Cyst
    Cancer, 1993
    Co-Authors: Franco Bertoni, Pietro Ruggieri, Patrizia Bacchini, R Capanna, R Biagini, A Ferruzzi, G Bettelli, P Picci, M Campanacci
    Abstract:

    Background and Methods. Of the 200 cases of ABC in the Rizzoli Institute files, 15 had solid features on both gross and histologic examination. Inasmuch as fibrous proliferation with giant cell and Bone production along with fibromyxoid areas and small Aneurysmal spaces were found in the solid parts of the Aneurysmal Bone Cyst, a grossly solid and radiographically osteolytic Bone lesion with these microscopic features was called a solid Aneurysmal Bone Cyst. Some authors call the same lesion extragnathic giant cell reparative granuloma. Results. Sixty percent of the patients were female. The metaphysis was the preferred location in the long Bones (8/11). Radiographic appearance was not specific, and sometimes a malignant lesion was very difficult to rule out. In seven patients, the lesion was considered radiographically “aggressive.” Intralesional excision (curettage) in 12 patients and marginal resection in 3 patients with diaphyseal location was effective in controlling the lesion. No recurrence was detected after a mean follow-up of 59 months. Conclusions. High proliferative activity of the benign-appearing proliferative spindle cells, often with fairly abundant mitoses, associated with benign giant cells and immature Bone production are the features of this pseudosarcomatous hyperplastic lesion. It is sometimes is mistaken for a malignant tumor.

S Boriani - One of the best experts on this subject based on the ideXlab platform.

  • Aneurysmal Bone Cyst of the mobile spine the therapeutic role of embolization
    European Spine Journal, 2013
    Co-Authors: Luca Amendola, L Simonetti, Christiano Esteves Simoes, S Bandiera, F De Iure, S Boriani
    Abstract:

    Purpose Our aim is to define the role of embolization in the treatment of Aneurysmal Bone Cyst of the spine in order to include this option in the decision making process.

  • Aneurysmal Bone Cyst of the mobile spine report on 41 cases
    Spine, 2001
    Co-Authors: S Boriani, Franco Bertoni, R Biagini, S Bandiera, De Iure F, Laura Campanacci, Alessandro Gasbarrini, P Picci
    Abstract:

    Study design Forty-one cases of Aneurysmal Bone Cyst of the mobile spine were retrospectively reviewed. Objectives To evaluate the role of surgical and nonsurgical treatment of Aneurysmal Bone Cyst of the spine. Summary of background data Ten to 30% of Aneurysmal Bone Cysts arise from the mobile spine, frequently occurring in pediatric patients. The course of the disease depends on the aggressiveness of the tumor, as well as the treatment. Intralesional surgery seems to be an effective treatment, as well as radiotherapy and embolization. Methods All charts, radiographs, and images were reviewed. The composite information provided by this review allowed for oncologic and surgical staging of these cases. Thirty-two patients underwent curettage (14 of them followed by radiotherapy), four were submitted to selective arterial embolization, three received radiotherapy alone, and two underwent en bloc-excision. Results All patients were found alive and disease free at final follow-up evaluation. Two recurrences followed one incomplete curettage and one embolization. The combination of curettage and radiotherapy, although effective, showed the greatest incidence of late axial deformity. Selective arterial embolization was curative in three of four cases and did not affect the possibility of surgery in case of local recurrence. Conclusions If confirmed on larger series, selective arterial embolization seems to be the first treatment option for spine Aneurysmal Bone Cyst, because of the low cost-to-benefit ratio. Diagnosis must be certain, based on pathognomonic radiographic pattern or on histologic study.- In case of neurologic involvement, pathologic fracture, technical impossibility of performing embolization, or local recurrence after at least two embolization procedures, complete intralesional excision would be the therapy of choice.

Panayiotis J. Papagelopoulos - One of the best experts on this subject based on the ideXlab platform.

  • Solid variant of Aneurysmal Bone Cyst of the hamate
    Musculoskeletal surgery, 2010
    Co-Authors: Andreas F. Mavrogenis, Evangelia Skarpidi, Panayiotis J. Papagelopoulos
    Abstract:

    Solid variant of Aneurysmal Bone Cyst is a variant of Aneurysmal Bone Cyst in which the predominant histology is that of the solid material of a Cystic Aneurysmal Bone Cyst. In this article, we present a patient with solid variant of Aneurysmal Bone Cyst of the hamate and discuss the differential diagnosis and current treatment for this lesion.

  • Aneurysmal Bone Cyst of the spine management and outcome
    Spine, 1998
    Co-Authors: Panayiotis J. Papagelopoulos, Franklin H Sim, Bradford L Currier, William J Shaughnessy, Michael J Ebersold, Jeffrey R Bond, Krishnan K Unni
    Abstract:

    Study design The clinical records, radiographs, histologic sections, and operative reports of 52 consecutive patients with an Aneurysmal Bone Cyst of the spine were reviewed to evaluate diagnostic and therapeutic options and to correlate treatment and outcome. Objectives To define the incidence, clinical presentation, diagnostic and therapeutic options, and prognosis of patients with Aneurysmal Bone Cyst of the spine. Summary of background data There are special considerations in the management of spinal lesions: relative inaccessibility of the lesions, associated intraoperative bleeding, necessity of removing the entire lesion to avoid the possibility of recurrence, proximity of the lesion to the spinal cord and nerve roots, and potential postoperative bony spinal instability. Methods Fifty-two consecutive patients with an Aneurysmal Bone Cyst of the spine were treated from 1910 to 1993. Forty patients initially treated for a primary lesion had operative treatment (19 intralesional excision and Bone grafting and 21 intralesional excision); four also had adjuvant radiation therapy. Preoperative arterial embolization was performed in two. Results There was a recurrence rate of 10% within 10 years. All recurrences were noted less than 6 months after surgery. Of 12 patients treated for a recurrent lesion, two had a subsequent recurrence (16.7%) within 9 years. At last follow-up examination, 50 patients (96%) were free of the disease. One patient died of postradiation osteosarcoma, and one died of intraoperative bleeding. Conclusion Current treatment recommendations involve preoperative selective arterial embolization, intralesional excision curettage, Bone grafting, and fusion of the affected area if instability is present.