The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Jian Zhang - One of the best experts on this subject based on the ideXlab platform.
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bioactivity guided fractionation and gc ms fingerprinting of Angelica sinensis and Angelica archAngelica root components for antifungal and mosquito deterrent activity
Journal of Agricultural and Food Chemistry, 2009Co-Authors: David E Wedge, Jerome A Klun, Nurhayat Tabanca, Betul Demirci, T Ozek, K H C Baser, Sui Zhang, Charles L Cantrell, Jian ZhangAbstract:Bioassay-guided fractionation of the chloroform extract from the roots of Angelica sinensis led to isolation and characterization of (Z)-ligustilide using direct-bioautography with Colletotrichum species. The structure of (Z)-ligustilide was confirmed by 1H and 13C NMR spectroscopy and GC/MS. (Z)-Ligustilide deterred the biting of two mosquito species more effectively than DEET. Three different A. sinensis accessions and one Angelica archAngelica root oil were evauated by GC and GC/MS, and the dominant component in A. sinensis was 61−69% (Z)-ligustilide. Two other prominent compounds in A. sinensis oils were 5.7−9.8% (E)-3-butylidene phthalide and 1.5−2.3% (Z)-3-butylidene phthalide. The main constituents that comprised A. archAngelica oil were monoterpene hydrocarbons such as 24.5% α-pinene, 13.8% δ-3-carene, 10.1% β-phellandrene, 8.8% p-cymene, 8.4% limonene, and 6.3% sabinene. Phthalides and monoterpene hydrocarbons were determined to be good systematic markers or chemical fingerprints for A. sinensis ...
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bioactivity guided fractionation and gc ms fingerprinting of Angelica sinensis and Angelica archAngelica root components for antifungal and mosquito deterrent activity
Journal of Agricultural and Food Chemistry, 2009Co-Authors: David E Wedge, Jerome A Klun, Nurhayat Tabanca, Betul Demirci, T Ozek, K H C Baser, Sui Zhang, Charles L Cantrell, Zhijun Liu, Jian ZhangAbstract:Bioassay-guided fractionation of the chloroform extract from the roots of Angelica sinensis led to isolation and characterization of (Z)-ligustilide using direct-bioautography with Colletotrichum species. The structure of (Z)-ligustilide was confirmed by (1)H and (13)C NMR spectroscopy and GC/MS. (Z)-Ligustilide deterred the biting of two mosquito species more effectively than DEET. Three different A. sinensis accessions and one Angelica archAngelica root oil were evauated by GC and GC/MS, and the dominant component in A. sinensis was 61-69% (Z)-ligustilide. Two other prominent compounds in A. sinensis oils were 5.7-9.8% (E)-3-butylidene phthalide and 1.5-2.3% (Z)-3-butylidene phthalide. The main constituents that comprised A. archAngelica oil were monoterpene hydrocarbons such as 24.5% alpha-pinene, 13.8% delta-3-carene, 10.1% beta-phellandrene, 8.8% p-cymene, 8.4% limonene, and 6.3% sabinene. Phthalides and monoterpene hydrocarbons were determined to be good systematic markers or chemical fingerprints for A. sinensis and A. archAngelica root oils. Chemical fingerprinting by GC/MS of A. sinensis also confirmed the misidentification of one A. archAngelica sample sold in the Chinese market.
David E Wedge - One of the best experts on this subject based on the ideXlab platform.
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bioactivity guided fractionation and gc ms fingerprinting of Angelica sinensis and Angelica archAngelica root components for antifungal and mosquito deterrent activity
Journal of Agricultural and Food Chemistry, 2009Co-Authors: David E Wedge, Jerome A Klun, Nurhayat Tabanca, Betul Demirci, T Ozek, K H C Baser, Sui Zhang, Charles L Cantrell, Jian ZhangAbstract:Bioassay-guided fractionation of the chloroform extract from the roots of Angelica sinensis led to isolation and characterization of (Z)-ligustilide using direct-bioautography with Colletotrichum species. The structure of (Z)-ligustilide was confirmed by 1H and 13C NMR spectroscopy and GC/MS. (Z)-Ligustilide deterred the biting of two mosquito species more effectively than DEET. Three different A. sinensis accessions and one Angelica archAngelica root oil were evauated by GC and GC/MS, and the dominant component in A. sinensis was 61−69% (Z)-ligustilide. Two other prominent compounds in A. sinensis oils were 5.7−9.8% (E)-3-butylidene phthalide and 1.5−2.3% (Z)-3-butylidene phthalide. The main constituents that comprised A. archAngelica oil were monoterpene hydrocarbons such as 24.5% α-pinene, 13.8% δ-3-carene, 10.1% β-phellandrene, 8.8% p-cymene, 8.4% limonene, and 6.3% sabinene. Phthalides and monoterpene hydrocarbons were determined to be good systematic markers or chemical fingerprints for A. sinensis ...
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bioactivity guided fractionation and gc ms fingerprinting of Angelica sinensis and Angelica archAngelica root components for antifungal and mosquito deterrent activity
Journal of Agricultural and Food Chemistry, 2009Co-Authors: David E Wedge, Jerome A Klun, Nurhayat Tabanca, Betul Demirci, T Ozek, K H C Baser, Sui Zhang, Charles L Cantrell, Zhijun Liu, Jian ZhangAbstract:Bioassay-guided fractionation of the chloroform extract from the roots of Angelica sinensis led to isolation and characterization of (Z)-ligustilide using direct-bioautography with Colletotrichum species. The structure of (Z)-ligustilide was confirmed by (1)H and (13)C NMR spectroscopy and GC/MS. (Z)-Ligustilide deterred the biting of two mosquito species more effectively than DEET. Three different A. sinensis accessions and one Angelica archAngelica root oil were evauated by GC and GC/MS, and the dominant component in A. sinensis was 61-69% (Z)-ligustilide. Two other prominent compounds in A. sinensis oils were 5.7-9.8% (E)-3-butylidene phthalide and 1.5-2.3% (Z)-3-butylidene phthalide. The main constituents that comprised A. archAngelica oil were monoterpene hydrocarbons such as 24.5% alpha-pinene, 13.8% delta-3-carene, 10.1% beta-phellandrene, 8.8% p-cymene, 8.4% limonene, and 6.3% sabinene. Phthalides and monoterpene hydrocarbons were determined to be good systematic markers or chemical fingerprints for A. sinensis and A. archAngelica root oils. Chemical fingerprinting by GC/MS of A. sinensis also confirmed the misidentification of one A. archAngelica sample sold in the Chinese market.
Heikki Kallio - One of the best experts on this subject based on the ideXlab platform.
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extraction of volatile compounds of Angelica Angelica archAngelica l root by liquid carbon dioxide
Journal of Agricultural and Food Chemistry, 1994Co-Authors: Kaisli Kerrola, Heikki KallioAbstract:The volatile components of Angelica roots were isolated by liquid carbon dioxide extraction. Operation conditions of 4.7 MPa/25 o C, 5.4 MPa/25 o C, and 6.9 MPa/45 o C were used. The effect of adding various quantities of water and a mixture of ethanol and water (1:1 v/v) to the extraction system on the relative amounts of the components was investigated. The extracts were analyzed by gas chromatography/mass spectrometry. Water as cosolvent increased the total yield of extract. In general, the cosolvents increased the percentage of monoterpene hydrocarbons and, to a smaller extent, the abundance of the oxygenated monoterpenes. Evidently the sorption of the cosolvent into the plant material enhanced the diffusion of the components from the matrix
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Characterization of volatile composition and odor of Angelica (Angelica archAngelica subsp. archAngelica L.) root extracts
Journal of Agricultural and Food Chemistry, 1994Co-Authors: Kaisli Kerrola, Bertalan Galambosi, Heikki KallioAbstract:The volatile components isolated from the root of two wild Angelica strains (Angelica archAngelica L. var. ArchAngelica) grown in the northern Finland were compared with the garden Angelica (var. Sativa) grown in the north and in the south of Finland. More than 80 compounds were determined in the Soxhlet extracts by gas chromatography, and 67 were identified by gas chromatography-mass spectrometry. Large variability in the relative amounts of the compounds was found. beta-Phellandrene was the main component in var. ArchAngelica and sabinene in var. Sativa. The relative proportion of both hydrocarbon monoterpenes and oxygenated monoterpenes was larger in var. Sativa cultivated in the north than in the south of Finland. Angelica strains were sensorially characterized as green, terpenic, fresh, celeriac, and sweet. Deviation-from-reference descriptive analysis was used to evaluate the intensity of these characteristics. Supercritical carbon dioxide extraction (12 MPa/50 degrees C) was used to isolate the aroma of the Angelica root into three fractions with distinctly different compositions. Sensory analysis of the carbon dioxide fractions revealed a terpenic, fresh, and pomerance-like character in the first fraction, and the same features but less pronounced were detected in the second fraction. The last fraction collected after exhaustive extraction was perceived as sweet and stale.
Rajbir Bhatti - One of the best experts on this subject based on the ideXlab platform.
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understanding the phytochemistry and molecular insights to the pharmacology of Angelica archAngelica l garden Angelica and its bioactive components
Phytotherapy Research, 2021Co-Authors: Anudeep Kaur, Rajbir BhattiAbstract:Plant-derived molecules have enduring usefulness in treating diseases, and herbal drugs have emerged as a vital component of global therapeutic demand. Angelica archAngelica L. (A. archAngelica), commonly known as garden Angelica, is an aromatic food plant used in culinary procedures as a flavoring agent. In the traditional medicine system, it is regarded as an "Angel plant" due to its miraculous curative power. This review aims to provide a comprehensive summary of the plant's taxonomic profile, ethnopharmacology, Phytochemistry, and pharmacological activities. Various in vivo and in vitro experiments have validated that the plant possesses broad pharmacological potential. The biological activities attributed to the plant include anti-anxiety activity, anti-convulsant activity, cognition enhancer, antiviral activity, cholinesterase inhibitory potential, antiinflammatory activity, gastroprotective activity, and radioprotective activity. The beneficial effects of the plant are credited to its bioactive components, that is, coumarins and volatile oils. The review summarizes the pharmacological activities of crude extract and its bioactive fractions and has also explored their target-oriented effects. This review will be of value in undertaking further investigations on the plant with regard to exploring mechanism-based pharmacological approaches on A. archAngelica.
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optimization of extraction conditions of Angelica archAngelica extract and activity evaluation in experimental fibromyalgia
Journal of Food Science, 2020Co-Authors: Anudeep Kaur, Nirmal Singh, Manpreet S Bhatti, Rajbir BhattiAbstract:The plant Angelica archAngelica, owing to its magnificent therapeutic effectiveness in folklore medicine system, has been regarded as an "angel plant." The current investigation was aimed to optimize extraction conditions of A. archAngelica roots and to investigate in vivo role of optimized extract in fibromyalgia. Plant material (dried roots) was subjected to methanol extraction at variable temperature (40 to 60 °C) and time (12 to 36 hr) conditions as per two-factorial design strategy, and responses in terms of antioxidant activity were determined. The optimized extraction conditions were found to be temperature of 60 °C and time of 36 hr. HPLC fingerprinting indicated the presence of coumarins in extract. To induce fibromyalgia, the mice were administered reserpine at a dose of 0.5 mg/kg. Mice were orally treated with 100, 200, and 400 mg/kg extract, and magnitude of fibromyalgia was quantified. In comparison to reserpine group, the extract treatment attenuated pain as shown by significant increase in paw withdrawal threshold against mechanical stimuli (P < 0.05), improved motor ability indicated by increase in fall-off time in inclined plane test (P < 0.05), improved locomotion indicated by increased square crossings in open field test (P < 0.05), and improved cognition as shown by significant reduction in time to reach platform in Morris water maze test and passive avoidance task test (P < 0.05). Extract treatment significantly halted reserpine-induced rise in serum cytokine level (P < 0.05) and brain oxidative stress (P < 0.05). Angelica archAngelica extract exerted its beneficial effects in fibromyalgia possibly through the attenuation of oxidative stress-mediated inflammatory cascade. PRACTICAL APPLICATION: Leads from natural products have become an integral part of drug designing processes and have high acceptability due to their better tolerance. The optimization of extraction conditions of plant yields better results and could reduce the processing time, thus increasing its industrial value.
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In Silico Studies and In Vivo MAOA Inhibitory Activity of Coumarins Isolated from Angelica archAngelica Extract: An Approach toward Antidepressant Activity
ACS omega, 2020Co-Authors: Anudeep Kaur, Saweta Garg, Bilal Ahmad Shiekh, Nirmal Singh, Palwinder Singh, Rajbir BhattiAbstract:The current investigation was aimed at in vivo MAOA inhibitory activity of coumarins angelicin, bergapten, and scopoletin isolated from the roots of Angelica archAngelica. The isolated compounds were screened for MAOA (pdb ID 2Z5y) binding through molecular docking studies. The molecular docking results displayed that bergapten has a maximum affinity for MAOA, followed by angelicin and scopoletin. In silico prediction of physicochemical parameters indicated that maximum blood-brain barrier (BBB) permeability was observed with angelicin (2.3), followed by bergapten (2.0) and least with scopoletin (0.644). In consonance to the results of molecular docking studies, appreciable in vivo antidepressant activity of angelicin and bergaptan was observed over the mouse model of reserpine-induced depression. The modulation of MAOA in the antidepressant effect of extract and its isolated fractions was also determined. Biochemical examination of the brain tissue indicated that bergapten has maximum MAOA inhibitory activity while scopoletin fails to inhibit brain MAOA.
Aldo Tava - One of the best experts on this subject based on the ideXlab platform.
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variation in the essential oil composition of Angelica archAngelica from three different altitudes in western himalaya india
Industrial Crops and Products, 2016Co-Authors: R S Chauhan, M C Nautiyal, Roberto Cecotti, Mariella Mella, Aldo TavaAbstract:Angelica archAngelica L. (Apiaceae) is one of the important perennial medicinal and aromatic plant, distributed in mid hill region of Europe and Asia. The essential oil composition of the rhizomes of Angelica archAngelica from three different altitudes of Western Himalaya was investigated. Essential oils were predominantly composed of dillapiole and nothoapiole quantified by GC and identified based on their GC/MS spectra and NMR data. Composition of the essential oil varied greatly with altitude of collection as well as previous studies. Dillapiole was quantified between 35.–91.5% of the total essential oil, while nothoapiole was quantified between 0.1–62.8% of the total essential oil, which is not reported so far. Such great variations in the composition of the essential oil may be attributed to existence of chemotype and adaptation of the species to particular habitat.