Angiokeratoma

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Ron Azaria - One of the best experts on this subject based on the ideXlab platform.

  • treatment of Angiokeratoma of fordyce with pulsed dye laser
    Dermatologic Surgery, 2006
    Co-Authors: Moshe Lapidoth, Dean Adel, Michael David, Ron Azaria
    Abstract:

    BACKGROUND: Angiokeratomas of Fordyce are typically asymptomatic vascular lesions characterized by blue-to-red papules with a scale surface, most often located on the scrotum. Although considered benign, the lesions may bleed, either spontaneously or secondary to rupture, leading to patient anxiety and social embarrassment. OBJECTIVE: The objective was to determine the safety and effectiveness of 585-nm pulsed dye laser for the treatment of Angiokeratomas of Fordyce. METHODS: Twelve patients with Fitzpatrick skin type II to IV were treated for Angiokeratomas of Fordyce with pulsed dye laser (5.5-8.0 J/cm(2)) in two to six sessions. Lesion clearance was evaluated by two specialists on the basis of digital photographs taken before the first treatment and 2 months after the last treatment. RESULTS: Seven patients had an excellent response (clearance rating 75%-100%) and five patients had a good response (clearance rating 50%-75%). Transient purpura and pain were present in all patients. Bleeding during treatment occurred in five patients. There were no permanent side effects. CONCLUSION: Pulsed dye laser is effective and safe for the treatment of Angiokeratoma of Fordyce, with minimum side effects, providing an additional nonablative therapeutic option.

Dean Adel - One of the best experts on this subject based on the ideXlab platform.

  • treatment of Angiokeratoma of fordyce with pulsed dye laser
    Dermatologic Surgery, 2006
    Co-Authors: Moshe Lapidoth, Dean Adel, Michael David, Ron Azaria
    Abstract:

    BACKGROUND: Angiokeratomas of Fordyce are typically asymptomatic vascular lesions characterized by blue-to-red papules with a scale surface, most often located on the scrotum. Although considered benign, the lesions may bleed, either spontaneously or secondary to rupture, leading to patient anxiety and social embarrassment. OBJECTIVE: The objective was to determine the safety and effectiveness of 585-nm pulsed dye laser for the treatment of Angiokeratomas of Fordyce. METHODS: Twelve patients with Fitzpatrick skin type II to IV were treated for Angiokeratomas of Fordyce with pulsed dye laser (5.5-8.0 J/cm(2)) in two to six sessions. Lesion clearance was evaluated by two specialists on the basis of digital photographs taken before the first treatment and 2 months after the last treatment. RESULTS: Seven patients had an excellent response (clearance rating 75%-100%) and five patients had a good response (clearance rating 50%-75%). Transient purpura and pain were present in all patients. Bleeding during treatment occurred in five patients. There were no permanent side effects. CONCLUSION: Pulsed dye laser is effective and safe for the treatment of Angiokeratoma of Fordyce, with minimum side effects, providing an additional nonablative therapeutic option.

Moshe Lapidoth - One of the best experts on this subject based on the ideXlab platform.

  • treatment of Angiokeratoma of fordyce with pulsed dye laser
    Dermatologic Surgery, 2006
    Co-Authors: Moshe Lapidoth, Dean Adel, Michael David, Ron Azaria
    Abstract:

    BACKGROUND: Angiokeratomas of Fordyce are typically asymptomatic vascular lesions characterized by blue-to-red papules with a scale surface, most often located on the scrotum. Although considered benign, the lesions may bleed, either spontaneously or secondary to rupture, leading to patient anxiety and social embarrassment. OBJECTIVE: The objective was to determine the safety and effectiveness of 585-nm pulsed dye laser for the treatment of Angiokeratomas of Fordyce. METHODS: Twelve patients with Fitzpatrick skin type II to IV were treated for Angiokeratomas of Fordyce with pulsed dye laser (5.5-8.0 J/cm(2)) in two to six sessions. Lesion clearance was evaluated by two specialists on the basis of digital photographs taken before the first treatment and 2 months after the last treatment. RESULTS: Seven patients had an excellent response (clearance rating 75%-100%) and five patients had a good response (clearance rating 50%-75%). Transient purpura and pain were present in all patients. Bleeding during treatment occurred in five patients. There were no permanent side effects. CONCLUSION: Pulsed dye laser is effective and safe for the treatment of Angiokeratoma of Fordyce, with minimum side effects, providing an additional nonablative therapeutic option.

Deborah J Dotters - One of the best experts on this subject based on the ideXlab platform.

  • laser treatment of recurrent vulvar Angiokeratoma associated with noonan syndrome
    Obstetrics & Gynecology, 1996
    Co-Authors: William R Meyer, Deborah J Dotters
    Abstract:

    Background: Vulvar Angiokeratoma is often confused with other, more common perineal lesions. Chronically elevated venous pressures may contribute to this rare disorder. Laser treatment may lend palliation for several years. Case: A woman with the characteristic cardiac abnormalities of Noonan syndrome initially responded to Argon laser treatment of vulvar Angiokeratoma. Excessive recurrent disease was treated satisfactorily with the Nd:YAG laser. Conclusion: Recurrent vulvar Angiokeratoma in Noonan syndrome supports the premise that increased persistent central venous pressure may be involved in the disease process.

Tamotsu Kanzaki - One of the best experts on this subject based on the ideXlab platform.

  • Angiokeratoma Corporis Circumscriptum Naeviforme with Transepidermal Elimination
    Journal of Dermatology, 1993
    Co-Authors: Norimasa Miwa, Taisuke Kobayashi, Tamotsu Kanzaki, Takuo Tsuji
    Abstract:

    A 5-year-old Japanese boy visited our clinic for treatment of a dark bluish papulonodular lesion on his right thigh. The histopathology of the lesion indicated Angiokeratoma corporis circumscriptum naeviforme. Topical antibiotics were prescribed for occasional bleeding from the site. Frequent bleeding started in April of 1992, when erythema and itching were observed around the Angiokeratoma. Histopathology of the lesion showed heavy lymphoid cell infiltration around dilated capillaries and irregular acanthosis engulfing dilated capillaries. Interestingly, there were confined masses of red blood cells in the epidermal layer as well as both in and on the horny layer. This is a feature of transepidermal elimination. This transepidermal elimination appeared to be triggered or enhanced by the concomitant contact dermatitis due to topical antibiotics. To the best of our knowledge, this is the first report of Angiokeratoma in which the Angiokeratoma itself reduced in size through transepidermal elimination, possibly caused by contact dermatitis.

  • Angiokeratoma corporis diffusum with glycopeptiduria due to deficient lysosomal a n acetylgalactosaminidase activity clinical morphologic and biochemical studies
    Archives of Dermatology, 1993
    Co-Authors: Tamotsu Kanzaki, Michiko Yokota, Fumitoshi Irie, Yoshio Hirabayashi, Anne M Wang, Robert J Desnick
    Abstract:

    • Background.— Angiokeratoma corporis diffusum is a prominent cutaneous feature of certain lysosomal storage diseases. In this article, the clinical, morphologic, and biochemical features of a new, adult-onset lysosomal disease with Angiokeratoma are described. Observations.— A 46-year-old Japanese woman had diffuse Angiokeratoma, mild intellectual impairment, and peripheral neuroaxonal degeneration. The Angiokeratoma first appeared on her lower torso when she was 28 years old, and then it became diffusely distributed. Histopathologically, the telangiectasia had localized hyperkeratosis; ultrastructural examination revealed clear cytoplasmic vacuoles in all dermal cells, particularly in vascular and lymphatic endothelial cells and in eccrine sweat gland cells. The lysosomal pathologic features and increased urinary excretion of O-linked glycopeptides suggested the deficiency of a specific glycosidase. Enzyme analyses revealed less than 2% of normal α-N-acetylgalactosaminidase activity and the absence of immunodetectable enzyme protein. Her two unaffected children had half-normal α-N-acetylgalactosaminidase levels, consistent with the autosomal recessive inheritance of the enzymatic defect. Conclusions.— Since this enzyme deficiency was previously identified in patients with an infantile form of inherited neuroaxonal dystrophy, the occurrence of the enzymopathy in the 46-year-old proband described herein represents an adult-onset form of α-N-acetylgalactosaminidase deficiency. This newly recognized entity should be considered in the differential diagnosis of Angiokeratoma corporis diffusum. ( Arch Dermatol. 1993;129:460-465)