The Experts below are selected from a list of 573768 Experts worldwide ranked by ideXlab platform
Ricki M Helm - One of the best experts on this subject based on the ideXlab platform.
-
Food allergy Animal Models: an overview.
Annals of the New York Academy of Sciences, 2006Co-Authors: Ricki M HelmAbstract:Specific food allergy is characterized by sensitization to innocuous food proteins with production of allergen-specific IgE that binds to receptors on basophils and mast cells. Upon recurrent exposure to the same allergen, an allergic response is induced by mediator release following cross-linking of cell-bound allergen-specific IgE. The determination of what makes an innocuous food protein an allergen in predisposed individuals is unknown; however, mechanistic and protein allergen predictive Models are being actively investigated in a number of Animal Models. Currently, there is no Animal model that will actively profile known food allergens, predict the allergic potential of novel food proteins, or demonstrate clinically the human food allergic sensitization/allergic response. Animal Models under investigation include mice, rats, the guinea pig, atopic dog, and neonatal swine. These Models are being assessed for production of IgE, clinical responses to re-exposure, and a ranking of food allergens (based on potency) including a nonfood allergen protein source. A selection of Animal Models actively being investigated that will contribute to our understanding of what makes a protein an allergen and future predictive Models for assessing the allergenicity of novel proteins is presented in this review.
-
food allergy Animal Models
Annals of the New York Academy of Sciences, 2006Co-Authors: Ricki M HelmAbstract:Specific food allergy is characterized by sensitization to innocuous food proteins with production of allergen-specific IgE that binds to receptors on basophils and mast cells. Upon recurrent exposure to the same allergen, an allergic response is induced by mediator release following cross-linking of cell-bound allergen-specific IgE. The determination of what makes an innocuous food protein an allergen in predisposed individuals is unknown; however, mechanistic and protein allergen predictive Models are being actively investigated in a number of Animal Models. Currently, there is no Animal model that will actively profile known food allergens, predict the allergic potential of novel food proteins, or demonstrate clinically the human food allergic sensitization/allergic response. Animal Models under investigation include mice, rats, the guinea pig, atopic dog, and neonatal swine. These Models are being assessed for production of IgE, clinical responses to re-exposure, and a ranking of food allergens (based on potency) including a nonfood allergen protein source. A selection of Animal Models actively being investigated that will contribute to our understanding of what makes a protein an allergen and future predictive Models for assessing the allergenicity of novel proteins is presented in this review.
-
Animal Models of food allergy
Current Opinion in Allergy and Clinical Immunology, 2002Co-Authors: Ricki M Helm, Arvil BurksAbstract:PURPOSE OF REVIEW The focus of this review will be on recent Animal Models of food allergy. Animal Models are being used to investigate underlying mechanisms of IgE-mediated disease and for prophylactic/intervention therapies to treat allergic disease. RECENT FINDINGS Considerable advances have been made in the dosage and use of sensitization routes with and without adjuvant and determinations of the pathophysiology of food allergy in murine, dog and swine food allergy Models. Continued research on the neuroendocrine and novel immunoregulatory peptides is also providing new insight into inflammatory regulation and immunity. With the advent of genetically modified food crops, Animal Models are becoming a central theme for prediction/assessment of allergenicity for novel proteins based upon known food allergens. Therapeutic strategies involving cytokine and allergen, DNA immunizations and the use of probiotics are receiving new interest. SUMMARY Although murine Models still predominate the literature with respect to Animal Models of food allergy, the atopic dog and neonatal swine model are contributing knowledge with respect to symptoms more closely related to human allergic responses. Continuing investigations into the mechanisms of IgE-mediated food allergy and therapeutic strategies are providing new insights into prevention and intervention therapies for food allergy.
Rajesh V Thakker - One of the best experts on this subject based on the ideXlab platform.
-
Animal Models of pituitary neoplasia.
Molecular and Cellular Endocrinology, 2015Co-Authors: Kate E Lines, Mark Stevenson, Rajesh V ThakkerAbstract:Pituitary neoplasias can occur as part of a complex inherited disorder, or more commonly as sporadic (non-familial) disease. Studies of the molecular and genetic mechanisms causing such pituitary tumours have identified dysregulation of >35 genes, with many revealed by studies in mice, rats and zebrafish. Strategies used to generate these Animal Models have included gene knockout, gene knockin and transgenic over-expression, as well as chemical mutagenesis and drug induction. These Animal Models provide an important resource for investigation of tissue-specific tumourigenic mechanisms, and evaluations of novel therapies, illustrated by studies into multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome in which ∼30% of patients develop pituitary adenomas. This review describes Animal Models of pituitary neoplasia that have been generated, together with some recent advances in gene editing technologies, and an illustration of the use of the Men1 mouse as a pre clinical model for evaluating novel therapies.
-
Animal Models of pituitary neoplasia.
Molecular and Cellular Endocrinology, 2015Co-Authors: Kate E Lines, Mark Stevenson, Rajesh V ThakkerAbstract:Pituitary neoplasias can occur as part of a complex inherited disorder, or more commonly as sporadic (non-familial) disease. Studies of the molecular and genetic mechanisms causing such pituitary tumours have identified dysregulation of >35 genes, with many revealed by studies in mice, rats and zebrafish. Strategies used to generate these Animal Models have included gene knockout, gene knockin and transgenic over-expression, as well as chemical mutagenesis and drug induction. These Animal Models provide an important resource for investigation of tissue-specific tumourigenic mechanisms, and evaluations of novel therapies, illustrated by studies into multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome in which ∼30% of patients develop pituitary adenomas. This review describes Animal Models of pituitary neoplasia that have been generated, together with some recent advances in gene editing technologies, and an illustration of the use of the Men1 mouse as a pre clinical model for evaluating novel therapies.
Kate E Lines - One of the best experts on this subject based on the ideXlab platform.
-
Animal Models of pituitary neoplasia.
Molecular and Cellular Endocrinology, 2015Co-Authors: Kate E Lines, Mark Stevenson, Rajesh V ThakkerAbstract:Pituitary neoplasias can occur as part of a complex inherited disorder, or more commonly as sporadic (non-familial) disease. Studies of the molecular and genetic mechanisms causing such pituitary tumours have identified dysregulation of >35 genes, with many revealed by studies in mice, rats and zebrafish. Strategies used to generate these Animal Models have included gene knockout, gene knockin and transgenic over-expression, as well as chemical mutagenesis and drug induction. These Animal Models provide an important resource for investigation of tissue-specific tumourigenic mechanisms, and evaluations of novel therapies, illustrated by studies into multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome in which ∼30% of patients develop pituitary adenomas. This review describes Animal Models of pituitary neoplasia that have been generated, together with some recent advances in gene editing technologies, and an illustration of the use of the Men1 mouse as a pre clinical model for evaluating novel therapies.
-
Animal Models of pituitary neoplasia.
Molecular and Cellular Endocrinology, 2015Co-Authors: Kate E Lines, Mark Stevenson, Rajesh V ThakkerAbstract:Pituitary neoplasias can occur as part of a complex inherited disorder, or more commonly as sporadic (non-familial) disease. Studies of the molecular and genetic mechanisms causing such pituitary tumours have identified dysregulation of >35 genes, with many revealed by studies in mice, rats and zebrafish. Strategies used to generate these Animal Models have included gene knockout, gene knockin and transgenic over-expression, as well as chemical mutagenesis and drug induction. These Animal Models provide an important resource for investigation of tissue-specific tumourigenic mechanisms, and evaluations of novel therapies, illustrated by studies into multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome in which ∼30% of patients develop pituitary adenomas. This review describes Animal Models of pituitary neoplasia that have been generated, together with some recent advances in gene editing technologies, and an illustration of the use of the Men1 mouse as a pre clinical model for evaluating novel therapies.
John Q Trojanowski - One of the best experts on this subject based on the ideXlab platform.
-
transgenic Animal Models of tauopathies
Biochimica et Biophysica Acta, 2005Co-Authors: Virginia M Y Lee, Theresa K Kenyon, John Q TrojanowskiAbstract:Tauopathies are a group of neurodegenerative disorders that include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases with prominent tau pathology. Research advances in the last several decades have characterized and defined tau neuropathologies of both neuron and glia in these diverse disorders and this has stimulated development of Animal Models of tauopathies. Indeed, Animal Models ranging from invertebrate species such as C. elegan to Drosophila melanogaster and mammalian transgenic mouse Models of tauopathies have been generated and reported. This review summarizes the salient features of many of the known Models of tauopathies.
Foo Y Liew - One of the best experts on this subject based on the ideXlab platform.
-
Animal Models of rheumatoid arthritis.
European Journal of Immunology, 2009Co-Authors: Darren L. Asquith, Ashley M. Miller, Iain B Mcinnes, Foo Y LiewAbstract:Animal Models have been used extensively in studies of rheumatoid arthritis pathogenesis. Despite the inherent limitations of all Animal Models, several rodent Models have significantly progressed our understanding of the fundamental mechanisms underpinning rheumatoid arthritis and contributed to several current major advances in treatment. These Models include the induced arthritis Models such as collagen-induced arthritis, collagen-antibody-induced arthritis, zymosan-induced arthritis, and the methylated BSA model, and the genetically manipulated or spontaneous arthritis Models such as the TNF-α-transgenic mouse, K/BxN mouse, and the Skg mouse. Here, we describe these Animal Models and discuss their advantages and limitations.
