The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform
Zdenek Hubálek - One of the best experts on this subject based on the ideXlab platform.
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Tick-borne viruses in Europe
Parasitology Research, 2012Co-Authors: Zdenek Hubálek, Ivo RudolfAbstract:The aim of this review is to present briefly background information on 27 tick-borne viruses (“tiboviruses”) that have been detected in Europe, viz flaviviruses tick-borne encephalitis (TBEV), louping-ill (LIV), Tyuleniy (TYUV), and Meaban (MEAV); orthobunyaviruses Bahig (BAHV) and Matruh (MTRV); phleboviruses Grand Arbaud (GAV), Ponteves (PTVV), Uukuniemi (UUKV), Zaliv Terpeniya (ZTV), and St. Abb's Head (SAHV); nairoviruses Soldado (SOLV), Puffin Island (PIV), Avalon (AVAV), Clo Mor (CMV), Crimean-Congo hemorrhagic fever (CCHFV); bunyavirus Bhanja (BHAV); coltivirus Eyach (EYAV); orbiviruses Tribec (TRBV), Okhotskiy (OKHV), Cape Wrath (CWV), Mykines (MYKV), Tindholmur (TDMV), and Bauline (BAUV); two thogotoviruses (Thogoto THOV, Dhori DHOV); and one asfivirus (African swine fever virus ASFV). Emphasis is laid on the taxonomic status of these viruses, range of their ixodid or argasid vectors and vertebrate hosts, pathogenicity for vertebrates including humans, and relevance to public health. In general, three groups of tibovirus diseases can be recognized according to main clinical symptoms produced: (i) febrile illness—usually with a rapid onset, fever, sweating, headache, nausea, weakness, myalgia, arthralgia, sometimes polyarthritis and rash; (ii) the CNS affection—meningitis, meningoencephalitis or encephalomyelitis with pareses, paralysis and other sequelae; (iii) hemorrhagic disease. Several “European” tiboviruses cause very serious human (TBEV, CCHFV) or Animal (LIV, ASFV) diseases. Other arboviruses play definite role in human or Animal Pathology though the disease is usually either less serious or infrequently reported (TYUV, BHAV, AVAV, EYAV, TRBV, DHOV, THOV). The other European arboviruses are “orphans” without a proven medical or veterinary significance (BAHV, MTRV, MEAV, GAV, PTVV, ZTV, SAHV, UUKV, SOLV, PIV, AVAV, CMV, OKHV, CWV, MYKV, TDMV, BAUV). However, certain arbovirus diseases of free-living vertebrates (but also those of domestic Animals and even man) may often pass unnoticed or misdiagnosed and eventually, they might potentially appear as emerging diseases. Active search for new tiboviruses or for new, pathogenic variants of the known tiboviruses in Europe should therefore continue.
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Mosquito-borne viruses in Europe
Parasitology Research, 2008Co-Authors: Zdenek HubálekAbstract:The number of mosquito-borne viruses (‘moboviruses’) occurring in Europe since the twentieth century now stands at ten; they belong to three families— Togaviridae (Sindbis, Chikungunya), Flaviviridae (West Nile, Usutu, Dengue), and Bunyaviridae (Batai, Ťahyňa, Snowshoe hare, Inkoo, Lednice). Several of them play a definite role in human or Animal Pathology (Sindbis, Chikungunya, Dengue, West Nile, Ťahyňa). Mobovirus outbreaks are strictly determined by the presence and/or import of particular competent vectors of the disease. Ecological variables affect moboviruses considerably; the main factors are population density of mosquito vectors and their vertebrate hosts, intense summer precipitations or floods, summer temperatures and drought, and presence of appropriate habitats, e.g., wetlands, small water pools, or intravillan sewage systems. A surveillance for moboviruses and the diseases they cause in Europe is recommendable, because the cases may often pass unnoticed or misdiagnosed not only in free-living vertebrates but also in domestic Animals and even in humans.
Iqbal Hamza - One of the best experts on this subject based on the ideXlab platform.
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The nematode C. elegans as an Animal model to explore toxicology in vivo: solid and axenic growth culture conditions and compound exposure parameters.
Current protocols in toxicology, 2020Co-Authors: Richard Nass, Iqbal HamzaAbstract:Significant limitations in vertebrate Animal model systems include the time involved, the expense, the fact that in vitro results may not reflect live Animal Pathology, difficulties in transporting the toxin past the blood brain barrier, and the inability to identify the mechanism of action without some a priori knowledge of the toxin's target. The availability of the complete genome sequence of the nematode C. elegans, coupled with the worm's size, growth rate, ease of culturing, and the realization that basic biological mechanisms and disease processes between worms and humans are highly conserved, makes this genetically tractable model a remarkable opportunity to dissect and identify in vivo the cellular processes involved in toxin-induced cell dysregulation and death. This unit includes protocols for culturing worms on solid and axenic media and acute and chronic exposure parameters for Parkinson's disease-associated toxins and hemin chloride. These methods provide the groundwork for using this powerful model system to further elucidate and understand the molecular mechanisms involved in nutrition as well as toxicological responses relevant to human diseases.
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the nematode c elegans as an Animal model to explore toxicology in vivo solid and axenic growth culture conditions and compound exposure parameters
Current protocols in immunology, 2007Co-Authors: Richard Nass, Iqbal HamzaAbstract:Significant limitations in vertebrate Animal model systems include the time involved, the expense, the fact that in vitro results may not reflect live Animal Pathology, difficulties in transporting the toxin past the blood brain barrier, and the inability to identify the mechanism of action without some a priori knowledge of the toxin's target. The availability of the complete genome sequence of the nematode C. elegans, coupled with the worm's size, growth rate, ease of culturing, and the realization that basic biological mechanisms and disease processes between worms and humans are highly conserved, makes this genetically tractable model a remarkable opportunity to dissect and identify in vivo the cellular processes involved in toxin-induced cell dysregulation and death. This unit includes protocols for culturing worms on solid and axenic media and acute and chronic exposure parameters for Parkinson's disease–associated toxins and hemin chloride. These methods provide the groundwork for using this powerful model system to further elucidate and understand the molecular mechanisms involved in nutrition as well as toxicological responses relevant to human diseases. Keywords: liquid media; 6-OHDA; Parkinson's Disease; high-throughput; metal; nutrition
Ivo Rudolf - One of the best experts on this subject based on the ideXlab platform.
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Tick-borne viruses in Europe
Parasitology Research, 2012Co-Authors: Zdenek Hubálek, Ivo RudolfAbstract:The aim of this review is to present briefly background information on 27 tick-borne viruses (“tiboviruses”) that have been detected in Europe, viz flaviviruses tick-borne encephalitis (TBEV), louping-ill (LIV), Tyuleniy (TYUV), and Meaban (MEAV); orthobunyaviruses Bahig (BAHV) and Matruh (MTRV); phleboviruses Grand Arbaud (GAV), Ponteves (PTVV), Uukuniemi (UUKV), Zaliv Terpeniya (ZTV), and St. Abb's Head (SAHV); nairoviruses Soldado (SOLV), Puffin Island (PIV), Avalon (AVAV), Clo Mor (CMV), Crimean-Congo hemorrhagic fever (CCHFV); bunyavirus Bhanja (BHAV); coltivirus Eyach (EYAV); orbiviruses Tribec (TRBV), Okhotskiy (OKHV), Cape Wrath (CWV), Mykines (MYKV), Tindholmur (TDMV), and Bauline (BAUV); two thogotoviruses (Thogoto THOV, Dhori DHOV); and one asfivirus (African swine fever virus ASFV). Emphasis is laid on the taxonomic status of these viruses, range of their ixodid or argasid vectors and vertebrate hosts, pathogenicity for vertebrates including humans, and relevance to public health. In general, three groups of tibovirus diseases can be recognized according to main clinical symptoms produced: (i) febrile illness—usually with a rapid onset, fever, sweating, headache, nausea, weakness, myalgia, arthralgia, sometimes polyarthritis and rash; (ii) the CNS affection—meningitis, meningoencephalitis or encephalomyelitis with pareses, paralysis and other sequelae; (iii) hemorrhagic disease. Several “European” tiboviruses cause very serious human (TBEV, CCHFV) or Animal (LIV, ASFV) diseases. Other arboviruses play definite role in human or Animal Pathology though the disease is usually either less serious or infrequently reported (TYUV, BHAV, AVAV, EYAV, TRBV, DHOV, THOV). The other European arboviruses are “orphans” without a proven medical or veterinary significance (BAHV, MTRV, MEAV, GAV, PTVV, ZTV, SAHV, UUKV, SOLV, PIV, AVAV, CMV, OKHV, CWV, MYKV, TDMV, BAUV). However, certain arbovirus diseases of free-living vertebrates (but also those of domestic Animals and even man) may often pass unnoticed or misdiagnosed and eventually, they might potentially appear as emerging diseases. Active search for new tiboviruses or for new, pathogenic variants of the known tiboviruses in Europe should therefore continue.
Richard Nass - One of the best experts on this subject based on the ideXlab platform.
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The nematode C. elegans as an Animal model to explore toxicology in vivo: solid and axenic growth culture conditions and compound exposure parameters.
Current protocols in toxicology, 2020Co-Authors: Richard Nass, Iqbal HamzaAbstract:Significant limitations in vertebrate Animal model systems include the time involved, the expense, the fact that in vitro results may not reflect live Animal Pathology, difficulties in transporting the toxin past the blood brain barrier, and the inability to identify the mechanism of action without some a priori knowledge of the toxin's target. The availability of the complete genome sequence of the nematode C. elegans, coupled with the worm's size, growth rate, ease of culturing, and the realization that basic biological mechanisms and disease processes between worms and humans are highly conserved, makes this genetically tractable model a remarkable opportunity to dissect and identify in vivo the cellular processes involved in toxin-induced cell dysregulation and death. This unit includes protocols for culturing worms on solid and axenic media and acute and chronic exposure parameters for Parkinson's disease-associated toxins and hemin chloride. These methods provide the groundwork for using this powerful model system to further elucidate and understand the molecular mechanisms involved in nutrition as well as toxicological responses relevant to human diseases.
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the nematode c elegans as an Animal model to explore toxicology in vivo solid and axenic growth culture conditions and compound exposure parameters
Current protocols in immunology, 2007Co-Authors: Richard Nass, Iqbal HamzaAbstract:Significant limitations in vertebrate Animal model systems include the time involved, the expense, the fact that in vitro results may not reflect live Animal Pathology, difficulties in transporting the toxin past the blood brain barrier, and the inability to identify the mechanism of action without some a priori knowledge of the toxin's target. The availability of the complete genome sequence of the nematode C. elegans, coupled with the worm's size, growth rate, ease of culturing, and the realization that basic biological mechanisms and disease processes between worms and humans are highly conserved, makes this genetically tractable model a remarkable opportunity to dissect and identify in vivo the cellular processes involved in toxin-induced cell dysregulation and death. This unit includes protocols for culturing worms on solid and axenic media and acute and chronic exposure parameters for Parkinson's disease–associated toxins and hemin chloride. These methods provide the groundwork for using this powerful model system to further elucidate and understand the molecular mechanisms involved in nutrition as well as toxicological responses relevant to human diseases. Keywords: liquid media; 6-OHDA; Parkinson's Disease; high-throughput; metal; nutrition
M L Dagli - One of the best experts on this subject based on the ideXlab platform.
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retrospective study of neoplasms in domestic Animals a survey between 1993 and 2002 of the service of Animal Pathology department of Pathology school of veterinary medicine and Animal science university of sao paulo southeast brazil
Brazilian Journal of Veterinary Pathology, 2012Co-Authors: Katia Cristina Kimura, Ana Paula Garate, M L DagliAbstract:The incidence of neoplasia in Animals is increasing, and cancer epidemiology can be considered an essential area in veterinary Pathology and clinics. The aim of this study was to present a survey of neoplasia in domestic Animals diagnosed at the Animal Pathology Service (Servico de Patologia Animal – SPA), Department of Pathology, School of Veterinary Medicine and Animal Science of the University of Sao Paulo, Brazil. Biopsy and necropsy archival specimens of the SPA were surveyed and all cases with the main diagnosis of neoplasia from 1993 to 2002 were retrieved. Animal species, breed, age, gender, location, and the histological type of neoplasm were recorded and the findings analyzed and formatted to display the epidemiological features of the tumors. A total of 12.118 biopsy and necropsy specimens were processed by the diagnostic service during this period. Among them, 1.971 cases (16%) of neoplasia were found. Most cases of neoplasia were diagnosed in canines (92%, n=1.813), followed by felines (4%, n=82), equines (3%, n=61) and bovines (1%, n=15). Cross breed was the most commonly found breed among dogs (27%, n=492) and cats (40%, n=33). Holstein (47%, n=7) and Mangalarga (28%, n=17) were the most commonly affected breeds in bovines and equines, respectively. The gender incidence of tumors was not significantly different in any species. Dogs, cats and horses were more frequently affected by neoplasia at the age range of 6 to 10 years while cattle were affected at an age range of 1 to 10 years. The most diagnosed neoplasm in dogs was mammary carcinoma (13%, n=244) whereas squamous cell carcinoma was the most diagnosed neoplasm in cats (18%, n=14), cattle (53%, n=8), and horses (33%, n=5). Due to the absence of a veterinary cancer registry in Brazil, epidemiological studies may represent important sources of information on neoplasia in Animals, and, additionally, may be a tool in the development of prevention methods in order to control cancer in domestic Animals.
