The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Paul Schnitzler - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of Anise Oil, dwarf-pine Oil and chamomile Oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses
Journal of Pharmacy and Pharmacology, 2008Co-Authors: Christine Koch, Mona M. Sharaf, Roland Kehm, Jurgen Schneele, Hanswalter Zentgraf, Jurgen Reichling, Paul SchnitzlerAbstract:The effect of Anise Oil, dwarf-pine Oil and chamomile Oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined. Clinical HSV-1 isolates containing frameshift mutations in the thymidine kinase (TK) gene, an insertion or a deletion, yield a non-functional thymidine kinase enzyme resulting in phenotypical resistance against aciclovir. The inhibitory activity of three different essential Oils against herpes simplex virus isolates was tested in-vitro using a plaque reduction assay. All essential Oils exhibited high levels of antiviral activity against aciclovir-sensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti. At maximum noncytotoxic concentrations of the plant Oils, plaque formation was significantly reduced by 96.6-99.9%, when herpesviruses were preincubated with drugs before attachment to host cells. No significant effect on viral infectivity could be achieved by adding these compounds during the replication phase. These results indicate that Anise Oil, dwarf-pine Oil and chamomile Oil affected the virus by interrupting adsorption of herpesviruses and in a different manner than aciclovir, which is effective after attachment inside the infected cells. Thus the investigated essential Oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses. Chamomile Oil did not reveal any irritating potential on hen's egg chorioallantoic membrane, demonstrated the highest selectivity index among the Oils tested and was highly active against clinically relevant aciclovir-resistant HSV-1 strains.
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Efficacy of Anise Oil, dwarf‐pine Oil and chamomile Oil against thymidine‐kinase‐positive and thymidine‐kinase‐negative herpesviruses
The Journal of pharmacy and pharmacology, 2008Co-Authors: Christine Koch, Mona M. Sharaf, Roland Kehm, Jurgen Schneele, Hanswalter Zentgraf, Jurgen Reichling, Paul SchnitzlerAbstract:The effect of Anise Oil, dwarf-pine Oil and chamomile Oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined. Clinical HSV-1 isolates containing frameshift mutations in the thymidine kinase (TK) gene, an insertion or a deletion, yield a non-functional thymidine kinase enzyme resulting in phenotypical resistance against aciclovir. The inhibitory activity of three different essential Oils against herpes simplex virus isolates was tested in-vitro using a plaque reduction assay. All essential Oils exhibited high levels of antiviral activity against aciclovir-sensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti. At maximum noncytotoxic concentrations of the plant Oils, plaque formation was significantly reduced by 96.6-99.9%, when herpesviruses were preincubated with drugs before attachment to host cells. No significant effect on viral infectivity could be achieved by adding these compounds during the replication phase. These results indicate that Anise Oil, dwarf-pine Oil and chamomile Oil affected the virus by interrupting adsorption of herpesviruses and in a different manner than aciclovir, which is effective after attachment inside the infected cells. Thus the investigated essential Oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses. Chamomile Oil did not reveal any irritating potential on hen's egg chorioallantoic membrane, demonstrated the highest selectivity index among the Oils tested and was highly active against clinically relevant aciclovir-resistant HSV-1 strains.
Christine Koch - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of Anise Oil, dwarf-pine Oil and chamomile Oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses
Journal of Pharmacy and Pharmacology, 2008Co-Authors: Christine Koch, Mona M. Sharaf, Roland Kehm, Jurgen Schneele, Hanswalter Zentgraf, Jurgen Reichling, Paul SchnitzlerAbstract:The effect of Anise Oil, dwarf-pine Oil and chamomile Oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined. Clinical HSV-1 isolates containing frameshift mutations in the thymidine kinase (TK) gene, an insertion or a deletion, yield a non-functional thymidine kinase enzyme resulting in phenotypical resistance against aciclovir. The inhibitory activity of three different essential Oils against herpes simplex virus isolates was tested in-vitro using a plaque reduction assay. All essential Oils exhibited high levels of antiviral activity against aciclovir-sensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti. At maximum noncytotoxic concentrations of the plant Oils, plaque formation was significantly reduced by 96.6-99.9%, when herpesviruses were preincubated with drugs before attachment to host cells. No significant effect on viral infectivity could be achieved by adding these compounds during the replication phase. These results indicate that Anise Oil, dwarf-pine Oil and chamomile Oil affected the virus by interrupting adsorption of herpesviruses and in a different manner than aciclovir, which is effective after attachment inside the infected cells. Thus the investigated essential Oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses. Chamomile Oil did not reveal any irritating potential on hen's egg chorioallantoic membrane, demonstrated the highest selectivity index among the Oils tested and was highly active against clinically relevant aciclovir-resistant HSV-1 strains.
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Efficacy of Anise Oil, dwarf‐pine Oil and chamomile Oil against thymidine‐kinase‐positive and thymidine‐kinase‐negative herpesviruses
The Journal of pharmacy and pharmacology, 2008Co-Authors: Christine Koch, Mona M. Sharaf, Roland Kehm, Jurgen Schneele, Hanswalter Zentgraf, Jurgen Reichling, Paul SchnitzlerAbstract:The effect of Anise Oil, dwarf-pine Oil and chamomile Oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined. Clinical HSV-1 isolates containing frameshift mutations in the thymidine kinase (TK) gene, an insertion or a deletion, yield a non-functional thymidine kinase enzyme resulting in phenotypical resistance against aciclovir. The inhibitory activity of three different essential Oils against herpes simplex virus isolates was tested in-vitro using a plaque reduction assay. All essential Oils exhibited high levels of antiviral activity against aciclovir-sensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti. At maximum noncytotoxic concentrations of the plant Oils, plaque formation was significantly reduced by 96.6-99.9%, when herpesviruses were preincubated with drugs before attachment to host cells. No significant effect on viral infectivity could be achieved by adding these compounds during the replication phase. These results indicate that Anise Oil, dwarf-pine Oil and chamomile Oil affected the virus by interrupting adsorption of herpesviruses and in a different manner than aciclovir, which is effective after attachment inside the infected cells. Thus the investigated essential Oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses. Chamomile Oil did not reveal any irritating potential on hen's egg chorioallantoic membrane, demonstrated the highest selectivity index among the Oils tested and was highly active against clinically relevant aciclovir-resistant HSV-1 strains.
Angélica Peñaranda Gómez - One of the best experts on this subject based on the ideXlab platform.
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One-Pot Diastereoselective Synthesis of Tetrahydroquinolines from Star Anise Oil in a Choline Chloride/Zinc Chloride Eutectic Mixture
ACS Sustainable Chemistry & Engineering, 2019Co-Authors: Angélica Peñaranda Gómez, Oscar Rodríguez Bejarano, Vladimir V. Kouznetsov, Cristian Ochoa-puentesAbstract:ABSTRACT: In this contribution a sustainable one-pot diastereoselective synthesis of tetrahydroquinolines through aza Diels-Alder reaction is reported starting from star Anise Oil, substituted anilines and aromatic aldehydes in choline chloride/zinc chloride eutectic mixture as new reaction media. Star Anise extracts and essential Oils obtained by soxhlet, ultrasound assisted extraction, steam distillation and hydrodistillation were analyzed by GC-MS finding the highest content of trans-anethol from hydrodistillation; in addition, the eutectic composition and temperature for choline chloride/zinc chloride mixture were revisited. All compounds were obtained in 28-98 % yield with diastereoselectivity towards the cis-(2e,4e) product. Furthermore, the DES was reused in three cycles without observing a detrimental catalytic activity and green metric analysis showed a favorable environmental impact of this synthetic method.
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one pot diastereoselective synthesis of tetrahydroquinolines from star Anise Oil in a choline chloride zinc chloride eutectic mixture
ACS Sustainable Chemistry & Engineering, 2019Co-Authors: Angélica Peñaranda Gómez, Oscar Rodríguez Bejarano, Vladimir V. Kouznetsov, Cristian OchoapuentesAbstract:ABSTRACT: In this contribution a sustainable one-pot diastereoselective synthesis of tetrahydroquinolines through aza Diels-Alder reaction is reported starting from star Anise Oil, substituted anilines and aromatic aldehydes in choline chloride/zinc chloride eutectic mixture as new reaction media. Star Anise extracts and essential Oils obtained by soxhlet, ultrasound assisted extraction, steam distillation and hydrodistillation were analyzed by GC-MS finding the highest content of trans-anethol from hydrodistillation; in addition, the eutectic composition and temperature for choline chloride/zinc chloride mixture were revisited. All compounds were obtained in 28-98 % yield with diastereoselectivity towards the cis-(2e,4e) product. Furthermore, the DES was reused in three cycles without observing a detrimental catalytic activity and green metric analysis showed a favorable environmental impact of this synthetic method.
Mona M. Sharaf - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of Anise Oil, dwarf-pine Oil and chamomile Oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses
Journal of Pharmacy and Pharmacology, 2008Co-Authors: Christine Koch, Mona M. Sharaf, Roland Kehm, Jurgen Schneele, Hanswalter Zentgraf, Jurgen Reichling, Paul SchnitzlerAbstract:The effect of Anise Oil, dwarf-pine Oil and chamomile Oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined. Clinical HSV-1 isolates containing frameshift mutations in the thymidine kinase (TK) gene, an insertion or a deletion, yield a non-functional thymidine kinase enzyme resulting in phenotypical resistance against aciclovir. The inhibitory activity of three different essential Oils against herpes simplex virus isolates was tested in-vitro using a plaque reduction assay. All essential Oils exhibited high levels of antiviral activity against aciclovir-sensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti. At maximum noncytotoxic concentrations of the plant Oils, plaque formation was significantly reduced by 96.6-99.9%, when herpesviruses were preincubated with drugs before attachment to host cells. No significant effect on viral infectivity could be achieved by adding these compounds during the replication phase. These results indicate that Anise Oil, dwarf-pine Oil and chamomile Oil affected the virus by interrupting adsorption of herpesviruses and in a different manner than aciclovir, which is effective after attachment inside the infected cells. Thus the investigated essential Oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses. Chamomile Oil did not reveal any irritating potential on hen's egg chorioallantoic membrane, demonstrated the highest selectivity index among the Oils tested and was highly active against clinically relevant aciclovir-resistant HSV-1 strains.
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Efficacy of Anise Oil, dwarf‐pine Oil and chamomile Oil against thymidine‐kinase‐positive and thymidine‐kinase‐negative herpesviruses
The Journal of pharmacy and pharmacology, 2008Co-Authors: Christine Koch, Mona M. Sharaf, Roland Kehm, Jurgen Schneele, Hanswalter Zentgraf, Jurgen Reichling, Paul SchnitzlerAbstract:The effect of Anise Oil, dwarf-pine Oil and chamomile Oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined. Clinical HSV-1 isolates containing frameshift mutations in the thymidine kinase (TK) gene, an insertion or a deletion, yield a non-functional thymidine kinase enzyme resulting in phenotypical resistance against aciclovir. The inhibitory activity of three different essential Oils against herpes simplex virus isolates was tested in-vitro using a plaque reduction assay. All essential Oils exhibited high levels of antiviral activity against aciclovir-sensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti. At maximum noncytotoxic concentrations of the plant Oils, plaque formation was significantly reduced by 96.6-99.9%, when herpesviruses were preincubated with drugs before attachment to host cells. No significant effect on viral infectivity could be achieved by adding these compounds during the replication phase. These results indicate that Anise Oil, dwarf-pine Oil and chamomile Oil affected the virus by interrupting adsorption of herpesviruses and in a different manner than aciclovir, which is effective after attachment inside the infected cells. Thus the investigated essential Oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses. Chamomile Oil did not reveal any irritating potential on hen's egg chorioallantoic membrane, demonstrated the highest selectivity index among the Oils tested and was highly active against clinically relevant aciclovir-resistant HSV-1 strains.
Jurgen Reichling - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of Anise Oil, dwarf-pine Oil and chamomile Oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses
Journal of Pharmacy and Pharmacology, 2008Co-Authors: Christine Koch, Mona M. Sharaf, Roland Kehm, Jurgen Schneele, Hanswalter Zentgraf, Jurgen Reichling, Paul SchnitzlerAbstract:The effect of Anise Oil, dwarf-pine Oil and chamomile Oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined. Clinical HSV-1 isolates containing frameshift mutations in the thymidine kinase (TK) gene, an insertion or a deletion, yield a non-functional thymidine kinase enzyme resulting in phenotypical resistance against aciclovir. The inhibitory activity of three different essential Oils against herpes simplex virus isolates was tested in-vitro using a plaque reduction assay. All essential Oils exhibited high levels of antiviral activity against aciclovir-sensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti. At maximum noncytotoxic concentrations of the plant Oils, plaque formation was significantly reduced by 96.6-99.9%, when herpesviruses were preincubated with drugs before attachment to host cells. No significant effect on viral infectivity could be achieved by adding these compounds during the replication phase. These results indicate that Anise Oil, dwarf-pine Oil and chamomile Oil affected the virus by interrupting adsorption of herpesviruses and in a different manner than aciclovir, which is effective after attachment inside the infected cells. Thus the investigated essential Oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses. Chamomile Oil did not reveal any irritating potential on hen's egg chorioallantoic membrane, demonstrated the highest selectivity index among the Oils tested and was highly active against clinically relevant aciclovir-resistant HSV-1 strains.
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Efficacy of Anise Oil, dwarf‐pine Oil and chamomile Oil against thymidine‐kinase‐positive and thymidine‐kinase‐negative herpesviruses
The Journal of pharmacy and pharmacology, 2008Co-Authors: Christine Koch, Mona M. Sharaf, Roland Kehm, Jurgen Schneele, Hanswalter Zentgraf, Jurgen Reichling, Paul SchnitzlerAbstract:The effect of Anise Oil, dwarf-pine Oil and chamomile Oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains was examined. Clinical HSV-1 isolates containing frameshift mutations in the thymidine kinase (TK) gene, an insertion or a deletion, yield a non-functional thymidine kinase enzyme resulting in phenotypical resistance against aciclovir. The inhibitory activity of three different essential Oils against herpes simplex virus isolates was tested in-vitro using a plaque reduction assay. All essential Oils exhibited high levels of antiviral activity against aciclovir-sensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti. At maximum noncytotoxic concentrations of the plant Oils, plaque formation was significantly reduced by 96.6-99.9%, when herpesviruses were preincubated with drugs before attachment to host cells. No significant effect on viral infectivity could be achieved by adding these compounds during the replication phase. These results indicate that Anise Oil, dwarf-pine Oil and chamomile Oil affected the virus by interrupting adsorption of herpesviruses and in a different manner than aciclovir, which is effective after attachment inside the infected cells. Thus the investigated essential Oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses. Chamomile Oil did not reveal any irritating potential on hen's egg chorioallantoic membrane, demonstrated the highest selectivity index among the Oils tested and was highly active against clinically relevant aciclovir-resistant HSV-1 strains.