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A. Martin Lerner - One of the best experts on this subject based on the ideXlab platform.

C. Stephen Foster - One of the best experts on this subject based on the ideXlab platform.

  • Herpes simplex Virus Type 2 induced retinal necrosis in BALB/c mice
    Acta Ophthalmologica, 2009
    Co-Authors: Manfred Zierhut, Ramzi K. Hemady, Tongzhen Zhao, Amyna Merchant, C. Stephen Foster
    Abstract:

    : We injected herpes simplex Virus Type 2 of MS- or G-strain into the anterior chamber of BALB/c mice. In the contralateral eye inflammatory cell infiltration began in the ciliary body; focal retinitis, detected by day 8, led to total destruction of the retina by day 10. Contralateral disease was observed in 75% of mice inoculated with 8 x 10(3) pfu herpes simplex Virus Type 2, but in only 20% of mice receiving 80 pfu herpes simplex Virus Type 2. Still this low concentration, however, produced a suppressed delayed-Type hypersensitivity response. Anti-herpes simplex Virus Type 2 antibody, first detected on day 8, reached high titers on day 10; by then, most of the mice had died of encephalitis. The G-strain of herpes simplex Virus Type 2 was more neurotoxic than the MS-strain, but produced the same incidence of contralateral retinitis. Herpes simplex Virus Type 2 products contralateral necrotizing retinitis comparable to that produced by herpes simplex Virus Type 1. These findings, like those of other authors, suggest a role for herpes simplex Virus Type 2 in some cases of acute retinal necrosis in humans.

David C. Nolan - One of the best experts on this subject based on the ideXlab platform.

Horacio Osiovich - One of the best experts on this subject based on the ideXlab platform.

  • Brainstem involvement in neonatal herpes simplex Virus Type 2 encephalitis.
    Pediatrics, 2007
    Co-Authors: Gustavo Pelligra, Niamh Lynch, Steven P. Miller, Michael A. Sargent, Horacio Osiovich
    Abstract:

    Herpes simplex Virus encephalitis in the newborn typically involves the cerebral cortex in a widespread manner. Herpes simplex Virus Type 2 rarely involves the brainstem. Here we report a 16-day-old infant with predominant brainstem and cerebellar involvement secondary to herpes simplex Virus Type 2 infection. Diffusion-weighted MRI performed 3 days after the onset of symptoms revealed restricted diffusion mainly in brainstem and cerebellar structures. No abnormal findings were seen on conventional MRI. Subsequent MRI scans showed evolution of the brain injury with extension along the corticospinal tracts. However, there was no evidence of any other supratentorial gray or white matter injury. This is the first report of predominant brainstem involvement in neonatal herpes simplex Virus Type 2 encephalitis. In addition, the importance of performing diffusion-weighted sequences to detect early central nervous system involvement and serial MRI to follow the evolution of central nervous system lesions is emphasized.

Guy Allaire - One of the best experts on this subject based on the ideXlab platform.

  • Herpes simplex Virus Type II is not a cofactor to human papillomaVirus in cancer of the uterine cervix
    American journal of obstetrics and gynecology, 2003
    Co-Authors: Danh Tran-thanh, Diane Provencher, Anita Koushik, Eliane Duarte-franco, Allegria Kessous, Pierre Drouin, Cosette M. Wheeler, Josée Dubuc-lissoir, Philippe Gauthier, Guy Allaire
    Abstract:

    Abstract Objective: Cells that were cotransfected with herpes simplex Virus–16 and the herpes simplex Virus Type 2 Xho -2 DNA induce tumors in nude mice. In a cross-sectional study, we investigated the role of herpes simplex Virus Type 2 as a cofactor to human papillomaVirus in cervical cancer. Study Design: Cervical cells that were obtained with an endocervical Cytobrush brush (Medscand) from 439 women (50 women with cancer lesions, 65 women with high-grade squamous intraepithelial lesions, 80 women with low-grade squamous intraepithelial lesions, 244 healthy subjects) and DNA that was extracted from 150 cervical cancer biopsy specimens were analyzed with polymerase chain reaction for herpes simplex Virus Type 2 Xho -2 and Bgl IIC transforming DNA sequences. Results: All 439 cervical samples and 150 cervical cancer biopsy specimens tested negative for herpes simplex Virus Type 2 Xho -2 and Bgl IIC DNA by polymerase chain reaction. Overall, none of 200 samples (0%) from women with invasive cervical cancer contained herpes simplex Virus Type 2 Xho -2 or Bgl IIC DNA (95% CI, 0.0-1.8). Conclusion: Although herpes simplex Virus Type 2 Bgl IIN transforms epithelial cells in vitro, it was not detected in cervical cancer specimens. (Am J Obstet Gynecol 2003;188:129-34.)