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Mayyung Yen - One of the best experts on this subject based on the ideXlab platform.
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association of ocular dominance and anisometropic myopia
Investigative Ophthalmology & Visual Science, 2004Co-Authors: Chingyu Cheng, Mayyung Yen, Hsin Yi Lin, Wei Wei Hsia, Wenming HsuAbstract:PURPOSE. To determine the association between ocular dominance and degree of myopia in patients with Anisometropia. METHODS. Fifty-five subjects with anisometropic myopia were recruited. None of them had amblyopia. Refractive error and axial length were measured in each subject. Ocular dominance was determined using the hole-in-the-card test and convergence near-point test. RESULTS. There was a threshold level of Anisometropia (1.75 D) beyond which the dominant eye was always more myopic than the nondominant eye. Of the 33 subjects with Anisometropia of ≤1.75 D, the dominant eye was more myopic in 17 (51.5%) subjects. Dominant eyes, determined by the hole-in-the-card test, had a significantly greater myopic spherical equivalent (-5.27 ± 2.45 D) than nondominant eyes (-3.94 ± 3.10 D; P 1.75 D), but was not significant in those with lower Anisometropia (≤1.75 D). Similar results were obtained using the convergence near-point test. CONCLUSIONS. The present study shows that the dominant eye has a greater degree of myopia than the nondominant eye in subjects with anisometropic myopia. Taking ocular dominance into account in the design of randomized clinical trails to assess the efficacy of myopia interventions may provide useful information.
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retinal nerve fiber layer thickness in unilateral amblyopia
Investigative Ophthalmology & Visual Science, 2004Co-Authors: Mayyung Yen, Chingyu Cheng, Anguor WangAbstract:PURPOSE To test the hypothesis that eyes with amblyopia may have thicker retina, retinal nerve fiber layer thickness (RNFLT) was investigated in patients with unilateral amblyopia. METHODS Thirty-eight patients with unilateral amblyopia were studied. Among them, 20 patients had amblyopia with strabismus and 18 had refractive amblyopia without strabismus. Nineteen of 38 had Anisometropia of 2.0 D or more. In addition, 17 patients with Anisometropia of 2.0 D or more but without amblyopia were enrolled as control subjects. RNFLT was measured by optical coherence tomography with scan pattern "Nerve Head 2.0R" (Carl Zeiss Meditec, Dublin, CA). Average RNFLT was multiplied with their corresponding scan circumferences to estimate the integral values of the total RNFL area (RNFLT(estimated integrals)). RESULTS In all 38 patients with unilateral amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes were statistically significant. Multivariate regression analysis with adjustment for axial length, spherical equivalence, age, and sex indicated significant differences as well. In the group of strabismic amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes did not reach statistical significance. However, in the group of refractive amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopia eyes and the normal fellow eyes both had a statistical significance. In the 19 patients with anisometropic amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes were statistically significant. In the control group of 17 patients with nonamblyopic Anisometropia, the difference in RNFLT and in RNFLT(estimated integrals) between both eyes did not reach statistical significance. CONCLUSIONS RNFLT may be affected by refractive amblyopia, but further histopathologic confirmation is needed.
Anguor Wang - One of the best experts on this subject based on the ideXlab platform.
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retinal nerve fiber layer thickness in unilateral amblyopia
Investigative Ophthalmology & Visual Science, 2004Co-Authors: Mayyung Yen, Chingyu Cheng, Anguor WangAbstract:PURPOSE To test the hypothesis that eyes with amblyopia may have thicker retina, retinal nerve fiber layer thickness (RNFLT) was investigated in patients with unilateral amblyopia. METHODS Thirty-eight patients with unilateral amblyopia were studied. Among them, 20 patients had amblyopia with strabismus and 18 had refractive amblyopia without strabismus. Nineteen of 38 had Anisometropia of 2.0 D or more. In addition, 17 patients with Anisometropia of 2.0 D or more but without amblyopia were enrolled as control subjects. RNFLT was measured by optical coherence tomography with scan pattern "Nerve Head 2.0R" (Carl Zeiss Meditec, Dublin, CA). Average RNFLT was multiplied with their corresponding scan circumferences to estimate the integral values of the total RNFL area (RNFLT(estimated integrals)). RESULTS In all 38 patients with unilateral amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes were statistically significant. Multivariate regression analysis with adjustment for axial length, spherical equivalence, age, and sex indicated significant differences as well. In the group of strabismic amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes did not reach statistical significance. However, in the group of refractive amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopia eyes and the normal fellow eyes both had a statistical significance. In the 19 patients with anisometropic amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes were statistically significant. In the control group of 17 patients with nonamblyopic Anisometropia, the difference in RNFLT and in RNFLT(estimated integrals) between both eyes did not reach statistical significance. CONCLUSIONS RNFLT may be affected by refractive amblyopia, but further histopathologic confirmation is needed.
Ilana Karshai - One of the best experts on this subject based on the ideXlab platform.
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phakic posterior chamber intraocular lens for the correction of Anisometropia and treatment of amblyopia
American Journal of Ophthalmology, 2000Co-Authors: David Benezra, Evelyne Cohen, Ilana KarshaiAbstract:Abstract PURPOSE: To assess the potential visual benefits of posterior chamber phakic intraocular lens implants in eyes of children with anisometropic amblyopia. METHODS: In a prospective study, three girls 9, 14, and 18 years old with high Anisometropia and deep amblyopia were included in this study. The phakic posterior chamber intraocular lens (ICL; STAAR Surgical AG, Nidau, Switzerland) was used to correct the Anisometropia. This intraocular lens was inserted in the anterior chamber through a 3.0-mm temporal clear cornea incision and manipulated into the posterior chamber using an iris manipulator. A peripheral iridectomy was performed using the Ocutome Probe (Storz; Premiere, St. Louis, Missouri). Local therapy with corticosteroids and antibiotics were prescribed for 2 weeks, and patients were followed regularly for a period of 6 to 9 months. RESULTS: In the three amblyopic eyes of the three patients, the preoperative best-corrected visual acuity of 6/30, 6/60, and 6/30 improved, to 6/7.5 (20/25), 6/30 (20/100), and 6/15 (20/50), respectively, 6 months after the surgery. Binocular functions with development of fusional abilities and stereopsis were observed in two of these patients after the intraocular lens implantation. In the third patient, the fusional abilities developed only after surgical correction of the exotropia. The intraocular pressure remained within normal limits, and there was no significant change in the corneal endothelial cell count during the period of follow-up. No major intraoperative or postoperative complications were observed, except for a temporary pigment dispersion. CONCLUSIONS: Implantation of phakic posterior chamber intraocular lenses may be beneficial for the treatment of amblyopia in children with Anisometropia. Although additional cases and long-term follow-up observations are necessary, it appears that amblyopia may be overcome by the use of posterior chamber phakic intraocular lens implants, even in eyes of children beyond the age generally considered to be responsive to anti-amblyopic treatment.
Chingyu Cheng - One of the best experts on this subject based on the ideXlab platform.
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association of ocular dominance and anisometropic myopia
Investigative Ophthalmology & Visual Science, 2004Co-Authors: Chingyu Cheng, Mayyung Yen, Hsin Yi Lin, Wei Wei Hsia, Wenming HsuAbstract:PURPOSE. To determine the association between ocular dominance and degree of myopia in patients with Anisometropia. METHODS. Fifty-five subjects with anisometropic myopia were recruited. None of them had amblyopia. Refractive error and axial length were measured in each subject. Ocular dominance was determined using the hole-in-the-card test and convergence near-point test. RESULTS. There was a threshold level of Anisometropia (1.75 D) beyond which the dominant eye was always more myopic than the nondominant eye. Of the 33 subjects with Anisometropia of ≤1.75 D, the dominant eye was more myopic in 17 (51.5%) subjects. Dominant eyes, determined by the hole-in-the-card test, had a significantly greater myopic spherical equivalent (-5.27 ± 2.45 D) than nondominant eyes (-3.94 ± 3.10 D; P 1.75 D), but was not significant in those with lower Anisometropia (≤1.75 D). Similar results were obtained using the convergence near-point test. CONCLUSIONS. The present study shows that the dominant eye has a greater degree of myopia than the nondominant eye in subjects with anisometropic myopia. Taking ocular dominance into account in the design of randomized clinical trails to assess the efficacy of myopia interventions may provide useful information.
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retinal nerve fiber layer thickness in unilateral amblyopia
Investigative Ophthalmology & Visual Science, 2004Co-Authors: Mayyung Yen, Chingyu Cheng, Anguor WangAbstract:PURPOSE To test the hypothesis that eyes with amblyopia may have thicker retina, retinal nerve fiber layer thickness (RNFLT) was investigated in patients with unilateral amblyopia. METHODS Thirty-eight patients with unilateral amblyopia were studied. Among them, 20 patients had amblyopia with strabismus and 18 had refractive amblyopia without strabismus. Nineteen of 38 had Anisometropia of 2.0 D or more. In addition, 17 patients with Anisometropia of 2.0 D or more but without amblyopia were enrolled as control subjects. RNFLT was measured by optical coherence tomography with scan pattern "Nerve Head 2.0R" (Carl Zeiss Meditec, Dublin, CA). Average RNFLT was multiplied with their corresponding scan circumferences to estimate the integral values of the total RNFL area (RNFLT(estimated integrals)). RESULTS In all 38 patients with unilateral amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes were statistically significant. Multivariate regression analysis with adjustment for axial length, spherical equivalence, age, and sex indicated significant differences as well. In the group of strabismic amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes did not reach statistical significance. However, in the group of refractive amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopia eyes and the normal fellow eyes both had a statistical significance. In the 19 patients with anisometropic amblyopia, the difference in RNFLT and in RNFLT(estimated integrals) between the amblyopic eyes and the normal fellow eyes were statistically significant. In the control group of 17 patients with nonamblyopic Anisometropia, the difference in RNFLT and in RNFLT(estimated integrals) between both eyes did not reach statistical significance. CONCLUSIONS RNFLT may be affected by refractive amblyopia, but further histopathologic confirmation is needed.
Ziad F Bashshur - One of the best experts on this subject based on the ideXlab platform.
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retinal nerve fibre layer and macular thickness in amblyopia as measured by spectral domain optical coherence tomography
British Journal of Ophthalmology, 2011Co-Authors: Christiane Alhaddad, Georges El Mollayess, Carol G Cherfan, Dalida Jaafar, Ziad F BashshurAbstract:Background/aims To study peripapillary retinal nerve fibre layer (RNFL) and macular thickness in amblyopia using high-definition spectral-domain optical coherence tomography (SD-OCT) and to compare the results with available literature using the time-domain modality. Methods This was a prospective institutional study of patients ≥6 years of age with unilateral amblyopia (strabismic or anisometropic) and non-amblyopic Anisometropia. RNFL and macular thicknesses were measured using SD-OCT and compared between fellow eyes. Results The mean age was 20 (±12) years; 45 patients had amblyopia: 14 strabismic and 31 anisometropic. 20 patients had non-amblyopic Anisometropia. The mean macular thickness was significantly increased in the amblyopic (273.8 μm) vs fellow eyes (257.9 μm), p=0.001. This difference remained significant in the anisometropic group (p=0.002) but not the strabismic group. The mean RNFL thickness was similar in amblyopic (95.4 μm) and fellow eyes (94.0 μm). Similar results were obtained regardless of the level of visual acuity, age or refractive error. In the control group of non-amblyopic Anisometropia, the interocular difference did not reach statistical significance. Conclusions Central macular thickness was significantly increased in anisometropic amblyopia using SD-OCT. Anisometropia alone did not produce such a difference, which points to a possible correlation between amblyopia and the development of the retinal layers.