The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform
Akira Ogawa - One of the best experts on this subject based on the ideXlab platform.
-
prediction of meningioma consistency using fractional Anisotropy Value measured by magnetic resonance imaging
Journal of Neurosurgery, 2007Co-Authors: Hiroshi Kashimura, Takashi Inoue, Kuniaki Ogasawara, Hiroshi Arai, Yasunari Otawara, Yoshiyuki Kanbara, Akira OgawaAbstract:Object Preoperative planning for meningiomas requires information about tumor consistency as well as location and size. In the present study the authors aimed to determine whether the fractional Anisotropy (FA) Value calculated on the basis of preoperative magnetic resonance (MR) diffusion tensor (DT) imaging could predict meningioma consistency. Methods In 29 patients with intracranial meningiomas, MR DT imaging was performed preoperatively, and the FA Values of the tumors were calculated. Tumor consistency was intraoperatively determined as hard or soft, and the histological diagnosis of the tumor was established. Results Of the 29 tumors, 11 were classified as hard and 18 as soft. The FA Values of fibroblastic meningiomas were significantly higher than those of meningothelial meningiomas (p = 0.002). The FA Values of hard tumors were significantly higher than those of soft tumors (p = 0.0003). Logistic regression analysis demonstrated that the FA Value was a significant independent predictor of tumor c...
-
fractional Anisotropy Value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas
Surgical Neurology, 2005Co-Authors: Takaaki Beppu, Takashi Inoue, Kuniaki Ogasawara, Akira Ogawa, Yuji Shibata, Noriyuki Yamada, Akira Kurose, Hiroyuki KabasawaAbstract:Abstract Background In vivo, water diffusion displays directionality due to presence of complex microstructural barriers in tissue. The extent of directionality of water diffusion can be expressed as a fractional Anisotropy (FA) Value using diffusion tensor magnetic resonance imaging (DTI). The FA Value has been suggested as an indicator of the cell density of astrocytic tumors. The aim of the present study was to confirm beyond doubt that FA Values indicate cell density even when limited in glioblastomas and to determine whether the FA Value of a given patient predicts proliferation activity in the individual glioblastoma. Methods We performed DTI in 19 patients with glioblastoma and measured the FA Values of tumor and normal brain regions prior to computed tomography–guided stereotactic biopsy. Differences in mean FA Value between normal brain regions and glioblastoma lesion were compared. Cell density and MIB-1 indices were examined using tumor specimens obtained from biopsies. Correlation among FA Values, cell density, and MIB-1 indices was also evaluated. Results The mean FA Value significantly differed between normal brain regions and glioblastoma lesions. Positive correlation was observed between FA Value and cell density (r = 0.73, P Conclusions Our results suggest that the FA Value of glioblastoma as determined by DTI prior to surgery is a good predictor of cell density and, consequently, proliferation activity.
-
use of fractional Anisotropy Value by diffusion tensor mri for preoperative diagnosis of astrocytic tumors case report
Journal of Neuro-oncology, 2004Co-Authors: Toshinari Misaki, Takashi Inoue, Kuniaki Ogasawara, Akira Ogawa, Takaaki Beppu, Hiroyuki KabasawaAbstract:The fractional Anisotropy (FA) Value calculated by diffusion tensor MRI can indicate the degree of directionality of water diffusion in astrocytic tumors. Here, we report a case of anaplastic astrocytoma in which FA proved invaluable for the preoperative differential diagnosis. A 60-year-old man complained of headache, and underwent routine neuroimaging and DTI. The routine images suggested a low-grade glioma in the left temporal lobe, based on lack of enhancement on MRI with contrast medium and lack of tumor staining on angiograms, whereas FA Value was very high. Based on these findings, a preoperative diagnosis of high-grade glioma was suspected. The surgical specimen exhibited the histological features of anaplastic astrocytoma with a high density of spindle shaped cells and low vascularity. In this report, we discuss the relationship between FA and other characteristics of the present tumor, and discuss the utility of FA measurement in astrocytic tumors.
Kuniaki Ogasawara - One of the best experts on this subject based on the ideXlab platform.
-
prediction of meningioma consistency using fractional Anisotropy Value measured by magnetic resonance imaging
Journal of Neurosurgery, 2007Co-Authors: Hiroshi Kashimura, Takashi Inoue, Kuniaki Ogasawara, Hiroshi Arai, Yasunari Otawara, Yoshiyuki Kanbara, Akira OgawaAbstract:Object Preoperative planning for meningiomas requires information about tumor consistency as well as location and size. In the present study the authors aimed to determine whether the fractional Anisotropy (FA) Value calculated on the basis of preoperative magnetic resonance (MR) diffusion tensor (DT) imaging could predict meningioma consistency. Methods In 29 patients with intracranial meningiomas, MR DT imaging was performed preoperatively, and the FA Values of the tumors were calculated. Tumor consistency was intraoperatively determined as hard or soft, and the histological diagnosis of the tumor was established. Results Of the 29 tumors, 11 were classified as hard and 18 as soft. The FA Values of fibroblastic meningiomas were significantly higher than those of meningothelial meningiomas (p = 0.002). The FA Values of hard tumors were significantly higher than those of soft tumors (p = 0.0003). Logistic regression analysis demonstrated that the FA Value was a significant independent predictor of tumor c...
-
fractional Anisotropy Value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas
Surgical Neurology, 2005Co-Authors: Takaaki Beppu, Takashi Inoue, Kuniaki Ogasawara, Akira Ogawa, Yuji Shibata, Noriyuki Yamada, Akira Kurose, Hiroyuki KabasawaAbstract:Abstract Background In vivo, water diffusion displays directionality due to presence of complex microstructural barriers in tissue. The extent of directionality of water diffusion can be expressed as a fractional Anisotropy (FA) Value using diffusion tensor magnetic resonance imaging (DTI). The FA Value has been suggested as an indicator of the cell density of astrocytic tumors. The aim of the present study was to confirm beyond doubt that FA Values indicate cell density even when limited in glioblastomas and to determine whether the FA Value of a given patient predicts proliferation activity in the individual glioblastoma. Methods We performed DTI in 19 patients with glioblastoma and measured the FA Values of tumor and normal brain regions prior to computed tomography–guided stereotactic biopsy. Differences in mean FA Value between normal brain regions and glioblastoma lesion were compared. Cell density and MIB-1 indices were examined using tumor specimens obtained from biopsies. Correlation among FA Values, cell density, and MIB-1 indices was also evaluated. Results The mean FA Value significantly differed between normal brain regions and glioblastoma lesions. Positive correlation was observed between FA Value and cell density (r = 0.73, P Conclusions Our results suggest that the FA Value of glioblastoma as determined by DTI prior to surgery is a good predictor of cell density and, consequently, proliferation activity.
-
use of fractional Anisotropy Value by diffusion tensor mri for preoperative diagnosis of astrocytic tumors case report
Journal of Neuro-oncology, 2004Co-Authors: Toshinari Misaki, Takashi Inoue, Kuniaki Ogasawara, Akira Ogawa, Takaaki Beppu, Hiroyuki KabasawaAbstract:The fractional Anisotropy (FA) Value calculated by diffusion tensor MRI can indicate the degree of directionality of water diffusion in astrocytic tumors. Here, we report a case of anaplastic astrocytoma in which FA proved invaluable for the preoperative differential diagnosis. A 60-year-old man complained of headache, and underwent routine neuroimaging and DTI. The routine images suggested a low-grade glioma in the left temporal lobe, based on lack of enhancement on MRI with contrast medium and lack of tumor staining on angiograms, whereas FA Value was very high. Based on these findings, a preoperative diagnosis of high-grade glioma was suspected. The surgical specimen exhibited the histological features of anaplastic astrocytoma with a high density of spindle shaped cells and low vascularity. In this report, we discuss the relationship between FA and other characteristics of the present tumor, and discuss the utility of FA measurement in astrocytic tumors.
Takashi Inoue - One of the best experts on this subject based on the ideXlab platform.
-
prediction of meningioma consistency using fractional Anisotropy Value measured by magnetic resonance imaging
Journal of Neurosurgery, 2007Co-Authors: Hiroshi Kashimura, Takashi Inoue, Kuniaki Ogasawara, Hiroshi Arai, Yasunari Otawara, Yoshiyuki Kanbara, Akira OgawaAbstract:Object Preoperative planning for meningiomas requires information about tumor consistency as well as location and size. In the present study the authors aimed to determine whether the fractional Anisotropy (FA) Value calculated on the basis of preoperative magnetic resonance (MR) diffusion tensor (DT) imaging could predict meningioma consistency. Methods In 29 patients with intracranial meningiomas, MR DT imaging was performed preoperatively, and the FA Values of the tumors were calculated. Tumor consistency was intraoperatively determined as hard or soft, and the histological diagnosis of the tumor was established. Results Of the 29 tumors, 11 were classified as hard and 18 as soft. The FA Values of fibroblastic meningiomas were significantly higher than those of meningothelial meningiomas (p = 0.002). The FA Values of hard tumors were significantly higher than those of soft tumors (p = 0.0003). Logistic regression analysis demonstrated that the FA Value was a significant independent predictor of tumor c...
-
fractional Anisotropy Value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas
Surgical Neurology, 2005Co-Authors: Takaaki Beppu, Takashi Inoue, Kuniaki Ogasawara, Akira Ogawa, Yuji Shibata, Noriyuki Yamada, Akira Kurose, Hiroyuki KabasawaAbstract:Abstract Background In vivo, water diffusion displays directionality due to presence of complex microstructural barriers in tissue. The extent of directionality of water diffusion can be expressed as a fractional Anisotropy (FA) Value using diffusion tensor magnetic resonance imaging (DTI). The FA Value has been suggested as an indicator of the cell density of astrocytic tumors. The aim of the present study was to confirm beyond doubt that FA Values indicate cell density even when limited in glioblastomas and to determine whether the FA Value of a given patient predicts proliferation activity in the individual glioblastoma. Methods We performed DTI in 19 patients with glioblastoma and measured the FA Values of tumor and normal brain regions prior to computed tomography–guided stereotactic biopsy. Differences in mean FA Value between normal brain regions and glioblastoma lesion were compared. Cell density and MIB-1 indices were examined using tumor specimens obtained from biopsies. Correlation among FA Values, cell density, and MIB-1 indices was also evaluated. Results The mean FA Value significantly differed between normal brain regions and glioblastoma lesions. Positive correlation was observed between FA Value and cell density (r = 0.73, P Conclusions Our results suggest that the FA Value of glioblastoma as determined by DTI prior to surgery is a good predictor of cell density and, consequently, proliferation activity.
-
use of fractional Anisotropy Value by diffusion tensor mri for preoperative diagnosis of astrocytic tumors case report
Journal of Neuro-oncology, 2004Co-Authors: Toshinari Misaki, Takashi Inoue, Kuniaki Ogasawara, Akira Ogawa, Takaaki Beppu, Hiroyuki KabasawaAbstract:The fractional Anisotropy (FA) Value calculated by diffusion tensor MRI can indicate the degree of directionality of water diffusion in astrocytic tumors. Here, we report a case of anaplastic astrocytoma in which FA proved invaluable for the preoperative differential diagnosis. A 60-year-old man complained of headache, and underwent routine neuroimaging and DTI. The routine images suggested a low-grade glioma in the left temporal lobe, based on lack of enhancement on MRI with contrast medium and lack of tumor staining on angiograms, whereas FA Value was very high. Based on these findings, a preoperative diagnosis of high-grade glioma was suspected. The surgical specimen exhibited the histological features of anaplastic astrocytoma with a high density of spindle shaped cells and low vascularity. In this report, we discuss the relationship between FA and other characteristics of the present tumor, and discuss the utility of FA measurement in astrocytic tumors.
Hiroshi Kashimura - One of the best experts on this subject based on the ideXlab platform.
-
prediction of meningioma consistency using fractional Anisotropy Value measured by magnetic resonance imaging
Journal of Neurosurgery, 2007Co-Authors: Hiroshi Kashimura, Takashi Inoue, Kuniaki Ogasawara, Hiroshi Arai, Yasunari Otawara, Yoshiyuki Kanbara, Akira OgawaAbstract:Object Preoperative planning for meningiomas requires information about tumor consistency as well as location and size. In the present study the authors aimed to determine whether the fractional Anisotropy (FA) Value calculated on the basis of preoperative magnetic resonance (MR) diffusion tensor (DT) imaging could predict meningioma consistency. Methods In 29 patients with intracranial meningiomas, MR DT imaging was performed preoperatively, and the FA Values of the tumors were calculated. Tumor consistency was intraoperatively determined as hard or soft, and the histological diagnosis of the tumor was established. Results Of the 29 tumors, 11 were classified as hard and 18 as soft. The FA Values of fibroblastic meningiomas were significantly higher than those of meningothelial meningiomas (p = 0.002). The FA Values of hard tumors were significantly higher than those of soft tumors (p = 0.0003). Logistic regression analysis demonstrated that the FA Value was a significant independent predictor of tumor c...
Hiroyuki Kabasawa - One of the best experts on this subject based on the ideXlab platform.
-
fractional Anisotropy Value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas
Surgical Neurology, 2005Co-Authors: Takaaki Beppu, Takashi Inoue, Kuniaki Ogasawara, Akira Ogawa, Yuji Shibata, Noriyuki Yamada, Akira Kurose, Hiroyuki KabasawaAbstract:Abstract Background In vivo, water diffusion displays directionality due to presence of complex microstructural barriers in tissue. The extent of directionality of water diffusion can be expressed as a fractional Anisotropy (FA) Value using diffusion tensor magnetic resonance imaging (DTI). The FA Value has been suggested as an indicator of the cell density of astrocytic tumors. The aim of the present study was to confirm beyond doubt that FA Values indicate cell density even when limited in glioblastomas and to determine whether the FA Value of a given patient predicts proliferation activity in the individual glioblastoma. Methods We performed DTI in 19 patients with glioblastoma and measured the FA Values of tumor and normal brain regions prior to computed tomography–guided stereotactic biopsy. Differences in mean FA Value between normal brain regions and glioblastoma lesion were compared. Cell density and MIB-1 indices were examined using tumor specimens obtained from biopsies. Correlation among FA Values, cell density, and MIB-1 indices was also evaluated. Results The mean FA Value significantly differed between normal brain regions and glioblastoma lesions. Positive correlation was observed between FA Value and cell density (r = 0.73, P Conclusions Our results suggest that the FA Value of glioblastoma as determined by DTI prior to surgery is a good predictor of cell density and, consequently, proliferation activity.
-
use of fractional Anisotropy Value by diffusion tensor mri for preoperative diagnosis of astrocytic tumors case report
Journal of Neuro-oncology, 2004Co-Authors: Toshinari Misaki, Takashi Inoue, Kuniaki Ogasawara, Akira Ogawa, Takaaki Beppu, Hiroyuki KabasawaAbstract:The fractional Anisotropy (FA) Value calculated by diffusion tensor MRI can indicate the degree of directionality of water diffusion in astrocytic tumors. Here, we report a case of anaplastic astrocytoma in which FA proved invaluable for the preoperative differential diagnosis. A 60-year-old man complained of headache, and underwent routine neuroimaging and DTI. The routine images suggested a low-grade glioma in the left temporal lobe, based on lack of enhancement on MRI with contrast medium and lack of tumor staining on angiograms, whereas FA Value was very high. Based on these findings, a preoperative diagnosis of high-grade glioma was suspected. The surgical specimen exhibited the histological features of anaplastic astrocytoma with a high density of spindle shaped cells and low vascularity. In this report, we discuss the relationship between FA and other characteristics of the present tumor, and discuss the utility of FA measurement in astrocytic tumors.