The Experts below are selected from a list of 5628 Experts worldwide ranked by ideXlab platform
Huanfeng Jiang - One of the best experts on this subject based on the ideXlab platform.
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access to phenothiazine derivatives via iodide mediated oxidative three component Annulation Reaction
Journal of Organic Chemistry, 2020Co-Authors: Qinghua Chen, Huanfeng Jiang, Rong Xie, Huanhuan Jia, Jialu Sun, Min ZhangAbstract:Herein, a new iodide-mediated three-component Annulation Reaction of secondary anilines, cyclohexanones, and elemental sulfur is demonstrated, which allows access to various phenothiazines with the merits of formation of multiple chemical bonds in one single operation, high step and atom efficiency, readily available feedstocks and catalyst system, and good substrate and functional group compatibility. The developed chemistry capable of constructing novel phenothiazines with structural diversity offers a significant basis for further applications.
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palladium catalyzed oxidative o h n h carbonylation of hydrazides access to substituted 1 3 4 oxadiazole 2 3h ones
Journal of Organic Chemistry, 2015Co-Authors: Wei Guo, Huanfeng JiangAbstract:A novel palladium-catalyzed oxidative Annulation Reaction for the C–O, C–N bond formations is developed. The intramolecular cyclocarbonylation provides an efficient and direct approach for the construction of valuable 1,3,4-oxadiazole-2(3H)-ones and their derivatives. The Reaction also facilitated the convenient synthesis of BMS-191011, an opener of the cloned large-conductance Ca2+-activated potassium channel, providing an attractive method for medicinal chemistry.
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Palladium-Catalyzed Oxidative O–H/N–H Carbonylation of Hydrazides: Access to Substituted 1,3,4-Oxadiazole-2(3H)‑ones
2015Co-Authors: Wei Guo, Huanfeng JiangAbstract:A novel palladium-catalyzed oxidative Annulation Reaction for the C–O, C–N bond formations is developed. The intramolecular cyclocarbonylation provides an efficient and direct approach for the construction of valuable 1,3,4-oxadiazole-2(3H)-ones and their derivatives. The Reaction also facilitated the convenient synthesis of BMS-191011, an opener of the cloned large-conductance Ca2+-activated potassium channel, providing an attractive method for medicinal chemistry
Hongchao Guo - One of the best experts on this subject based on the ideXlab platform.
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phosphine catalyzed 3 2 and 4 2 Annulation Reactions of ynones with barbiturate derived alkenes
Organic and Biomolecular Chemistry, 2017Co-Authors: Xing Gao, Wenjun Yang, Yang Liu, Wufeng Chen, Cheng Zhang, Lufei Zheng, Hongchao GuoAbstract:The phosphine-catalyzed [3 + 2] Annulation Reaction of ynones and barbiturate-derived alkenes has been developed with the assistance of a weak acid, giving functionalized spirobarbiturate-cyclopentanones in moderate to excellent yields with excellent E/Z stereoselectivity. An unprecedented [4 + 2] Annulation of ynones with barbiturate-derived alkenes was also achieved in the presence of a phosphine catalyst and an inorganic base, affording biologically interesting 1,5-dihydro-2H-pyrano[2,3-d]pyrimidine-2,4(3H)-dione derivatives. An asymmetric variant of the [3 + 2] Annulation Reaction has been explored and a moderate enantioselectivity was obtained when a bifunctional chiral phosphine was used as a chiral catalyst. A plausible mechanism was proposed to illuminate two different Reaction pathways.
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dabco catalyzed 3 2 Annulation of sulfamate derived cyclic imines with isocyanoacetates synthesis of sulfamate fused 2 imidazoline
Organic and Biomolecular Chemistry, 2014Co-Authors: Zhenzhen Gao, Lei Zhang, Zhanhu Sun, Yumei Xiao, Hongchao GuoAbstract:DABCO-catalyzed [3 + 2] Annulation Reaction of sulfamate-derived cyclic imines with isocyanoacetate proceeds under mild conditions, providing sulfamate-fused 2-imidazolines in moderate to excellent yields with moderate to excellent diastereoselectivities.
Yingchun Chen - One of the best experts on this subject based on the ideXlab platform.
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Sequential Assembly of Morita–Baylis–Hillman Carbonates and Activated ortho-Vinylbenzaldehydes To Construct Chiral Methanobenzo[7]annulenone Frameworks
2019Co-Authors: Bo Jiang, Ben-xian Xiao, Qin Ouyang, Hua-ping Liang, Yingchun ChenAbstract:The α-regioselective asymmetric [3 + 2] Annulation Reaction of Morita–Baylis–Hillman carbonates from isatins and activated ortho-vinylbenzaldehyses was developed by the catalysis of a chiral tertiary amine. The sequential N-heterocyclic carbene-mediated intramolecular Stetter Reaction was conducted to finally furnish the bridged 5,8-methanobenzo[7]annulen-9-one architectures incorporating a spirooxindole motif with excellent stereoselectivity
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rhodium iii catalyzed direct selective c 5 h oxidative Annulations of 2 substituted imidazoles and alkynes by double c h activation
ChemInform, 2013Co-Authors: Jirong Huang, Qianru Zhang, Xunhao Sun, Lin Dong, Yingchun ChenAbstract:An Annulation Reaction of diverse imidazoles and pyrroles via Rh(III)-catalyzed double C—H activations is reported.
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rhodium iii catalyzed direct selective c 5 h oxidative Annulations of 2 substituted imidazoles and alkynes by double c h activation
Organic Letters, 2013Co-Authors: Jirong Huang, Qianru Zhang, Xunhao Sun, Lin Dong, Yingchun ChenAbstract:Double C–H activations of C(5)–H and Csp2–H of 2-substituted N-vinyl- or arylimidazoles were realized without heteroatom-directing assistance by rhodium(III) catalyst. A subsequent oxidative Annulation Reaction with alkynes efficiently produced aza-fused heterocycles with high molecular complexity in low to excellent yields.
Lin Dong - One of the best experts on this subject based on the ideXlab platform.
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rhodium iii catalyzed oxidative Annulation of 7 azaindoles and alkynes via double c h activation
Organic Letters, 2015Co-Authors: Shuaishuai Li, Chengqi Wang, Xiaomei Zhang, Lin DongAbstract:Rhodium(III)-catalyzed double C–H activation involving N-directed ortho C–H activation and subsequent roll-over C–H activation of the heterocycle ring has been developed to form complex 7-azaindole derivatives in moderate to excellent yields. A broad scope of 7-azaindoles and internal alkynes has been demonstrated in this oxidative Annulation Reaction.
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rhodium iii catalyzed direct selective c 5 h oxidative Annulations of 2 substituted imidazoles and alkynes by double c h activation
ChemInform, 2013Co-Authors: Jirong Huang, Qianru Zhang, Xunhao Sun, Lin Dong, Yingchun ChenAbstract:An Annulation Reaction of diverse imidazoles and pyrroles via Rh(III)-catalyzed double C—H activations is reported.
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rhodium iii catalyzed direct selective c 5 h oxidative Annulations of 2 substituted imidazoles and alkynes by double c h activation
Organic Letters, 2013Co-Authors: Jirong Huang, Qianru Zhang, Xunhao Sun, Lin Dong, Yingchun ChenAbstract:Double C–H activations of C(5)–H and Csp2–H of 2-substituted N-vinyl- or arylimidazoles were realized without heteroatom-directing assistance by rhodium(III) catalyst. A subsequent oxidative Annulation Reaction with alkynes efficiently produced aza-fused heterocycles with high molecular complexity in low to excellent yields.
Gang Zhao - One of the best experts on this subject based on the ideXlab platform.
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asymmetric robinson type Annulation Reaction between β ketoamides and α β unsaturated ketones
ChemInform, 2015Co-Authors: Youming Huang, Changwu Zheng, Gang ZhaoAbstract:Enantioselective Robinson-type Annulation Reaction between β-ketoamide and α,β-unsaturated ketone is developed by utilizing the amino acid derived diamine catalysts.
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asymmetric robinson type Annulation Reaction between β ketoamides and α β unsaturated ketones
Journal of Organic Chemistry, 2015Co-Authors: Youming Huang, Changwu Zheng, Gang ZhaoAbstract:Enantioselective Robinson-type Annulation Reaction between β-ketoamide and α,β-unsaturated ketone was developed by utilizing the amino acid derived primary–secondary diamine catalysts. The less reactive acyclic β-ketoamides employed as both electrophile and nucleophile are reported in this asymmetric tandem Reaction. A number of chiral cyclohexenone derivatives containing an amide group were obtained in high yields and good selectivities.
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Asymmetric Robinson-Type Annulation Reaction between β‑Ketoamides and α,β-Unsaturated Ketones
2015Co-Authors: Youming Huang, Changwu Zheng, Gang ZhaoAbstract:Enantioselective Robinson-type Annulation Reaction between β-ketoamide and α,β-unsaturated ketone was developed by utilizing the amino acid derived primary–secondary diamine catalysts. The less reactive acyclic β-ketoamides employed as both electrophile and nucleophile are reported in this asymmetric tandem Reaction. A number of chiral cyclohexenone derivatives containing an amide group were obtained in high yields and good selectivities