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Lisa A Ruml - One of the best experts on this subject based on the ideXlab platform.
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effect of Potassium magnesium citrate on thiazide induced hypokalemia and magnesium loss
American Journal of Kidney Diseases, 1999Co-Authors: Lisa A RumlAbstract:The study was performed to ascertain the value of Potassium magnesium citrate, magnesium citrate, and Potassium citrate in overcoming thiazide-induced hypokalemia and magnesium loss. Sixty-two healthy subjects were first administered hydrochlorothiazide, 50 mg/d. After 3 weeks of thiazide treatment (or earlier for Potassium level thiazide: Potassium magnesium citrate (49 mEq of Potassium, 24.5 mEq of magnesium), magnesium citrate (24.5 mEq/d of magnesium), or Potassium citrate (49 mEq/d of Potassium). Outcome measures were changes in serum Potassium and magnesium levels and urinary Potassium, magnesium, pH, and citrate values. All three drugs increased serum Potassium concentration compared with that resulting from thiazide alone. Potassium magnesium citrate increased serum Potassium levels from 3.3 +/- 0.2 to 3.8 +/- 0.3 mEq/L (P < 0.001), Potassium citrate increased serum Potassium levels from 3.4 +/- 0.4 to 3.9 +/-0.3 mEq/L (P < 0.001), and magnesium citrate from 3.4 +/- 0.4 to 3.7 +/- 0.3 mEq/L (P < 0.001). Potassium magnesium citrate led to a significant increase in urinary magnesium levels by the third week of supplementation (from 120 +/- 34 to 149 +/- 58 mg/d; P < 0.01) and produced a small but significant increase in serum magnesium level. Magnesium citrate significantly increased 24-hour urinary magnesium after the first week of supplementation and maintained this increase throughout the study. Potassium magnesium citrate and Potassium citrate, but not magnesium citrate, significantly increased urinary pH and citrate values. Potassium magnesium citrate not only corrects thiazide-induced hypokalemia, but also may avert magnesium loss while providing an alkali load.
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Effect of Potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
American Journal of Kidney Diseases, 1999Co-Authors: Lisa A RumlAbstract:Abstract The study was performed to ascertain the value of Potassium magnesium citrate, magnesium citrate, and Potassium citrate in overcoming thiazide-induced hypokalemia and magnesium loss. Sixty-two healthy subjects were first administered hydrochlorothiazide, 50 mg/d. After 3 weeks of thiazide treatment (or earlier for Potassium level ≤3.5 mEq/L), they were randomized to receive one of three drugs while continuing to receive thiazide: Potassium magnesium citrate (49 mEq of Potassium, 24.5 mEq of magnesium), magnesium citrate (24.5 mEq/d of magnesium), or Potassium citrate (49 mEq/d of Potassium). Outcome measures were changes in serum Potassium and magnesium levels and urinary Potassium, magnesium, pH, and citrate values. All three drugs increased serum Potassium concentration compared with that resulting from thiazide alone. Potassium magnesium citrate increased serum Potassium levels from 3.3 ± 0.2 to 3.8 ± 0.3 mEq/L ( P P P P
Zbigniew Gaciong - One of the best experts on this subject based on the ideXlab platform.
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diagnostic value of Potassium level in a spot urine sample as an index of 24 hour urinary Potassium excretion in unselected patients hospitalized in a hypertension unit
PLOS ONE, 2017Co-Authors: Piotr Jedrusik, Bartosz Symonides, Ewa Wojciechowska, Adam Gryglas, Zbigniew GaciongAbstract:Background Primary hyperaldosteronism may be associated with elevated 24-hour urinary Potassium excretion. We evaluated the diagnostic value of spot urine (SU) Potassium as an index of 24-hour urinary Potassium excretion. Methods We measured SU and 24-hour urinary collection Potassium and creatinine in 382 patients. Correlations between SU and 24-hour collections were assessed for Potassium levels and Potassium/creatinine ratios. We used the PAHO formula to estimate 24-hour urinary Potassium excretion based on SU Potassium level. The agreement between estimated and measured 24-hour urinary Potassium excretion was evaluated using the Bland-Altman method. To evaluate diagnostic performance of SU Potassium, we calculated areas under the curve (AUC) for SU Potassium/creatinine ratio and 24-hour urinary Potassium excretion estimated using the PAHO formula. Results Strongest correlation between SU and 24-hour collection was found for Potassium/creatinine ratio (r = 0.69, P<0.001). The PAHO formula underestimated 24-hour urinary Potassium excretion by mean 8.3±18 mmol/d (95% limits of agreement -28 to +44 mmol/d). Diagnostic performance of SU Potassium/creatinine ratio was borderline good only if 24-hour urinary Potassium excretion was largely elevated (AUC 0.802 for 120 mmol K+/24 h) but poor with lower values (AUC 0.696 for 100 mmol K+/24 h, 0.636 for 80 mmol K+/24 h, 0.675 for 40 mmol K+/24 h). Diagnostic performance of 24-hour urinary Potassium excretion estimated by the PAHO formula was excellent with values above 120 mmol/d and good with lower values (AUC 0.941 for 120 mmol K+/24 h, 0.819 for 100 mmol K+/24 h, 0.823 for 80 mmol K+/24 h, 0.836 for 40 mmol K+/24 h). Conclusions Spot urine Potassium/creatinine ratio might be a marker of increased 24-hour urinary Potassium excretion and a potentially useful screening test when reliable 24-hour urine collection is not available. The PAHO formula allowed estimation of the 24-hour urinary Potassium excretion based on SU measurements with reasonable clinical accuracy.
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Diagnostic value of Potassium level in a spot urine sample as an index of 24-hour urinary Potassium excretion in unselected patients hospitalized in a hypertension unit
PloS one, 2017Co-Authors: Piotr Jędrusik, Bartosz Symonides, Ewa Wojciechowska, Adam Gryglas, Zbigniew GaciongAbstract:Background Primary hyperaldosteronism may be associated with elevated 24-hour urinary Potassium excretion. We evaluated the diagnostic value of spot urine (SU) Potassium as an index of 24-hour urinary Potassium excretion. Methods We measured SU and 24-hour urinary collection Potassium and creatinine in 382 patients. Correlations between SU and 24-hour collections were assessed for Potassium levels and Potassium/creatinine ratios. We used the PAHO formula to estimate 24-hour urinary Potassium excretion based on SU Potassium level. The agreement between estimated and measured 24-hour urinary Potassium excretion was evaluated using the Bland-Altman method. To evaluate diagnostic performance of SU Potassium, we calculated areas under the curve (AUC) for SU Potassium/creatinine ratio and 24-hour urinary Potassium excretion estimated using the PAHO formula. Results Strongest correlation between SU and 24-hour collection was found for Potassium/creatinine ratio (r = 0.69, P
Adam Gryglas - One of the best experts on this subject based on the ideXlab platform.
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diagnostic value of Potassium level in a spot urine sample as an index of 24 hour urinary Potassium excretion in unselected patients hospitalized in a hypertension unit
PLOS ONE, 2017Co-Authors: Piotr Jedrusik, Bartosz Symonides, Ewa Wojciechowska, Adam Gryglas, Zbigniew GaciongAbstract:Background Primary hyperaldosteronism may be associated with elevated 24-hour urinary Potassium excretion. We evaluated the diagnostic value of spot urine (SU) Potassium as an index of 24-hour urinary Potassium excretion. Methods We measured SU and 24-hour urinary collection Potassium and creatinine in 382 patients. Correlations between SU and 24-hour collections were assessed for Potassium levels and Potassium/creatinine ratios. We used the PAHO formula to estimate 24-hour urinary Potassium excretion based on SU Potassium level. The agreement between estimated and measured 24-hour urinary Potassium excretion was evaluated using the Bland-Altman method. To evaluate diagnostic performance of SU Potassium, we calculated areas under the curve (AUC) for SU Potassium/creatinine ratio and 24-hour urinary Potassium excretion estimated using the PAHO formula. Results Strongest correlation between SU and 24-hour collection was found for Potassium/creatinine ratio (r = 0.69, P<0.001). The PAHO formula underestimated 24-hour urinary Potassium excretion by mean 8.3±18 mmol/d (95% limits of agreement -28 to +44 mmol/d). Diagnostic performance of SU Potassium/creatinine ratio was borderline good only if 24-hour urinary Potassium excretion was largely elevated (AUC 0.802 for 120 mmol K+/24 h) but poor with lower values (AUC 0.696 for 100 mmol K+/24 h, 0.636 for 80 mmol K+/24 h, 0.675 for 40 mmol K+/24 h). Diagnostic performance of 24-hour urinary Potassium excretion estimated by the PAHO formula was excellent with values above 120 mmol/d and good with lower values (AUC 0.941 for 120 mmol K+/24 h, 0.819 for 100 mmol K+/24 h, 0.823 for 80 mmol K+/24 h, 0.836 for 40 mmol K+/24 h). Conclusions Spot urine Potassium/creatinine ratio might be a marker of increased 24-hour urinary Potassium excretion and a potentially useful screening test when reliable 24-hour urine collection is not available. The PAHO formula allowed estimation of the 24-hour urinary Potassium excretion based on SU measurements with reasonable clinical accuracy.
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Diagnostic value of Potassium level in a spot urine sample as an index of 24-hour urinary Potassium excretion in unselected patients hospitalized in a hypertension unit
PloS one, 2017Co-Authors: Piotr Jędrusik, Bartosz Symonides, Ewa Wojciechowska, Adam Gryglas, Zbigniew GaciongAbstract:Background Primary hyperaldosteronism may be associated with elevated 24-hour urinary Potassium excretion. We evaluated the diagnostic value of spot urine (SU) Potassium as an index of 24-hour urinary Potassium excretion. Methods We measured SU and 24-hour urinary collection Potassium and creatinine in 382 patients. Correlations between SU and 24-hour collections were assessed for Potassium levels and Potassium/creatinine ratios. We used the PAHO formula to estimate 24-hour urinary Potassium excretion based on SU Potassium level. The agreement between estimated and measured 24-hour urinary Potassium excretion was evaluated using the Bland-Altman method. To evaluate diagnostic performance of SU Potassium, we calculated areas under the curve (AUC) for SU Potassium/creatinine ratio and 24-hour urinary Potassium excretion estimated using the PAHO formula. Results Strongest correlation between SU and 24-hour collection was found for Potassium/creatinine ratio (r = 0.69, P
Ewa Wojciechowska - One of the best experts on this subject based on the ideXlab platform.
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diagnostic value of Potassium level in a spot urine sample as an index of 24 hour urinary Potassium excretion in unselected patients hospitalized in a hypertension unit
PLOS ONE, 2017Co-Authors: Piotr Jedrusik, Bartosz Symonides, Ewa Wojciechowska, Adam Gryglas, Zbigniew GaciongAbstract:Background Primary hyperaldosteronism may be associated with elevated 24-hour urinary Potassium excretion. We evaluated the diagnostic value of spot urine (SU) Potassium as an index of 24-hour urinary Potassium excretion. Methods We measured SU and 24-hour urinary collection Potassium and creatinine in 382 patients. Correlations between SU and 24-hour collections were assessed for Potassium levels and Potassium/creatinine ratios. We used the PAHO formula to estimate 24-hour urinary Potassium excretion based on SU Potassium level. The agreement between estimated and measured 24-hour urinary Potassium excretion was evaluated using the Bland-Altman method. To evaluate diagnostic performance of SU Potassium, we calculated areas under the curve (AUC) for SU Potassium/creatinine ratio and 24-hour urinary Potassium excretion estimated using the PAHO formula. Results Strongest correlation between SU and 24-hour collection was found for Potassium/creatinine ratio (r = 0.69, P<0.001). The PAHO formula underestimated 24-hour urinary Potassium excretion by mean 8.3±18 mmol/d (95% limits of agreement -28 to +44 mmol/d). Diagnostic performance of SU Potassium/creatinine ratio was borderline good only if 24-hour urinary Potassium excretion was largely elevated (AUC 0.802 for 120 mmol K+/24 h) but poor with lower values (AUC 0.696 for 100 mmol K+/24 h, 0.636 for 80 mmol K+/24 h, 0.675 for 40 mmol K+/24 h). Diagnostic performance of 24-hour urinary Potassium excretion estimated by the PAHO formula was excellent with values above 120 mmol/d and good with lower values (AUC 0.941 for 120 mmol K+/24 h, 0.819 for 100 mmol K+/24 h, 0.823 for 80 mmol K+/24 h, 0.836 for 40 mmol K+/24 h). Conclusions Spot urine Potassium/creatinine ratio might be a marker of increased 24-hour urinary Potassium excretion and a potentially useful screening test when reliable 24-hour urine collection is not available. The PAHO formula allowed estimation of the 24-hour urinary Potassium excretion based on SU measurements with reasonable clinical accuracy.
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Diagnostic value of Potassium level in a spot urine sample as an index of 24-hour urinary Potassium excretion in unselected patients hospitalized in a hypertension unit
PloS one, 2017Co-Authors: Piotr Jędrusik, Bartosz Symonides, Ewa Wojciechowska, Adam Gryglas, Zbigniew GaciongAbstract:Background Primary hyperaldosteronism may be associated with elevated 24-hour urinary Potassium excretion. We evaluated the diagnostic value of spot urine (SU) Potassium as an index of 24-hour urinary Potassium excretion. Methods We measured SU and 24-hour urinary collection Potassium and creatinine in 382 patients. Correlations between SU and 24-hour collections were assessed for Potassium levels and Potassium/creatinine ratios. We used the PAHO formula to estimate 24-hour urinary Potassium excretion based on SU Potassium level. The agreement between estimated and measured 24-hour urinary Potassium excretion was evaluated using the Bland-Altman method. To evaluate diagnostic performance of SU Potassium, we calculated areas under the curve (AUC) for SU Potassium/creatinine ratio and 24-hour urinary Potassium excretion estimated using the PAHO formula. Results Strongest correlation between SU and 24-hour collection was found for Potassium/creatinine ratio (r = 0.69, P
Bartosz Symonides - One of the best experts on this subject based on the ideXlab platform.
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diagnostic value of Potassium level in a spot urine sample as an index of 24 hour urinary Potassium excretion in unselected patients hospitalized in a hypertension unit
PLOS ONE, 2017Co-Authors: Piotr Jedrusik, Bartosz Symonides, Ewa Wojciechowska, Adam Gryglas, Zbigniew GaciongAbstract:Background Primary hyperaldosteronism may be associated with elevated 24-hour urinary Potassium excretion. We evaluated the diagnostic value of spot urine (SU) Potassium as an index of 24-hour urinary Potassium excretion. Methods We measured SU and 24-hour urinary collection Potassium and creatinine in 382 patients. Correlations between SU and 24-hour collections were assessed for Potassium levels and Potassium/creatinine ratios. We used the PAHO formula to estimate 24-hour urinary Potassium excretion based on SU Potassium level. The agreement between estimated and measured 24-hour urinary Potassium excretion was evaluated using the Bland-Altman method. To evaluate diagnostic performance of SU Potassium, we calculated areas under the curve (AUC) for SU Potassium/creatinine ratio and 24-hour urinary Potassium excretion estimated using the PAHO formula. Results Strongest correlation between SU and 24-hour collection was found for Potassium/creatinine ratio (r = 0.69, P<0.001). The PAHO formula underestimated 24-hour urinary Potassium excretion by mean 8.3±18 mmol/d (95% limits of agreement -28 to +44 mmol/d). Diagnostic performance of SU Potassium/creatinine ratio was borderline good only if 24-hour urinary Potassium excretion was largely elevated (AUC 0.802 for 120 mmol K+/24 h) but poor with lower values (AUC 0.696 for 100 mmol K+/24 h, 0.636 for 80 mmol K+/24 h, 0.675 for 40 mmol K+/24 h). Diagnostic performance of 24-hour urinary Potassium excretion estimated by the PAHO formula was excellent with values above 120 mmol/d and good with lower values (AUC 0.941 for 120 mmol K+/24 h, 0.819 for 100 mmol K+/24 h, 0.823 for 80 mmol K+/24 h, 0.836 for 40 mmol K+/24 h). Conclusions Spot urine Potassium/creatinine ratio might be a marker of increased 24-hour urinary Potassium excretion and a potentially useful screening test when reliable 24-hour urine collection is not available. The PAHO formula allowed estimation of the 24-hour urinary Potassium excretion based on SU measurements with reasonable clinical accuracy.
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Diagnostic value of Potassium level in a spot urine sample as an index of 24-hour urinary Potassium excretion in unselected patients hospitalized in a hypertension unit
PloS one, 2017Co-Authors: Piotr Jędrusik, Bartosz Symonides, Ewa Wojciechowska, Adam Gryglas, Zbigniew GaciongAbstract:Background Primary hyperaldosteronism may be associated with elevated 24-hour urinary Potassium excretion. We evaluated the diagnostic value of spot urine (SU) Potassium as an index of 24-hour urinary Potassium excretion. Methods We measured SU and 24-hour urinary collection Potassium and creatinine in 382 patients. Correlations between SU and 24-hour collections were assessed for Potassium levels and Potassium/creatinine ratios. We used the PAHO formula to estimate 24-hour urinary Potassium excretion based on SU Potassium level. The agreement between estimated and measured 24-hour urinary Potassium excretion was evaluated using the Bland-Altman method. To evaluate diagnostic performance of SU Potassium, we calculated areas under the curve (AUC) for SU Potassium/creatinine ratio and 24-hour urinary Potassium excretion estimated using the PAHO formula. Results Strongest correlation between SU and 24-hour collection was found for Potassium/creatinine ratio (r = 0.69, P
