The Experts below are selected from a list of 664809 Experts worldwide ranked by ideXlab platform

E. Sukumar - One of the best experts on this subject based on the ideXlab platform.

Guang Han - One of the best experts on this subject based on the ideXlab platform.

  • Synthesis and structure Anti-Inflammatory Activity relationships studies of andrographolide derivatives
    Natural product research, 2019
    Co-Authors: Ling Liu, Yan Yan, Lihua Zheng, Haiyan Jia, Guang Han
    Abstract:

    Andrographolide is a main bioactive diterpene lactone in A. paniculata with Anti-Inflammatory Activity. In this study, a series of andrographolide derivatives were synthesized and evaluated for their structure-Anti-Inflammatory Activity relationships in vivo. Among all compounds, isoandrographolide and 14-deoxyandrographolide showed stronger Anti-Inflammatory Activity than andrographolide. The results indicated that the introduction of tetrahydrofuran ring and cyclic olefinic bond plays an important role in enhancing the Anti-Inflammatory Activity of andrographolide derivatives. Isoandrographolide and 14-deoxyandrographolide are potent inhibitor of inflammation.[Formula: see text].

  • Synthesis and structure Anti-Inflammatory Activity relationships studies of andrographolide derivatives
    2019
    Co-Authors: Ling Liu, Yan Yan, Lihua Zheng, Haiyan Jia, Guang Han
    Abstract:

    Andrographolide is a main bioactive diterpene lactone in A. paniculata with Anti-Inflammatory Activity. In this study, a series of andrographolide derivatives were synthesized and evaluated for their structure-Anti-Inflammatory Activity relationships in vivo. Among all compounds, isoandrographolide and 14-deoxyandrographolide showed stronger Anti-Inflammatory Activity than andrographolide. The results indicated that the introduction of tetrahydrofuran ring and cyclic olefinic bond plays an important role in enhancing the Anti-Inflammatory Activity of andrographolide derivatives. Isoandrographolide and 14-deoxyandrographolide are potent inhibitor of inflammation.

João Carvalho - One of the best experts on this subject based on the ideXlab platform.

  • Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
    Marine drugs, 2010
    Co-Authors: João C. Fernandes, Humberto M. Spindola, Vanessa P. De Sousa, Alice Santos-silva, Manuela Pintado, Francisco Xavier Malcata, João Carvalho
    Abstract:

    All the reports to date on the Anti-Inflammatory Activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the Anti-Inflammatory Activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the Anti-Inflammatory effect of drugs. Our data suggest that COS possess Anti-InflammatoryActivity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.

C.s. Vijayakumar - One of the best experts on this subject based on the ideXlab platform.

Ling Liu - One of the best experts on this subject based on the ideXlab platform.

  • Synthesis and structure Anti-Inflammatory Activity relationships studies of andrographolide derivatives
    Natural product research, 2019
    Co-Authors: Ling Liu, Yan Yan, Lihua Zheng, Haiyan Jia, Guang Han
    Abstract:

    Andrographolide is a main bioactive diterpene lactone in A. paniculata with Anti-Inflammatory Activity. In this study, a series of andrographolide derivatives were synthesized and evaluated for their structure-Anti-Inflammatory Activity relationships in vivo. Among all compounds, isoandrographolide and 14-deoxyandrographolide showed stronger Anti-Inflammatory Activity than andrographolide. The results indicated that the introduction of tetrahydrofuran ring and cyclic olefinic bond plays an important role in enhancing the Anti-Inflammatory Activity of andrographolide derivatives. Isoandrographolide and 14-deoxyandrographolide are potent inhibitor of inflammation.[Formula: see text].

  • Synthesis and structure Anti-Inflammatory Activity relationships studies of andrographolide derivatives
    2019
    Co-Authors: Ling Liu, Yan Yan, Lihua Zheng, Haiyan Jia, Guang Han
    Abstract:

    Andrographolide is a main bioactive diterpene lactone in A. paniculata with Anti-Inflammatory Activity. In this study, a series of andrographolide derivatives were synthesized and evaluated for their structure-Anti-Inflammatory Activity relationships in vivo. Among all compounds, isoandrographolide and 14-deoxyandrographolide showed stronger Anti-Inflammatory Activity than andrographolide. The results indicated that the introduction of tetrahydrofuran ring and cyclic olefinic bond plays an important role in enhancing the Anti-Inflammatory Activity of andrographolide derivatives. Isoandrographolide and 14-deoxyandrographolide are potent inhibitor of inflammation.