Anti-Inflammatory Agents - Explore the Science & Experts | ideXlab

Are anti‐inflammatory Agents effective in treating gingivitis as solo or adjunct therapies? A systematic review

Objective
Systematically review the scientific evidence for efficiency of Anti-Inflammatory Agents against gingivitis, either as solo treatments or adjunctive therapies.

Methods
A protocol was developed aimed to answer the following focused question: “Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies?” RCTs and cohort studies on Anti-Inflammatory Agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub-analysis was performed dividing the active Agents into Anti-Inflammatory and other drugs.

Results
The search identified 3188 studies, of which 14 RCTs met the inclusion criteria. The use of Anti-Inflammatory or other Agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCTs on inflammatory drugs could be meta-analysed, showing a statistically significant reduction in the GI in the experimental group [WMD = −0.090; 95% CI (−0.105; −0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively).

Conclusions
Most of the tested material showed beneficial effect as Anti-Inflammatory Agents against gingivitis, either as a single treatment modality or as an adjunctive therapy.

Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies? A systematic review.

Systematically review the scientific evidence for efficiency of Anti-Inflammatory Agents against gingivitis, either as solo treatments or adjunctive therapies.
A protocol was developed aimed to answer the following focused question: “Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies?” RCTs and cohort studies on Anti-Inflammatory Agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub-analysis was performed dividing the active Agents into Anti-Inflammatory and other drugs.
The search identified 3188 studies, of which 14 RCTs met the inclusion criteria. The use of Anti-Inflammatory or other Agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCTs on inflammatory drugs could be meta-analysed, showing a statistically significant reduction in the GI in the experimental group [WMD = -0.090; 95% CI (-0.105; -0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively).
Most of the tested material showed beneficial effect as Anti-Inflammatory Agents against gingivitis, either as a single treatment modality or as an adjunctive therapy.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Topical nonsteroidal Anti-Inflammatory Agents in ophthalmology.

Nonsteroidal Anti-Inflammatory Agents or NSAIDs are potent inhibitors of prostaglandin synthesis. As such, they have found many useful roles in ophthalmology. NSAIDs are approved by the FDA to prevent intraoperative miosis during cataract surgery, reduce postoperative inflammation following cataract

Synthesis and biological evaluation of pyridazinone derivatives as potential Anti-Inflammatory Agents

Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for Anti-Inflammatory therapy in respiratory diseases. Here we describe the development of two families of pyridazinone derivatives as potential PDE4 inhibitors and their evaluation as Anti-Inflammatory Agents. Among these derivatives, 4,5-dihydropyridazinone representatives possess promising activity, selectivity towards PDE4 isoenzymes and are able to reduce IL-8 production by human primary polymorphonuclear cells.