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Lior Shapira - One of the best experts on this subject based on the ideXlab platform.

  • Are anti‐inflammatory Agents effective in treating gingivitis as solo or adjunct therapies? A systematic review
    Journal of Clinical Periodontology, 2015
    Co-Authors: David Polak, Conchita Martin, Ignacio Sanz-sánchez, Nurit Beyth, Lior Shapira
    Abstract:

    Objective Systematically review the scientific evidence for efficiency of Anti-Inflammatory Agents against gingivitis, either as solo treatments or adjunctive therapies. Methods A protocol was developed aimed to answer the following focused question: “Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies?” RCTs and cohort studies on Anti-Inflammatory Agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub-analysis was performed dividing the active Agents into Anti-Inflammatory and other drugs. Results The search identified 3188 studies, of which 14 RCTs met the inclusion criteria. The use of Anti-Inflammatory or other Agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCTs on inflammatory drugs could be meta-analysed, showing a statistically significant reduction in the GI in the experimental group [WMD = −0.090; 95% CI (−0.105; −0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively). Conclusions Most of the tested material showed beneficial effect as Anti-Inflammatory Agents against gingivitis, either as a single treatment modality or as an adjunctive therapy.

  • Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies? A systematic review.
    Journal of clinical periodontology, 2015
    Co-Authors: David Polak, Conchita Martin, Ignacio Sanz-sánchez, Nurit Beyth, Lior Shapira
    Abstract:

    Systematically review the scientific evidence for efficiency of Anti-Inflammatory Agents against gingivitis, either as solo treatments or adjunctive therapies. A protocol was developed aimed to answer the following focused question: "Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies?" RCTs and cohort studies on Anti-Inflammatory Agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub-analysis was performed dividing the active Agents into Anti-Inflammatory and other drugs. The search identified 3188 studies, of which 14 RCTs met the inclusion criteria. The use of Anti-Inflammatory or other Agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCTs on inflammatory drugs could be meta-analysed, showing a statistically significant reduction in the GI in the experimental group [WMD = -0.090; 95% CI (-0.105; -0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively). Most of the tested material showed beneficial effect as Anti-Inflammatory Agents against gingivitis, either as a single treatment modality or as an adjunctive therapy. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Robert W. Snyder - One of the best experts on this subject based on the ideXlab platform.

Eric Hénon - One of the best experts on this subject based on the ideXlab platform.

  • Synthesis and biological evaluation of pyridazinone derivatives as potential Anti-Inflammatory Agents
    European Journal of Medicinal Chemistry, 2018
    Co-Authors: Chantal Barberot, Aurélie Moniot, Ingrid Allart-simon, Laurette Malleret, Tatyana Yegorova, Marie Laronze-cochard, A. Bentaher, Maurice Médebielle, J.-p. Bouillon, Eric Hénon
    Abstract:

    Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for Anti-Inflammatory therapy in respiratory diseases. Here we describe the development of two families of pyridazinone derivatives as potential PDE4 inhibitors and their evaluation as Anti-Inflammatory Agents. Among these derivatives, 4,5-dihydropyridazinone representatives possess promising activity, selectivity towards PDE4 isoenzymes and are able to reduce IL-8 production by human primary polymorphonuclear cells.

Merav Lidar - One of the best experts on this subject based on the ideXlab platform.

  • Attempts at suppression of amyloidogenesis in a mouse model by a variety of Anti-Inflammatory Agents.
    Autoimmunity reviews, 2012
    Co-Authors: Shmuel Shtrasburg, Mordechai Pras, Einat Rabinovich, Rivka Gal, Avi Livneh, Merav Lidar
    Abstract:

    Abstract Objective The mainstay of AA amyloidosis prevention and treatment is suppression of inflammation. In the present study we have tried to determine the efficacy of a variety of Anti-Inflammatory Agents at suppressing AA amyloidosis in a mouse model of the disease. Methods AA amyloidosis was induced in Swiss male mice using amyloid enhancing factor and AgNO 3 . Suppression of amyloid formation was studied in comparison to saline, using i.p. injections of several non-steroidal Anti-Inflammatory Agents, TNF-α inhibitors, interferon-α, leflunomide and a variety of chemotherapeutic Agents, commonly used in the treatment of inflammatory illnesses such as methotrexate, azathioprine, chlorambucil and cyclophosphamide. The degree of splenic amyloid deposition was determined using Congo red staining of smears and a 5 grade scale. Results The alkylating Agents, chlorambucil and cyclophosphamide, each resulted in a significant 88% reduction in amyloid deposition, yielded the most striking effect on amyloidogenesis suppression in the enhanced mouse model (p  Conclusion Our findings suggest that alkylating Agents may have a role in the prevention of amyloidogenesis. Further testing of these Agents in animal models and in the clinical setting is needed.

David Polak - One of the best experts on this subject based on the ideXlab platform.

  • Are anti‐inflammatory Agents effective in treating gingivitis as solo or adjunct therapies? A systematic review
    Journal of Clinical Periodontology, 2015
    Co-Authors: David Polak, Conchita Martin, Ignacio Sanz-sánchez, Nurit Beyth, Lior Shapira
    Abstract:

    Objective Systematically review the scientific evidence for efficiency of Anti-Inflammatory Agents against gingivitis, either as solo treatments or adjunctive therapies. Methods A protocol was developed aimed to answer the following focused question: “Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies?” RCTs and cohort studies on Anti-Inflammatory Agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub-analysis was performed dividing the active Agents into Anti-Inflammatory and other drugs. Results The search identified 3188 studies, of which 14 RCTs met the inclusion criteria. The use of Anti-Inflammatory or other Agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCTs on inflammatory drugs could be meta-analysed, showing a statistically significant reduction in the GI in the experimental group [WMD = −0.090; 95% CI (−0.105; −0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively). Conclusions Most of the tested material showed beneficial effect as Anti-Inflammatory Agents against gingivitis, either as a single treatment modality or as an adjunctive therapy.

  • Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies? A systematic review.
    Journal of clinical periodontology, 2015
    Co-Authors: David Polak, Conchita Martin, Ignacio Sanz-sánchez, Nurit Beyth, Lior Shapira
    Abstract:

    Systematically review the scientific evidence for efficiency of Anti-Inflammatory Agents against gingivitis, either as solo treatments or adjunctive therapies. A protocol was developed aimed to answer the following focused question: "Are Anti-Inflammatory Agents effective in treating gingivitis as solo or adjunct therapies?" RCTs and cohort studies on Anti-Inflammatory Agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub-analysis was performed dividing the active Agents into Anti-Inflammatory and other drugs. The search identified 3188 studies, of which 14 RCTs met the inclusion criteria. The use of Anti-Inflammatory or other Agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCTs on inflammatory drugs could be meta-analysed, showing a statistically significant reduction in the GI in the experimental group [WMD = -0.090; 95% CI (-0.105; -0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively). Most of the tested material showed beneficial effect as Anti-Inflammatory Agents against gingivitis, either as a single treatment modality or as an adjunctive therapy. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.