influence of different gases and intraperitoneal instillation of Antiadherent or cytotoxic agents on peritoneal tumor cell growth and implantation with laparoscopic surgery in a rat model

Background: A generally accepted approach to prevent tumor implantation with laparoscopic surgery does not exist. Alternative gases in combination with intraperitoneal instillation of different Antiadherent or cytotoxic agents have not been evaluated.

Influence of different gases and intraperitoneal instillation of Antiadherent or cytotoxic agents on peritoneal tumor cell growth and implantation with laparoscopic surgery in a rat model

Background: A generally accepted approach to prevent tumor implantation with laparoscopic surgery does not exist. Alternative gases in combination with intraperitoneal instillation of different Antiadherent or cytotoxic agents have not been evaluated. Methods: The effect of taurolidine, heparin, and povidone-iodine on the growth of colon adenocarcinoma DHD/K12/TRb was measured in rats undergoing laparoscopy with carbon dioxide ( n = 40), helium ( n = 40), or xenon ( n = 40). In the procedure, 10^4 tumor cells were administered intraperitoneally, and pneumoperitoneum was established over 30 min at 8 mmHg with the different gases. The rats additionally received intraperitoneal instillation with one of the following: 1 ml of Ringer’s solution, 1 ml of 0.5% taurolidine, 1 ml 0.5% taurolidine with heparin (10 U/ml), or 1 ml 0.25% of povidone-iodine. Tumor growth was measured after 4 weeks. Results: Median intraperitoneal tumor weight was lower in rats receiving taurolidine (CO_2: 10 mg; helium: 50 mg; xenon: 39.5 mg) or taurolidine with heparin (CO_2: 4 mg; helium: 4.5 mg; xenon: 46.5 mg) in all gas groups than in the control groups (CO_2: 427 mg; helium: 268 mg; xenon: 345 mg) ( p < 0.001). Whereas povidone-iodine caused significantly lower tumor growth in the CO_2 group (56.5 mg) ( p < 0.01), the combination of helium (145 mg) and xenon (457 mg) with povidone-iodine produced no reduction of tumor growth as compared with the control groups (helium: 268 mg; xenon: 345 mg). Conclusions: Taurolidine and taurolidine with heparin significantly inhibit intraperitoneal tumor growth, with different gases used for pneumoperitoneum. Only povidone-iodine caused significant decrease of tumor growth in combination with CO_2. The combination of xenon and povidone-iodine should not be used in patients with cancer because of increased tumor growth.

Desenvolupament d’un tractament Antiadherent de superfícies de titani per a aplicacions biomèdiques

L’ús d’implants de titani per a traumatologia i odontologia és una pràctica molt estesa actualment. El seu èxit, però, es veu afectat pels casos de infeccions que pateixen. En el cas concret dels implants dentals, el 14% dels implants pateixen infeccions bacterianes i entre el 5 i el 8% presenten infecció bacteriana que desenvolupa una peri-implantitis i una conseqüent pèrdua de l’implant. Per aquest motiu, en els darrers anys s’ha estudiat el desenvolupament de superfícies antibacterianes.

En aquest treball s’optimitza un tractament Antiadherent per a superfícies de titani amb l’objectiu de minimitzar l’adhesió bacteriana que pugui produir una infecció posterior. S’ha desenvolupat un tractament de la superfície de titani per formar un recobriment amb un polímer Antiadherent. S’han estudiat les característiques fisicoquímiques de la superfície que en resulta. També s’ha estudiat la seva biocompatibilitat i capacitat per evitar l’adhesió de proteïnes i bacteris.The use of titanium implants for orthopedic and dental practice is currently widespread. Its success, however, is affected by implant-related infections. In the case of dental implants, 14% of implants suffered bacterial infections and between 5 and 8% have a bacterial infection that develops peri-implantitis and consequent loss of the implant. For this reason, in the recent years the development of antibacterial surfaces has been thoroughly studied.

In this paper, a treatment has been optimized for creating antifouling titanium surfaces with the objective to minimize bacterial adhesion that may result in an infection. The titanium surface treatment produces a coating with an antifouling polymer. The physicochemical characteristics of the resulting surface have been studied, as well as the biocompatibility and the ability to prevent the adhesion of proteins and bacteria.Peer Reviewe

Desenvolupament d’un tractament Antiadherent de superfícies de titani per a aplicacions biomèdiques

L’ús d’implants de titani per a traumatologia i odontologia és una pràctica molt estesa actualment. El seu èxit, però, es veu afectat pels casos de infeccions que pateixen. En el cas concret dels implants dentals, el 14% dels implants pateixen infeccions bacterianes i entre el 5 i el 8% presenten infecció bacteriana
que desenvolupa una peri-implantitis i una conseqüent pèrdua de l’implant. Per aquest motiu, en els darrers anys s’ha estudiat el desenvolupament de superfícies antibacterianes.
En aquest treball s’optimitza un tractament Antiadherent per a superfícies de titani amb l’objectiu de minimitzar l’adhesió bacteriana que pugui produir una infecció posterior. S’ha desenvolupat un tractament de la superfície de titani per formar un recobriment amb un polímer Antiadherent. S’han estudiat les característiques fisicoquímiques de la superfície que en resulta. També s’ha estudiat la seva biocompatibilitat i capacitat per evitar l’adhesió de proteïnes i bacteris.Postprint (published version

Desenvolupament d’un tractament Antiadherent de superfícies de titani per a aplicacions biomèdiques

L’ús d’implants de titani per a traumatologia i odontologia és una pràctica molt estesa actualment. El seu èxit, però, es veu afectat pels casos de infeccions que pateixen. En el cas concret dels implants dentals, el 14% dels implants pateixen infeccions bacterianes i entre el 5 i el 8% presenten infecció bacteriana
que desenvolupa una peri-implantitis i una conseqüent pèrdua de l’implant. Per aquest motiu, en els darrers anys s’ha estudiat el desenvolupament de superfícies antibacterianes.
En aquest treball s’optimitza un tractament Antiadherent per a superfícies de titani amb l’objectiu de minimitzar l’adhesió bacteriana que pugui produir una infecció posterior. S’ha desenvolupat un tractament de la superfície de titani per formar un recobriment amb un polímer Antiadherent. S’han estudiat les característiques fisicoquímiques de la superfície que en resulta. També s’ha estudiat la seva biocompatibilitat i capacitat per evitar l’adhesió de proteïnes i bacteris

Antiadherent and antibacterial properties of stainless steel and niti orthodontic wires coated with silver against lactobacillus acidophilus an in vitro study

Background
The purpose of the study is to assess the Antiadherent and antibacterial properties of surface-modified stainless steel and NiTi orthodontic wires with silver against Lactobacillus acidophilus.

Antiadherent and antibacterial properties of stainless steel and NiTi orthodontic wires coated with silver against Lactobacillus acidophilus—an in vitro study

Background The purpose of the study is to assess the Antiadherent and antibacterial properties of surface-modified stainless steel and NiTi orthodontic wires with silver against Lactobacillus acidophilus . Methods This study was done on 80 specimens of stainless steel and NiTi orthodontic wires. The specimens were divided into eight test groups. Each group consisted of 10 specimens. Groups containing uncoated wires acted as a control group for their respective experimental group containing coated wires. Surface modification of wires was carried out by the thermal vacuum evaporation method with silver. Wires were then subjected to microbiological tests for assessment of the Antiadherent and antibacterial properties of silver coating against L. acidophilus . Mann–Whitney U test was used to analyze the colony-forming units (CFUs) in control and test groups; and Student’s t test (two-tailed, dependent) was used to find the significance of study parameters on a continuous scale within each group. Results Orthodontic wires coated with silver showed an Antiadherent effect against L. acidophilus compared with uncoated wires. Uncoated stainless steel and NiTi wires respectively showed 35.4 and 20.5 % increase in weight which was statistically significant ( P   0.001). The groups containing surface-modified wires showed statistically significant decrease in the survival rate of L. acidophilus expressed as CFU and as log of colony count when compared to groups containing uncoated wires. It was 836.60 ± 48.97 CFU in the case of uncoated stainless steel whereas it was 220.90 ± 30.73 CFU for silver-modified stainless steel, 748.90 ± 35.64 CFU for uncoated NiTi, and 203.20 ± 41.94 CFU for surface-modified NiTi. Conclusions Surface modification of orthodontic wires with silver can be used to prevent the accumulation of dental plaque and the development of dental caries during orthodontic treatment.