The Experts below are selected from a list of 576 Experts worldwide ranked by ideXlab platform

Bahar Ahmed - One of the best experts on this subject based on the ideXlab platform.

  • ANTI-HEPATOTOXIC ACTIVITY OF CLERODENDRUM PHLOMIDIS
    2014
    Co-Authors: Amita Verma, Bahar Ahmed
    Abstract:

    ABSTRACT: In the present study, we evaluated the Antihepatotoxic activity of the different fractions of Clerodendrum phlomidis by performing biochemical parameters and histopathological studies against toxicity caused by the carbon tetrachloride. The histopathological studies of the liver showed swelling and necrosis in hepatocytes in CCl4 treated rats, treatment with different fractions have reduced significantly the necrosis and swelling of the hepatocytes. The biochemical parameters also showed the significant Antihepatotoxic activity. KEY WORDS: Carbon tetrachloride, wistar rats, per oral, Clerodendrum phlomidis

  • Antihepatotoxic ACTIVITY OF TWO NEW QUERCETIN DERIVATIVES IN CARBON TETRACHLORIDE INDUCED HEPATOXICITY IN RATS
    'Indonesian Journal of Pharmacy', 2013
    Co-Authors: Shah Alam Khan, Bahar Ahmed
    Abstract:

    Quercetin, a bioflavonol is widely found in nature and possesses diverse pharmacological properties. A heterocyclic 1,4 dioxane nucleus was incorporated in Quercetin structure to obtain two structural analogues of silybin. The aim of the study was to Antihepatotoxic potential of Quercetin derivatives containing 1,4 dioxane heterocyclic ring in Carbon tetrachloride (CCl4) induced hepatotoxicity in female Wistar Albino rats. Two Quercetin derivatives (QD) were synthesized by reported method. QD were administered orally at dose of 10 mg/kg, once daily for 7 days to Wistar Albino rats. A single dose of CCl4(1mL/kg) was used for inducing liver damage. Antihepatotoxic activity was evaluated by measuring levels of total proteins (TP), total albumin (TA), alkaline phosphatase (ALKP) and liver enzymes such as serum glutamate oxaloacetate (SGOT) and serum glutamate pyruvate transaminase (SGPT).QD exhibited potent Antihepatotoxic activity with respect to standard drug silybon-70. However, it was observed that the Quercetin derivative having –CH2OH group in the dioxane ring exhibited better activity in comparision to unsubstituted 1,4 dixoane ring derivative.The exact mechanism by which QD protects the liver is unknown however the observed effects could be attributed to presence of 1,4 dioxane ring and due to the significant antioxidant activity of Quercetin flavone

  • discovery of novel 1 4 benzodioxane containing thiazolidinone derivatives as potential Antihepatotoxic agent
    Bulletin of The Korean Chemical Society, 2012
    Co-Authors: Habibullah Khalilullah, Shamshir Khan, Mohamed Jawed Ahsan, Bahar Ahmed
    Abstract:

    In continuance of our search for newer Antihepatotoxic agents some novel thiazolidinone derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were evaluated for Antihepatotoxic activity against -induced hepatotoxicity in rats. Among them some compounds have shown significant Antihepatotoxic activity comparable to standard drug silymarin.

  • lead finding from whole plant of marrubium vulgare l with hepatoprotective potentials through in silico methods
    Asian pacific Journal of Tropical Biomedicine, 2012
    Co-Authors: Amita Verma, Mubashir H Masoodi, Bahar Ahmed
    Abstract:

    Abstract Objective In the present study an attempt has been made to study the Antihepatotoxic activity of active compounds in this plant through in silico methods. Methods We have taken 12 compounds form this plant. All the compounds were further subjected to molecular propertied prediction and drug likeness by Molinspiration and found in compliance with Lipinski's rule of five. Biochemical parameters like SGOT and SGPT were determined by Reitman and Frankel, ALP by Kind and King, TP by reported methods of Wooton. Results All the compounds were showed expected similar bioactivity especially in case of enzyme inhibition. Compound Vulgarin showed no violation with good drug likeness score and biological activity as compare to standard drug Silibinin. Vulgarin exhibited a significant Antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) serum glutamate pyruvate oxaloacetate transaminase (SGPT) and alkaline phosphatase (ALP) while the total protein (TP) levels were increased when compared with standard drug silymarin against CCl4-induced toxicity in Wistar rats. These biochemical observations were also supplemented by histopathological examinations of the liver sections. Conclusions We found that Vulgarin one of the twelve compounds is showed better drug likeness and biological activity against Silibinin. So this particular compound can be taken as lead compound for further drug discovery for hepatotoxic activity.

  • synthesis and Antihepatotoxic activity of 5 2 3 dihydro 1 4 benzodioxane 6 yl 3 substituted phenyl 4 5 dihydro 1h pyrazole derivatives
    Bioorganic & Medicinal Chemistry Letters, 2011
    Co-Authors: Habibullah Khalilullah, Shamshir Khan, Mohamed Jawed Ahsan, Bahar Ahmed
    Abstract:

    In continuance of our search for newer Antihepatotoxic agents some novel pyrazoline derivatives containing 1,4-dioxane ring system were synthesized starting from 3-(2,3-dihydro-1,4-benzodioxane-6-yl)-1-substituted-phenylprop-2-en-1-one. Some of the synthesized compounds were evaluated for Antihepatotoxic activity against CCl(4)-induced hepatotoxicity in rats. Among them some compounds have shown significant Antihepatotoxic activity comparable to standard drug silymarin.

Shamshir Khan - One of the best experts on this subject based on the ideXlab platform.

Habibullah Khalilullah - One of the best experts on this subject based on the ideXlab platform.

S. S. Handa - One of the best experts on this subject based on the ideXlab platform.

  • Antihepatotoxic activity of swertia chirata on carbon tetrachloride induced hepatotoxicity in rats
    Phytotherapy Research, 1999
    Co-Authors: M Karan, S. S. Handa, K Vasisht
    Abstract:

    The methanol extract of Swertia chirata was evaluated for Antihepatotoxic activity against carbon tetrachloride induced liver toxicity in experimental rats. The extract was found to be active and on fractionation into butanol soluble and chloroform soluble fractions, the activity was traced and found more profound in the chloroform soluble fraction. The butanol soluble bitter rich fraction showed marginal activity. The results based on biochemical estimations have been expressed statistically and are additionally supported by histopathological examination of the liver of experimental rats and pentobarbitone induced sleep time studies in mice.

  • hepatoprotective activity of apium graveolens and hygrophila auriculata against paracetamol and thioacetamide intoxication in rats
    Journal of Ethnopharmacology, 1995
    Co-Authors: Anubha Singh, S. S. Handa
    Abstract:

    Seeds of Apium graveolens L. (Apiaceae) and Hygrophila auriculata (K. Schum.) Heine (Syn. Astercantha auriculata Nees, Acanthaceae) are used in Indian systems of medicine for the treatment of liver ailments. The Antihepatotoxic effect of methanolic extracts of the seeds of these two plants was studied on rat liver damage induced by a single dose of paracetamol (3 g/kg p.o.) or thioacetamide (100 mg/kg, s.c.) by monitoring several liver function tests, viz. serum transaminases (SGOT and SGPT), alkaline phosphatase, sorbitol dehydrogenase, glutamate dehydrogenase and bilirubin in serum. Furthermore, hepatic tissues were processed for assay of triglycerides and histopathological alterations simultaneously. A significant hepatoprotective activity of the methanolic extract of the seeds of both the plants was reported.

Mohamed Jawed Ahsan - One of the best experts on this subject based on the ideXlab platform.