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Mohamed Bouaziz - One of the best experts on this subject based on the ideXlab platform.
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Antihyperlipidemic and antioxidant activities of edible tunisian ficus carica l fruits in high fat diet induced hyperlipidemic rats
Plant Foods for Human Nutrition, 2016Co-Authors: Olfa Belguithhadriche, Sonda Ammar, Maria Del Mar Contreras, Mouna Turki, Antonio Seguracarretero, Abdelfattah El Feki, Fatma Makniayedi, Mohamed BouazizAbstract:The phenolic constituents of the aqueous-ethanolic extract of Tunisian Ficus carica (F. carica) fruit (FE) and its Antihyperlipidemic and antioxidant activities in high-fat diet-induced hyperlipidemic rats (HFD) were evaluated. The obtained results demonstrated that the FE improved the lipid profile by decreasing the total cholesterol, triglyceride, low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol levels. It also reduced the content of thiobarbituric acid-reactive substances and increased the antioxidant enzymes in liver, heart and kidney in HFD-fed rats. These Antihyperlipidemic effects and in vivo antioxidative effects correlated with the in vitro phenolic content scavenging ability. Thus, the major phenolic compounds were identified using reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) coupled with two detection systems: diode-array detection (DAD) and quadrupole time-of-flight (QTOF) mass spectrometry (MS). Therefore, in the negative ionization mode, 28 phenolic compounds, including hydroxybenzoic acids, hydroxycinnamic acids, flavanoids and hydroxycoumarins were characterized. Dihydroxybenzoic acid di-pentoside, the flavonol quercetin 3-O-rutinoside and the flavone assigned as apigenin 8-C-glucoside were the main representative compounds in ‘Tounsi’ fruits. This work was complemented by the detection of seven other phenolic compounds in the positive ionization mode, including anthocyanins and furanocoumarins. Overall, these results have shown that the FE has a significant hypocholesterolemic effect and antioxidant activity in HFD-fed rats. This beneficial effect may be partly due to these phenolic constituents, especially vitexin, dihydroxybenzoic acid di-pentoside as well as rutin.
Mohd Mujeeb - One of the best experts on this subject based on the ideXlab platform.
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paederia foetida linn leaf extract an Antihyperlipidemic antihyperglycaemic and antioxidant activity
BMC Complementary and Alternative Medicine, 2014Co-Authors: Vikas Kumar, Danish Ahmed, Amita Verma, Firoz Anwar, Aftab Ahmed, Zoheir A Damanhouri, Vatsala Mishra, Pramod W Ramteke, Prakash Chandra Bhatt, Mohd MujeebAbstract:The primary objective of the present investigation is to evaluate the antidiabetic, antihyperlidemic and antioxidant activity of the methanolic extract of the Paederia foetida Linn. (PF) leaf extract in the streptozotocin induced diabetic rats. Single intraperitoneal injection (IP) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes is swiss albino (wistar strain) rats. The induction of diabetes was confirmed after 3 days as noticing the increase in blood sugar level of tested rats. PF at a once a daily dose of 100 mg/kg, 250 mg/kg, 500 mg/kg, p.o. along with glibenclamide 10 mg/kg, p.o. was also given for 28 days. On the 28th day rats from all the groups fasted overnight fasted and the blood was collected from the puncturing the retro orbit of the eye under mild anesthetic condition. There collected blood sample was used to determine the Antihyperlipidemic, hypoglycemic and antioxidant parameters. The oral acute toxicity studies did not show any toxic effect till the dose at 2000 mg/kg. While oral glucose tolerance test showed better glucose tolerance in tested rats. The statistical data indicated that the different dose of the PF significantly increased the body weight, hexokinase, plasma insulin, high density lipoprotein cholesterol, superoxide dismutase, catalase and glutathione peroxides. It also decreases the level of fasting blood glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, malonaldehyde, glucose-6-phosphate, fructose-1-6-biphosphate and glycated hemoglobin in STZ induced diabetic rats. The histopathology of STZ induce diabetic rats, as expected the test dose of PF extract considerably modulates the pathological condition of various vital organ viz. heart, kidney, liver, pancreas as shown in the histopathology examinations. Our investigation has clearly indicated that the leaf extract of Paederia foetida Linn. showed remarkable antihyperglycemic activity due to its possible systematic effect involving in the pancreatic and extra pancreatic mechanism. Forever, the Antihyperlipidemic activity was exerted possible by lowering the higher level of lipid profile and decreasing the intercalated disc space in the heart. The antioxidant activity of extract was due to inhibition of lipid peroxidation and increasing the SOD, GPx and CAT. It was corroborate that the extract shown the Paederia foetida Linn leaves potential to be act as antidiabetic, Antihyperlipidemic and antioxidant properties.
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umbelliferone β d galactopyranoside from aegle marmelos l corr an ethnomedicinal plant with antidiabetic Antihyperlipidemic and antioxidative activity
BMC Complementary and Alternative Medicine, 2013Co-Authors: Vikas Kumar, Danish Ahmed, Amita Verma, Firoz Anwar, Mohammed Ali, Mohd MujeebAbstract:Aegle marmelos (L.) Corr. (Rutaceae), commonly known as bael, is used to treat fevers, abdomen pain, palpitation of the heart, urinary troubles, melancholia, anorexia, dyspepsia, diabetes and diarrhea in Indian traditional systems of medicine. The object of the present study was to evaluate the antidiabetic, Antihyperlipidemic and antioxidant oxidative stress of umbelliferone β-D-galactopyranoside (UFG) from stem bark of Aegle marmelos Correa. in STZ (streptozotocin) induced diabetic rat. Diabetes was induced in rat by single intraperitoneal injection of STZ (60 mg/kg). The rat was divided into the following groups; I – normal control, II – diabetic control, III – UFG (10 mg/kg), IV – UFG (20 mg/kg), V – UFG (40 mg/kg), VI – Glibenclamide (10 mg/kg, p.o., once a daily dose). Diabetes was measured by change the level blood glucose, plasma insulin and the oxidative stress were assessed in the liver by estimation of the level of antioxidant markers i.e. superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and Malondialdehyde (MDA) and Antihyperlipidemic effect was measured by estimation of total cholesterol, triglycerides, LDL (low density lipoprotein) cholesterol, HDL (high density lipoprotein) cholesterol, VLDL (very low density lipoprotein) cholesterol. However in a study, the increased body weight was observed and utilization of glucose was in the oral glucose tolerance test. Daily oral administration of different dose of UFG for 28 days showed significantly (P < 0.001) decreased in fasting blood glucose level and improve plasma insulin level as compared to the diabetic control group. Also it significantly (P < 0.001) decreased the level of glycated hemoglobin, glucose-6-phosphatase, fructose-1-6-biphosphate and increased the level of hexokinase. UFG treatment decreased liver MDA and increased the level of SOD, GPx and CAT. UFG treatment of lipids it’s increased the level of cholesterol, triglycerides, VLDL, LDL cholesterol and decreased the level of HDL cholesterol. Histologically, inflammatory cell in blood vessels, intercalated disc, fat degeneration and focal necrosis observed in diabetic rat organ but was less obvious in UFG treated groups. The mechanism of action of UFG may be due to the increased level of pancreatic insulin secretion and effect on the antioxidant marker. UFG posses an antidiabetic, antioxidant and Antihyperlipidemic effect on the STZ induced diabetic rat. Hence it could be the better choice to cure the diabetes.
Olfa Belguithhadriche - One of the best experts on this subject based on the ideXlab platform.
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Antihyperlipidemic and antioxidant activities of edible tunisian ficus carica l fruits in high fat diet induced hyperlipidemic rats
Plant Foods for Human Nutrition, 2016Co-Authors: Olfa Belguithhadriche, Sonda Ammar, Maria Del Mar Contreras, Mouna Turki, Antonio Seguracarretero, Abdelfattah El Feki, Fatma Makniayedi, Mohamed BouazizAbstract:The phenolic constituents of the aqueous-ethanolic extract of Tunisian Ficus carica (F. carica) fruit (FE) and its Antihyperlipidemic and antioxidant activities in high-fat diet-induced hyperlipidemic rats (HFD) were evaluated. The obtained results demonstrated that the FE improved the lipid profile by decreasing the total cholesterol, triglyceride, low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol levels. It also reduced the content of thiobarbituric acid-reactive substances and increased the antioxidant enzymes in liver, heart and kidney in HFD-fed rats. These Antihyperlipidemic effects and in vivo antioxidative effects correlated with the in vitro phenolic content scavenging ability. Thus, the major phenolic compounds were identified using reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) coupled with two detection systems: diode-array detection (DAD) and quadrupole time-of-flight (QTOF) mass spectrometry (MS). Therefore, in the negative ionization mode, 28 phenolic compounds, including hydroxybenzoic acids, hydroxycinnamic acids, flavanoids and hydroxycoumarins were characterized. Dihydroxybenzoic acid di-pentoside, the flavonol quercetin 3-O-rutinoside and the flavone assigned as apigenin 8-C-glucoside were the main representative compounds in ‘Tounsi’ fruits. This work was complemented by the detection of seven other phenolic compounds in the positive ionization mode, including anthocyanins and furanocoumarins. Overall, these results have shown that the FE has a significant hypocholesterolemic effect and antioxidant activity in HFD-fed rats. This beneficial effect may be partly due to these phenolic constituents, especially vitexin, dihydroxybenzoic acid di-pentoside as well as rutin.
Yingyong Zhao - One of the best experts on this subject based on the ideXlab platform.
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the Antihyperlipidemic effect of fu ling pi is associated with abnormal fatty acid metabolism as assessed by uplc hdms based lipidomics
RSC Advances, 2015Co-Authors: Hua Miao, Xu Zhang, Shengjun Yuan, Yingyong ZhaoAbstract:The surface layer of Poria cocos (SLPC), a traditional Chinese medicine, has been commonly used for diuretic and antihyperlipidemia in Asia. In order to understand its biochemical mechanism of antihyperlipidemia, a lipidomic approach based on ultra-performance liquid chromatography coupled with a quadrupole time-of-flight synapt high-definition mass spectrometry was carried out to characterize the plasma lipid metabolic profile of the Antihyperlipidemic effect of SLPC in rats fed with a high fat diet. Lipid metabolites with significant changes were characterized as potential biomarkers associated with the development of hyperlipidemia and antihyperlipidemia of SLPC using partial least-squares-discriminate analysis, heatmap display, correlation coefficient analysis and receiver-operating characteristic curves. The analysis of the biological pathway was performed with metabolomics pathway analysis (MetPA). The lipid metabolic profile of hyperlipidemia rats separated from control rats and SLPC treated rats was closer to the control rats. Six lipid metabolites including the five fatty acyl lipids palmitic acid, dodecanoic acid, L-palmitoylcarnitine, oleoylcarnitine and linoleyl carnitine and one sphingolipid phytosphingosine were considered as biomarkers of diet-induced hyperlipidemia and Antihyperlipidemic effect of SLPC. MetPA revealed that the identified lipid biomarkers were responsible for diet-induced hyperlipidemia and Antihyperlipidemic effect of SLPC. These biomarkers were associated with fatty acid metabolism, fatty acid biosynthesis, sphingolipid metabolism, fatty acid elongation in mitochondria and unsaturated fatty acids biosynthesis. The findings suggest that a high fat diet led to the perturbation of fatty acid metabolism and sphingolipid metabolism, which may be the pharmacological basis of an Antihyperlipidemic effect of SLPC.
Jian Zhang - One of the best experts on this subject based on the ideXlab platform.
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antihyperglycemic Antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of cyclocarya paliurus leaves in type 2 diabetic rats
Journal of Ethnopharmacology, 2013Co-Authors: Qingqing Wang, Cuihua Jiang, Shengzuo Fang, Junhu Wang, Xulan Shang, Zhiqi Yin, Jian ZhangAbstract:Ethnopharmacological relevance Cyclocarya paliurus (CP) Batal., the sole species in its genus and native to China, is a herbal tea, which has been traditionally used in the folk medicine for the treatment of diabetes and hyperlipidemia in China. To evaluate the antihyperglycemic, Antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts from CP in high fat diet (HFD) and streptozotocin (STZ) induced diabetic rats.