The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Ashok Kumar - One of the best experts on this subject based on the ideXlab platform.
-
New diorganotin(IV) derivatives of 7-hydroxycoumarin (Umbelliferone) and their adducts with 1,10-phenanthroline.
Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2020Co-Authors: Mala Nath, Ruchi Jairath, Xueqing Song, Ashok KumarAbstract:New diorganotin(IV) derivatives of the general formula R2Sn(Umb)2 (where R = n-Bu, n-Oct and Ph; Umb = Umbelliferone anion) have been synthesized either by the reaction of R2SnO with Umbelliferone under azeotropic removal of water or by the reaction of R2SnCl2 with sodium salt of Umbelliferone. Further, the adducts of the general formula R2Sn(Umb)2.phen (where R = n-Bu and n-Oct; phen = 1,10-phenanthroline) have also been synthesized by the interaction of R2Sn(Umb)2 with 1,10-phenanthroline. The bonding and coordination behavior in these derivatives are discussed on the basis of IR and 119Sn Mössbauer spectroscopic studies in solid state. Their coordination behavior in solution is discussed by the multinuclear (1H, 13C and 119Sn) NMR spectral studies. The Mössbauer and IR studies indicate that Umbelliferone acts as a monoanionic bidentate ligand in R2Sn(Umb)2 coordinating through O(7) and O(1). A distorted octahedral geometry around tin has been proposed for R2Sn(Umb)2 as well as for R2Sn(Umb)2.phen in solid state. The newly synthesized derivatives have been tested for their anti-inflammatory and cardiovascular activities. The average LD50 value >1000 mg kg(-1) of these compounds indicates their safety margin.
-
new diorganotin iv derivatives of 7 hydroxycoumarin Umbelliferone and their adducts with 1 10 phenanthroline
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005Co-Authors: Mala Nath, Ruchi Jairath, Xueqing Song, Ashok KumarAbstract:Abstract New diorganotin(IV) derivatives of the general formula R2Sn(Umb)2 (where R = n-Bu, n-Oct and Ph; Umb = Umbelliferone anion) have been synthesized either by the reaction of R2SnO with Umbelliferone under azeotropic removel of water or by the reaction of R2SnCl2 with sodium salt of Umbelliferone. Further, the adducts of the general formula R2Sn(Umb)2·phen (where R = n-Bu and n-Oct; phen = 1,10-phenanthroline) have also been synthesized by the interaction of R2Sn(Umb)2 with 1,10-phenanthroline. The bonding and coordination behavior in these derivatives are discussed on the basis of IR and 119Sn Mossbauer spectroscopic studies in solid state. Their coordination behavior in solution is discussed by the multinuclear (1H, 13C and 119Sn) NMR spectral studies. The Mossbauer and IR studies indicate that Umbelliferone acts as a monoanionic bidentate ligand in R2Sn(Umb)2 coordinating through O(7) and O(1). A distorted octahedral geometry around tin has been proposed for R2Sn(Umb)2 as well as for R2Sn(Umb)2·phen in solid state. The newly synthesized derivatives have been tested for their anti-inflammatory and cardiovascular activities. The average LD50 value >1000 mg kg−1 of these compounds indicates their safety margin.
-
triorganotin iv derivatives of Umbelliferone 7 hydroxycoumarin and their adducts with 1 10 phenanthroline synthesis structural and biological studies
Journal of Organometallic Chemistry, 2005Co-Authors: Mala Nath, Ruchi Jairath, Xueqing Song, Ashok KumarAbstract:Abstract New triorganotin(IV) derivatives of the general formula R3Sn(Umb) (where, R = Me, n-Bu and Ph; Umb = Umbelliferone anion) have been synthesized using sodium salt method. Further, the adducts of the general formula R3Sn(Umb) · phen (where R = Me and Ph; phen = 1,10-phenanthroline) have also been synthesized by the interaction of the triorganotin(IV) derivatives of Umbelliferone with 1,10-phenanthroline. The bonding and coordination behavior of these derivatives are discussed on the basis of IR, NMR (1H, 13C and 119Sn), and 119Sn Mossbauer spectroscopic studies. These investigations indicate that Umbelliferone acts as a monoanionic bidentate ligand in R3Sn(Umb) coordinating through O(7) and O(1) in the solid-state. These polymeric R3Sn(Umb) derivatives (where R = Me and n-Bu) have been proposed to have a trans-trigonal bipyramidal geometry with the three R groups in equatorial positions, while the axial positions are occupied by a phenolic oxygen and the O(1) atom from the adjacent molecule. A pseudotetrahedral geometry has been suggested for Ph3Sn(Umb). A distorted octahedral geometry around tin has been proposed for R3Sn(Umb) · phen, in which Umbelliferone anion acts as a monodentate ligand coordinating through phenolic oxygen O(7). The newly synthesized derivatives have been assayed for their anti-inflammatory, cardiovascular and anti-microbial activities. The average LD50 values >1000 mg kg−1 of these derivatives indicate their safety margin. Among all the compounds tested, Ph3Sn(Umb) · phen has been found to show potent anti-inflammatory activity with low mammalian toxicity and mild hypotensive activity.
Kodukkur Viswanathan Pugalendi - One of the best experts on this subject based on the ideXlab platform.
-
Umbelliferone modulates gamma radiation induced reactive oxygen species generation and subsequent oxidative damage in human blood lymphocytes
European Journal of Pharmacology, 2011Co-Authors: Govindasamy Kanimozhi, Nagarajan Rajendra Prasad, S Ramachandran, Kodukkur Viswanathan PugalendiAbstract:Abstract The purpose of this study was to investigate the antioxidant potential of Umbelliferone, 7-hydroxy coumarin, and its role in the protection against radiation-induced oxidative damage in cultured human blood lymphocytes. It was found that the antioxidant effect of Umbelliferone was dose dependent in hydroxyl (OH • ), superoxide anion (O 2 •− ), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid radical cation (ABTS •+ ) and 1,1-diphenyl-2-picrylhydrazyl (DPPH • ) radical scavenging assays. To explore the radioprotective effect of Umbelliferone, freshly isolated human blood lymphocytes were treated with 124 μM Umbelliferone (optimum dose-fixed by MTT assay) 30 min before 3 Gy irradiation. It was found that Umbelliferone pretreatment inhibited radiation-induced reactive oxygen species generation in 3 Gy exposed lymphocytes. Microscopic observations showed that there was a significant apoptotic cells (ethidium bromide/acridine orange staining) and decreased mitochondrial membrane potential (Rhodamine 123 staining) in irradiated lymphocytes. On the other hand, 124 μM Umbelliferone treatment significantly decreased % of apoptotic cells and prevented radiation induced mitochondrial depolarization in lymphocytes. Further, it was noticed that there was an increased DNA damage (comet assay), lipid peroxidation with decreased antioxidant enzymatic i.e., superoxide dismutase, catalase and, glutathione peroxidase activities in 3 Gy irradiated lymphocytes. Conversely, Umbelliferone (124 μM) treatment before irradiation decreased comet attributes and lipid peroxidative markers with improved antioxidant enzyme activities in irradiated lymphocytes. Taken together, the results of this study clearly suggest the radioprotective effect of Umbelliferone in human lymphocytes by inhibiting reactive oxygen species generation and its subsequent toxicity.
-
Effect of Umbelliferone on Tail Tendon Collagen and Haemostatic Function in Streptozotocin-Diabetic Rats
Basic & Clinical Pharmacology & Toxicology, 2007Co-Authors: Balakrishnan Ramesh, Kodukkur Viswanathan PugalendiAbstract:Diabetes mellitus is known to affect collagen in various tissues. Umbelliferone (7-hydroxycoumarin), a natural antioxidant and benzopyrone, is found in golden apple ( Aegle marmelos Correa) and bitter orange ( Citrus aurantium ). Plant-derived phenolic coumarins have been shown to act as dietary antioxidants. In this study, we have investigated the influence of Umbelliferone on collagen content and its effects on the tail tendon in streptozotocin-diabetic rats. Male albino Wistar rats (180-200 g) were made diabetic by intraperitoneal administration of streptozotocin (40 mg/kg). Normal and diabetic rats were treated with Umbelliferone for 45 days. Diabetic rats had increased glucose and decreased insulin levels. Tail tendons of diabetic rats had increased total collagen, glycation and fluorescence, and decreased levels of neutral, acid and pepsin-soluble collagens. We have studied the effect of Umbelliferone on haemostatic function because Umbelliferone is also a coumarin derivative like the anticoagulant, warfarin. Diabetic rats had a significant decrease in prothrombin, clotting and bleeding time, and treatment with Umbelliferone made these parameters almost normal. Our results show that umbel- liferone controls glycaemia and has a beneficial effect on collagen content and its properties, i.e. collagen related parameters, in the tail tendon, which indicates recovery from the risk (recovery of animals from the risk of complications) of collagen- mediated diabetic polyneuropathy and diabetic nephropathy. Collagen is a protein and major constituent of the extra- cellular matrix of connective tissue. It is the main load carrying element, i.e. major supporting material in the soft tissues, in a wide variety of soft tissues such as tendons, liga- ments, blood vessels, skin or articular cartilages. Most of the collagen molecule consists of three amino acids, glycine (33%), which enhances the stability of the molecule, proline (15%) and hydroxyproline (1). Glucose and other circulating and reducing sugars react non-enzymatically with amino groups of macromolecules (proteins, lipids and nucleic acids) to produce a heterogenous group of irreversibly bound moieties called advanced glycation end-products (2). Non-enzymatic glycation and advanced glycation end-product formation inevitably occur during chronic diabetes and have been suggested to be the primary cause of late diabetic complications (3). Increased amounts of advanced glycation end-product-modified molecules, measured by methods on the fluorescent properties of some advanced glycation end-products, have been demonstrated in diabetic patients (4,5). Activation of cell surface receptors specific for advanced glycation end-product-modified pro- teins leads to cytokine activation, and advanced glycation end-product formation on extracellular matrix collagen results in protein cross-linking (6). It has been reported that the solubility of collagen is decreased in tail tendons of diabetic rats, which has been supported by demonstration of increased cross-linking (7). Many oral hypoglycaemic agents, such as biguanides and sulfonylurea, are used together with insulin for the treatment of diabetes mellitus (8). Glibenclamide is a standard anti- diabetic drug belonging to the sulfonylurea group. The K ATP channels in the plasma membrane of pancreatic β -cells contain 4 sulfonylurea receptor-1 (SUR-1) and 4 pore-forming Kir6.2 inwardly rectifying potassium channels. The SUR-1 contains high-affinity binding sites for sulfonylurea. Binding of sulfonylurea at this site closes the Kir6.2 and prevents potassium efflux. This favours local depolarization of the plasma membrane and initiates a calcium-dependent path- way to insulin exocytosis (9,10). The efficacy therefore depends upon the presence of enough active β -cells, and thus, this drug has been used as a reference drug for comparison. Plant-derived phenolic coumarins found in fruit and veget- ables might play a role as dietary antioxidants (11). Umbelliferone, a naturally occurring antioxidant and benzopyrone, is found in the edible fruits of golden apple ( Aegle marmelos Correa) (12) and bitter orange ( Citrus aurantium ) (13). The parent compound coumarin has been reported to reduce plasma glucose (14). Recently, we have reported that Umbelliferone has antihyper- glycaemic and antihyperlipidaemic (15,16) and antioxidant (17-19) properties in streptozotocin-diabetic rats. We have analysed the effect of Umbelliferone on collagen content and its properties in the tail tendon, as so far no detailed study has been carried out. Synthetic 4-hydroxycoumarin, warfarin acts as an anticoagulant by interfering with the conversion of pro-vitamin K to the functional hydroquinone, and thereby suppresses the formation of prothrombin (20). Because Umbelliferone is also a coumarin derivative, we studied its effect on haemostatic function such as prothrombin time, bleeding and clotting time. The structure of Umbelliferone appears from fig. 1.
-
protective effect of Umbelliferone on membranous fatty acid composition in streptozotocin induced diabetic rats
European Journal of Pharmacology, 2007Co-Authors: Balakrishnan Ramesh, P Viswanathan, Kodukkur Viswanathan PugalendiAbstract:Abstract Umbelliferone (UMB), a natural antioxidant, is benzopyrone in nature, and it is present in the fruits of golden apple and bitter orange. Earlier we evaluated and reported the effect of Umbelliferone on antidiabetic, antioxidant and antihyperlipidemic properties, and this study was designed to evaluate the effect of Umbelliferone on membrane fatty acid composition and histopathology of liver and kidney of control and streptozotocin (STZ) diabetic rats. Male albino Wistar rats (180–200 g) were made diabetic by an intraperitonial administration of STZ (40 mg/kg). The control and diabetic rats were treated with Umbelliferone and glibenclamide dissolved in 10% dimethyl sulfoxide for 45 days. Diabetic rats had decreased insulin and increased glucose, and increased levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes. The levels of palmitic, stearic and oleic acids increased and the levels of linolenic and arachidonic acids decreased in diabetic rats as compared with control rats. Thus, the saturated fatty acids and monounsaturated fatty acids increased and the polyunsaturated fatty acids decreased in diabetic rats. Diabetic rats had decreased liver weight and increased activities of alanine transaminase and aspartate transaminase; increased kidney weight and urine albumin, and decreased levels of urea, uric acid and creatinine in the urine. Histopathological studies of liver and kidney in diabetic rats showed fatty changes surrounding portal triad; enlargement of lining cells of tubules, fatty infiltration, large area of hemorrhage and lymphocyte infiltration. Treatment with Umbelliferone and glibenclamide reversed these changes to near normalcy. Our results showed that Umbelliferone has a protective effect on membrane fatty acid composition of liver and kidney as supported by antioxidant and antihyperlipidemic effects of Umbelliferone reported earlier as evidenced by improved histopathological changes, hepatic and nephritic markers, indicating recovery from the risk of diabetic complications.
Juliana Fraga Vasconcelos - One of the best experts on this subject based on the ideXlab platform.
-
effects of Umbelliferone in a murine model of allergic airway inflammation
European Journal of Pharmacology, 2009Co-Authors: Juliana Fraga Vasconcelos, Mauro M Teixeira, Jose Maria Barbosafilho, Maria De Fatima Agra, Xirley Pereira Nunes, Ana Maria Giulietti, Ricardo Ribeirodossantos, Milena Botelho Pereira SoaresAbstract:The therapeutic effects of Umbelliferone (30, 60 and 90 mg/kg), a coumarin isolated from Typha domingensis (Typhaceae) were investigated in a mouse model of bronchial asthma. BALB/c mice were immunized and challenged by nasal administration of ovalbumin. Treatment with Umbelliferone (60 and 90 mg/kg) caused a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition, a decrease in mucus production and lung inflammation were observed in mice treated with Umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-gamma, was found in bronchoalveolar lavage fluids of mice treated with Umbelliferone, similar to that observed with dexamethasone. The levels of ovalbumin-specific IgE were not significantly altered after treatment with Umbelliferone. In conclusion, our results demonstrate that Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. The investigation of the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.
-
Pulmonary, Gastrointestinal and Urogenital Pharmacology Effects of Umbelliferone in a murine model of allergic airway inflammation
2009Co-Authors: Juliana Fraga Vasconcelos, Mauro M Teixeira, Maria De Fatima Agra, Xirley Pereira Nunes, Ana Maria Giulietti, José Maria Barbosa-filho, Ricardo Ribeiro-dos-santos, Milena Botelho Pereira SoaresAbstract:article i nfo The therapeutic effects of Umbelliferone (30, 60 and 90 mg/kg), a coumarin isolated from Typha domingensis (Typhaceae) were investigated in a mouse model of bronchial asthma. BALB/c mice were immunized and challenged by nasal administration of ovalbumin. Treatment with Umbelliferone (60 and 90 mg/kg) caused a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition,a decrease in mucus production andlung inflammationwere observed in mice treated with Umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-γ, was found in bronchoalveolar lavage fluids of mice treated with Umbelliferone, similar to that observed with dexamethasone. The levels of ovalbumin-specifi cI gE were not significantly altered after treatment with Umbelliferone. In conclusion, our results demonstrate that Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. The investigation of the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.
Mala Nath - One of the best experts on this subject based on the ideXlab platform.
-
New diorganotin(IV) derivatives of 7-hydroxycoumarin (Umbelliferone) and their adducts with 1,10-phenanthroline.
Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2020Co-Authors: Mala Nath, Ruchi Jairath, Xueqing Song, Ashok KumarAbstract:New diorganotin(IV) derivatives of the general formula R2Sn(Umb)2 (where R = n-Bu, n-Oct and Ph; Umb = Umbelliferone anion) have been synthesized either by the reaction of R2SnO with Umbelliferone under azeotropic removal of water or by the reaction of R2SnCl2 with sodium salt of Umbelliferone. Further, the adducts of the general formula R2Sn(Umb)2.phen (where R = n-Bu and n-Oct; phen = 1,10-phenanthroline) have also been synthesized by the interaction of R2Sn(Umb)2 with 1,10-phenanthroline. The bonding and coordination behavior in these derivatives are discussed on the basis of IR and 119Sn Mössbauer spectroscopic studies in solid state. Their coordination behavior in solution is discussed by the multinuclear (1H, 13C and 119Sn) NMR spectral studies. The Mössbauer and IR studies indicate that Umbelliferone acts as a monoanionic bidentate ligand in R2Sn(Umb)2 coordinating through O(7) and O(1). A distorted octahedral geometry around tin has been proposed for R2Sn(Umb)2 as well as for R2Sn(Umb)2.phen in solid state. The newly synthesized derivatives have been tested for their anti-inflammatory and cardiovascular activities. The average LD50 value >1000 mg kg(-1) of these compounds indicates their safety margin.
-
new diorganotin iv derivatives of 7 hydroxycoumarin Umbelliferone and their adducts with 1 10 phenanthroline
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005Co-Authors: Mala Nath, Ruchi Jairath, Xueqing Song, Ashok KumarAbstract:Abstract New diorganotin(IV) derivatives of the general formula R2Sn(Umb)2 (where R = n-Bu, n-Oct and Ph; Umb = Umbelliferone anion) have been synthesized either by the reaction of R2SnO with Umbelliferone under azeotropic removel of water or by the reaction of R2SnCl2 with sodium salt of Umbelliferone. Further, the adducts of the general formula R2Sn(Umb)2·phen (where R = n-Bu and n-Oct; phen = 1,10-phenanthroline) have also been synthesized by the interaction of R2Sn(Umb)2 with 1,10-phenanthroline. The bonding and coordination behavior in these derivatives are discussed on the basis of IR and 119Sn Mossbauer spectroscopic studies in solid state. Their coordination behavior in solution is discussed by the multinuclear (1H, 13C and 119Sn) NMR spectral studies. The Mossbauer and IR studies indicate that Umbelliferone acts as a monoanionic bidentate ligand in R2Sn(Umb)2 coordinating through O(7) and O(1). A distorted octahedral geometry around tin has been proposed for R2Sn(Umb)2 as well as for R2Sn(Umb)2·phen in solid state. The newly synthesized derivatives have been tested for their anti-inflammatory and cardiovascular activities. The average LD50 value >1000 mg kg−1 of these compounds indicates their safety margin.
-
triorganotin iv derivatives of Umbelliferone 7 hydroxycoumarin and their adducts with 1 10 phenanthroline synthesis structural and biological studies
Journal of Organometallic Chemistry, 2005Co-Authors: Mala Nath, Ruchi Jairath, Xueqing Song, Ashok KumarAbstract:Abstract New triorganotin(IV) derivatives of the general formula R3Sn(Umb) (where, R = Me, n-Bu and Ph; Umb = Umbelliferone anion) have been synthesized using sodium salt method. Further, the adducts of the general formula R3Sn(Umb) · phen (where R = Me and Ph; phen = 1,10-phenanthroline) have also been synthesized by the interaction of the triorganotin(IV) derivatives of Umbelliferone with 1,10-phenanthroline. The bonding and coordination behavior of these derivatives are discussed on the basis of IR, NMR (1H, 13C and 119Sn), and 119Sn Mossbauer spectroscopic studies. These investigations indicate that Umbelliferone acts as a monoanionic bidentate ligand in R3Sn(Umb) coordinating through O(7) and O(1) in the solid-state. These polymeric R3Sn(Umb) derivatives (where R = Me and n-Bu) have been proposed to have a trans-trigonal bipyramidal geometry with the three R groups in equatorial positions, while the axial positions are occupied by a phenolic oxygen and the O(1) atom from the adjacent molecule. A pseudotetrahedral geometry has been suggested for Ph3Sn(Umb). A distorted octahedral geometry around tin has been proposed for R3Sn(Umb) · phen, in which Umbelliferone anion acts as a monodentate ligand coordinating through phenolic oxygen O(7). The newly synthesized derivatives have been assayed for their anti-inflammatory, cardiovascular and anti-microbial activities. The average LD50 values >1000 mg kg−1 of these derivatives indicate their safety margin. Among all the compounds tested, Ph3Sn(Umb) · phen has been found to show potent anti-inflammatory activity with low mammalian toxicity and mild hypotensive activity.
Milena Botelho Pereira Soares - One of the best experts on this subject based on the ideXlab platform.
-
effects of Umbelliferone in a murine model of allergic airway inflammation
European Journal of Pharmacology, 2009Co-Authors: Juliana Fraga Vasconcelos, Mauro M Teixeira, Jose Maria Barbosafilho, Maria De Fatima Agra, Xirley Pereira Nunes, Ana Maria Giulietti, Ricardo Ribeirodossantos, Milena Botelho Pereira SoaresAbstract:The therapeutic effects of Umbelliferone (30, 60 and 90 mg/kg), a coumarin isolated from Typha domingensis (Typhaceae) were investigated in a mouse model of bronchial asthma. BALB/c mice were immunized and challenged by nasal administration of ovalbumin. Treatment with Umbelliferone (60 and 90 mg/kg) caused a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition, a decrease in mucus production and lung inflammation were observed in mice treated with Umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-gamma, was found in bronchoalveolar lavage fluids of mice treated with Umbelliferone, similar to that observed with dexamethasone. The levels of ovalbumin-specific IgE were not significantly altered after treatment with Umbelliferone. In conclusion, our results demonstrate that Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. The investigation of the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.
-
Pulmonary, Gastrointestinal and Urogenital Pharmacology Effects of Umbelliferone in a murine model of allergic airway inflammation
2009Co-Authors: Juliana Fraga Vasconcelos, Mauro M Teixeira, Maria De Fatima Agra, Xirley Pereira Nunes, Ana Maria Giulietti, José Maria Barbosa-filho, Ricardo Ribeiro-dos-santos, Milena Botelho Pereira SoaresAbstract:article i nfo The therapeutic effects of Umbelliferone (30, 60 and 90 mg/kg), a coumarin isolated from Typha domingensis (Typhaceae) were investigated in a mouse model of bronchial asthma. BALB/c mice were immunized and challenged by nasal administration of ovalbumin. Treatment with Umbelliferone (60 and 90 mg/kg) caused a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition,a decrease in mucus production andlung inflammationwere observed in mice treated with Umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-γ, was found in bronchoalveolar lavage fluids of mice treated with Umbelliferone, similar to that observed with dexamethasone. The levels of ovalbumin-specifi cI gE were not significantly altered after treatment with Umbelliferone. In conclusion, our results demonstrate that Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. The investigation of the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.
