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S Iu Mashina - One of the best experts on this subject based on the ideXlab platform.
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The role of preventing nitric oxide deficiency in the Antihypertensive Effect of adaptation to hypoxia
Izvestiia Akademii nauk. Seriia biologicheskaia, 2001Co-Authors: S Iu Mashina, B V Smirin, D A Pokidyshev, I Iu Malyshev, N P Liamina, V N Senchikin, Kh M Markov, E B ManukhinAbstract:Shortage of endothelial nitric oxide (NO) manifested as decreased daily urinary excretion of nitrate and nitrite as well as attenuated endothelium-dependent relaxation of conduit and resistance vessels progresses with age-related increase of blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Simultaneous NO-dependent suppression of vascular contractions is, apparently, due to the inducible NO synthase activity in vascular smooth muscle specific for spontaneously hypertensive rat. Adaptation of rats to hypobaric hypoxia initiated at early hypertensive stage (at the age of 5-6 weeks) decelerates hypertension progress. The Antihypertensive Effect of the adaptation was accompanied by stimulation of endothelial NO synthesis and prevention of impaired NO-dependent response in isolated blood vessels. Nitric oxide stores were formed in the vascular wall of SHRSP and WKY rats at the same time. The obtained data indicate a significant role of correction of endothelial NO deficiency in the Antihypertensive Effect of adaptation to hypoxia.
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The role of preventing nitric oxide deficiency in the Antihypertensive Effect of adaptation to hypoxia
Biology Bulletin of the Russian Academy of Sciences, 2001Co-Authors: S Iu Mashina, D A Pokidyshev, Kh M Markov, I. Yu. Malyshev, N P Lyamina, Eugenia B. ManukhinaAbstract:Shortage of endothelial nitric oxide (NO) manifested as decreased daily urinary excretion of nitrate and nitrite as well as attenuated endothelium-dependent relaxation of conduit and resistance vessels progresses with age-related increase of blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Simultaneous NO-dependent suppression of vascular contractions is, apparently, due to the inducible NO synthase activity in vascular smooth muscle specific for spontaneously hypertensive rat. The adaptation of rats to hypobaric hypoxia initiated at early hypertensive stage (at the age of 5–6 weeks) decelerates hypertension progress. The Antihypertensive Effect of the adaptation was accompanied by stimulation of endothelial NO synthesis and prevention of impaired NO-dependent response in isolated blood vessels. Nitric oxide stores were formed in the vascular wall of SHRSP and WKY rats at the same time. The obtained data indicate that the correction of endothelial NO deficiency plays a significant role in the Antihypertensive Effect of adaptation to hypoxia.
A. D. Deev - One of the best experts on this subject based on the ideXlab platform.
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ASSESSMENT OF AMLODIPINE Antihypertensive Effect HOMOGENEITY IN CONTROLLED TRIAL
Rational Pharmacotherapy in Cardiology, 2009Co-Authors: V. M. Gorbunov, M. I. Smirnova, A. D. DeevAbstract:Aim. To compare influence of amlodipine and spirapril on ambulatory blood pressure profile, including Antihypertensive Effect smoothness in patients with arterial hypertension (HT). Methods. 39 patients (aged 53,7±10,0 y.o.) with HT were included in the open, randomized, cross-over study, 30 patients completed study. The duration of every therapies was 4 weeks, initial control period and wash-out period between therapies lasted 1 week. The initial daily dose of amlodipine was 5 mg, standard dose of spirapril (6 mg/daily) was not changed during the trial. After 1-2 weeks of treatment amlodipine dose was increased up to 10 mg/daily as well as dihydrochlorothiazide was added, if necessary. Ambulatory blood pressure monitoring (ABPM) was performed initially and at the end of both therapies. Results. Both drugs demonstrated good Antihypertensive Effect according to ABPM data. Decrease of systolic/diastolic blood pressure was 11,2±1,8/7,6±1,2 mm Hg in amlodipine therapy and 10,0±1,8/7,1±1,2 in spirapril therapy (p
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ESTIMATION OF Antihypertensive Effect EQUABILITY FOR TWO PRESENTATIONS OF NIFEDIPINE WITH DAILY BLOOD PRESSURE MONITORING
Rational Pharmacotherapy in Cardiology, 2005Co-Authors: V. M. Gorbunov, E. V. Alimova, A. D. DeevAbstract:Aim. To compare information value of Antihypertensive Effect equability parameters for two drug formulations of nifedipine: long-acting one (nifedipine-XL) and short-acting one (nifedipine-sa). Material and methods. 147 patients with arterial hypertension (age 53,8±12,5 years) were included into multicenter, cross over design study. Duration of wash-out period was 2 weeks; duration of each treatment course – 4 weeks; interval between courses – 1 week. The following doses of drugs were used: nifedipine-XL – 30-60 mg once daily, nifedipine-sa – 10-20 mg three times a day. Daily blood pressure monitoring (DBPM – Schiller BR-102) was made initially, at the end of each treatment course and at the end of interval between courses. To assess the equability of drug Antihypertensive Effect “smoothness index” (SI) and coefficient trough Effect/peak Effect were used (COTP). Information value of these indexes (treatment vs. initial) was assessed by the logical regress analysis. Results. Nifedipine-XL and nifedipine-sa had significant Antihypertensive Effect according to DBPM data and clinical measurements. Equability of both drugs was similar. χ2 Wald range was 14,7-18,7 (p
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Evaluation of the evenness of the Antihypertensive Effect of losartan and captopril by using a 24-hour monitoring of arterial pressure
Terapevticheskii arkhiv, 2001Co-Authors: L V Savina, A. D. DeevAbstract:AIM: To investigate 24-h evenness of an Antihypertensive Effect of angiotensin II receptor blocker losartan vs captopril by four parameters of arterial pressure (AP) monitoring. MATERIAL AND METHODS: An open, cross-over, placebo-controlled trial was made in 22 patients with mild/moderate arterial hypertension (AH). Four parameters of AP monitoring were assessed: TPR, SI, rate of AP morning rise, index of AP morning rise. RESULTS: In losartan treatment TPR for systolic and diastolic AP were 61.5 and 61.3%, respectively, IS made up 0.74 +/- 0.13 and 0.64 +/- 0.09, respectively. For captopril these values reached 21.2 and 26.9%, 0.51 +/- 0.14 and 0.47 +/- 0.10, respectively. Differences by SI between the two drugs were statistically insignificant. Both drugs did not raise the rate and index of AP morning rise significantly. CONCLUSION: When administered in a single daily dose 100 mg, losartan produced a regular Antihypertensive Effect throughout 24 hours. Captopril (twice a day in a dose 50 mg) Effect was not regular enough. This means that some patients need a three-times-a day regimen of captopril. Of the four parameters, SI is most informative for evaluation of Antihypertensive Effect evenness.
E B Manukhin - One of the best experts on this subject based on the ideXlab platform.
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The role of preventing nitric oxide deficiency in the Antihypertensive Effect of adaptation to hypoxia
Izvestiia Akademii nauk. Seriia biologicheskaia, 2001Co-Authors: S Iu Mashina, B V Smirin, D A Pokidyshev, I Iu Malyshev, N P Liamina, V N Senchikin, Kh M Markov, E B ManukhinAbstract:Shortage of endothelial nitric oxide (NO) manifested as decreased daily urinary excretion of nitrate and nitrite as well as attenuated endothelium-dependent relaxation of conduit and resistance vessels progresses with age-related increase of blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Simultaneous NO-dependent suppression of vascular contractions is, apparently, due to the inducible NO synthase activity in vascular smooth muscle specific for spontaneously hypertensive rat. Adaptation of rats to hypobaric hypoxia initiated at early hypertensive stage (at the age of 5-6 weeks) decelerates hypertension progress. The Antihypertensive Effect of the adaptation was accompanied by stimulation of endothelial NO synthesis and prevention of impaired NO-dependent response in isolated blood vessels. Nitric oxide stores were formed in the vascular wall of SHRSP and WKY rats at the same time. The obtained data indicate a significant role of correction of endothelial NO deficiency in the Antihypertensive Effect of adaptation to hypoxia.
Eugenia B. Manukhina - One of the best experts on this subject based on the ideXlab platform.
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The role of preventing nitric oxide deficiency in the Antihypertensive Effect of adaptation to hypoxia
Biology Bulletin of the Russian Academy of Sciences, 2001Co-Authors: S Iu Mashina, D A Pokidyshev, Kh M Markov, I. Yu. Malyshev, N P Lyamina, Eugenia B. ManukhinaAbstract:Shortage of endothelial nitric oxide (NO) manifested as decreased daily urinary excretion of nitrate and nitrite as well as attenuated endothelium-dependent relaxation of conduit and resistance vessels progresses with age-related increase of blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Simultaneous NO-dependent suppression of vascular contractions is, apparently, due to the inducible NO synthase activity in vascular smooth muscle specific for spontaneously hypertensive rat. The adaptation of rats to hypobaric hypoxia initiated at early hypertensive stage (at the age of 5–6 weeks) decelerates hypertension progress. The Antihypertensive Effect of the adaptation was accompanied by stimulation of endothelial NO synthesis and prevention of impaired NO-dependent response in isolated blood vessels. Nitric oxide stores were formed in the vascular wall of SHRSP and WKY rats at the same time. The obtained data indicate that the correction of endothelial NO deficiency plays a significant role in the Antihypertensive Effect of adaptation to hypoxia.
Hans Ibsen - One of the best experts on this subject based on the ideXlab platform.
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The Antihypertensive Effect of fermented milk in individuals with prehypertension or borderline hypertension
Journal of Human Hypertension, 2010Co-Authors: Lotte Usinger, Lars Thorbjørn Jensen, B Flambard, A Linneberg, Hans IbsenAbstract:Fermented milk (FM) with putative Antihypertensive Effect in humans could be an easy applicable lifestyle intervention against hypertension. The mode of action is supposed to be through active milk peptides, shown to possess in vitro ACE-inhibitory Effect. Blood pressure (BP) reductions upto 23 mm Hg have been reported in spontaneously hypertensive rats fed FM. Results from human studies of the Antihypertensive Effect are inconsistent. However, many studies suffer from methodological weaknesses, as insufficient blinding and the use of office BP measurements. We conducted a randomised, double-blind placebo-controlled study of the Antihypertensive Effect of Lactobacillus helveticus FM in 94 prehypertensive and borderline hypertensive subjects. The participants were randomised into three treatment groups with a daily intake of 150 ml of FM, 300 ml of FM or placebo (chemically acidified milk). The primary outcome was repeated 24-h ambulatory BP measurements. There were no statistically significant differences in the outcome between the groups (systolic BP (SBP), P =0.9; diastolic BP (DBP), P =0.2). However, the group receiving 300 ml FM had reduced BP across the 8-week period in several readings, which could be compatible with a minor Antihypertensive Effect. Heart rate and lipids remained unchanged between groups. Hence, our study does not support earlier studies measuring office BP-measurements, reporting Antihypertensive Effect of FM. Based on straight performed 24-h ambulatory BP measurements, milk fermented with Lactobacillus helveticus does not posses significant Antihypertensive Effect.
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The Antihypertensive Effect of fermented milk in individuals with prehypertension or borderline hypertension
Journal of Human Hypertension, 2010Co-Authors: Lotte Usinger, Lars Thorbjørn Jensen, B Flambard, A Linneberg, Hans IbsenAbstract:Fermented milk (FM) with putative Antihypertensive Effect in humans could be an easy applicable lifestyle intervention against hypertension. The mode of action is supposed to be through active milk peptides, shown to possess in vitro ACE-inhibitory Effect. Blood pressure (BP) reductions upto 23 mm Hg have been reported in spontaneously hypertensive rats fed FM. Results from human studies of the Antihypertensive Effect are inconsistent. However, many studies suffer from methodological weaknesses, as insufficient blinding and the use of office BP measurements. We conducted a randomised, double-blind placebo-controlled study of the Antihypertensive Effect of Lactobacillus helveticus FM in 94 prehypertensive and borderline hypertensive subjects. The participants were randomised into three treatment groups with a daily intake of 150 ml of FM, 300 ml of FM or placebo (chemically acidified milk). The primary outcome was repeated 24-h ambulatory BP measurements. There were no statistically significant differences in the outcome between the groups (systolic BP (SBP), P=0.9; diastolic BP (DBP), P=0.2). However, the group receiving 300 ml FM had reduced BP across the 8-week period in several readings, which could be compatible with a minor Antihypertensive Effect. Heart rate and lipids remained unchanged between groups. Hence, our study does not support earlier studies measuring office BP-measurements, reporting Antihypertensive Effect of FM. Based on straight performed 24-h ambulatory BP measurements, milk fermented with Lactobacillus helveticus does not posses significant Antihypertensive Effect.
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Does fermented milk possess Antihypertensive Effect in humans
Journal of Hypertension, 2009Co-Authors: Lotte Usinger, Hans Ibsen, Lars Thorbjørn JensenAbstract:The putative Antihypertensive Effect of milk after fermentation by lactic bacteria has attracted attention over the past 20 years. Research on fermented milk and hypertension has mainly focused on the content of peptides with in-vitro angiotensin converting enzyme-inhibitor Effect. However, fermented milk products contain several proteins, peptides and minerals, all with possible different Antihypertensive modes of actions. The burden of cardiovascular events in industrialized countries caused by hypertension is considerable. Diet modifications are one way to lower blood pressure, and fermented milk could be a feasible way. In this review, interventional human studies of the possible Antihypertensive Effect of fermented milk are evaluated. The results are diverging, and the Antihypertensive Effect is still debatable. Additionally, present knowledge of bioavailability and in-vivo actions of the peptides in fermented milk are discussed.