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S Iu Mashina – One of the best experts on this subject based on the ideXlab platform.

  • The role of preventing nitric oxide deficiency in the Antihypertensive Effect of adaptation to hypoxia
    Izvestiia Akademii nauk. Seriia biologicheskaia, 2001
    Co-Authors: S Iu Mashina, B V Smirin, D A Pokidyshev, I Iu Malyshev, N P Liamina, V N Senchikin, Kh M Markov, E B Manukhin

    Abstract:

    Shortage of endothelial nitric oxide (NO) manifested as decreased daily urinary excretion of nitrate and nitrite as well as attenuated endothelium-dependent relaxation of conduit and resistance vessels progresses with age-related increase of blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Simultaneous NO-dependent suppression of vascular contractions is, apparently, due to the inducible NO synthase activity in vascular smooth muscle specific for spontaneously hypertensive rat. Adaptation of rats to hypobaric hypoxia initiated at early hypertensive stage (at the age of 5-6 weeks) decelerates hypertension progress. The Antihypertensive Effect of the adaptation was accompanied by stimulation of endothelial NO synthesis and prevention of impaired NO-dependent response in isolated blood vessels. Nitric oxide stores were formed in the vascular wall of SHRSP and WKY rats at the same time. The obtained data indicate a significant role of correction of endothelial NO deficiency in the Antihypertensive Effect of adaptation to hypoxia.

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  • The role of preventing nitric oxide deficiency in the Antihypertensive Effect of adaptation to hypoxia
    Biology Bulletin of the Russian Academy of Sciences, 2001
    Co-Authors: S Iu Mashina, D A Pokidyshev, Kh M Markov, I. Yu. Malyshev, N P Lyamina, Eugenia B. Manukhina

    Abstract:

    Shortage of endothelial nitric oxide (NO) manifested as decreased daily urinary excretion of nitrate and nitrite as well as attenuated endothelium-dependent relaxation of conduit and resistance vessels progresses with age-related increase of blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Simultaneous NO-dependent suppression of vascular contractions is, apparently, due to the inducible NO synthase activity in vascular smooth muscle specific for spontaneously hypertensive rat. The adaptation of rats to hypobaric hypoxia initiated at early hypertensive stage (at the age of 5–6 weeks) decelerates hypertension progress. The Antihypertensive Effect of the adaptation was accompanied by stimulation of endothelial NO synthesis and prevention of impaired NO-dependent response in isolated blood vessels. Nitric oxide stores were formed in the vascular wall of SHRSP and WKY rats at the same time. The obtained data indicate that the correction of endothelial NO deficiency plays a significant role in the Antihypertensive Effect of adaptation to hypoxia.

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A. D. Deev – One of the best experts on this subject based on the ideXlab platform.

  • ASSESSMENT OF AMLODIPINE Antihypertensive Effect HOMOGENEITY IN CONTROLLED TRIAL
    Rational Pharmacotherapy in Cardiology, 2009
    Co-Authors: V. M. Gorbunov, M. I. Smirnova, A. D. Deev

    Abstract:

    Aim. To compare influence of amlodipine and spirapril on ambulatory blood pressure profile, including Antihypertensive Effect smoothness in patients with arterial hypertension (HT). Methods. 39 patients (aged 53,7±10,0 y.o.) with HT were included in the open, randomized, cross-over study, 30 patients completed study. The duration of every therapies was 4 weeks, initial control period and wash-out period between therapies lasted 1 week. The initial daily dose of amlodipine was 5 mg, standard dose of spirapril (6 mg/daily) was not changed during the trial. After 1-2 weeks of treatment amlodipine dose was increased up to 10 mg/daily as well as dihydrochlorothiazide was added, if necessary. Ambulatory blood pressure monitoring (ABPM) was performed initially and at the end of both therapies. Results. Both drugs demonstrated good Antihypertensive Effect according to ABPM data. Decrease of systolic/diastolic blood pressure was 11,2±1,8/7,6±1,2 mm Hg in amlodipine therapy and 10,0±1,8/7,1±1,2 in spirapril therapy (p

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  • ESTIMATION OF Antihypertensive Effect EQUABILITY FOR TWO PRESENTATIONS OF NIFEDIPINE WITH DAILY BLOOD PRESSURE MONITORING
    Rational Pharmacotherapy in Cardiology, 2005
    Co-Authors: V. M. Gorbunov, E. V. Alimova, A. D. Deev

    Abstract:

    Aim. To compare information value of Antihypertensive Effect equability parameters for two drug formulations of nifedipine: long-acting one (nifedipine-XL) and short-acting one (nifedipine-sa). Material and methods. 147 patients with arterial hypertension (age 53,8±12,5 years) were included into multicenter, cross over design study. Duration of wash-out period was 2 weeks; duration of each treatment course – 4 weeks; interval between courses – 1 week. The following doses of drugs were used: nifedipine-XL – 30-60 mg once daily, nifedipine-sa – 10-20 mg three times a day. Daily blood pressure monitoring (DBPM – Schiller BR-102) was made initially, at the end of each treatment course and at the end of interval between courses. To assess the equability of drug Antihypertensive Effect “smoothness index” (SI) and coefficient trough Effect/peak Effect were used (COTP). Information value of these indexes (treatment vs. initial) was assessed by the logical regress analysis. Results. Nifedipine-XL and nifedipine-sa had significant Antihypertensive Effect according to DBPM data and clinical measurements. Equability of both drugs was similar. χ2 Wald range was 14,7-18,7 (p

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  • Evaluation of the evenness of the Antihypertensive Effect of losartan and captopril by using a 24-hour monitoring of arterial pressure
    Terapevticheskii arkhiv, 2001
    Co-Authors: L V Savina, A. D. Deev

    Abstract:

    AIM: To investigate 24-h evenness of an Antihypertensive Effect of angiotensin II receptor blocker losartan vs captopril by four parameters of arterial pressure (AP) monitoring. MATERIAL AND METHODS: An open, cross-over, placebo-controlled trial was made in 22 patients with mild/moderate arterial hypertension (AH). Four parameters of AP monitoring were assessed: TPR, SI, rate of AP morning rise, index of AP morning rise. RESULTS: In losartan treatment TPR for systolic and diastolic AP were 61.5 and 61.3%, respectively, IS made up 0.74 +/- 0.13 and 0.64 +/- 0.09, respectively. For captopril these values reached 21.2 and 26.9%, 0.51 +/- 0.14 and 0.47 +/- 0.10, respectively. Differences by SI between the two drugs were statistically insignificant. Both drugs did not raise the rate and index of AP morning rise significantly. CONCLUSION: When administered in a single daily dose 100 mg, losartan produced a regular Antihypertensive Effect throughout 24 hours. Captopril (twice a day in a dose 50 mg) Effect was not regular enough. This means that some patients need a three-times-a day regimen of captopril. Of the four parameters, SI is most informative for evaluation of Antihypertensive Effect evenness.

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E B Manukhin – One of the best experts on this subject based on the ideXlab platform.

  • The role of preventing nitric oxide deficiency in the Antihypertensive Effect of adaptation to hypoxia
    Izvestiia Akademii nauk. Seriia biologicheskaia, 2001
    Co-Authors: S Iu Mashina, B V Smirin, D A Pokidyshev, I Iu Malyshev, N P Liamina, V N Senchikin, Kh M Markov, E B Manukhin

    Abstract:

    Shortage of endothelial nitric oxide (NO) manifested as decreased daily urinary excretion of nitrate and nitrite as well as attenuated endothelium-dependent relaxation of conduit and resistance vessels progresses with age-related increase of blood pressure (BP) in stroke-prone spontaneously hypertensive rats (SHRSP). Simultaneous NO-dependent suppression of vascular contractions is, apparently, due to the inducible NO synthase activity in vascular smooth muscle specific for spontaneously hypertensive rat. Adaptation of rats to hypobaric hypoxia initiated at early hypertensive stage (at the age of 5-6 weeks) decelerates hypertension progress. The Antihypertensive Effect of the adaptation was accompanied by stimulation of endothelial NO synthesis and prevention of impaired NO-dependent response in isolated blood vessels. Nitric oxide stores were formed in the vascular wall of SHRSP and WKY rats at the same time. The obtained data indicate a significant role of correction of endothelial NO deficiency in the Antihypertensive Effect of adaptation to hypoxia.

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