The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform

Clarissa Gerhauser - One of the best experts on this subject based on the ideXlab platform.

  • broad spectrum Antiinfective potential of xanthohumol from hop humulus lupulus l in comparison with activities of other hop constituents and xanthohumol metabolites
    Molecular Nutrition & Food Research, 2005
    Co-Authors: Clarissa Gerhauser
    Abstract:

    This review summarizes the capacity of xanthohumol (XN) in comparison with additional hop constituents and metabolites to act as an Antiinfective Agent against microorganisms including bacteria, viruses, fungi and malarial protozoa. XN was shown to inhibit the Gram-positive bacteria Staphylococcus aureus and Streptococcus mutans. Antiviral activity was demonstrated against bovine viral diarrhea virus, cytomegalovirus, herpes simplex virus type 1 and 2 and human immunodeficiency virus 1. Inhibition of two Trichophyton spp. was indicative of antifungal activity. Finally, XN potently inhibited the replication of Plasmodium falciparum, the causative Agent of malaria. This effect was linked to the inhibition of glutathione-mediated degradation and detoxification of haemin, a by-product of the parasitic digestion of haemoglobin. Overall, these activities further contribute to the broad spectrum of biological effects observed with XN.

  • broad spectrum anti infective potential of xanthohumol from hop humulus lupulus l in comparison with activities of other hop constituents and xanthohumol metabolites
    Molecular Nutrition & Food Research, 2005
    Co-Authors: Clarissa Gerhauser
    Abstract:

    This review summarizes the capacity of xanthohumol (XN) in comparison with additional hop constituents and metabolites to act as an Antiinfective Agent against microorganisms including bacteria, viruses, fungi and malarial protozoa. XN was shown to inhibit the Gram-positive bacteria Staphylococcus aureus and Streptococcus mutans. Antiviral activity was demonstrated against bovine viral diarrhea virus, cytomegalovirus, herpes simplex virus type 1 and 2 and human immunodeficiency virus 1. Inhibition of two Trichophyton spp. was indicative of antifungal activity. Finally, XN potently inhibited the replication of Plasmodium falciparum, the causative Agent of malaria. This effect was linked to the inhibition of glutathione-mediated degradation and detoxification of haemin, a by-product of the parasitic digestion of haemoglobin. Overall, these activities further contribute to the broad spectrum of biological effects observed with XN.

Wadih Arap - One of the best experts on this subject based on the ideXlab platform.

  • mechanism of action and initial evaluation of a membrane active all d enantiomer antimicrobial peptidomimetic
    Proceedings of the National Academy of Sciences of the United States of America, 2013
    Co-Authors: Danielle M Mcgrath, Magda E Barbu, Wouter H P Driessen, Todd M Lasco, Jeffrey J Tarrand, Pablo C Okhuysen, Dimitrios P Kontoyiannis, Richard L Sidman, Renata Pasqualini, Wadih Arap
    Abstract:

    Development of therapy against infections caused by antibiotic-resistant pathogens is a major unmet need in contemporary medicine. In previous work, our group chemically modified an antimicrobial peptidomimetic motif for targeted applications against cancer and obesity. Here, we show that the modified motif per se is resistant to proteolytic degradation and is a candidate Antiinfective Agent. We also show that the susceptibility of microorganisms to the drug is independent of bacterial growth phase. Moreover, this peptidomimetic selectively interferes with the integrity and function of the microbial surface lipid bilayer, data indicative that bacterial death results from membrane disruption followed by dissipation of membrane potential. Finally, we demonstrate two potential translational applications: use against biofilms and synergy with antibiotics in use. In summary, we introduce the mechanism of action and the initial evaluation of a prototype drug and a platform for the development of D-enantiomer antimicrobial peptidomimetics that target bacterial membranes of certain Gram-negative problem pathogens with promising translational applications.

James N Wemple - One of the best experts on this subject based on the ideXlab platform.

Danielle M Mcgrath - One of the best experts on this subject based on the ideXlab platform.

  • mechanism of action and initial evaluation of a membrane active all d enantiomer antimicrobial peptidomimetic
    Proceedings of the National Academy of Sciences of the United States of America, 2013
    Co-Authors: Danielle M Mcgrath, Magda E Barbu, Wouter H P Driessen, Todd M Lasco, Jeffrey J Tarrand, Pablo C Okhuysen, Dimitrios P Kontoyiannis, Richard L Sidman, Renata Pasqualini, Wadih Arap
    Abstract:

    Development of therapy against infections caused by antibiotic-resistant pathogens is a major unmet need in contemporary medicine. In previous work, our group chemically modified an antimicrobial peptidomimetic motif for targeted applications against cancer and obesity. Here, we show that the modified motif per se is resistant to proteolytic degradation and is a candidate Antiinfective Agent. We also show that the susceptibility of microorganisms to the drug is independent of bacterial growth phase. Moreover, this peptidomimetic selectively interferes with the integrity and function of the microbial surface lipid bilayer, data indicative that bacterial death results from membrane disruption followed by dissipation of membrane potential. Finally, we demonstrate two potential translational applications: use against biofilms and synergy with antibiotics in use. In summary, we introduce the mechanism of action and the initial evaluation of a prototype drug and a platform for the development of D-enantiomer antimicrobial peptidomimetics that target bacterial membranes of certain Gram-negative problem pathogens with promising translational applications.

Victor Fadij - One of the best experts on this subject based on the ideXlab platform.