The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform
Bret J Chisholm - One of the best experts on this subject based on the ideXlab platform.
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Antimicrobial activity of polysiloxane coatings containing quaternary ammonium functionalized polyhedral oligomeric silsesquioxane
Journal of Coatings Technology and Research, 2010Co-Authors: Partha Majumdar, Nathan Gubbins, Shane J Stafslien, Justin Daniels, Jie He, Alekhya Kallam, Bret J ChisholmAbstract:An array of quaternary ammonium functionalized-polyhedral oligomeric silsesquioxane (Q-POSS) compounds with different alkyl chain lengths and counter ions were synthesized using a two-step process. First, octasilane POSS was functionalized with dimethylamino groups by hydrosilylation with allyldimethylamine. Next, partial quaternization of the tertiaryamino-functional POSS was achieved using an alkyl halide to produce the Q-POSS. Alkyl chain length of the Q-POSS compounds varied from –C12H25 to –C18H37 and the counter ions varied between chlorine, bromine, and iodine. Moisture-cured polysiloxane coatings were prepared by dispersing Q-POSS molecules into a solution blend of silanol-terminated polydimethylsiloxane, methylacetoxysilane, and a catalyst. To evaluate the utility of the Q-POSS molecules as a broad-spectrum Antimicrobial Additive, the Antimicrobial activity of the coatings toward the Gram-negative bacterium, Escherichia coli, the Gram-positive bacterium, Staphylococcus aureus, and the opportunistic fungal pathogen, Candida albicans, was determined using an agar plating method. The results obtained showed that both the composition of the Q-POSS and the composition of the polysiloxane matrix affected Antimicrobial properties. Compositions were identified that inhibited the growth of all three microorganisms on the coating surface. Surface Raman spectroscopic analysis was performed on selected set of coatings to understand the relative concentration of Q-POSS molecules at the coating surface.
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synthesis and Antimicrobial activity of quaternary ammonium functionalized poss q poss and polysiloxane coatings containing q poss
Polymer, 2009Co-Authors: Partha Majumdar, Nathan Gubbins, Shane J Stafslien, Justin Daniels, Clayton J Thorson, Bret J ChisholmAbstract:An array of quaternary ammonium-functionalized POSS (Q-POSS) compounds were synthesized and their Antimicrobial properties toward the Gram-negative bacterium, Escherichia coli, and the Gram-positive bacterium, Staphylococcus aureus, determined in aqueous solution. Using Q-POSS compositions that exhibited broad spectrum Antimicrobial activity in solution, the utility of the Q-POSS compounds as an Antimicrobial Additive for polysiloxane coatings was determined. The results of the investigation showed that Q-POSSs possessing a relatively low extent of quaternization and longer alkyl chain lengths provided the highest Antimicrobial activity in solution. For polysiloxane coatings containing Q-POSS molecules as an Antimicrobial Additive, coating surface energy, surface morphology, and Antimicrobial properties were found to be strongly dependent on Q-POSS composition. Coatings based on Q-POSSs possessing the lowest extent of quaternization displayed Antimicrobial activity while analogous coatings produced using Q-POSSs possessing the highest extent of quaternization showed no Antimicrobial activity. The lack of Antimicrobial activity exhibited by coatings possessing Q-POSSs with a relatively high extent of quaternization was attributed to agglomeration of Q-POSS molecules through the formation of intermolecular interactions involving the quaternary ammonium moieties. Agglomeration would be expected to reduce diffusivity and inhibit interaction of the Q-POSS molecules with microbial cells.
Eleni Likotrafiti - One of the best experts on this subject based on the ideXlab platform.
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Oregano essential oil as an Antimicrobial Additive to detergent for hand washing and food contact surface cleaning.
Journal of Applied Microbiology, 2013Co-Authors: Jonathan Rhoades, K. Gialagkolidou, Maria Gogou, O. Mavridou, N. Blatsiotis, Christos Ritzoulis, Eleni LikotrafitiAbstract:AIMS: To investigate the potential use of oregano essential oil as an Antimicrobial agent in liquid soap for hand washing and for food contact surface cleaning. METHODS AND RESULTS: Oregano essential oil (O.E.O.) was emulsified in liquid detergent solution. This was challenge tested against a commercial Antimicrobial soap in hand washing trials using natural flora. Soap with O.E.O. was as effective as the commercial Antimicrobial soap at reducing aerobic plate count on the hands and more effective than plain soap with no Additives. Cloths wetted with soap with O.E.O. were used to clean three different surfaces contaminated with four bacterial pathogens. For three of the four pathogens, the addition of 0·5% v/v O.E.O. to the soap solution enhanced cleaning performance and also reduced bacterial survival on the cloth after cleaning. CONCLUSIONS: Oregano essential oil (0·5%) is effective as an Antimicrobial Additive to detergent solutions for hand washing and surface cleaning. SIGNIFICANCE AND IMPACT OF STUDY: This preliminary study has shown that oregano essential oil is a potential alternative to Antimicrobials used in various detergents, such as chloroxylenol and triclosan, which can have adverse environmental and health effects. Further development could lead to a commercial product.
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Oregano essential oil as an Antimicrobial Additive to detergent for hand washing and food contact surface cleaning.
Journal of Applied Microbiology, 2013Co-Authors: Jonathan Rhoades, K. Gialagkolidou, Maria Gogou, O. Mavridou, N. Blatsiotis, Christos Ritzoulis, Eleni LikotrafitiAbstract:AIMS: To investigate the potential use of oregano essential oil as an Antimicrobial agent in liquid soap for hand washing and for food contact surface cleaning. METHODS AND RESULTS: Oregano essential oil (O.E.O.) was emulsified in liquid detergent solution. This was challenge tested against a commercial Antimicrobial soap in hand washing trials using natural flora. Soap with O.E.O. was as effective as the commercial Antimicrobial soap at reducing aerobic plate count on the hands and more effective than plain soap with no Additives. Cloths wetted with soap with O.E.O. were used to clean three different surfaces contaminated with four bacterial pathogens. For three of the four pathogens, the addition of 0·5% v/v O.E.O. to the soap solution enhanced cleaning performance and also reduced bacterial survival on the cloth after cleaning. CONCLUSIONS: Oregano essential oil (0·5%) is effective as an Antimicrobial Additive to detergent solutions for hand washing and surface cleaning. SIGNIFICANCE AND IMPACT OF STUDY: This preliminary study has shown that oregano essential oil is a potential alternative to Antimicrobials used in various detergents, such as chloroxylenol and triclosan, which can have adverse environmental and health effects. Further development could lead to a commercial product.
Partha Majumdar - One of the best experts on this subject based on the ideXlab platform.
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Antimicrobial activity of polysiloxane coatings containing quaternary ammonium functionalized polyhedral oligomeric silsesquioxane
Journal of Coatings Technology and Research, 2010Co-Authors: Partha Majumdar, Nathan Gubbins, Shane J Stafslien, Justin Daniels, Jie He, Alekhya Kallam, Bret J ChisholmAbstract:An array of quaternary ammonium functionalized-polyhedral oligomeric silsesquioxane (Q-POSS) compounds with different alkyl chain lengths and counter ions were synthesized using a two-step process. First, octasilane POSS was functionalized with dimethylamino groups by hydrosilylation with allyldimethylamine. Next, partial quaternization of the tertiaryamino-functional POSS was achieved using an alkyl halide to produce the Q-POSS. Alkyl chain length of the Q-POSS compounds varied from –C12H25 to –C18H37 and the counter ions varied between chlorine, bromine, and iodine. Moisture-cured polysiloxane coatings were prepared by dispersing Q-POSS molecules into a solution blend of silanol-terminated polydimethylsiloxane, methylacetoxysilane, and a catalyst. To evaluate the utility of the Q-POSS molecules as a broad-spectrum Antimicrobial Additive, the Antimicrobial activity of the coatings toward the Gram-negative bacterium, Escherichia coli, the Gram-positive bacterium, Staphylococcus aureus, and the opportunistic fungal pathogen, Candida albicans, was determined using an agar plating method. The results obtained showed that both the composition of the Q-POSS and the composition of the polysiloxane matrix affected Antimicrobial properties. Compositions were identified that inhibited the growth of all three microorganisms on the coating surface. Surface Raman spectroscopic analysis was performed on selected set of coatings to understand the relative concentration of Q-POSS molecules at the coating surface.
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synthesis and Antimicrobial activity of quaternary ammonium functionalized poss q poss and polysiloxane coatings containing q poss
Polymer, 2009Co-Authors: Partha Majumdar, Nathan Gubbins, Shane J Stafslien, Justin Daniels, Clayton J Thorson, Bret J ChisholmAbstract:An array of quaternary ammonium-functionalized POSS (Q-POSS) compounds were synthesized and their Antimicrobial properties toward the Gram-negative bacterium, Escherichia coli, and the Gram-positive bacterium, Staphylococcus aureus, determined in aqueous solution. Using Q-POSS compositions that exhibited broad spectrum Antimicrobial activity in solution, the utility of the Q-POSS compounds as an Antimicrobial Additive for polysiloxane coatings was determined. The results of the investigation showed that Q-POSSs possessing a relatively low extent of quaternization and longer alkyl chain lengths provided the highest Antimicrobial activity in solution. For polysiloxane coatings containing Q-POSS molecules as an Antimicrobial Additive, coating surface energy, surface morphology, and Antimicrobial properties were found to be strongly dependent on Q-POSS composition. Coatings based on Q-POSSs possessing the lowest extent of quaternization displayed Antimicrobial activity while analogous coatings produced using Q-POSSs possessing the highest extent of quaternization showed no Antimicrobial activity. The lack of Antimicrobial activity exhibited by coatings possessing Q-POSSs with a relatively high extent of quaternization was attributed to agglomeration of Q-POSS molecules through the formation of intermolecular interactions involving the quaternary ammonium moieties. Agglomeration would be expected to reduce diffusivity and inhibit interaction of the Q-POSS molecules with microbial cells.
Erin K. Lipp - One of the best experts on this subject based on the ideXlab platform.
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Patterns of triclosan resistance in Vibrionaceae.
PeerJ, 2018Co-Authors: Keri A. Lydon, Megan J Robertson, Erin K. LippAbstract:The Antimicrobial Additive triclosan has been used in personal care products widely across the globe for decades. Triclosan resistance has been noted among Vibrio spp., but reports have been anecdotal and the extent of phenotypic triclosan resistance across the Vibrionaceae family has not been established. Here, triclosan resistance was determined for Vibrionaceae strains across nine distinct clades. Minimum inhibitory concentrations (MIC) were determined for 70 isolates from clinical (n = 6) and environmental sources (n = 64); only two were susceptible to triclosan. The mean MIC for all resistant Vibrionaceae was 53 µg mL-1 (range 3.1-550 µg mL-1), but was significantly different between clades (p
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patterns of triclosan resistance in vibrionaceae
PeerJ, 2018Co-Authors: Keri A. Lydon, Megan J Robertson, Erin K. LippAbstract:The Antimicrobial Additive triclosan has been used in personal care products widely across the globe for decades. Triclosan resistance has been noted among Vibrio spp., but reports have been anecdotal and the extent of phenotypic triclosan resistance across the Vibrionaceae family has not been established. Here, triclosan resistance was determined for Vibrionaceae strains across nine distinct clades. Minimum inhibitory concentrations (MIC) were determined for 70 isolates from clinical (n = 6) and environmental sources (n = 64); only two were susceptible to triclosan. The mean MIC for all resistant Vibrionaceae was 53 µg mL-1 (range 3.1-550 µg mL-1), but was significantly different between clades (p < 0.001). The highest mean triclosan MIC was observed in the Splendidus clade (200 µg mL-1; n = 3). Triclosan mean MICs were 68.8 µg mL-1 in the Damselae clade and 45.3 µg mL-1 in the Harveyi clade. The lowest mean MIC was observed in the Cholerae clade with 14.4 µg mL-1, which was primarily represented by clinical strains. There were no significant differences in triclosan MIC among individual species or among environmental strains isolated from different locations. Overall, phenotypic triclosan resistance appears to be widespread across multiple clades of Vibrionaceae.
Jonathan Rhoades - One of the best experts on this subject based on the ideXlab platform.
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Oregano essential oil as an Antimicrobial Additive to detergent for hand washing and food contact surface cleaning.
Journal of Applied Microbiology, 2013Co-Authors: Jonathan Rhoades, K. Gialagkolidou, Maria Gogou, O. Mavridou, N. Blatsiotis, Christos Ritzoulis, Eleni LikotrafitiAbstract:AIMS: To investigate the potential use of oregano essential oil as an Antimicrobial agent in liquid soap for hand washing and for food contact surface cleaning. METHODS AND RESULTS: Oregano essential oil (O.E.O.) was emulsified in liquid detergent solution. This was challenge tested against a commercial Antimicrobial soap in hand washing trials using natural flora. Soap with O.E.O. was as effective as the commercial Antimicrobial soap at reducing aerobic plate count on the hands and more effective than plain soap with no Additives. Cloths wetted with soap with O.E.O. were used to clean three different surfaces contaminated with four bacterial pathogens. For three of the four pathogens, the addition of 0·5% v/v O.E.O. to the soap solution enhanced cleaning performance and also reduced bacterial survival on the cloth after cleaning. CONCLUSIONS: Oregano essential oil (0·5%) is effective as an Antimicrobial Additive to detergent solutions for hand washing and surface cleaning. SIGNIFICANCE AND IMPACT OF STUDY: This preliminary study has shown that oregano essential oil is a potential alternative to Antimicrobials used in various detergents, such as chloroxylenol and triclosan, which can have adverse environmental and health effects. Further development could lead to a commercial product.
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Oregano essential oil as an Antimicrobial Additive to detergent for hand washing and food contact surface cleaning.
Journal of Applied Microbiology, 2013Co-Authors: Jonathan Rhoades, K. Gialagkolidou, Maria Gogou, O. Mavridou, N. Blatsiotis, Christos Ritzoulis, Eleni LikotrafitiAbstract:AIMS: To investigate the potential use of oregano essential oil as an Antimicrobial agent in liquid soap for hand washing and for food contact surface cleaning. METHODS AND RESULTS: Oregano essential oil (O.E.O.) was emulsified in liquid detergent solution. This was challenge tested against a commercial Antimicrobial soap in hand washing trials using natural flora. Soap with O.E.O. was as effective as the commercial Antimicrobial soap at reducing aerobic plate count on the hands and more effective than plain soap with no Additives. Cloths wetted with soap with O.E.O. were used to clean three different surfaces contaminated with four bacterial pathogens. For three of the four pathogens, the addition of 0·5% v/v O.E.O. to the soap solution enhanced cleaning performance and also reduced bacterial survival on the cloth after cleaning. CONCLUSIONS: Oregano essential oil (0·5%) is effective as an Antimicrobial Additive to detergent solutions for hand washing and surface cleaning. SIGNIFICANCE AND IMPACT OF STUDY: This preliminary study has shown that oregano essential oil is a potential alternative to Antimicrobials used in various detergents, such as chloroxylenol and triclosan, which can have adverse environmental and health effects. Further development could lead to a commercial product.