The Experts below are selected from a list of 140511 Experts worldwide ranked by ideXlab platform
Gautam Dantas - One of the best experts on this subject based on the ideXlab platform.
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Sequencing-based methods and resources to study Antimicrobial Resistance
Nature Reviews Genetics, 2019Co-Authors: Manish Boolchandani, Alaric W. D’souza, Gautam DantasAbstract:Antimicrobial Resistance extracts high morbidity, mortality and economic costs yearly by rendering bacteria immune to antibiotics. Identifying and understanding Antimicrobial Resistance are imperative for clinical practice to treat resistant infections and for public health efforts to limit the spread of Resistance. Technologies such as next-generation sequencing are expanding our abilities to detect and study Antimicrobial Resistance. This Review provides a detailed overview of Antimicrobial Resistance identification and characterization methods, from traditional Antimicrobial susceptibility testing to recent deep-learning methods. We focus on sequencing-based Resistance discovery and discuss tools and databases used in Antimicrobial Resistance studies.Next-generation sequencing has improved the identification and characterization of Antimicrobial Resistance. Focusing on sequence-based discovery of antibiotic Resistance genes, this Review discusses computational strategies and resources for Resistance gene identification in genomic and metagenomic samples, including recent deep-learning approaches.
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Sequencing-based methods and resources to study Antimicrobial Resistance.
Nature reviews. Genetics, 2019Co-Authors: Manish Boolchandani, Alaric W. D’souza, Gautam DantasAbstract:Antimicrobial Resistance extracts high morbidity, mortality and economic costs yearly by rendering bacteria immune to antibiotics. Identifying and understanding Antimicrobial Resistance are imperative for clinical practice to treat resistant infections and for public health efforts to limit the spread of Resistance. Technologies such as next-generation sequencing are expanding our abilities to detect and study Antimicrobial Resistance. This Review provides a detailed overview of Antimicrobial Resistance identification and characterization methods, from traditional Antimicrobial susceptibility testing to recent deep-learning methods. We focus on sequencing-based Resistance discovery and discuss tools and databases used in Antimicrobial Resistance studies.
Manish Boolchandani - One of the best experts on this subject based on the ideXlab platform.
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Sequencing-based methods and resources to study Antimicrobial Resistance
Nature Reviews Genetics, 2019Co-Authors: Manish Boolchandani, Alaric W. D’souza, Gautam DantasAbstract:Antimicrobial Resistance extracts high morbidity, mortality and economic costs yearly by rendering bacteria immune to antibiotics. Identifying and understanding Antimicrobial Resistance are imperative for clinical practice to treat resistant infections and for public health efforts to limit the spread of Resistance. Technologies such as next-generation sequencing are expanding our abilities to detect and study Antimicrobial Resistance. This Review provides a detailed overview of Antimicrobial Resistance identification and characterization methods, from traditional Antimicrobial susceptibility testing to recent deep-learning methods. We focus on sequencing-based Resistance discovery and discuss tools and databases used in Antimicrobial Resistance studies.Next-generation sequencing has improved the identification and characterization of Antimicrobial Resistance. Focusing on sequence-based discovery of antibiotic Resistance genes, this Review discusses computational strategies and resources for Resistance gene identification in genomic and metagenomic samples, including recent deep-learning approaches.
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Sequencing-based methods and resources to study Antimicrobial Resistance.
Nature reviews. Genetics, 2019Co-Authors: Manish Boolchandani, Alaric W. D’souza, Gautam DantasAbstract:Antimicrobial Resistance extracts high morbidity, mortality and economic costs yearly by rendering bacteria immune to antibiotics. Identifying and understanding Antimicrobial Resistance are imperative for clinical practice to treat resistant infections and for public health efforts to limit the spread of Resistance. Technologies such as next-generation sequencing are expanding our abilities to detect and study Antimicrobial Resistance. This Review provides a detailed overview of Antimicrobial Resistance identification and characterization methods, from traditional Antimicrobial susceptibility testing to recent deep-learning methods. We focus on sequencing-based Resistance discovery and discuss tools and databases used in Antimicrobial Resistance studies.
Diane Ashiru-oredope - One of the best experts on this subject based on the ideXlab platform.
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Antimicrobial Resistance and Stewardship in National Action Plans
Current Treatment Options in Infectious Diseases, 2016Co-Authors: Mohammed Sadak, Emma Cramp, Diane Ashiru-oredopeAbstract:Tackling Antimicrobial Resistance has global focus due to the significant threat Resistance poses to human and animal health and its potential impact on the global economy as a result of reduced productivity caused by sickness and higher treatment costs. Therefore, the importance of strengthening health systems ensuring Antimicrobial agents are used and accessed appropriately has never been more important. A potential solution to combating Antimicrobial Resistance globally is implementing comprehensive and sustainably resourced national plans based on a multi-sector approach. In May 2014, the World Health Organisation passed a resolution that reflects global agreement on the huge threat Antimicrobial Resistance poses to human health; this was followed by publication of a draft global action plan on which all national action plans being developed are expected to be based. The global action plan seeks to preserve and maintain the responsible and accessible use of Antimicrobials for all. The main strategic objectives focus on improving the understanding and awareness of Antimicrobial Resistance, strengthening knowledge via research and surveillance, reducing infection incidence, optimising the use of Antimicrobial treatments and countering Antimicrobial Resistance through sustainable investment. This paper seeks to explore the global adoption and implementation of national action plans and specifically the use of Antimicrobial stewardship (AMS) strategies to promote the optimal use of Antimicrobials.
Axel Cloeckaert - One of the best experts on this subject based on the ideXlab platform.
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Antimicrobial Resistance and Virulence Common Mechanisms - Antimicrobial Resistance and virulence common mechanisms (ebook)
Frontiers Research Topics, 2017Co-Authors: Etienne Giraud, Ivan Rychlik, Axel CloeckaertAbstract:Multiple relationships exist between Antimicrobial Resistance and bacterial virulence, and the spread of clones combining multiple antibiotic Resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired Resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both Resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between Antimicrobial Resistance and virulence in bacteria, and describe their potential therapeutic consequences.
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Editorial: Antimicrobial Resistance and virulence common mechanisms
Frontiers in Microbiology, 2017Co-Authors: Etienne Giraud, Ivan Rychlik, Axel CloeckaertAbstract:Editorial: Antimicrobial Resistance and virulence common mechanisms
Mohammed Sadak - One of the best experts on this subject based on the ideXlab platform.
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Antimicrobial Resistance and Stewardship in National Action Plans
Current Treatment Options in Infectious Diseases, 2016Co-Authors: Mohammed Sadak, Emma Cramp, Diane Ashiru-oredopeAbstract:Tackling Antimicrobial Resistance has global focus due to the significant threat Resistance poses to human and animal health and its potential impact on the global economy as a result of reduced productivity caused by sickness and higher treatment costs. Therefore, the importance of strengthening health systems ensuring Antimicrobial agents are used and accessed appropriately has never been more important. A potential solution to combating Antimicrobial Resistance globally is implementing comprehensive and sustainably resourced national plans based on a multi-sector approach. In May 2014, the World Health Organisation passed a resolution that reflects global agreement on the huge threat Antimicrobial Resistance poses to human health; this was followed by publication of a draft global action plan on which all national action plans being developed are expected to be based. The global action plan seeks to preserve and maintain the responsible and accessible use of Antimicrobials for all. The main strategic objectives focus on improving the understanding and awareness of Antimicrobial Resistance, strengthening knowledge via research and surveillance, reducing infection incidence, optimising the use of Antimicrobial treatments and countering Antimicrobial Resistance through sustainable investment. This paper seeks to explore the global adoption and implementation of national action plans and specifically the use of Antimicrobial stewardship (AMS) strategies to promote the optimal use of Antimicrobials.
