The Experts below are selected from a list of 3735 Experts worldwide ranked by ideXlab platform
Bonnie L Bassler - One of the best experts on this subject based on the ideXlab platform.
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bacterial quorum sensing its role in virulence and possibilities for its control
Cold Spring Harbor Perspectives in Medicine, 2012Co-Authors: Steven T Rutherford, Bonnie L BasslerAbstract:Quorum sensing is a process of cell–cell communication that allows bacteria to share information about cell density and adjust gene expression accordingly. This process enables bacteria to express energetically expensive processes as a collective only when the impact of those processes on the environment or on a host will be maximized. Among the many traits controlled by quorum sensing is the expression of virulence factors by pathogenic bacteria. Here we review the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae. We outline these canonical quorum-sensing mechanisms and how each uniquely controls virulence factor production. Additionally,weexaminerecenteffortstoinhibitquorumsensinginthesepathogenswiththe goal of designing novel Antimicrobial Therapeutics.
Amulya K. Panda - One of the best experts on this subject based on the ideXlab platform.
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Antimicrobial Therapeutics delivery systems based on biodegradable polylactide/polylactide-co-glycolide particles
Environmental Chemistry Letters, 2019Co-Authors: Robin Kumar, Divya Jha, Amulya K. PandaAbstract:Infectious diseases are globally associated with high mortality in spite of the availability of therapeutic agents against most pathogenic microorganisms. This is due to the emergence of new infectious diseases and novel pathogen strategies to evade host defenses. There is thus a need to develop potent Therapeutics and techniques for effective delivery of vaccines and drugs. Particles based on poly(lactic acid) and poly(lactic- co -glycolic acid) polymer-based particles are suitable delivery systems due to their biodegradable and biocompatible nature. They can be tailored to display various properties such as sustained release, dose sparing, bioactivity maintenance and targeted delivery. This review focuses on polymeric particle-based delivery systems to develop novel vaccines or drugs. Cellular interactions of particulate systems and the mechanism of action in animal models are also discussed.
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Antimicrobial Therapeutics delivery systems based on biodegradable polylactide polylactide co glycolide particles
Environmental Chemistry Letters, 2019Co-Authors: Robin Kumar, Divya Jha, Amulya K. PandaAbstract:Infectious diseases are globally associated with high mortality in spite of the availability of therapeutic agents against most pathogenic microorganisms. This is due to the emergence of new infectious diseases and novel pathogen strategies to evade host defenses. There is thus a need to develop potent Therapeutics and techniques for effective delivery of vaccines and drugs. Particles based on poly(lactic acid) and poly(lactic-co-glycolic acid) polymer-based particles are suitable delivery systems due to their biodegradable and biocompatible nature. They can be tailored to display various properties such as sustained release, dose sparing, bioactivity maintenance and targeted delivery. This review focuses on polymeric particle-based delivery systems to develop novel vaccines or drugs. Cellular interactions of particulate systems and the mechanism of action in animal models are also discussed.
Robin Kumar - One of the best experts on this subject based on the ideXlab platform.
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Antimicrobial Therapeutics delivery systems based on biodegradable polylactide/polylactide-co-glycolide particles
Environmental Chemistry Letters, 2019Co-Authors: Robin Kumar, Divya Jha, Amulya K. PandaAbstract:Infectious diseases are globally associated with high mortality in spite of the availability of therapeutic agents against most pathogenic microorganisms. This is due to the emergence of new infectious diseases and novel pathogen strategies to evade host defenses. There is thus a need to develop potent Therapeutics and techniques for effective delivery of vaccines and drugs. Particles based on poly(lactic acid) and poly(lactic- co -glycolic acid) polymer-based particles are suitable delivery systems due to their biodegradable and biocompatible nature. They can be tailored to display various properties such as sustained release, dose sparing, bioactivity maintenance and targeted delivery. This review focuses on polymeric particle-based delivery systems to develop novel vaccines or drugs. Cellular interactions of particulate systems and the mechanism of action in animal models are also discussed.
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Antimicrobial Therapeutics delivery systems based on biodegradable polylactide polylactide co glycolide particles
Environmental Chemistry Letters, 2019Co-Authors: Robin Kumar, Divya Jha, Amulya K. PandaAbstract:Infectious diseases are globally associated with high mortality in spite of the availability of therapeutic agents against most pathogenic microorganisms. This is due to the emergence of new infectious diseases and novel pathogen strategies to evade host defenses. There is thus a need to develop potent Therapeutics and techniques for effective delivery of vaccines and drugs. Particles based on poly(lactic acid) and poly(lactic-co-glycolic acid) polymer-based particles are suitable delivery systems due to their biodegradable and biocompatible nature. They can be tailored to display various properties such as sustained release, dose sparing, bioactivity maintenance and targeted delivery. This review focuses on polymeric particle-based delivery systems to develop novel vaccines or drugs. Cellular interactions of particulate systems and the mechanism of action in animal models are also discussed.
Divya Jha - One of the best experts on this subject based on the ideXlab platform.
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Antimicrobial Therapeutics delivery systems based on biodegradable polylactide/polylactide-co-glycolide particles
Environmental Chemistry Letters, 2019Co-Authors: Robin Kumar, Divya Jha, Amulya K. PandaAbstract:Infectious diseases are globally associated with high mortality in spite of the availability of therapeutic agents against most pathogenic microorganisms. This is due to the emergence of new infectious diseases and novel pathogen strategies to evade host defenses. There is thus a need to develop potent Therapeutics and techniques for effective delivery of vaccines and drugs. Particles based on poly(lactic acid) and poly(lactic- co -glycolic acid) polymer-based particles are suitable delivery systems due to their biodegradable and biocompatible nature. They can be tailored to display various properties such as sustained release, dose sparing, bioactivity maintenance and targeted delivery. This review focuses on polymeric particle-based delivery systems to develop novel vaccines or drugs. Cellular interactions of particulate systems and the mechanism of action in animal models are also discussed.
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Antimicrobial Therapeutics delivery systems based on biodegradable polylactide polylactide co glycolide particles
Environmental Chemistry Letters, 2019Co-Authors: Robin Kumar, Divya Jha, Amulya K. PandaAbstract:Infectious diseases are globally associated with high mortality in spite of the availability of therapeutic agents against most pathogenic microorganisms. This is due to the emergence of new infectious diseases and novel pathogen strategies to evade host defenses. There is thus a need to develop potent Therapeutics and techniques for effective delivery of vaccines and drugs. Particles based on poly(lactic acid) and poly(lactic-co-glycolic acid) polymer-based particles are suitable delivery systems due to their biodegradable and biocompatible nature. They can be tailored to display various properties such as sustained release, dose sparing, bioactivity maintenance and targeted delivery. This review focuses on polymeric particle-based delivery systems to develop novel vaccines or drugs. Cellular interactions of particulate systems and the mechanism of action in animal models are also discussed.
Robert Robinson - One of the best experts on this subject based on the ideXlab platform.
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Synthetic Polyketide Enzymology: Platform for Biosynthesis of Antimicrobial Polyketides
ACS Catalysis, 2015Co-Authors: Maybelle Kho Go, Jantana Wongsantichon, Vivian Wing Ngar Cheung, Jeng Yeong Chow, Robert RobinsonAbstract:Synthetic biology often employs enzymes in the biosynthesis of compounds for purposeful function. Here, we define synthetic enzymology as the application of enzymological principles in synthetic biology and describe its use as an enabling platform in synthetic biology for the purposeful production of compounds of biomedical and commercial importance. In particular, we demonstrated the use of synthetic polyketide enzymology as a means to develop lead polyketide based compounds for Antimicrobial Therapeutics, as exemplified by the modular coupling of acid:CoA ligases to type III polyketide synthases in the biosynthesis and development of polyketide-based biochemicals. Using wild-type and rationally designed mutants of a type III polyketide synthase isolated from Oryza sativa (OsPKS), we produced a chemically diverse library of novel polyketides and identified two bioactive Antimicrobials, 4-hydroxy-6-[(1E)-2-(4-hydroxyphenyl)ethenyl]-2H-pyran-2-one (bisnoryangonin) and 3,6,7-trihydroxy-2-(4-methoxybenzyl)-4...
