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Naohide Inoue - One of the best experts on this subject based on the ideXlab platform.

  • Testicular toxicity evaluation of two Antimony Compounds, Antimony trioxide and Antimony potassium tartrate, in rats and mice
    Environmental Health and Preventive Medicine, 2002
    Co-Authors: Minoru Omura, Akiyo Tanaka, Miyuki Hirata, Naohide Inoue
    Abstract:

    Objectives Testicular toxicities of Antimony Compounds were evaluated in rats and mice. The slightly water-soluble Antimony compound Antimony trioxide (ATO) and the highly water-soluble Antimony compound Antimony potassium tartrate (APT) were examined. Methods Daily doses of the Compounds were 27.4, 12.0 and 1,200 mg/kg body weight in the APT group, low-ATO group and high-ATO group, respectively. The corresponding daily doses of Antimony were 10, 10 and 1,000 mg/kg body weight, in the APT group, low-ATO group and high-ATO group, respectively. Both Compounds were administered by gavage: rats, 3 days per week for 4 weeks; mice, 5 days per week for 4 weeks. Results Neither compound reduced the weights of reproductive organs or accessory sex organs nor affected sperm parameters. Few marked histopathologic changes were found in the testes of the treated animals. Even at 1,200 mg/kg body weight, which is greater than the LD_50 of APT, ATO produced no effects. Conclusions In this study, it was found that ATO and APT are not toxic to testes in rodents.

  • Testicular toxicity evaluation of two Antimony Compounds, Antimony trioxide and Antimony potassium tartrate, in rats and mice.
    Environmental health and preventive medicine, 2002
    Co-Authors: Minoru Omura, Akiyo Tanaka, Miyuki Hirata, Naohide Inoue
    Abstract:

    Objectives Testicular toxicities of Antimony Compounds were evaluated in rats and mice. The slightly water-soluble Antimony compound Antimony trioxide (ATO) and the highly water-soluble Antimony compound Antimony potassium tartrate (APT) were examined.

Minoru Omura - One of the best experts on this subject based on the ideXlab platform.

  • Testicular toxicity evaluation of two Antimony Compounds, Antimony trioxide and Antimony potassium tartrate, in rats and mice
    Environmental Health and Preventive Medicine, 2002
    Co-Authors: Minoru Omura, Akiyo Tanaka, Miyuki Hirata, Naohide Inoue
    Abstract:

    Objectives Testicular toxicities of Antimony Compounds were evaluated in rats and mice. The slightly water-soluble Antimony compound Antimony trioxide (ATO) and the highly water-soluble Antimony compound Antimony potassium tartrate (APT) were examined. Methods Daily doses of the Compounds were 27.4, 12.0 and 1,200 mg/kg body weight in the APT group, low-ATO group and high-ATO group, respectively. The corresponding daily doses of Antimony were 10, 10 and 1,000 mg/kg body weight, in the APT group, low-ATO group and high-ATO group, respectively. Both Compounds were administered by gavage: rats, 3 days per week for 4 weeks; mice, 5 days per week for 4 weeks. Results Neither compound reduced the weights of reproductive organs or accessory sex organs nor affected sperm parameters. Few marked histopathologic changes were found in the testes of the treated animals. Even at 1,200 mg/kg body weight, which is greater than the LD_50 of APT, ATO produced no effects. Conclusions In this study, it was found that ATO and APT are not toxic to testes in rodents.

  • Testicular toxicity evaluation of two Antimony Compounds, Antimony trioxide and Antimony potassium tartrate, in rats and mice.
    Environmental health and preventive medicine, 2002
    Co-Authors: Minoru Omura, Akiyo Tanaka, Miyuki Hirata, Naohide Inoue
    Abstract:

    Objectives Testicular toxicities of Antimony Compounds were evaluated in rats and mice. The slightly water-soluble Antimony compound Antimony trioxide (ATO) and the highly water-soluble Antimony compound Antimony potassium tartrate (APT) were examined.

Akiyo Tanaka - One of the best experts on this subject based on the ideXlab platform.

  • Testicular toxicity evaluation of two Antimony Compounds, Antimony trioxide and Antimony potassium tartrate, in rats and mice
    Environmental Health and Preventive Medicine, 2002
    Co-Authors: Minoru Omura, Akiyo Tanaka, Miyuki Hirata, Naohide Inoue
    Abstract:

    Objectives Testicular toxicities of Antimony Compounds were evaluated in rats and mice. The slightly water-soluble Antimony compound Antimony trioxide (ATO) and the highly water-soluble Antimony compound Antimony potassium tartrate (APT) were examined. Methods Daily doses of the Compounds were 27.4, 12.0 and 1,200 mg/kg body weight in the APT group, low-ATO group and high-ATO group, respectively. The corresponding daily doses of Antimony were 10, 10 and 1,000 mg/kg body weight, in the APT group, low-ATO group and high-ATO group, respectively. Both Compounds were administered by gavage: rats, 3 days per week for 4 weeks; mice, 5 days per week for 4 weeks. Results Neither compound reduced the weights of reproductive organs or accessory sex organs nor affected sperm parameters. Few marked histopathologic changes were found in the testes of the treated animals. Even at 1,200 mg/kg body weight, which is greater than the LD_50 of APT, ATO produced no effects. Conclusions In this study, it was found that ATO and APT are not toxic to testes in rodents.

  • Testicular toxicity evaluation of two Antimony Compounds, Antimony trioxide and Antimony potassium tartrate, in rats and mice.
    Environmental health and preventive medicine, 2002
    Co-Authors: Minoru Omura, Akiyo Tanaka, Miyuki Hirata, Naohide Inoue
    Abstract:

    Objectives Testicular toxicities of Antimony Compounds were evaluated in rats and mice. The slightly water-soluble Antimony compound Antimony trioxide (ATO) and the highly water-soluble Antimony compound Antimony potassium tartrate (APT) were examined.

Miyuki Hirata - One of the best experts on this subject based on the ideXlab platform.

  • Testicular toxicity evaluation of two Antimony Compounds, Antimony trioxide and Antimony potassium tartrate, in rats and mice
    Environmental Health and Preventive Medicine, 2002
    Co-Authors: Minoru Omura, Akiyo Tanaka, Miyuki Hirata, Naohide Inoue
    Abstract:

    Objectives Testicular toxicities of Antimony Compounds were evaluated in rats and mice. The slightly water-soluble Antimony compound Antimony trioxide (ATO) and the highly water-soluble Antimony compound Antimony potassium tartrate (APT) were examined. Methods Daily doses of the Compounds were 27.4, 12.0 and 1,200 mg/kg body weight in the APT group, low-ATO group and high-ATO group, respectively. The corresponding daily doses of Antimony were 10, 10 and 1,000 mg/kg body weight, in the APT group, low-ATO group and high-ATO group, respectively. Both Compounds were administered by gavage: rats, 3 days per week for 4 weeks; mice, 5 days per week for 4 weeks. Results Neither compound reduced the weights of reproductive organs or accessory sex organs nor affected sperm parameters. Few marked histopathologic changes were found in the testes of the treated animals. Even at 1,200 mg/kg body weight, which is greater than the LD_50 of APT, ATO produced no effects. Conclusions In this study, it was found that ATO and APT are not toxic to testes in rodents.

  • Testicular toxicity evaluation of two Antimony Compounds, Antimony trioxide and Antimony potassium tartrate, in rats and mice.
    Environmental health and preventive medicine, 2002
    Co-Authors: Minoru Omura, Akiyo Tanaka, Miyuki Hirata, Naohide Inoue
    Abstract:

    Objectives Testicular toxicities of Antimony Compounds were evaluated in rats and mice. The slightly water-soluble Antimony compound Antimony trioxide (ATO) and the highly water-soluble Antimony compound Antimony potassium tartrate (APT) were examined.

Lode Godderis - One of the best experts on this subject based on the ideXlab platform.

  • Risk of Cancer for Workers Exposed to Antimony Compounds: A Systematic Review.
    International journal of environmental research and public health, 2019
    Co-Authors: Anton Saerens, Manosij Ghosh, Jelle Verdonck, Lode Godderis
    Abstract:

    Background: Antimony (Sb) trioxide and Antimony trisulfide are “2B: Possibly carcinogenic to humans” and “3: Unclassifiable” according to the International Agency for Research on Cancer (IARC). The U.S. National Toxicology Program (NTP) concluded that Antimony trioxide “is reasonably anticipated to be a human carcinogen based on studies in rats and mice”. We investigated the cancer hazard of Antimony Compounds for workers, a population with high exposure to Antimony substances. Methods: Using the “Guidelines for performing systematic reviews in the development of toxicity factors” (Texas Commission on Environmental Quality (TCEQ) 2017) as a guidance, we established a human and an animal toxicology data stream in Medline and ToxLine. Data from this review were applied in a human health risk assessment. Results: A final pool of 10 occupational and 13 animal toxicology articles resulted after application of TCEQ guidelines. Conclusions: Antimony carcinogenicity evidence involving workers is inadequate, based on confounding, small sample sizes, incomparability across studies, and inadequate reference populations. An increased lung cancer risk cannot be excluded. Evidence for lung neoplasms caused by Antimony trioxide inhalation in experimental animals is sufficient. Overall, carcinogenicity in workers is probable (International Agency for Research on Cancer (IARC) 2A). It remains unclear from what occupational exposure duration and dose this effect arises and whether exposure threshold values should be reconsidered.