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Wlodzimierz Lewandowski - One of the best experts on this subject based on the ideXlab platform.
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spectroscopic theoretical and Antioxidant Study of 3d transition metals co ii ni ii cu ii zn ii complexes with cichoric acid
Materials, 2020Co-Authors: Grzegorz świderski, Agata Jablonskatrypuc, Monika Kalinowska, Renata świslocka, Danuta Karpowicz, Marta Magnuszewska, Wlodzimierz LewandowskiAbstract:Cichoric acid (CA) is a derivative of both caffeic acid and tartaric acid. It was isolated for the first time from Cichorium intybus L. (chicory) but it also occurs in significant amounts in Echinacea, particularly E. purpurea, dandelion leaves, basil, lemon balm and in aquatic plants, including algae and sea grasses. It has a wide spectrum of biological properties, including Antioxidant, antiviral, anti-inflammatory and other. The work yielded cichoric acid complexes with selected transition metals, i.e., copper(II), nickel(II), zinc(II) and cobalt(II). In this work the dependency between the molecular structure and biological activity was discussed. The molecular structure was studied by means of infrared spectroscopy (Fourier transform infrared (FT-IR) Raman (FT-Raman)), electronic absorption spectroscopy (ultraviolet-visible (UV/VIS)) and theoretical calculations (density functional theory (DFT), Hartree-Fock (HF)). Understanding the mechanism of the effect of metals on the electronic system of ligands with biological importance will facilitate in the future the search for new, effective and natural Antioxidants. The composition of the studied complexes in aqueous solutions was determined at a constant pH by the Job's method. Antioxidative properties of the tested compounds were determined using the ferric-reducing Antioxidant power (FRAP), DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate free radical method), cupric-reducing Antioxidant capacity (CUPRAC) and Superoxide Dismutase Activity Assay (SOD).
B A Golakiya - One of the best experts on this subject based on the ideXlab platform.
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nontargeted metabolomics approach to determine metabolites profile and Antioxidant Study of tropical almond terminalia catappa l fruit peels using gc qtof ms and lc qtof ms
Journal of Pharmaceutical and Biomedical Analysis, 2018Co-Authors: Mital Kaneria, Kalpna Rakholiya, L R Marsonia, Rajesh Dave, B A GolakiyaAbstract:Abstract The objective of the present Study was to identify the metabolome pattern and Study the biological efficacy of Almond (Terminalia catappa L.) peels. In the present Study, metabolite profiling was carried out using GC-QTOF-MS and LC-QTOF-MS techniques, from the potent extract showed highest Antioxidant efficacy. Antioxidant efficacy of the various extracts derived by six different extraction methods was assessed by different assays viz. 2,2-diphenyl-1-picrylhydrazyl, superoxide, 2,2′-Azino-bis-(3-ethyl)benzothiazoline)-6-sulfonic acid diammonium salt radical cation inhibition assays and ferric reducing Antioxidant power. The methanolic maceration extract showed significant Antioxidant activity in all assays and richest source of flavonoid content. The results showed that the extraction method significantly altered the Antioxidant activity. The correlation between the Antioxidant activities and total flavonoid content were ranging between 0.939 to 0.628. Methanolic maceration extraction method proved to be the best extraction method for the extraction of Antioxidant. During the metabolite profiling employed by GC-QTOF-MS and LC-QTOF-MS and total 24 and 53 compounds belongs to different groups were detected and identified, will help to uncover the relation with potent Antioxidant activity.
Grzegorz świderski - One of the best experts on this subject based on the ideXlab platform.
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spectroscopic theoretical and Antioxidant Study of 3d transition metals co ii ni ii cu ii zn ii complexes with cichoric acid
Materials, 2020Co-Authors: Grzegorz świderski, Agata Jablonskatrypuc, Monika Kalinowska, Renata świslocka, Danuta Karpowicz, Marta Magnuszewska, Wlodzimierz LewandowskiAbstract:Cichoric acid (CA) is a derivative of both caffeic acid and tartaric acid. It was isolated for the first time from Cichorium intybus L. (chicory) but it also occurs in significant amounts in Echinacea, particularly E. purpurea, dandelion leaves, basil, lemon balm and in aquatic plants, including algae and sea grasses. It has a wide spectrum of biological properties, including Antioxidant, antiviral, anti-inflammatory and other. The work yielded cichoric acid complexes with selected transition metals, i.e., copper(II), nickel(II), zinc(II) and cobalt(II). In this work the dependency between the molecular structure and biological activity was discussed. The molecular structure was studied by means of infrared spectroscopy (Fourier transform infrared (FT-IR) Raman (FT-Raman)), electronic absorption spectroscopy (ultraviolet-visible (UV/VIS)) and theoretical calculations (density functional theory (DFT), Hartree-Fock (HF)). Understanding the mechanism of the effect of metals on the electronic system of ligands with biological importance will facilitate in the future the search for new, effective and natural Antioxidants. The composition of the studied complexes in aqueous solutions was determined at a constant pH by the Job's method. Antioxidative properties of the tested compounds were determined using the ferric-reducing Antioxidant power (FRAP), DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate free radical method), cupric-reducing Antioxidant capacity (CUPRAC) and Superoxide Dismutase Activity Assay (SOD).
Naif Abdullah Aldhabi - One of the best experts on this subject based on the ideXlab platform.
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Antioxidant free radical scavenging and liver protective effects of friedelin isolated from azima tetracantha lam leaves
Food Chemistry, 2013Co-Authors: Christudas Sunil, Naif Abdullah AldhabiAbstract:The aim of the present Study was to evaluate the Antioxidant, free radical scavenging and liver protective effects of friedelin isolated from Azima tetracantha Lam. leaves. In in vitro Antioxidant Study, the free radical scavenging effect of friedelin on 2,2-diphenyl-picrylhydrazyl (DPPH), hydroxyl, nitric oxide and superoxide radicals were evaluated. Friedelin showed very good scavenging effect on DPPH (IC50 21.1 mM), hydroxyl (IC50 19.8 mM), nitric oxide (IC50 22.1 mM) and superoxide (IC50 21.9 mM) radicals. Friedelin also showed strong suppressive effect on lipid peroxidation. In in vivo Antioxidant Study, CCl4 induced oxidative stress on rats produced significant increase in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) levels along with reduction in liver superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels. Pre-treatment of rats with friedelin at 40 mg/kg for 7 days restored these levels to normality and showed liver protection, comparable to the standard, silymarin (25 mg/kg). These results clearly demonstrated that friedelin possessed marked Antioxidant and liver protective effects.
D. Susanti - One of the best experts on this subject based on the ideXlab platform.
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Hepatoprotective Activity of Methanolic Extract of Bauhinia purpurea Leaves against Paracetamol-Induced Hepatic Damage in Rats
Hindawi Limited, 2013Co-Authors: F. Yahya, Mff Kamarolzaman, Zarizal Suhaili, Norhafizah Mohtarrudin, S. S. Mamat, A. A. Seyedan, K. F. Jakius, N. D. Mahmood, M. S. Shahril, D. SusantiAbstract:In an attempt to further establish the pharmacological properties of Bauhinia purpurea (Fabaceae), hepatoprotective potential of methanol extract of B. purpurea leaves (MEBP) was investigated using the paracetamol- (PCM-) induced liver toxicity in rats. Five groups of rats (n=6) were used and administered orally once daily with 10% DMSO (negative control), 200 mg/kg silymarin (positive control), or MEBP (50, 250, and 500 mg/kg) for 7 days, followed by the hepatotoxicity induction using paracetamol (PCM). The blood samples and livers were collected and subjected to biochemical and microscopical analysis. The extract was also subjected to Antioxidant Study using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay with the total phenolic content (TPC) also determined. From the histological observation, lymphocyte infiltration and marked necrosis were observed in PCM-treated groups (negative control), whereas maintenance of the normal hepatic structural was observed in group pretreated with silymarin and MEBP. Hepatotoxic rats pretreated with silymarin or MEBP exhibited significant decrease (P
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hepatoprotective activity of methanolic extract of bauhinia purpurea leaves against paracetamol induced hepatic damage in rats
Evidence-based Complementary and Alternative Medicine, 2013Co-Authors: F. Yahya, Mff Kamarolzaman, Zarizal Suhaili, Norhafizah Mohtarrudin, S. S. Mamat, A. A. Seyedan, K. F. Jakius, N. D. Mahmood, M. S. Shahril, D. SusantiAbstract:In an attempt to further establish the pharmacological properties of Bauhinia purpurea (Fabaceae), hepatoprotective potential of methanol extract of B. purpurea leaves (MEBP) was investigated using the paracetamol- (PCM-) induced liver toxicity in rats. Five groups of rats () were used and administered orally once daily with 10% DMSO (negative control), 200 mg/kg silymarin (positive control), or MEBP (50, 250, and 500 mg/kg) for 7 days, followed by the hepatotoxicity induction using paracetamol (PCM). The blood samples and livers were collected and subjected to biochemical and microscopical analysis. The extract was also subjected to Antioxidant Study using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay with the total phenolic content (TPC) also determined. From the histological observation, lymphocyte infiltration and marked necrosis were observed in PCM-treated groups (negative control), whereas maintenance of the normal hepatic structural was observed in group pretreated with silymarin and MEBP. Hepatotoxic rats pretreated with silymarin or MEBP exhibited significant decrease () in ALT and AST enzyme level. Moreover, the extract also exhibited Antioxidant activity and contained high TPC. In conclusion, MEBP exerts potential hepatoprotective activity that could be partly attributed to its Antioxidant activity and high phenolic content and thus warrants further investigation.