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Alain Pineau - One of the best experts on this subject based on the ideXlab platform.
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if exposure to aluminium in Antiperspirants presents health risks its content should be reduced
Journal of Trace Elements in Medicine and Biology, 2014Co-Authors: Alain Pineau, Bernard Fauconneau, Andrepascal Sappino, Roger Deloncle, Olivier GuillardAbstract:Since aluminium (Al) pervades our environment, the scientific community has for many years raised concerns regarding its safety in humans. Al is present in numerous cosmetics such as Antiperspirants, lipsticks and sunscreens. Al chlorohydrate is the active Antiperspirant agent in underarm cosmetics and may constitute for Al a key exposure route to the human body and a potential source of damage. An in vitro study has demonstrated that Al from Antiperspirant can be absorbed through viable human stripped skin. The potential toxicity of Al has been clearly shown and recent works convincingly argue that Al could be involved in cancerogenic processes. Nowadays, for example, Al is suspected of being involved in breast cancer. Recent work in cells in culture has lent credence to the hypothesis that this metal could accumulate in the mammary gland and selectively interfere with the biological properties of breast epithelial cells, thereby promoting a cascade of alterations reminiscent of the early phases of malignant transformation. In addition, several studies suggest that the presence of Al in human breast could influence metastatic process. As a consequence, given that the toxicity of Al has been widely recognized and that it is not a physiological component in human tissues, reducing the concentration of this metal in Antiperspirants is a matter of urgency.
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corrigendum to in vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the franz diffusion cell j inorg biochem 110 2012 21 26
Journal of Inorganic Biochemistry, 2012Co-Authors: Alain Pineau, Olivier Guillard, Frederic Favreau, Annie Marrauld, Bernard FauconneauAbstract:Corrigendum to “In vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the FranzTM diffusion cell” [J Inorg Biochem 110 (2012) 21–26] Alain Pineau, Olivier Guillard⁎, Frederic Favreau, Annie Marrauld, Bernard Fauconneau a CHU Poitiers, Laboratoire de Biochimie 86021 Poitiers, France, Universite Poitiers, 86034 Poitiers, France b Universite Nantes, Faculte de Pharmacie, Laboratoire de Toxicologie 44035 Nantes, France c CHU Poitiers, Service de Pharmacologie Clinique, 86021 Poitiers, France, Universite Poitiers, 86034 Poitiers, France
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in vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the franz diffusion cell
Journal of Inorganic Biochemistry, 2012Co-Authors: Alain Pineau, Bernard Fauconneau, Olivier Guillard, Frederic Favreau, Mariehelene Marty, Angeline Gaudin, Claire Marie Vincent, Annie Marrauld, J P MartyAbstract:Aluminum salts such as aluminum chlorohydrate (ACH) are known for use as an active Antiperspirant agent that blocks the secretion of sweat. A local case report of hyperaluminemia in a woman using an aluminum-containing Antiperspirant for 4 years raises the problem of transdermal absorption of aluminum (Al). Only a very limited number of studies have shown that the skin is an effective barrier to transdermal uptake of Al. In accordance with our analytical procedure, the aim of this study with an in vitro Franz™ diffusion cell was to measure aluminum uptake from three cosmetic formulations of Antiperspirant: the base for an "aerosol" (38.5% of ACH), a "roll-on" emulsion (14.5% ACH), and a "stick" (21.2%), by samples of intact and stripped human skin (5 donors). The Al assays were performed by Zeeman Electrothermal Atomic Absorption Spectrophotometry (ZEAAS). Following contacts lasting 6, 12 and 24h, the Al assays showed only insignificant transdermal absorption of Al (≤0.07% of the quantity of Al deposited) and particularly low cutaneous quantities that varied according to the formulations (1.8 μg/cm² for "aerosol base" and "stick" - 0.5 μg/cm² for the "roll-on"). On stripped skin, for which only the "stick" formulation was tested, the measured uptake was significantly higher (11.50 μg/cm² versus 1.81 μg/cm² for normal skin). These results offer reassurance as regards to the use of Antiperspirants for topical application of ACH-containing cosmetic formulations on healthy skin over a limited time span (24h). On the other hand, high transdermal Al uptake on stripped skin should compel Antiperspirant manufacturers to proceed with the utmost caution.
Bernard Fauconneau - One of the best experts on this subject based on the ideXlab platform.
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if exposure to aluminium in Antiperspirants presents health risks its content should be reduced
Journal of Trace Elements in Medicine and Biology, 2014Co-Authors: Alain Pineau, Bernard Fauconneau, Andrepascal Sappino, Roger Deloncle, Olivier GuillardAbstract:Since aluminium (Al) pervades our environment, the scientific community has for many years raised concerns regarding its safety in humans. Al is present in numerous cosmetics such as Antiperspirants, lipsticks and sunscreens. Al chlorohydrate is the active Antiperspirant agent in underarm cosmetics and may constitute for Al a key exposure route to the human body and a potential source of damage. An in vitro study has demonstrated that Al from Antiperspirant can be absorbed through viable human stripped skin. The potential toxicity of Al has been clearly shown and recent works convincingly argue that Al could be involved in cancerogenic processes. Nowadays, for example, Al is suspected of being involved in breast cancer. Recent work in cells in culture has lent credence to the hypothesis that this metal could accumulate in the mammary gland and selectively interfere with the biological properties of breast epithelial cells, thereby promoting a cascade of alterations reminiscent of the early phases of malignant transformation. In addition, several studies suggest that the presence of Al in human breast could influence metastatic process. As a consequence, given that the toxicity of Al has been widely recognized and that it is not a physiological component in human tissues, reducing the concentration of this metal in Antiperspirants is a matter of urgency.
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corrigendum to in vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the franz diffusion cell j inorg biochem 110 2012 21 26
Journal of Inorganic Biochemistry, 2012Co-Authors: Alain Pineau, Olivier Guillard, Frederic Favreau, Annie Marrauld, Bernard FauconneauAbstract:Corrigendum to “In vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the FranzTM diffusion cell” [J Inorg Biochem 110 (2012) 21–26] Alain Pineau, Olivier Guillard⁎, Frederic Favreau, Annie Marrauld, Bernard Fauconneau a CHU Poitiers, Laboratoire de Biochimie 86021 Poitiers, France, Universite Poitiers, 86034 Poitiers, France b Universite Nantes, Faculte de Pharmacie, Laboratoire de Toxicologie 44035 Nantes, France c CHU Poitiers, Service de Pharmacologie Clinique, 86021 Poitiers, France, Universite Poitiers, 86034 Poitiers, France
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in vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the franz diffusion cell
Journal of Inorganic Biochemistry, 2012Co-Authors: Alain Pineau, Bernard Fauconneau, Olivier Guillard, Frederic Favreau, Mariehelene Marty, Angeline Gaudin, Claire Marie Vincent, Annie Marrauld, J P MartyAbstract:Aluminum salts such as aluminum chlorohydrate (ACH) are known for use as an active Antiperspirant agent that blocks the secretion of sweat. A local case report of hyperaluminemia in a woman using an aluminum-containing Antiperspirant for 4 years raises the problem of transdermal absorption of aluminum (Al). Only a very limited number of studies have shown that the skin is an effective barrier to transdermal uptake of Al. In accordance with our analytical procedure, the aim of this study with an in vitro Franz™ diffusion cell was to measure aluminum uptake from three cosmetic formulations of Antiperspirant: the base for an "aerosol" (38.5% of ACH), a "roll-on" emulsion (14.5% ACH), and a "stick" (21.2%), by samples of intact and stripped human skin (5 donors). The Al assays were performed by Zeeman Electrothermal Atomic Absorption Spectrophotometry (ZEAAS). Following contacts lasting 6, 12 and 24h, the Al assays showed only insignificant transdermal absorption of Al (≤0.07% of the quantity of Al deposited) and particularly low cutaneous quantities that varied according to the formulations (1.8 μg/cm² for "aerosol base" and "stick" - 0.5 μg/cm² for the "roll-on"). On stripped skin, for which only the "stick" formulation was tested, the measured uptake was significantly higher (11.50 μg/cm² versus 1.81 μg/cm² for normal skin). These results offer reassurance as regards to the use of Antiperspirants for topical application of ACH-containing cosmetic formulations on healthy skin over a limited time span (24h). On the other hand, high transdermal Al uptake on stripped skin should compel Antiperspirant manufacturers to proceed with the utmost caution.
Olivier Guillard - One of the best experts on this subject based on the ideXlab platform.
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if exposure to aluminium in Antiperspirants presents health risks its content should be reduced
Journal of Trace Elements in Medicine and Biology, 2014Co-Authors: Alain Pineau, Bernard Fauconneau, Andrepascal Sappino, Roger Deloncle, Olivier GuillardAbstract:Since aluminium (Al) pervades our environment, the scientific community has for many years raised concerns regarding its safety in humans. Al is present in numerous cosmetics such as Antiperspirants, lipsticks and sunscreens. Al chlorohydrate is the active Antiperspirant agent in underarm cosmetics and may constitute for Al a key exposure route to the human body and a potential source of damage. An in vitro study has demonstrated that Al from Antiperspirant can be absorbed through viable human stripped skin. The potential toxicity of Al has been clearly shown and recent works convincingly argue that Al could be involved in cancerogenic processes. Nowadays, for example, Al is suspected of being involved in breast cancer. Recent work in cells in culture has lent credence to the hypothesis that this metal could accumulate in the mammary gland and selectively interfere with the biological properties of breast epithelial cells, thereby promoting a cascade of alterations reminiscent of the early phases of malignant transformation. In addition, several studies suggest that the presence of Al in human breast could influence metastatic process. As a consequence, given that the toxicity of Al has been widely recognized and that it is not a physiological component in human tissues, reducing the concentration of this metal in Antiperspirants is a matter of urgency.
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corrigendum to in vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the franz diffusion cell j inorg biochem 110 2012 21 26
Journal of Inorganic Biochemistry, 2012Co-Authors: Alain Pineau, Olivier Guillard, Frederic Favreau, Annie Marrauld, Bernard FauconneauAbstract:Corrigendum to “In vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the FranzTM diffusion cell” [J Inorg Biochem 110 (2012) 21–26] Alain Pineau, Olivier Guillard⁎, Frederic Favreau, Annie Marrauld, Bernard Fauconneau a CHU Poitiers, Laboratoire de Biochimie 86021 Poitiers, France, Universite Poitiers, 86034 Poitiers, France b Universite Nantes, Faculte de Pharmacie, Laboratoire de Toxicologie 44035 Nantes, France c CHU Poitiers, Service de Pharmacologie Clinique, 86021 Poitiers, France, Universite Poitiers, 86034 Poitiers, France
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in vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the franz diffusion cell
Journal of Inorganic Biochemistry, 2012Co-Authors: Alain Pineau, Bernard Fauconneau, Olivier Guillard, Frederic Favreau, Mariehelene Marty, Angeline Gaudin, Claire Marie Vincent, Annie Marrauld, J P MartyAbstract:Aluminum salts such as aluminum chlorohydrate (ACH) are known for use as an active Antiperspirant agent that blocks the secretion of sweat. A local case report of hyperaluminemia in a woman using an aluminum-containing Antiperspirant for 4 years raises the problem of transdermal absorption of aluminum (Al). Only a very limited number of studies have shown that the skin is an effective barrier to transdermal uptake of Al. In accordance with our analytical procedure, the aim of this study with an in vitro Franz™ diffusion cell was to measure aluminum uptake from three cosmetic formulations of Antiperspirant: the base for an "aerosol" (38.5% of ACH), a "roll-on" emulsion (14.5% ACH), and a "stick" (21.2%), by samples of intact and stripped human skin (5 donors). The Al assays were performed by Zeeman Electrothermal Atomic Absorption Spectrophotometry (ZEAAS). Following contacts lasting 6, 12 and 24h, the Al assays showed only insignificant transdermal absorption of Al (≤0.07% of the quantity of Al deposited) and particularly low cutaneous quantities that varied according to the formulations (1.8 μg/cm² for "aerosol base" and "stick" - 0.5 μg/cm² for the "roll-on"). On stripped skin, for which only the "stick" formulation was tested, the measured uptake was significantly higher (11.50 μg/cm² versus 1.81 μg/cm² for normal skin). These results offer reassurance as regards to the use of Antiperspirants for topical application of ACH-containing cosmetic formulations on healthy skin over a limited time span (24h). On the other hand, high transdermal Al uptake on stripped skin should compel Antiperspirant manufacturers to proceed with the utmost caution.
Philippa D. Darbre - One of the best experts on this subject based on the ideXlab platform.
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underarm Antiperspirants deodorants and breast cancer
Breast Cancer Research, 2009Co-Authors: Philippa D. DarbreAbstract:Clinical studies dating back decades report a disproportionately high number of female breast cancers originating in the upper outer quadrant of the breast [1], and although this is attributed to a greater amount of epithelial tissue in that region, it is also the area to which underarm cosmetic products are applied [2,3]. Early studies reported 31% of cancers in the upper outer quadrant [1], but later studies in the 1990s report up to 61% [2,3]. The annually recorded quadrant incidence of breast cancer in Britain documents a rise in England and Wales from 47.9% in the upper outer quadrant in 1979 to 53.3% in 2000, and in Scotland a rise from 38.3% in the upper outer quadrant in 1980 to 54.7% in 2001 [4]. Any increase in the disproportionality of breast cancer in the upper outer quadrant would be inconsistent with an explanation relating to the greater amount of target epithelial tissue in that region but does parallel the increasing use of cosmetics in the underarm area [2-5].
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concentration of aluminium in breast cyst fluids collected from women affected by gross cystic breast disease
Journal of Applied Toxicology, 2009Co-Authors: Ferdinando Mannello, Gaetana A Tonti, Philippa D. DarbreAbstract:Gross cystic breast disease (GCBD) is the most common benign breast disorder, but the molecular basis of cyst formation remains to be identified. If the use of aluminium-based Antiperspirant salts is involved in the etiology of gross breast cyst formation, it might be expected that aluminium would be at elevated levels in human breast cyst fluid (BCF). Aluminium was measured by ICP-MS in 48 samples of BCF, 30 samples of human blood serum and 45 samples of human breast milk at different stages of lactation (colostrum, intermediate, mature). The median level of aluminium in apocrine type I BCF (n:= 27, 150 mu g I-1) was significantly higher than in transuclative type II BCF (n = 21, 32 mu g I-1; P < 0.0001). By comparison, aluminium measurements gave a median concentration of 6 mu g I-1 in human serum and 25 mu g I-1 in human breast milk, with no difference between colostrum, intermediate and mature milk. Levels of aluminium were significantly higher in both types of BCF than in human serum (P < 0.0001). However when compared with human breast milk, aluminium levels were only significantly higher in apocrine type I BCF (P < 0.0001) and not in transudative type II BCF (P = 0.152). It remains to be identified why such high levels of aluminium were found in the apocrine type I BCF and from where the aluminium originated. However, if aluminium-based Antiperspirants are found to be the source and to play any causal role in development of breast cysts, then it might become possible to prevent this common breast disorder. Copyright (C) 2008 John Wiley & Sons, Ltd.
J P Marty - One of the best experts on this subject based on the ideXlab platform.
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in vitro study of percutaneous absorption of aluminum from Antiperspirants through human skin in the franz diffusion cell
Journal of Inorganic Biochemistry, 2012Co-Authors: Alain Pineau, Bernard Fauconneau, Olivier Guillard, Frederic Favreau, Mariehelene Marty, Angeline Gaudin, Claire Marie Vincent, Annie Marrauld, J P MartyAbstract:Aluminum salts such as aluminum chlorohydrate (ACH) are known for use as an active Antiperspirant agent that blocks the secretion of sweat. A local case report of hyperaluminemia in a woman using an aluminum-containing Antiperspirant for 4 years raises the problem of transdermal absorption of aluminum (Al). Only a very limited number of studies have shown that the skin is an effective barrier to transdermal uptake of Al. In accordance with our analytical procedure, the aim of this study with an in vitro Franz™ diffusion cell was to measure aluminum uptake from three cosmetic formulations of Antiperspirant: the base for an "aerosol" (38.5% of ACH), a "roll-on" emulsion (14.5% ACH), and a "stick" (21.2%), by samples of intact and stripped human skin (5 donors). The Al assays were performed by Zeeman Electrothermal Atomic Absorption Spectrophotometry (ZEAAS). Following contacts lasting 6, 12 and 24h, the Al assays showed only insignificant transdermal absorption of Al (≤0.07% of the quantity of Al deposited) and particularly low cutaneous quantities that varied according to the formulations (1.8 μg/cm² for "aerosol base" and "stick" - 0.5 μg/cm² for the "roll-on"). On stripped skin, for which only the "stick" formulation was tested, the measured uptake was significantly higher (11.50 μg/cm² versus 1.81 μg/cm² for normal skin). These results offer reassurance as regards to the use of Antiperspirants for topical application of ACH-containing cosmetic formulations on healthy skin over a limited time span (24h). On the other hand, high transdermal Al uptake on stripped skin should compel Antiperspirant manufacturers to proceed with the utmost caution.