The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform

Rui Wang - One of the best experts on this subject based on the ideXlab platform.

  • enantioselective synthesis of cyclic thioureas via mannich reaction and concise synthesis of highly optically active methylthioimidazolines discovery of a more potent Antipyretic Agent
    Advanced Synthesis & Catalysis, 2011
    Co-Authors: Xianxing Jiang, Yiqing Wang, Gen Zhang, Futing Zhang, Ming Kai, Rui Wang
    Abstract:

    Drug lead synthesis by the rapid construction of chiral molecular complexity around the biologically relevant framework using a highly efficient strategy is a key goal of organic synthesis. Herein, a highly efficient and convenient strategy that allows the rapid synthesis of highly optically active methylthioimidazolines through the novel rosin-derived thiourea-catalyzed asymmetric synthesis of cyclic thioureas with high levels of enantio- and diastereoselectivity (up to 99% ee, and 20:1 dr) via Mannich reaction is described fior the first time. Several of the new methylthioimidazolines showed extremely promising Antipyretic activity in the development of neuroinflammation through preliminary biological studies. Additionally, to gain a better understanding of the structural stability-activity relationships, explicit molecular dynamics (MD) simulations in water at room temperature and at body temperature were investigated.

Xianxing Jiang - One of the best experts on this subject based on the ideXlab platform.

  • enantioselective synthesis of cyclic thioureas via mannich reaction and concise synthesis of highly optically active methylthioimidazolines discovery of a more potent Antipyretic Agent
    Advanced Synthesis & Catalysis, 2011
    Co-Authors: Xianxing Jiang, Yiqing Wang, Gen Zhang, Futing Zhang, Ming Kai, Rui Wang
    Abstract:

    Drug lead synthesis by the rapid construction of chiral molecular complexity around the biologically relevant framework using a highly efficient strategy is a key goal of organic synthesis. Herein, a highly efficient and convenient strategy that allows the rapid synthesis of highly optically active methylthioimidazolines through the novel rosin-derived thiourea-catalyzed asymmetric synthesis of cyclic thioureas with high levels of enantio- and diastereoselectivity (up to 99% ee, and 20:1 dr) via Mannich reaction is described fior the first time. Several of the new methylthioimidazolines showed extremely promising Antipyretic activity in the development of neuroinflammation through preliminary biological studies. Additionally, to gain a better understanding of the structural stability-activity relationships, explicit molecular dynamics (MD) simulations in water at room temperature and at body temperature were investigated.

Dilip Kumar Nandi - One of the best experts on this subject based on the ideXlab platform.

  • Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats
    Clinical and Experimental Nephrology, 2015
    Co-Authors: Arpita Mandal, Arpita Patra, Shreya Mandal, Suchismita Roy, Tanmay Paul, Koushik Das, Keshab Chandra Mondal, Shreya Mahapatra, Tapasi Mahapatra, Dilip Kumar Nandi
    Abstract:

    Background Currently kidney disease appears a foremost problem across the world. Acetaminophen is a commonly used Antipyretic Agent, which in high doses, causes uremia and used for experimentally induction of kidney disease. Bacteriotherapy affords a promising approach to mitigate uremic toxins by ingestion of urease positive bacteria, probiotics and symbiotic able to catabolize uremic solutes within the gut. The present study evaluates the effect of seven commercial symbiotic on kidney disease. Methods Fifty-four albino male rats were randomly divided into nine groups. Control group (Group-I) received distilled water interperitoneally for 7 days. Positive control group (Group-II) received 500 mg/kg acetaminophen interperitoneally for 7 days. Commercially available seven symbiotic combinations at a dose of 10^9cells/day for 3 weeks was administered to the tested groups (Group III–IX) after receiving 500 mg/kg/day acetaminophen interperitoneally for 7 days. Blood, kidney, liver and stool samples were collected after scarification for biochemical tests and DNA fragmentation assay of kidney tissue, kidney histological studies. Limited fecal analysis was conducted. Result Blood urea nitrogen and toxicity indicators were increased, and antioxidant enzymes were decreased in Group-II. Blood urea nitrogen, toxicity indicators, glomerular necrosis, DNA damage of kidney tissue were reduced, and antioxidant enzymes were increased significantly in the treated Groups IV and IX (p 

  • Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats
    Clinical and Experimental Nephrology, 2014
    Co-Authors: Arpita Mandal, Arpita Patra, Shreya Mandal, Suchismita Roy, Shreya Das Mahapatra, Tapasi Das Mahapatra, Tanmay Paul, Koushik Das, Keshab Chandra Mondal, Dilip Kumar Nandi
    Abstract:

    Background Currently kidney disease appears a foremost problem across the world. Acetaminophen is a commonly used Antipyretic Agent, which in high doses, causes uremia and used for experimentally induction of kidney disease. Bacteriotherapy affords a promising approach to mitigate uremic toxins by ingestion of urease positive bacteria, probiotics and symbiotic able to catabolize uremic solutes within the gut. The present study evaluates the effect of seven commercial symbiotic on kidney disease.

Mathias B. Forrester - One of the best experts on this subject based on the ideXlab platform.

  • Pattern of Dipyrone Exposure in Texas, 1998 to 2004
    Journal of Medical Toxicology, 2006
    Co-Authors: Mathias B. Forrester
    Abstract:

    Introduction Dipyrone is an analgesic and Antipyretic Agent. The purpose of this study was to describe the pattern of dipyrone exposures reported to poison centers.

  • Pattern of dipyrone exposure in Texas, 1998 to 2004
    Journal of Medical Toxicology, 2006
    Co-Authors: Mathias B. Forrester
    Abstract:

    Introduction Dipyrone is an analgesic and Antipyretic Agent. The purpose of this study was to describe the pattern of dipyrone exposures reported to poison centers. Methods Human dipyrone exposures reported to 6 Texas poison centers from 1998 to 2004 were identified. Isolated and non-isolated cases were compared with respect to various factors. Results When compared to the Census, dipyrone exposures were significantly more likely to have been reported from regions closer to the Mexican border (53% vs 9%). Of 81 dipyrone exposures, 52 (64%) were isolated and 29 (36%) were non-isolated. Most of the dipyrone exposures occurred at the patient’s own residence (72/76 or 95%) and the patients were more likely to be female (54/81 or 67%). Although the majority of both types of dipyrone exposures were adults (47/78 or 60%), children, less than 6 years of age, accounted for a higher proportion of isolated exposures (33% vs 10%) while a higher proportion of non-isolated exposures involved older children (28% vs 8%). Twenty-two percent (11/51) of isolated cases were intentional while 59% (17/29) of non-isolated cases were intentional. Of those cases with a known medical outcome, the medical outcome was no adverse clinical effect for 76% (16/21) of isolated exposures and 42% (8/19) of non-isolated exposures. The specific adverse clinical effects reported for isolated exposures were primarily neurological (n = 6), gastrointestinal (n = 4), and dermal (n = 3). The most frequently reported treatment for isolated exposures was some form of decontamination (n = 11). Conclusions Isolated and non-isolated dipyrone exposures varied with respect to patient age, exposure reason, management site, medical outcome.

Eric Woode - One of the best experts on this subject based on the ideXlab platform.

  • © UDS Publishers Limited All Right Reserved 2026-6294 ORIGINAL ARTICLE
    2016
    Co-Authors: Hook F. Var, Kofi Annan, Kwame Sarpong, C Asare, K I Amponsah, R.a. Dickson, Eric Woode
    Abstract:

    Fever is a complex physiological response triggered by infectious or aseptic stimuli. The present investigation was carried out to study the Antipyretic activity of Polyalthia longifolia extracts in Wistar rats against Lipopolysaccharide (LPS)-induced pyrexia. P. longifolia Benth. & Hook. f. var. Pendula (Annonaceae) is an evergreen tropical tree well known for its numerous medicinal proper-ties. Methanol extracts of the leaves, stem bark and root of the plant were tested for their antipyret-ic activities at doses of 30, 100 and 300 mg kg-1 body weight using LPS-induced Antipyretic activity model. All extracts showed significant (p < 0.001) dose-dependent Antipyretic activity. At 300 mg kg-1, all extracts exhibited activities higher than that of Acetylsalicyclic acid (Aspirin) whose per-centage inhibition of pyrexia was 86%. The root extract was the most active with a percentage inhi-bition of 127.5%, followed by the leaf extract (123.0%) and the stem bark extract (99.2%). This study proves P. longifolia as an effective Antipyretic Agent and could be used as an adjunct in the treat-ment of other ailments

  • Antipyretic activity of polyalthia longifolia benth hook f var pendula annonaceae on lipopolysaccharide induced fever in rats
    Journal of Medical and Biomedical Sciences, 2013
    Co-Authors: Kofi Annan, Kwame Sarpong, C Asare, K I Amponsah, R.a. Dickson, Eric Woode
    Abstract:

    Fever is a complex physiological response triggered by infectious or aseptic stimuli. The present investigation was carried out to study the Antipyretic activity of Polyalthia longifolia extracts in Wistar rats against Lipopolysaccharide (LPS) -induced pyrexia. P. longifolia Benth. & Hook. f. var. Pendula (Annonaceae) is an evergreen tropical tree well known for its numerous medicinal properties. Methanol extracts of the leaves, stem bark and root of the plant were tested for their Antipyretic activities at doses of 30, 100 and 300 mg kg-1 body weight using LPS-induced Antipyretic activity model. All extracts showed significant (p < 0.001) dose-dependent Antipyretic activity. At 300 mg kg-1, all extracts exhibited activities higher than that of Acetylsalicyclic acid (Aspirin) whose percentage inhibition of pyrexia was 86%. The root extract was the most active with a percentage inhibition of 127.5%, followed by the leaf extract (123.0%) and the stem bark extract (99.2%). This study proves P. longifolia as an effective Antipyretic Agent and could be used as an adjunct in the treatment of other ailments. Journal of Medical and Biomedical Sciences (2013) 2(1), 8-12

  • Antipyretic activity of Polyalthia longifolia Benth. & Hook. F. var. pendula (Annonaceae), on lipopolysaccharide-induced fever in rats
    2013
    Co-Authors: Kofi Annan, Kwame Sarpong, C Asare, K I Amponsah, R.a. Dickson, Eric Woode
    Abstract:

    Fever is a complex physiological response triggered by infectious or aseptic stimuli. The present investigation was carried out to study the Antipyretic activity of Polyalthia longifolia extracts in Wistar rats against Lipopolysaccharide (LPS) -induced pyrexia. P. longifolia Benth. & Hook. f. var. Pendula (Annonaceae) is an evergreen tropical tree well known for its numerous medicinal properties. Methanol extracts of the leaves, stem bark and root of the plant were tested for their Antipyretic activities at doses of 30, 100 and 300 mg kg-1 body weight using LPS-induced Antipyretic activity model. All extracts showed significant (p < 0.001) dose-dependent Antipyretic activity. At 300 mg kg-1, all extracts exhibited activities higher than that of Acetylsalicyclic acid (Aspirin) whose percentage inhibition of pyrexia was 86%. The root extract was the most active with a percentage inhibition of 127.5%, followed by the leaf extract (123.0%) and the stem bark extract (99.2%). This study proves P. longifolia as an effective Antipyretic Agent and could be used as an adjunct in the treatment of other ailments. Journal of Medical and Biomedical Sciences (2013) 2(1), 8-12