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Antipyretic Agent
The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Rui Wang – One of the best experts on this subject based on the ideXlab platform.
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enantioselective synthesis of cyclic thioureas via mannich reaction and concise synthesis of highly optically active methylthioimidazolines discovery of a more potent Antipyretic Agent
Advanced Synthesis & Catalysis, 2011Co-Authors: Xianxing Jiang, Rui Wang, Yiqing Wang, Gen Zhang, Futing Zhang, Ming KaiAbstract:Drug lead synthesis by the rapid construction of chiral molecular complexity around the biologically relevant framework using a highly efficient strategy is a key goal of organic synthesis. Herein, a highly efficient and convenient strategy that allows the rapid synthesis of highly optically active methylthioimidazolines through the novel rosin-derived thiourea-catalyzed asymmetric synthesis of cyclic thioureas with high levels of enantio- and diastereoselectivity (up to 99% ee, and 20:1 dr) via Mannich reaction is described fior the first time. Several of the new methylthioimidazolines showed extremely promising Antipyretic activity in the development of neuroinflammation through preliminary biological studies. Additionally, to gain a better understanding of the structural stability-activity relationships, explicit molecular dynamics (MD) simulations in water at room temperature and at body temperature were investigated.
Xianxing Jiang – One of the best experts on this subject based on the ideXlab platform.
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enantioselective synthesis of cyclic thioureas via mannich reaction and concise synthesis of highly optically active methylthioimidazolines discovery of a more potent Antipyretic Agent
Advanced Synthesis & Catalysis, 2011Co-Authors: Xianxing Jiang, Rui Wang, Yiqing Wang, Gen Zhang, Futing Zhang, Ming KaiAbstract:Drug lead synthesis by the rapid construction of chiral molecular complexity around the biologically relevant framework using a highly efficient strategy is a key goal of organic synthesis. Herein, a highly efficient and convenient strategy that allows the rapid synthesis of highly optically active methylthioimidazolines through the novel rosin-derived thiourea-catalyzed asymmetric synthesis of cyclic thioureas with high levels of enantio- and diastereoselectivity (up to 99% ee, and 20:1 dr) via Mannich reaction is described fior the first time. Several of the new methylthioimidazolines showed extremely promising Antipyretic activity in the development of neuroinflammation through preliminary biological studies. Additionally, to gain a better understanding of the structural stability-activity relationships, explicit molecular dynamics (MD) simulations in water at room temperature and at body temperature were investigated.
Dilip Kumar Nandi – One of the best experts on this subject based on the ideXlab platform.
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Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats
Clinical and Experimental Nephrology, 2015Co-Authors: Arpita Mandal, Arpita Patra, Shreya Mandal, Suchismita Roy, Tanmay Paul, Koushik Das, Keshab Chandra Mondal, Shreya Mahapatra, Tapasi Mahapatra, Dilip Kumar NandiAbstract:Background Currently kidney disease appears a foremost problem across the world. Acetaminophen is a commonly used Antipyretic Agent, which in high doses, causes uremia and used for experimentally induction of kidney disease. Bacteriotherapy affords a promising approach to mitigate uremic toxins by ingestion of urease positive bacteria, probiotics and symbiotic able to catabolize uremic solutes within the gut. The present study evaluates the effect of seven commercial symbiotic on kidney disease. Methods Fifty-four albino male rats were randomly divided into nine groups. Control group (Group-I) received distilled water interperitoneally for 7 days. Positive control group (Group-II) received 500 mg/kg acetaminophen interperitoneally for 7 days. Commercially available seven symbiotic combinations at a dose of 10^9cells/day for 3 weeks was administered to the tested groups (Group III–IX) after receiving 500 mg/kg/day acetaminophen interperitoneally for 7 days. Blood, kidney, liver and stool samples were collected after scarification for biochemical tests and DNA fragmentation assay of kidney tissue, kidney histological studies. Limited fecal analysis was conducted. Result Blood urea nitrogen and toxicity indicators were increased, and antioxidant enzymes were decreased in Group-II. Blood urea nitrogen, toxicity indicators, glomerular necrosis, DNA damage of kidney tissue were reduced, and antioxidant enzymes were increased significantly in the treated Groups IV and IX (p
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Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats
Clinical and Experimental Nephrology, 2014Co-Authors: Arpita Mandal, Arpita Patra, Shreya Mandal, Suchismita Roy, Shreya Das Mahapatra, Tapasi Das Mahapatra, Tanmay Paul, Koushik Das, Keshab Chandra Mondal, Dilip Kumar NandiAbstract:Background
Currently kidney disease appears a foremost problem across the world. Acetaminophen is a commonly used Antipyretic Agent, which in high doses, causes uremia and used for experimentally induction of kidney disease. Bacteriotherapy affords a promising approach to mitigate uremic toxins by ingestion of urease positive bacteria, probiotics and symbiotic able to catabolize uremic solutes within the gut. The present study evaluates the effect of seven commercial symbiotic on kidney disease.