The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Barry W - One of the best experts on this subject based on the ideXlab platform.
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Do Antipyretics prevent febrile convulsions
Archives of Disease in Childhood, 2003Co-Authors: A Sahib El-radhi, Barry WAbstract:A 1 year old child is admitted following their first febrile seizure (FS). We wish to prevent recurrences during further febrile episodes. The nursing staff ask you to prescribe an antipyretic. Later you come to advise the parents on methods of preventing further febrile seizures. In children who have experienced a febrile seizure [patient] does prescribing Antipyretics [intervention] reduce recurrences of febrile seizures [outcome]? ### Secondary sources Cochrane Library and DARE—“febrile convulsions/seizures and Antipyretics”, “febrile convulsions/seizures and paracetamol”, “febrile convulsions/seizures and ibuprofen”; one systematic review found (paracetamol for treating fever in children); two protocols. Prodigy Evidence Based Clinical guidance—“febrile convulsions”; nil relevant found. ### Primary resources Pubmed clinical queries (1966 to Jan 2003): “Antipyretics and febrile convulsions”—80 references. Of these, three were randomised controlled trials but one was irrelevant (investigating antipyretic effects rather than subsequent seizure reduction). As …
Prem Chandra - One of the best experts on this subject based on the ideXlab platform.
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Antipyretics in the emergency department intravenous paracetamol versus intramuscular diclofenac a comparative study
Critical Care, 2014Co-Authors: Nishan K Purayil, N Vamanjore, Firjeeth Paramba, Osama Hashim Mohammad, Prem ChandraAbstract:Fever is a common problem in adults visiting the emergency department (ED) [1]. Although it is important to treat the cause of fever, symptomatic management of fever is also necessary. Multiple studies are available on the efficacy of various Antipyretics in children, but very little has been done in adults [1],[2]. Hence we aimed to compare the antipyretic efficacy of intravenous (i.v.) paracetamol and intramuscular (i.m.) diclofenac in adult patients presenting with fever to the ED.
Alison While - One of the best experts on this subject based on the ideXlab platform.
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does the use of Antipyretics in children who have acute infections prolong febrile illness a systematic review and meta analysis
The Journal of Pediatrics, 2013Co-Authors: Edward Purssell, Alison WhileAbstract:Objective To review the literature and test the hypothesis that the use of antipyretic drugs in children with acute infections slows recovery. Study design A systematic review and meta-analysis of the literature was undertaken to investigate the effect of antipyretic drugs upon recovery from infectious diseases in children. A search of Medline (1946 until November 2012) and EMBASE (1980 until November 1, 2012) was undertaken to identify studies in which the authors compared the use of antipyretic medications with nonpharmacologic treatments for fever. Results Six papers were identified, 5 of which were included in the meta-analysis. Three studies focused on children with malaria and the other 3 considered general viral and respiratory infections and varicella. The pooled mean difference in time to fever clearance was 4.16 hours and was faster in those receiving Antipyretics compared with those not (95% CI −6.35 to −1.96 hours; P = .0002). There was little evidence of statistical heterogeneity (χ 2 4.84; 4 df; P = .3; I 2 17%). Conclusion There is no evidence from these studies that the use of Antipyretics slows the resolution of fever in children.
Eran Kozer - One of the best experts on this subject based on the ideXlab platform.
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do Antipyretics prevent the recurrence of febrile seizures in children a systematic review of randomized controlled trials and meta analysis
European Journal of Paediatric Neurology, 2013Co-Authors: Ehud Rosenbloom, Yaron Finkelstein, Thomasin Adamswebber, Eran KozerAbstract:Abstract Objectives To determine the effectiveness of Antipyretics use in prevention of subsequent febrile seizures in children. Data sources A search for all available electronic databases (MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, ACP Journal Club, Database of Abstracts of Reviews of Effects (DARE), Cochrane Central Register of Controlled Trials, Cochrane Methodology Register) from 1950 to July 2011 was done. No language restrictions were applied, but English abstract required. Study selection We included randomized controlled trials comparing the efficacy of antipyretic drugs to placebo in reducing the recurrence rate of febrile seizures in children (6–72 months) with previous febrile seizures. We excluded reviews, letters, and uncontrolled or non-randomized studies. Data extraction and synthesis The literature search was performed by a professional medical librarian. Based of the preliminary search, two reviewers independently pooled studies for detailed manual review per the inclusion criteria. We used the Cochrane Review Manager software (Revman 5) to calculate the odds ratio and 95% confidence intervals (CI) for seizure recurrence, assuming a random-effects model. Results Initial search identified 479 citations, five articles underwent further rigorous evaluation by two reviewers and three papers met the inclusion criteria. In these three studies, 540 children were included, of whom 348 received Antipyretics (acetaminophen (15 mg/kg), ibuprofen (5–10 mg/kg) or diclofenac (1.5 mg/kg)) and 192 received placebo for prevention of subsequent febrile seizures during a 1–2 year follow-up period. Seventy-nine patients (22.7%) in the Antipyretics group and forty-seven patients (24.4%) in the placebo group had febrile seizure recurrence during follow up. No statistically significant difference was found between the Antipyretics and the placebo groups in the recurrence rate of febrile seizures (OR 0.9, 95% CI: 0.57–1.43). Conclusion Antipyretics were ineffective in reducing the recurrence of febrile seizures.
Masaya Kubota - One of the best experts on this subject based on the ideXlab platform.
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use of Antipyretics for preventing febrile seizure recurrence in children a systematic review and meta analysis
European Journal of Pediatrics, 2021Co-Authors: Risa Hashimoto, Maiko Suto, Mariko Tsuji, Hatoko Sasaki, Kenji Takehara, Akira Ishiguro, Masaya KubotaAbstract:The efficacy of Antipyretics for preventing febrile seizure recurrence has been reported by a recent study, and the results might overturn previous evidence. We systematically reviewed the efficacy of Antipyretics in the prevention of febrile seizure recurrence in children focused on the timing of its administration. We searched the Medline, Embase, and Cochrane Central Register of Controlled Trials databases for randomized and quasi-randomized trials and prospective non-randomized studies of aged up to 60 months, diagnosed with febrile seizure, who were treated with Antipyretics. Data were extracted from eight studies. Only one study reported that Antipyretics prevented the recurrence of febrile seizures within the same fever episode (9.1% in the acetaminophen group vs. 23.5% in the control group, p < 0.01). Four studies found no evidence for the efficacy of Antipyretics in preventing febrile seizure recurrence in distant fever episodes (odds ratio, 0.92; 95% confidence interval, 0.57-1.48, for two randomized controlled studies).Conclusion: This review provides very limited support for the use of Antipyretics in preventing febrile seizure recurrence within the same fever episode and no evidence for its use in distant fever episodes. New studies are required to evaluate this topic further and determine whether the effectiveness of Antipyretics is based on intervention timing. What is Known: • Reviews of prophylactic drug management among febrile seizure children found that Antipyretics had no significant benefits. • Recent data suggest that Antipyretics are effective in preventing febrile seizures. What is New: • Weak evidence suggests a possible role in preventing febrile seizure recurrence within the same fever episode. • There is clearly no role for antipyretic prophylaxis in preventing febrile seizures during distant fever episodes.