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Andrea R. Guastalli – One of the best experts on this subject based on the ideXlab platform.

  • Osmolarity and root canal Antiseptics
    International Endodontic Journal, 2013
    Co-Authors: Giampiero Rossi-fedele, Andrea R. Guastalli

    Abstract:

    Abstract Rossi-Fedele G , Guastalli AR. Osmolarity and root canalAntiseptics. International Endodontic Journal, 47, 314–320,2014. Antiseptics used in endodontics for disinfection pur-poses include root canal dressings and irrigants.Osmotic shock is known to cause the alteration ofmicrobial cell viability and might have a role in themechanism of action of root canal Antiseptics. Theaim of this review was to determine the role of osmo-larity on the performance of Antiseptics in root canaltreatment. A literature search using the Medline elec-tronic database was conducted up to 30 May 2013using the following search terms and combinations:‘osmolarity AND root canal or endodontic or antisep-tic or irrigation or irrigant or medication or dressingor biofilm; osmolality AND root canal or endodonticor antiseptic or irrigation or irrigant or medication ordressing or biofilm; osmotic AND root canal or end-odontic or antiseptic or irrigation or irrigant or medi-cation or dressing or biofilm; osmosis AND root canalor endodontic or antiseptic or irrigation or irrigant ormedication or dressing or biofilm; sodium chlorideAND root canal or endodontic or antiseptic orirrigation or irrigant or medication or dressing or bio-film’. Publications were included if the effects of osmo-larity on the clinical performance of Antiseptics inroot canal treatment were stated, if preparations withdifferent osmolarities values were compared and ifthey were published in English. A hand search of arti-cles published online, ‘in press’ and ‘early view’, andin the reference list of the included papers was carriedout following the same criteria. A total of 3274 publi-cations were identified using the database, and threewere included in the review. The evidence availablein endodontics suggests a possible role for hyper-osmotic root canal medicaments as disinfectants, andthat there is no influence of osmolarity on the tissuedissolution capacity of sodium hypochlorite. There areinsufficient data to obtain a sound conclusion regard-ing the role of hypo-osmosis in root canal disinfection,or osmosis in any further desirable ability.Keywords: Antiseptics, osmolarity, osmotic shock,root canal irrigant, root canal medicament, sodiumhypochlorite.

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  • Osmolarity and root canal Antiseptics
    International endodontic journal, 2013
    Co-Authors: Giampiero Rossi-fedele, Andrea R. Guastalli

    Abstract:

    Antiseptics used in endodontics for disinfection purposes include root canal dressings and irrigants. Osmotic shock is known to cause the alteration of microbial cell viability and might have a role in the mechanism of action of root canal Antiseptics. The aim of this review was to determine the role of osmolarity on the performance of Antiseptics in root canal treatment. A literature search using the Medline electronic database was conducted up to 30 May 2013 using the following search terms and combinations: ‘osmolarity AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmolality AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmotic AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmosis AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; sodium chloride AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm’. Publications were included if the effects of osmolarity on the clinical performance of Antiseptics in root canal treatment were stated, if preparations with different osmolarities values were compared and if they were published in English. A hand search of articles published online, ‘in press’ and ‘early view’, and in the reference list of the included papers was carried out following the same criteria. A total of 3274 publications were identified using the database, and three were included in the review. The evidence available in endodontics suggests a possible role for hyperosmotic root canal medicaments as disinfectants, and that there is no influence of osmolarity on the tissue dissolution capacity of sodium hypochlorite. There are insufficient data to obtain a sound conclusion regarding the role of hypo-osmosis in root canal disinfection, or osmosis in any further desirable ability.

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Giampiero Rossi-fedele – One of the best experts on this subject based on the ideXlab platform.

  • Osmolarity and root canal Antiseptics
    International Endodontic Journal, 2013
    Co-Authors: Giampiero Rossi-fedele, Andrea R. Guastalli

    Abstract:

    Abstract Rossi-Fedele G , Guastalli AR. Osmolarity and root canalAntiseptics. International Endodontic Journal, 47, 314–320,2014. Antiseptics used in endodontics for disinfection pur-poses include root canal dressings and irrigants.Osmotic shock is known to cause the alteration ofmicrobial cell viability and might have a role in themechanism of action of root canal Antiseptics. Theaim of this review was to determine the role of osmo-larity on the performance of Antiseptics in root canaltreatment. A literature search using the Medline elec-tronic database was conducted up to 30 May 2013using the following search terms and combinations:‘osmolarity AND root canal or endodontic or antisep-tic or irrigation or irrigant or medication or dressingor biofilm; osmolality AND root canal or endodonticor antiseptic or irrigation or irrigant or medication ordressing or biofilm; osmotic AND root canal or end-odontic or antiseptic or irrigation or irrigant or medi-cation or dressing or biofilm; osmosis AND root canalor endodontic or antiseptic or irrigation or irrigant ormedication or dressing or biofilm; sodium chlorideAND root canal or endodontic or antiseptic orirrigation or irrigant or medication or dressing or bio-film’. Publications were included if the effects of osmo-larity on the clinical performance of Antiseptics inroot canal treatment were stated, if preparations withdifferent osmolarities values were compared and ifthey were published in English. A hand search of arti-cles published online, ‘in press’ and ‘early view’, andin the reference list of the included papers was carriedout following the same criteria. A total of 3274 publi-cations were identified using the database, and threewere included in the review. The evidence availablein endodontics suggests a possible role for hyper-osmotic root canal medicaments as disinfectants, andthat there is no influence of osmolarity on the tissuedissolution capacity of sodium hypochlorite. There areinsufficient data to obtain a sound conclusion regard-ing the role of hypo-osmosis in root canal disinfection,or osmosis in any further desirable ability.Keywords: Antiseptics, osmolarity, osmotic shock,root canal irrigant, root canal medicament, sodiumhypochlorite.

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  • Osmolarity and root canal Antiseptics
    International endodontic journal, 2013
    Co-Authors: Giampiero Rossi-fedele, Andrea R. Guastalli

    Abstract:

    Antiseptics used in endodontics for disinfection purposes include root canal dressings and irrigants. Osmotic shock is known to cause the alteration of microbial cell viability and might have a role in the mechanism of action of root canal Antiseptics. The aim of this review was to determine the role of osmolarity on the performance of Antiseptics in root canal treatment. A literature search using the Medline electronic database was conducted up to 30 May 2013 using the following search terms and combinations: ‘osmolarity AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmolality AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmotic AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmosis AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; sodium chloride AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm’. Publications were included if the effects of osmolarity on the clinical performance of Antiseptics in root canal treatment were stated, if preparations with different osmolarities values were compared and if they were published in English. A hand search of articles published online, ‘in press’ and ‘early view’, and in the reference list of the included papers was carried out following the same criteria. A total of 3274 publications were identified using the database, and three were included in the review. The evidence available in endodontics suggests a possible role for hyperosmotic root canal medicaments as disinfectants, and that there is no influence of osmolarity on the tissue dissolution capacity of sodium hypochlorite. There are insufficient data to obtain a sound conclusion regarding the role of hypo-osmosis in root canal disinfection, or osmosis in any further desirable ability.

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Brigitte Milpied – One of the best experts on this subject based on the ideXlab platform.

  • allergic contact reaction to Antiseptics in very young children
    Journal of The European Academy of Dermatology and Venereology, 2018
    Co-Authors: A S Darrigade, C Leautelabreze, F Boralevi, A Taieb, Brigitte Milpied

    Abstract:

    BACKGROUND: Contact dermatitis from topical antiseptic use has been reported mostly in adults, but rare cases of chlorhexidine contact dermatitis have also been described in young children. OBJECTIVE: To evaluate contact allergic dermatitis to Antiseptics in young children. METHODS: The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an Antiseptics series and the personal topical products used. RESULTS: Fourteen children (8 boys, 6 girls) received a diagnosis of contact dermatitis to Antiseptics between May 2010 and December 2017. The mean age at diagnosis was 38 months (8 months to 8 years); three children only had a personal history of atopy. Chlorhexidine gluconate was positive in seven cases, and benzalkonium chloride in eight cases, and in four cases, both allergens were positive. CONCLUSION: These small case series confirm that both chlorhexidine and benzalkonium chloride are implicated in contact dermatitis from antiseptic use in the paediatric population. We emphasize the initial misdiagnose of these patients, the very young age of the children and the allergenic potential of common Antiseptics in non-atopic children. We hypothesize that the systematic use of Antiseptics for umbilical cord care could be responsible for the sensitization in newborns.

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  • allergic contact reaction to Antiseptics in very young children
    Journal of The European Academy of Dermatology and Venereology, 2018
    Co-Authors: A S Darrigade, C Leautelabreze, F Boralevi, A Taieb, Brigitte Milpied

    Abstract:

    BACKGROUND Contact dermatitis from topical antiseptic use has been reported mostly in adults, but rare cases of chlorhexidine contact dermatitis have also been described in young children. OBJECTIVE To evaluate contact allergic dermatitis to Antiseptics in young children. METHODS The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an Antiseptics series and the personal topical products used. RESULTS Fourteen children (8 boys, 6 girls) received a diagnosis of contact dermatitis to Antiseptics between May 2010 and December 2017. The mean age at diagnosis was 38 months (8 months to 8 years); three children only had a personal history of atopy. Chlorhexidine gluconate was positive in seven cases, and benzalkonium chloride in eight cases, and in four cases, both allergens were positive. CONCLUSION These small case series confirm that both chlorhexidine and benzalkonium chloride are implicated in contact dermatitis from antiseptic use in the paediatric population. We emphasize the initial misdiagnose of these patients, the very young age of the children and the allergenic potential of common Antiseptics in non-atopic children. We hypothesize that the systematic use of Antiseptics for umbilical cord care could be responsible for the sensitization in newborns.

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