The Experts below are selected from a list of 39909 Experts worldwide ranked by ideXlab platform
Andrea R. Guastalli - One of the best experts on this subject based on the ideXlab platform.
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Osmolarity and root canal Antiseptics
International Endodontic Journal, 2013Co-Authors: Giampiero Rossi-fedele, Andrea R. GuastalliAbstract:Abstract Rossi-Fedele G , Guastalli AR. Osmolarity and root canalAntiseptics. International Endodontic Journal, 47, 314–320,2014. Antiseptics used in endodontics for disinfection pur-poses include root canal dressings and irrigants.Osmotic shock is known to cause the alteration ofmicrobial cell viability and might have a role in themechanism of action of root canal Antiseptics. Theaim of this review was to determine the role of osmo-larity on the performance of Antiseptics in root canaltreatment. A literature search using the Medline elec-tronic database was conducted up to 30 May 2013using the following search terms and combinations:‘osmolarity AND root canal or endodontic or antisep-tic or irrigation or irrigant or medication or dressingor biofilm; osmolality AND root canal or endodonticor antiseptic or irrigation or irrigant or medication ordressing or biofilm; osmotic AND root canal or end-odontic or antiseptic or irrigation or irrigant or medi-cation or dressing or biofilm; osmosis AND root canalor endodontic or antiseptic or irrigation or irrigant ormedication or dressing or biofilm; sodium chlorideAND root canal or endodontic or antiseptic orirrigation or irrigant or medication or dressing or bio-film’. Publications were included if the effects of osmo-larity on the clinical performance of Antiseptics inroot canal treatment were stated, if preparations withdifferent osmolarities values were compared and ifthey were published in English. A hand search of arti-cles published online, ‘in press’ and ‘early view’, andin the reference list of the included papers was carriedout following the same criteria. A total of 3274 publi-cations were identified using the database, and threewere included in the review. The evidence availablein endodontics suggests a possible role for hyper-osmotic root canal medicaments as disinfectants, andthat there is no influence of osmolarity on the tissuedissolution capacity of sodium hypochlorite. There areinsufficient data to obtain a sound conclusion regard-ing the role of hypo-osmosis in root canal disinfection,or osmosis in any further desirable ability.Keywords: Antiseptics, osmolarity, osmotic shock,root canal irrigant, root canal medicament, sodiumhypochlorite.
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Osmolarity and root canal Antiseptics
International endodontic journal, 2013Co-Authors: Giampiero Rossi-fedele, Andrea R. GuastalliAbstract:Antiseptics used in endodontics for disinfection purposes include root canal dressings and irrigants. Osmotic shock is known to cause the alteration of microbial cell viability and might have a role in the mechanism of action of root canal Antiseptics. The aim of this review was to determine the role of osmolarity on the performance of Antiseptics in root canal treatment. A literature search using the Medline electronic database was conducted up to 30 May 2013 using the following search terms and combinations: 'osmolarity AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmolality AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmotic AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmosis AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; sodium chloride AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm'. Publications were included if the effects of osmolarity on the clinical performance of Antiseptics in root canal treatment were stated, if preparations with different osmolarities values were compared and if they were published in English. A hand search of articles published online, 'in press' and 'early view', and in the reference list of the included papers was carried out following the same criteria. A total of 3274 publications were identified using the database, and three were included in the review. The evidence available in endodontics suggests a possible role for hyperosmotic root canal medicaments as disinfectants, and that there is no influence of osmolarity on the tissue dissolution capacity of sodium hypochlorite. There are insufficient data to obtain a sound conclusion regarding the role of hypo-osmosis in root canal disinfection, or osmosis in any further desirable ability.
Giampiero Rossi-fedele - One of the best experts on this subject based on the ideXlab platform.
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Osmolarity and root canal Antiseptics
International Endodontic Journal, 2013Co-Authors: Giampiero Rossi-fedele, Andrea R. GuastalliAbstract:Abstract Rossi-Fedele G , Guastalli AR. Osmolarity and root canalAntiseptics. International Endodontic Journal, 47, 314–320,2014. Antiseptics used in endodontics for disinfection pur-poses include root canal dressings and irrigants.Osmotic shock is known to cause the alteration ofmicrobial cell viability and might have a role in themechanism of action of root canal Antiseptics. Theaim of this review was to determine the role of osmo-larity on the performance of Antiseptics in root canaltreatment. A literature search using the Medline elec-tronic database was conducted up to 30 May 2013using the following search terms and combinations:‘osmolarity AND root canal or endodontic or antisep-tic or irrigation or irrigant or medication or dressingor biofilm; osmolality AND root canal or endodonticor antiseptic or irrigation or irrigant or medication ordressing or biofilm; osmotic AND root canal or end-odontic or antiseptic or irrigation or irrigant or medi-cation or dressing or biofilm; osmosis AND root canalor endodontic or antiseptic or irrigation or irrigant ormedication or dressing or biofilm; sodium chlorideAND root canal or endodontic or antiseptic orirrigation or irrigant or medication or dressing or bio-film’. Publications were included if the effects of osmo-larity on the clinical performance of Antiseptics inroot canal treatment were stated, if preparations withdifferent osmolarities values were compared and ifthey were published in English. A hand search of arti-cles published online, ‘in press’ and ‘early view’, andin the reference list of the included papers was carriedout following the same criteria. A total of 3274 publi-cations were identified using the database, and threewere included in the review. The evidence availablein endodontics suggests a possible role for hyper-osmotic root canal medicaments as disinfectants, andthat there is no influence of osmolarity on the tissuedissolution capacity of sodium hypochlorite. There areinsufficient data to obtain a sound conclusion regard-ing the role of hypo-osmosis in root canal disinfection,or osmosis in any further desirable ability.Keywords: Antiseptics, osmolarity, osmotic shock,root canal irrigant, root canal medicament, sodiumhypochlorite.
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Osmolarity and root canal Antiseptics
International endodontic journal, 2013Co-Authors: Giampiero Rossi-fedele, Andrea R. GuastalliAbstract:Antiseptics used in endodontics for disinfection purposes include root canal dressings and irrigants. Osmotic shock is known to cause the alteration of microbial cell viability and might have a role in the mechanism of action of root canal Antiseptics. The aim of this review was to determine the role of osmolarity on the performance of Antiseptics in root canal treatment. A literature search using the Medline electronic database was conducted up to 30 May 2013 using the following search terms and combinations: 'osmolarity AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmolality AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmotic AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; osmosis AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm; sodium chloride AND root canal or endodontic or antiseptic or irrigation or irrigant or medication or dressing or biofilm'. Publications were included if the effects of osmolarity on the clinical performance of Antiseptics in root canal treatment were stated, if preparations with different osmolarities values were compared and if they were published in English. A hand search of articles published online, 'in press' and 'early view', and in the reference list of the included papers was carried out following the same criteria. A total of 3274 publications were identified using the database, and three were included in the review. The evidence available in endodontics suggests a possible role for hyperosmotic root canal medicaments as disinfectants, and that there is no influence of osmolarity on the tissue dissolution capacity of sodium hypochlorite. There are insufficient data to obtain a sound conclusion regarding the role of hypo-osmosis in root canal disinfection, or osmosis in any further desirable ability.
Brigitte Milpied - One of the best experts on this subject based on the ideXlab platform.
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allergic contact reaction to Antiseptics in very young children
Journal of The European Academy of Dermatology and Venereology, 2018Co-Authors: A S Darrigade, C Leautelabreze, F Boralevi, A Taieb, Brigitte MilpiedAbstract:BACKGROUND: Contact dermatitis from topical antiseptic use has been reported mostly in adults, but rare cases of chlorhexidine contact dermatitis have also been described in young children. OBJECTIVE: To evaluate contact allergic dermatitis to Antiseptics in young children. METHODS: The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an Antiseptics series and the personal topical products used. RESULTS: Fourteen children (8 boys, 6 girls) received a diagnosis of contact dermatitis to Antiseptics between May 2010 and December 2017. The mean age at diagnosis was 38 months (8 months to 8 years); three children only had a personal history of atopy. Chlorhexidine gluconate was positive in seven cases, and benzalkonium chloride in eight cases, and in four cases, both allergens were positive. CONCLUSION: These small case series confirm that both chlorhexidine and benzalkonium chloride are implicated in contact dermatitis from antiseptic use in the paediatric population. We emphasize the initial misdiagnose of these patients, the very young age of the children and the allergenic potential of common Antiseptics in non-atopic children. We hypothesize that the systematic use of Antiseptics for umbilical cord care could be responsible for the sensitization in newborns.
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allergic contact reaction to Antiseptics in very young children
Journal of The European Academy of Dermatology and Venereology, 2018Co-Authors: A S Darrigade, C Leautelabreze, F Boralevi, A Taieb, Brigitte MilpiedAbstract:BACKGROUND Contact dermatitis from topical antiseptic use has been reported mostly in adults, but rare cases of chlorhexidine contact dermatitis have also been described in young children. OBJECTIVE To evaluate contact allergic dermatitis to Antiseptics in young children. METHODS The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an Antiseptics series and the personal topical products used. RESULTS Fourteen children (8 boys, 6 girls) received a diagnosis of contact dermatitis to Antiseptics between May 2010 and December 2017. The mean age at diagnosis was 38 months (8 months to 8 years); three children only had a personal history of atopy. Chlorhexidine gluconate was positive in seven cases, and benzalkonium chloride in eight cases, and in four cases, both allergens were positive. CONCLUSION These small case series confirm that both chlorhexidine and benzalkonium chloride are implicated in contact dermatitis from antiseptic use in the paediatric population. We emphasize the initial misdiagnose of these patients, the very young age of the children and the allergenic potential of common Antiseptics in non-atopic children. We hypothesize that the systematic use of Antiseptics for umbilical cord care could be responsible for the sensitization in newborns.
A S Darrigade - One of the best experts on this subject based on the ideXlab platform.
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allergic contact reaction to Antiseptics in very young children
Journal of The European Academy of Dermatology and Venereology, 2018Co-Authors: A S Darrigade, C Leautelabreze, F Boralevi, A Taieb, Brigitte MilpiedAbstract:BACKGROUND: Contact dermatitis from topical antiseptic use has been reported mostly in adults, but rare cases of chlorhexidine contact dermatitis have also been described in young children. OBJECTIVE: To evaluate contact allergic dermatitis to Antiseptics in young children. METHODS: The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an Antiseptics series and the personal topical products used. RESULTS: Fourteen children (8 boys, 6 girls) received a diagnosis of contact dermatitis to Antiseptics between May 2010 and December 2017. The mean age at diagnosis was 38 months (8 months to 8 years); three children only had a personal history of atopy. Chlorhexidine gluconate was positive in seven cases, and benzalkonium chloride in eight cases, and in four cases, both allergens were positive. CONCLUSION: These small case series confirm that both chlorhexidine and benzalkonium chloride are implicated in contact dermatitis from antiseptic use in the paediatric population. We emphasize the initial misdiagnose of these patients, the very young age of the children and the allergenic potential of common Antiseptics in non-atopic children. We hypothesize that the systematic use of Antiseptics for umbilical cord care could be responsible for the sensitization in newborns.
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allergic contact reaction to Antiseptics in very young children
Journal of The European Academy of Dermatology and Venereology, 2018Co-Authors: A S Darrigade, C Leautelabreze, F Boralevi, A Taieb, Brigitte MilpiedAbstract:BACKGROUND Contact dermatitis from topical antiseptic use has been reported mostly in adults, but rare cases of chlorhexidine contact dermatitis have also been described in young children. OBJECTIVE To evaluate contact allergic dermatitis to Antiseptics in young children. METHODS The children mostly referred for a misdiagnose (cellulitis) were patch tested with a selection of the European baseline series, an Antiseptics series and the personal topical products used. RESULTS Fourteen children (8 boys, 6 girls) received a diagnosis of contact dermatitis to Antiseptics between May 2010 and December 2017. The mean age at diagnosis was 38 months (8 months to 8 years); three children only had a personal history of atopy. Chlorhexidine gluconate was positive in seven cases, and benzalkonium chloride in eight cases, and in four cases, both allergens were positive. CONCLUSION These small case series confirm that both chlorhexidine and benzalkonium chloride are implicated in contact dermatitis from antiseptic use in the paediatric population. We emphasize the initial misdiagnose of these patients, the very young age of the children and the allergenic potential of common Antiseptics in non-atopic children. We hypothesize that the systematic use of Antiseptics for umbilical cord care could be responsible for the sensitization in newborns.
Lars Steinstraesser - One of the best experts on this subject based on the ideXlab platform.
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evaluation of toxic side effects of clinically used skin Antiseptics in vitro
Journal of Surgical Research, 2010Co-Authors: Tobias Hirsch, Andreas Koerber, Frank Jacobsen, Joachim Dissemond, H U Steinau, Soren Gatermann, Sammy Albenna, Marco R Kesting, Hansmartin Seipp, Lars SteinstraesserAbstract:Background. Skin Antiseptics are widely used in health-care worldwide. However, there is a need to determine cytotoxicity of these medications on wounds. The aim of this study was to evaluate cytotoxic effects of five clinically used Antiseptics on human skin cells. Material and Methods. Five clinically used skin Antiseptics (Prontosan, Lavasept, Braunol, Octenisept, and Betaisodona) were tested. The minimal inhibitory concentration was determined against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli). The cytotoxic effects on primary keratinocytes, fibroblasts, and a HaCaT cell line were determined (MTT-assay and BrdU-ELISA) at a wide range of concentrations. Results. The agents tested showed effective antibacterial properties (Octenisept, Lavasept, and Prontosan showed higher efficacy than Braunoland Betaisodona) and different degrees of cytotoxicity. Lavasept and Prontosan demonstrated less toxicity on primary human fibroblasts and keratinocytes, whereas Octenisept, Betaisodona, and Braunol showed a significant (P <0.05) decrease in cell viability to 0% on keratinocytes at concentrations of 4%, 7.5%, and 12.5%, and on fibroblasts at 7.5% and 10%, respectively. Conclusion. Due to the cytotoxic effect of some Antiseptics on human skin cells, it is advised that health care professionals balance the cytotoxicity of the medication, their antiseptic properties, and the severity of colonization when selecting a wound care antiseptic. In this study, Lavasept and Prontosan showed
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Antiseptics in surgery.
Eplasty, 2010Co-Authors: Tobias Hirsch, Frank Jacobsen, Hansmartin Seipp, Ole Goertz, Hans-ulrich Steinau, Lars SteinstraesserAbstract:Surgeons are constantly challenged to find the optimal treatment of difficult-to-heal wounds, such as chronic ulcers, trauma-induced wounds, and deep burns. Open wounds, particularly in diabetic and immunosuppressed patients, are susceptible to invading pathogens such as bacteria. Chronic wounds present an attractive environment for bacterial infection, and more than 80% of leg ulcers are colonized by bacteria.1,2 Bacterial colonization is associated with delayed wound healing and causes severe morbidity from sepsis and multiorgan failure.3,4 In the United States, delayed wound healing and bacterial infection due to diabetes are the leading causes of nontraumatic amputations (approximately 71,000 per year or 190 per day).5,6 At present, Staphylococcus aureus is the most common single isolate in chronic wounds (76% in foot ulcers) leading to impaired wound healing.7 Methicillin-resistant S aureus (MRSA) has become endemic in some hospitals,8 and in 2002, the first clinical isolate of vancomycin-resistant S aureus was identified in a diabetic patient with a foot ulcer.7,9 Primary strategies used to prevent and treat wound infection include systemic antibiotics and topical Antiseptics/antibiotics. Insufficient accumulation in the soft tissue is still a major limitation of systemic antibiotics. Furthermore, systemic antibiotics struggle with increasing bacterial resistance and wound colonization with multiresistant strains.3,8 Thus, their clinical employment remains controversial.10 Topical Antiseptics therefore play a key role for the treatment of wounds in current clinical practice. The philosophy behind local delivery of skin Antiseptics is to raise tissue levels of antimicrobials to a level where sensitive and relatively insensitive organisms are inhibited and to avoid potential systemic side effects of high-dose antibiotics. The first modern, chemically derived antiseptic agent was discovered by Friedlieb Ferdinand Runge in 1834, describing the structure and properties of carbolic acid (phenol).11 A further monumental advance toward the improvement of wound-healing outcome came from the work of Joseph Lister. The famous surgeon was the first to employ this striking agent in March 1865 in a complicated case of tibia fracture.12,13 In 1867, he described his technique for the use of carbolic acid spray for surgical antisepsis and direct prophylaxis of high-risk wounds.12,13 Within approximately 20 years, the aseptic techniques of Semmelweis and surgical antisepsis based on Lister's principles became the standard of care. In 1919, Alexander Fleming stated, “Antiseptics will only exercise a beneficial effect in a septic wound if they possess the property of stimulating or conserving the natural defensive mechanism of the body against infection.”(p. 127) He further proclaimed that in estimating the value of an antiseptic, it is more important to study its effects on tissues than any effects on bacteria.14 Because Antiseptics often have to be applied on human skin and wounds for therapy, it is important to evaluate their efficacy and the possible cytotoxicity. However, this important fact has been neglected in the past and still little is known about the cytotoxicity of clinically used skin Antiseptics to date. Furthermore, compatibility of wound dressings with skin Antiseptics is hardly investigated to date. This fact seems to be alarming since wound dressings present a huge market and these products are used widely by different healthcare professionals.
