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Sandra E. File - One of the best experts on this subject based on the ideXlab platform.
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Unconditioned and conditioned Anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test.
Pharmacology biochemistry and behavior, 2004Co-Authors: Rachel F. Genn, Sonia Tucci, Eva María Marco, M Paz Viveros, Sandra E. FileAbstract:In spite of the addictive properties of cannabinoids, under certain circumstances, they can evoke strong Anxiogenic and aversive responses in humans and in animal tests of anxiety. Effects of different doses of CP 55,940 (10, 20, and 40 μg/kg) were tested in the low-light, familiar (LF) apparatus test condition of the social interaction test. The 40-μg/kg dose of CP 55,940 significantly decreased the time spent in social interaction, indicating an Anxiogenic effect. This dose also had an independent effect of reducing locomotor activity. In rats tested undrugged 24 h after testing with 40 μg/kg, there was a significant Anxiogenic effect, indicating conditioned anxiety. The group of rats injected with 40 μg/kg immediately after the social interaction test showed an unexpected significant anxiolytic effect when tested undrugged 24 h later. In an additional experiment, rats were tested in the high-light, familiar (HF) apparatus test condition after 10 or 40 μg/kg, and only those that were tested after 40 μg/kg showed an Anxiogenic effect on the test day and a conditioned Anxiogenic effect when tested undrugged 24 h later. Once again, those injected with 40 μg/kg after the social interaction test displayed an anxiolytic effect when tested undrugged 24 h later. We provide the first evidence for unconditioned and conditioned Anxiogenic-like responses to a cannabinoid agonist in the social interaction test.
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Do different mechanisms underlie two Anxiogenic effects of systemic nicotine
Behavioural pharmacology, 2003Co-Authors: Sonia Tucci, Rachel F. Genn, Eva María Marco, Sandra E. FileAbstract:α7 Nicotinic acetylcholine receptors (α7 nAChRs) and 5-hydroxytryptamine 1A (5-HT1A) receptors have been implicated in the Anxiogenic effects of centrally administered nicotine, but the receptors that mediate the Anxiogenic effects of systemic nicotine are not known. This study explored whether comp
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Anxiogenic effects of nicotine in the dorsal hippocampus are mediated by 5-HT1A and not by muscarinic M1 receptors.
Neuropharmacology, 2000Co-Authors: Paul J. Kenny, Survjit Cheeta, Sandra E. FileAbstract:After direct administration into the dorsal hippocampus nicotine decreased the time spent in social interaction, without changing locomotor activity, indicating an Anxiogenic effect. The possibility that post-synaptic M1 muscarinic receptors mediated this effect was examined by determining whether dorsal hippocampal administration of a specific M1 receptor agonist (McN-A-343) had Anxiogenic effects, and whether the Anxiogenic effect of nicotine could be reversed by co-administration of the M1 receptor antagonist, pirenzepine. McN-A-343 (0.3, 1.6, 3.2, 15.8 nmol) was without effect on social interaction, and pirenzepine (0.7 and 2.4 nmol) injection into the dorsal hippocampus failed to reverse the decrease in social interaction caused by nicotine (6.3 nmol) injection into this area. However, the decrease in social interaction after nicotine (50 nmol) was completely reversed by the specific 5-HT1A receptor antagonist, WAY 100635 (0.4 nmol) after co-administration of both drugs into the dorsal hippocampus. Thus, the Anxiogenic effect of nicotine in this brain region seems to be mediated by 5-HT1A, but not M1, receptors. In contrast to the effect of nicotine in naive animals, those retested after a second injection of 50 nmol did not show a significant Anxiogenic effect. The theoretical implications of this are discussed and from a practical point of view this suggests caution in the retesting of animals after central injections.
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The role of 5-HT1A receptors in mediating the Anxiogenic effects of nicotine following lateral septal administration.
The European journal of neuroscience, 2000Co-Authors: Survjit Cheeta, Paul J. Kenny, Sandra E. FileAbstract:The purpose of the present study was to determine the role of the 5-HT1A receptors in the lateral septum in the mediation of the Anxiogenic effects of nicotine in the social interaction and elevated plus maze tests of anxiety in the rat. Bilateral infusion of (-)-nicotine (4 and 8 microg) and of the 5-HT1A receptor agonist 8-OH-DPAT (200 and 500 ng) into the lateral septum decreased the time spent in social interaction, indicating Anxiogenic effects. The Anxiogenic effect of 8-OH-DPAT (500 ng) was completely reversed by coadministration of a behaviourally inactive dose of the 5-HT1A receptor antagonist, WAY 100635 (200 ng). The Anxiogenic effect of the lower dose of (-)-nicotine (4 microg) was completely reversed by WAY 100635 (200 ng), but the reversal was only partial following administration of 8 microg nicotine. In a second test of anxiety, the elevated plus maze, lateral septal administration of 8-OH-DPAT (500 ng) and nicotine (4 microg) induced Anxiogenic effects. In this test, the Anxiogenic effect of nicotine (4 microg) was completely reversed by coadministration of WAY 100635 (200 ng). The effects of 8-OH-DPAT demonstrate that stimulation of 5-HT1A receptors in the lateral septum has Anxiogenic effects in two animal tests and that the Anxiogenic effects of nicotine are mediated at least in part by these 5-HT1A receptors.
Rachel F. Genn - One of the best experts on this subject based on the ideXlab platform.
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Unconditioned and conditioned Anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test.
Pharmacology biochemistry and behavior, 2004Co-Authors: Rachel F. Genn, Sonia Tucci, Eva María Marco, M Paz Viveros, Sandra E. FileAbstract:In spite of the addictive properties of cannabinoids, under certain circumstances, they can evoke strong Anxiogenic and aversive responses in humans and in animal tests of anxiety. Effects of different doses of CP 55,940 (10, 20, and 40 μg/kg) were tested in the low-light, familiar (LF) apparatus test condition of the social interaction test. The 40-μg/kg dose of CP 55,940 significantly decreased the time spent in social interaction, indicating an Anxiogenic effect. This dose also had an independent effect of reducing locomotor activity. In rats tested undrugged 24 h after testing with 40 μg/kg, there was a significant Anxiogenic effect, indicating conditioned anxiety. The group of rats injected with 40 μg/kg immediately after the social interaction test showed an unexpected significant anxiolytic effect when tested undrugged 24 h later. In an additional experiment, rats were tested in the high-light, familiar (HF) apparatus test condition after 10 or 40 μg/kg, and only those that were tested after 40 μg/kg showed an Anxiogenic effect on the test day and a conditioned Anxiogenic effect when tested undrugged 24 h later. Once again, those injected with 40 μg/kg after the social interaction test displayed an anxiolytic effect when tested undrugged 24 h later. We provide the first evidence for unconditioned and conditioned Anxiogenic-like responses to a cannabinoid agonist in the social interaction test.
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Do different mechanisms underlie two Anxiogenic effects of systemic nicotine
Behavioural pharmacology, 2003Co-Authors: Sonia Tucci, Rachel F. Genn, Eva María Marco, Sandra E. FileAbstract:α7 Nicotinic acetylcholine receptors (α7 nAChRs) and 5-hydroxytryptamine 1A (5-HT1A) receptors have been implicated in the Anxiogenic effects of centrally administered nicotine, but the receptors that mediate the Anxiogenic effects of systemic nicotine are not known. This study explored whether comp
Adam K. Klein - One of the best experts on this subject based on the ideXlab platform.
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Attenuation of the Anxiogenic effects of cocaine by 5-HT_1B autoreceptor stimulation in the bed nucleus of the stria terminalis of rats
Psychopharmacology, 2017Co-Authors: Adam K. Klein, Michael A. Brito, Sayeh Akhavan, Dylan R. Flanagan, Tatum A. Ohana, Anand S. Patil, Erin M. Purvis, Carl Provenzano, Nikki Le, Lucy ZhouAbstract:Rationale Cocaine produces significant aversive/Anxiogenic actions whose underlying neurobiology remains unclear. A possible substrate contributing to these actions is the serotonergic (5-HT) pathway projecting from the dorsal raphé (DRN) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (BNST) which have been implicated in the production of Anxiogenic states. Objectives The present study examined the contribution of 5-HT signaling within the BNST to the Anxiogenic effects of cocaine as measured in a runway model of drug self-administration. Methods Male Sprague–Dawley rats were fitted with bilateral infusion cannula aimed at the BNST and then trained to traverse a straight alley once a day for a single 1 mg/kg i.v. cocaine infusion delivered upon goal-box entry on each of 16 consecutive days/trials. Intracranial infusions of CP 94,253 (0, 0.25, 0.5, or 1.0 μg/side) were administered to inhibit local 5-HT release via activation of 5-HT_1B autoreceptors. To confirm receptor specificity, the effects of this treatment were then challenged by co-administration of the selective 5-HT_1B antagonist NAS-181. Results Intra-BNST infusions of the 5-HT_1B autoreceptor agonist attenuated the Anxiogenic effects of cocaine as reflected by a decrease in runway approach-avoidance conflict behavior. This effect was reversed by the 5-HT_1B antagonist. Neither start latencies (a measure of the subject’s motivation to seek cocaine) nor spontaneous locomotor activity (an index of motoric capacity) were altered by either treatment. Conclusions Inhibition of 5-HT_1B signaling within the BNST selectively attenuated the Anxiogenic effects of cocaine, while leaving unaffected the positive incentive properties of the drug.
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Attenuation of the Anxiogenic effects of cocaine by 5-HT1B autoreceptor stimulation in the bed nucleus of the stria terminalis of rats.
Psychopharmacology, 2016Co-Authors: Adam K. Klein, Michael A. Brito, Sayeh Akhavan, Dylan R. Flanagan, Tatum A. Ohana, Anand S. Patil, Erin M. Purvis, Carl Provenzano, Alex WeiAbstract:Rationale Cocaine produces significant aversive/Anxiogenic actions whose underlying neurobiology remains unclear. A possible substrate contributing to these actions is the serotonergic (5-HT) pathway projecting from the dorsal raphe (DRN) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (BNST) which have been implicated in the production of Anxiogenic states.
Georges Chapouthier - One of the best experts on this subject based on the ideXlab platform.
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Anxiogenic-like effects of yohimbine and idazoxan in two behavioral situations in mice.
Life sciences, 1993Co-Authors: Patrice Venault, F. Jacquot, E. Save, S. Sara, Georges ChapouthierAbstract:In a light-dark choice situation, the alpha-2 adrenoceptor antagonist idazoxan shows Anxiogenic-like effects, which cannot be blocked by the alpha-2 adrenoceptor agonist clonidine, or by the benzodiazepine receptor antagonist Ro 15-1788. In a conditioned conflict situation, both idazoxan and the alpha-2-adrenoceptor yohimbine show Anxiogenic-like effects; the effect of idazoxan could not be blocked by clonidine or Ro 15-1788. These data suggest that systems other than alpha-2 adrenoceptors or benzodiazepine receptors must be found to explain these Anxiogenic-like properties.
Akbar Hajizadeh Moghaddam - One of the best experts on this subject based on the ideXlab platform.
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Role of Endocannabinoid System in the Ventral Hippocampus of Rats in the Modulation of Anxiety-Like Behaviours
Basic & Clinical Pharmacology & Toxicology, 2009Co-Authors: Ali Roohbakhsh, Parisa Hasanein, Samaneh Keshavarz, Mohammad Ebrahim Rezvani, Akbar Hajizadeh MoghaddamAbstract:The effects of unilateral intra-ventral hippocampus injection of URB597, a fatty acid amid hydrolase inhibitor, and AM251, a selective CB(1) receptor antagonist, on anxiety-related behaviours using elevated plus-maze test of anxiety were evaluated in the present study. Possible involvement of GABAergic system in those effects of URB597 was also evaluated. Injection of URB597 at the doses of 0.01, 0.1 and 1 microg/rat showed significant Anxiogenic-like effects at 0.1 and 1 microg/rat. However, intra-ventral hippocampus injection of AM251 at the doses of 0.001, 0.01 and 0.1 microg/rat did not produce any significant effect in the elevated plus-maze. The ineffective doses of selective GABA(A) receptor antagonist, bicuculline (2 microg/rat) and selective GABA(B) receptor antagonist, phaclofen (1 microg/rat) on anxiety-related behaviours were also injected with URB597 (0.1 microg/rat). The present data showed that neither bicuculline nor phaclofen affected the Anxiogenic-like effects of URB597. The results showed that injection of URB597 into the ventral hippocampus may be Anxiogenic and GABAergic system may not be involved in its Anxiogenic-like effects.