Aortic Intima - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Aortic Intima

The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform

David Burgner – 1st expert on this subject based on the ideXlab platform

  • increased Aortic Intima media thickness following kawasaki disease
    Atherosclerosis, 2017
    Co-Authors: David Burgner, Michael Cheung, Katherine Y H Chen, Diana Zannino, Nigel Curtis

    Abstract:

    Abstract Background and aims The cardiovascular risk following Kawasaki disease (KD), especially in those without coronary artery changes or with regressed coronary artery lesions, is unclear. We assessed markers of early atherosclerosis in individuals following KD, including those with and without coronary artery abnormalities. Methods We performed a cross-sectional case-control study of 60 patients (25 with always normal coronary arteries and 35 with abnormalities) and 60 controls, at least two years after KD. Non-invasive assessment of arterial structure (carotid and Aortic Intima-media thickness (IMT)) and function (pulse wave velocity, carotid artery distensibility and diameter compliance) was done. Analyses were adjusted for traditional cardiovascular risk factors. Results Kawasaki disease patients had increased Aortic IMT compared to controls (0.53 mm (95% CI 0.51–0.56) versus 0.49 (95% CI 0.47–0.52), p  = 0.04), largely driven by those with abnormal coronary arteries. There were no differences in carotid IMT. Kawasaki disease patients with coronary artery abnormalities had reduced carotid distensibility compared to controls (15.16% (95% CI 13.67–16.65) versus 17.50 (95% CI 16.43–18.58), p  = 0.02). Conclusions Patients with KD have increased Aortic IMT and reduced carotid distensibility, indicating heightened cardiovascular risk, especially in those with coronary artery abnormalities. In our study, we used validated surrogates for cardiovascular disease risk. Our findings, therefore, warrant follow-up investigations in KD patients.

  • inflammation lipids and Aortic Intima media thickness in newborns following chorioamnionitis
    Acta Paediatrica, 2016
    Co-Authors: Anthony R Rafferty, Michael Cheung, Lorraine Mcgrory, Sheryle Rogerson, Diana Ziannino, Jan Pyman, Peter G Davis, David Burgner

    Abstract:

    AIM: This study investigated whether chorioamnionitis was associated with increased inflammation, dyslipidaemia and adverse cardiovascular phenotypes in the immediate postnatal period. METHODS: This prospective case-control study included preterm infants (30(+0) -35(+6) weeks gestational age, GA) whose mothers did not have pregnancy-related conditions that may influence outcomes. Chorioamnionitis was diagnosed by placental histology, and infants were divided retrospectively into cases (chorioamnionitis-exposed) and controls (unexposed). Serum high-sensitivity C-reactive protein (hsCRP), lipid profile, far-wall abdominal Aortic Intima-media thickness (aIMT) and blood pressure (BP) were measured in the first week of life. RESULTS: There were 20 (16 male, mean GA 32.4 weeks) cases and 31 (12 male, mean GA 32.6 weeks) controls. Histological chorioamnionitis was associated with a significant increase in hsCRP and a non-significant trend towards an adverse lipid profile. There was no evidence of differences in aIMT or BP. CONCLUSION: Preterm infants exposed to chorioamnionitis have greater postnatal inflammation. There were no early postnatal differences in aIMT or BP. The inflammatory stimulus of chorioamnionitis late in gestation may be of insufficient intensity and duration to result in immediate postnatal alterations to arterial structure. Cardiovascular follow-up of infants exposed to chorioamnionitis may identify differential risk trajectories and subsequent inflammatory responses.

  • Aortic Intima media thickness measured by trans abdominal ultrasound as an early life marker of subclinical atherosclerosis
    Acta Paediatrica, 2014
    Co-Authors: Michael R Skilton, Kate Mccloskey, Peter Vuillermin, Annelouise Ponsonby, Michael Cheung, David Burgner

    Abstract:

    UNLABELLED: Atherosclerosis is a chronic inflammatory process that begins in early life. Improved identification of markers of early atherosclerosis via neonatal Aortic Intima-media thickness (aIMT) measurement may allow the development of interventions to prevent or reduce later cardiovascular disease. CONCLUSION: Using aIMT, studies have shown that antenatal factors such as intra-uterine growth retardation, prematurity, maternal factors and inflammation are associated with early cardiovascular changes.

Michael Cheung – 2nd expert on this subject based on the ideXlab platform

  • increased Aortic Intima media thickness following kawasaki disease
    Atherosclerosis, 2017
    Co-Authors: David Burgner, Michael Cheung, Katherine Y H Chen, Diana Zannino, Nigel Curtis

    Abstract:

    Abstract Background and aims The cardiovascular risk following Kawasaki disease (KD), especially in those without coronary artery changes or with regressed coronary artery lesions, is unclear. We assessed markers of early atherosclerosis in individuals following KD, including those with and without coronary artery abnormalities. Methods We performed a cross-sectional case-control study of 60 patients (25 with always normal coronary arteries and 35 with abnormalities) and 60 controls, at least two years after KD. Non-invasive assessment of arterial structure (carotid and Aortic Intima-media thickness (IMT)) and function (pulse wave velocity, carotid artery distensibility and diameter compliance) was done. Analyses were adjusted for traditional cardiovascular risk factors. Results Kawasaki disease patients had increased Aortic IMT compared to controls (0.53 mm (95% CI 0.51–0.56) versus 0.49 (95% CI 0.47–0.52), p  = 0.04), largely driven by those with abnormal coronary arteries. There were no differences in carotid IMT. Kawasaki disease patients with coronary artery abnormalities had reduced carotid distensibility compared to controls (15.16% (95% CI 13.67–16.65) versus 17.50 (95% CI 16.43–18.58), p  = 0.02). Conclusions Patients with KD have increased Aortic IMT and reduced carotid distensibility, indicating heightened cardiovascular risk, especially in those with coronary artery abnormalities. In our study, we used validated surrogates for cardiovascular disease risk. Our findings, therefore, warrant follow-up investigations in KD patients.

  • perinatal microbial exposure may influence Aortic Intima media thickness in early infancy
    International Journal of Epidemiology, 2017
    Co-Authors: Kate Mccloskey, Peter Vuillermin, Michael Cheung, John B Carlin

    Abstract:

    Background: The maternal and infant microbiome may influence infant cardiovascular risk through immune programming. The maternal vagino-enteric microbiome is often sampled for group B streptococcus (GBS) colonization during pregnancy. Our aim was to investigate the association between maternal GBS colonization, intrapartum antibiotics, antenatal pet exposure and infant Aortic Intima-media thickness (aIMT), an intermediate vascular phenotype, and whether this association varied by mode of delivery. Methods: The Barwon Infant Study is a population-derived pre-birth cohort. Perinatal data were collected on participants. Women were tested for vagino-enteric group B streptococcus (GBS) colonization during third trimester. Six-week infant aIMT was measured by trans-abdominal ultrasound. Adjustment for confounders included maternal age, pre-pregnancy body mass index (BMI), smoking, socioeconomic status, gestational diabetes, length of gestation, infant sex, birthweight and Aortic internal diameter. Results: Data were available on 835 mother-infant pairs. Of these, 574 (69%) women delivered vaginally; of those, 129 (22%) were GBS-colonized; and of these women, 111 (86%) received prophylactic intrapartum antibiotics. An association between maternal GBS colonization and infant aIMT was observed among those delivered vaginally (β = 19.5 µm, 95% CI 9.5, 29.4; P  < 0.0001) but not by Caesarean section ( P for interaction = 0.02). A similar pattern was seen for intrapartum antibiotics. There was a negative association between antenatal pet exposure and aIMT observed in those delivered vaginally. Conclusion: Maternal GBS colonization and intrapartum antibiotics were associated with increased infant aIMT in those delivered vaginally, whereas antenatal pet exposure was associated with decreased aIMT. These data suggest that differences in early life microbial experience may contribute to an increased cardiovascular risk.

  • inflammation lipids and Aortic Intima media thickness in newborns following chorioamnionitis
    Acta Paediatrica, 2016
    Co-Authors: Anthony R Rafferty, Michael Cheung, Lorraine Mcgrory, Sheryle Rogerson, Diana Ziannino, Jan Pyman, Peter G Davis, David Burgner

    Abstract:

    AIM: This study investigated whether chorioamnionitis was associated with increased inflammation, dyslipidaemia and adverse cardiovascular phenotypes in the immediate postnatal period. METHODS: This prospective case-control study included preterm infants (30(+0) -35(+6) weeks gestational age, GA) whose mothers did not have pregnancy-related conditions that may influence outcomes. Chorioamnionitis was diagnosed by placental histology, and infants were divided retrospectively into cases (chorioamnionitis-exposed) and controls (unexposed). Serum high-sensitivity C-reactive protein (hsCRP), lipid profile, far-wall abdominal Aortic Intima-media thickness (aIMT) and blood pressure (BP) were measured in the first week of life. RESULTS: There were 20 (16 male, mean GA 32.4 weeks) cases and 31 (12 male, mean GA 32.6 weeks) controls. Histological chorioamnionitis was associated with a significant increase in hsCRP and a non-significant trend towards an adverse lipid profile. There was no evidence of differences in aIMT or BP. CONCLUSION: Preterm infants exposed to chorioamnionitis have greater postnatal inflammation. There were no early postnatal differences in aIMT or BP. The inflammatory stimulus of chorioamnionitis late in gestation may be of insufficient intensity and duration to result in immediate postnatal alterations to arterial structure. Cardiovascular follow-up of infants exposed to chorioamnionitis may identify differential risk trajectories and subsequent inflammatory responses.

Kate Mccloskey – 3rd expert on this subject based on the ideXlab platform

  • perinatal microbial exposure may influence Aortic Intima media thickness in early infancy
    International Journal of Epidemiology, 2017
    Co-Authors: Kate Mccloskey, Peter Vuillermin, Michael Cheung, John B Carlin

    Abstract:

    Background: The maternal and infant microbiome may influence infant cardiovascular risk through immune programming. The maternal vagino-enteric microbiome is often sampled for group B streptococcus (GBS) colonization during pregnancy. Our aim was to investigate the association between maternal GBS colonization, intrapartum antibiotics, antenatal pet exposure and infant Aortic Intima-media thickness (aIMT), an intermediate vascular phenotype, and whether this association varied by mode of delivery. Methods: The Barwon Infant Study is a population-derived pre-birth cohort. Perinatal data were collected on participants. Women were tested for vagino-enteric group B streptococcus (GBS) colonization during third trimester. Six-week infant aIMT was measured by trans-abdominal ultrasound. Adjustment for confounders included maternal age, pre-pregnancy body mass index (BMI), smoking, socioeconomic status, gestational diabetes, length of gestation, infant sex, birthweight and Aortic internal diameter. Results: Data were available on 835 mother-infant pairs. Of these, 574 (69%) women delivered vaginally; of those, 129 (22%) were GBS-colonized; and of these women, 111 (86%) received prophylactic intrapartum antibiotics. An association between maternal GBS colonization and infant aIMT was observed among those delivered vaginally (β = 19.5 µm, 95% CI 9.5, 29.4; P  < 0.0001) but not by Caesarean section ( P for interaction = 0.02). A similar pattern was seen for intrapartum antibiotics. There was a negative association between antenatal pet exposure and aIMT observed in those delivered vaginally. Conclusion: Maternal GBS colonization and intrapartum antibiotics were associated with increased infant aIMT in those delivered vaginally, whereas antenatal pet exposure was associated with decreased aIMT. These data suggest that differences in early life microbial experience may contribute to an increased cardiovascular risk.

  • Aortic Intima media thickness measured by trans abdominal ultrasound as an early life marker of subclinical atherosclerosis
    Acta Paediatrica, 2014
    Co-Authors: Michael R Skilton, Kate Mccloskey, Peter Vuillermin, Annelouise Ponsonby, Michael Cheung, David Burgner

    Abstract:

    UNLABELLED: Atherosclerosis is a chronic inflammatory process that begins in early life. Improved identification of markers of early atherosclerosis via neonatal Aortic Intima-media thickness (aIMT) measurement may allow the development of interventions to prevent or reduce later cardiovascular disease. CONCLUSION: Using aIMT, studies have shown that antenatal factors such as intra-uterine growth retardation, prematurity, maternal factors and inflammation are associated with early cardiovascular changes.

  • Aortic Intima‐media thickness measured by trans‐abdominal ultrasound as an early life marker of subclinical atherosclerosis
    Acta Paediatrica, 2013
    Co-Authors: Kate Mccloskey, Michael R Skilton, Peter Vuillermin, Annelouise Ponsonby, Michael Cheung, David Burgner

    Abstract:

    UNLABELLED: Atherosclerosis is a chronic inflammatory process that begins in early life. Improved identification of markers of early atherosclerosis via neonatal Aortic Intima-media thickness (aIMT) measurement may allow the development of interventions to prevent or reduce later cardiovascular disease. CONCLUSION: Using aIMT, studies have shown that antenatal factors such as intra-uterine growth retardation, prematurity, maternal factors and inflammation are associated with early cardiovascular changes.